WEST CHESTER, PA — Centinel Spine®, LLC has announced the findings of a landmark study validating the long-term clinical success of its prodisc L Lumbar Total Disc Replacement (LTDR) technology. Published by The Journal of Bone & Joint Surgery, the research highlights the durability and effectiveness of the device in treating lumbar degenerative disc disease (DDD). The study analyzed outcomes from 1,187 patients who underwent 1- or 2-level LTDR procedures between 1999 and 2013 at Montpellier Spine Institute in France. Patients were followed for an average of nearly 12 years, with some tracked for up to 21 years. The results demonstrated an exceptionally low revision rate of 0.67% and a 1.85% rate of adjacent-level surgery, confirming the system’s ability to preserve spinal mobility and reduce the risk of further surgeries. Outcomes were consistent regardless of whether patients underwent 1- or 2-level LTDR or had prior discectomy surgeries, showcasing the versatility of prodisc L across a broad patient spectrum. “Total disc replacement, and especially the prodisc technology, is a concept we started to develop in the 1980s,” said Dr. Thierry Marnay, inventor of prodisc. “The quality and robustness of this study’s results fundamentally confirm the long-term efficiency and safety of LTDR. There is a direct link between restored, pain-free mobility and improved quality of life.” With more than 125,000 prodisc L devices implanted worldwide and nearly 35 years of clinical use, the technology continues to serve as a proven motion-preserving alternative to fusion. The system is FDA-approved for one-level, two-level, and Anatomic EndplateTM indications, further solidifying its position as a leader in spine care innovation. For the latest news on everything happening in Chester County and the surrounding area, be sure to follow MyChesCo on Google News and MSN .

The Ohtani family’s roster is going to be a little bigger. Dodgers superstar Shohei Ohtani and his wife, Mamiko Tanaka, are expecting their first child together, he shared on his Instagram account Saturday. “Can’t wait for the little rookie to join our family soon!” Ohtani wrote in the caption of his post, which included an image of a covered-up sonogram, a salmon-colored onesie, baby shoes and their beloved dog, Decoy. It has been a whirlwind year-plus for Ohtani, who signed a 10-year, $700 million deal with the Dodgers last December after winning two MVP awards with the Angels. In February, on the eve of the baseball season, Ohtani announced he got married in the offseason . “To all my friends and fans throughout, I have an announcement to make: Not only have I began a new chapter in my career with the Dodgers but I also have began a new life with someone from my Native country of Japan who is very special to me and I wanted everyone to know I am now married,” Ohtani wrote on social media then. It was revealed later that he had tied the knot with Tanaka , a former professional basketball player. On the field, Ohtani’s first season with the Dodgers couldn’t have gone much better as he claimed his third MVP award — and first in the National League — after becoming the first player in MLB history to join the 50-50 club with 50 homers and 50 steals . He capped it off with his first World Series win when his Dodgers beat the Yankees in five games.Interactive Brokers chairman Thomas Peterffy sees a crash as one of the biggest risks that could lead to a stock market decline in 2025. In an interview with last week, Peterffy explained why he is concerned that the stock market could decline in 2025. The problem Petterffy sees is the high levels of leverage coursing through the system. "A downturn is a very big risk because margin balances have been growing very, very quickly," Peterffy said. According to Peterffy, one area that has seen a big spike in margin-based risk-taking is bitcoin, which benefits from low fees on bitcoin futures charged by the CME. "I am very worried that people overextended themselves," Peterffy said. Margin based on the value of their investment account, and use the proceeds to buy more assets. While the strategy can juice returns while the market is rising, a correction could unravel the margin debt strategy if an investor's account falls below a certain threshold. This would force them to exit their positions at a lower price and likely at a loss or add new cash to the account to meet the margin threshold imposed by the brokerage firm. FINRA margin debt hit its highest level since February 2022 in October, at about $815 billion, according to YCharts data. Meanwhile, to add to its bitcoin stash. But if bitcoin saw a sudden and sharp decline, it could unravel the margin debt as investors could be forced to sell their assets to meet margin calls, putting further pressure on prices. "Bitcoin falls say 30, 40, 50% from one day to the next. There would be many bankruptcies, the clearing houses would be unable to pick up the pieces," Peterffy warned. When asked directly about his views on bitcoin, Peterffy admitted he was "scared" by it, adding, "they can go to any price because it's basically just a figment of the imagination, so it doesn't have any underlying value." To limit his firm's exposure to a potential meltdown in cryptocurrencies, Peterffy noted that Interactive Brokers limits its customers from investing more than 10% of their assets directly into bitcoin because he thinks "that would be very dangerous." In a statement to Business Insider, Interactive Brokers confirmed that the platform applies limits to clients' maximum bitcoin exposure. "To ensure cryptocurrencies remain a complement to our core business, we will limit clients from opening cryptocurrency positions above certain thresholds through any IBKR-linked Cryptocurrency Service Providers," Interactive Brokers told Business Insider. Despite Peterffy's concerns surrounding cryptocurrencies, bitcoin has been on a tear, above $107,000. But Peterffy isn't alone in his cautious stance on the world's largest cryptocurrency. In BCA Research strategist Peter Berezin argued that the token is nothing more than a leveraged bet on technology stocks and warned investors that it could crash 57% to $45,000 in 2025. Read the original article on

NEW YORK — If you’re a Blues player, you might check your phone and get a notification that your new head coach has sent you a TikTok. “(If) I see something that when I’m sitting at home reading, or I do like to do TikTok, and I get something that I think relates and connects to our group, I’ll send it out in a text thread,” new Blues coach Jim Montgomery said Monday morning before making his Blues coaching debut in New York. Blues players should know to expect this, of course, since Montgomery did this when he was an assistant coach in St. Louis from 2020-22. His familiarity with the Blues roster is part of the reason why both Montgomery and general manager Doug Armstrong felt he was a good fit back in St. Louis. “He used to send me a lot of motivational stuff, and mindset stuff,” Blues forward Robert Thomas said. “I really enjoyed it. I obviously don’t have TikTok and I can’t watch them anymore, but it was pretty funny and really cool part about our relationship.” Montgomery: “Because to me, even though when I’m at home, I try to be very present with my own family. Your mind when something connects with me emotionally, I’m going to share that. That lets the players know what kind of person I am, and that I’m thinking about them.” Montgomery’s relationship with Blues players was something that was a topic of conversation on his first game day as the St. Louis coach. Of the current 23-man active roster, 14 Blues players were around when Montgomery was an assistant back in 2021-22. That was also the year that Thomas, Jordan Kyrou and Pavel Buchnevich each became point-per-game players for the first time in their careers. “A lot of us give him a lot of credit for taking big steps in our career to him: myself, Buchy, Rouzy,” Thomas said. “He was a big part of getting us to the players we are today. It’s really exciting to be back with him and back on the ice with him today.” What aspects of Thomas’ game did Montgomery help bring out? “A big thing was making the right play at the right time, puck possession, being on the right side of things,” Thomas said. “At times, you can be a little bit more opportunistic and, at times, you need to play into the system. He was a huge help for me, someone that I really relied on a couple years ago. Can’t say enough how excited I am to see him back here.” So many times in recent NHL seasons, the mood is tense after a coach is fired. Most times, the team is underperforming and the coach pays the price with his job. But general manager Doug Armstrong made it clear that Montgomery’s availability — and not the Blues’ 9-12-1 record — was the motivating factor behind the change. “This one does feel different for sure,” Blues captain Brayden Schenn said. “One, because he does know his players. Two, he’s so well-respected in this locker room. Three, when we was here, he got a lot out of a lot of guys, self included. He’s a guy that he’s fun to be around, but at the same time, he’s detailed and smart and guys respect him.” Montgomery will have to sort out how to squeeze more offense out of the Blues, particularly guys like Kyrou and Buchnevich, who Montgomery called “skilled guys that think the game at a high level that compete.” “To me, this is an offensive-slanted team,” Montgomery said. “It just shows you how hard it is to score. We’ve got to get the details and being in the right areas, the hard areas at the right times to be able to score more. But we have the ability to score goals.” The Blues entered Monday’s game in New York 30th in the league scoring 2.36 goals per game. (Montgomery’s former team Boston was last at 2.32.) “He’s detailed and structured, but at the same time, he lets his guys play hockey,” Schenn said. “He wants his creative guys to be creative. He wants his guys to play hard, he wants them to be aggressive, everything within the system. He doesn’t want everyone to play the same. He doesn’t want everyone to be robotic out there. That was kind of his messaging.” Broberg on the ice Blues defenseman Philip Broberg was on the ice for morning skate on Monday, joining the team in New York and on the ice with the Blues for the first time since his lower-body injury on Nov. 2. Broberg is three weeks into a projected 4-6 week timetable, but did not participate in every drill during skate on Monday. On Sunday, Blues general manager Doug Armstrong was asked about the progress of both Broberg and Nick Leddy (lower-body). “I’m not sure what close is anymore,” Armstrong said. “They’re skating, which is a positive. They’re not on the road trip (as of Sunday), which is a negative. ... We can’t worry about when they get back. We have to be prepared to work tomorrow night. When they get back, that’s a bonus.” Monday night’s game was the 11th that Broberg missed since he was injured against the Maple Leafs when Mitch Marner fell on his right knee. On Bannister Before Thomas spoke about Montgomery, he wanted to make sure he talked about Drew Bannister, who was fired Sunday in order to make way for Montgomery’s hiring. “He was a great person, great hockey mind, great coach,” Thomas said. “I learned a lot from him as a player and also as a person. I just want to say thank you to him. It’s always tough going through a change, and I wish him and his family all the best.” In the 64 games that Thomas was in the lineup under Bannister, he racked up 68 points and averaged 21:08 of ice time, more than a minute above the next closest Blues forward.DAMASCUS (AP) — Exuberant Syrians observed the first Friday prayers since the ouster of President Bashar Assad , gathering in the capital's historic main mosque, its largest square and around the country to celebrate the end of half a century of authoritarian rule. The newly installed interim prime minister delivered the sermon at the Umayyad Mosque, declaring that a new era of “freedom, dignity and justice” was dawning for Syria. The gatherings illustrated the dramatic changes that have swept over Syria less than a week after insurgents marched into Damascus and toppled Assad. Amid the jubilation, U.S. Secretary of State Antony Blinken met with allies around the region and called for an “inclusive and non-sectarian” interim government. Blinken arrived in Iraq on a previously unannounced stop after talks in Jordan and Turkey, which backs some of the Syrian insurgent factions. So far, U.S. officials have not talked of direct meetings with Syria's new rulers. The main insurgent force, Hayat Tahrir al-Sham, has worked to establish security and start a political transition after seizing Damascus early Sunday. The group has tried to reassure a public both stunned by Assad's fall and concerned about extremist jihadis among the rebels. Insurgent leaders say the group has broken with its extremist past, though HTS is still labeled a terrorist group by the United States and European countries. HTS's leader, Ahmad al-Sharaa, formerly known as Abu Mohammed al-Golani, appeared in a video message Friday congratulating “the great Syrian people for the victory of the blessed revolution.” “I invite them to head to the squares to show their happiness without shooting bullets and scaring people,” he said. “And then after, we will work to build this country, and as I said in the beginning, we will be victorious by the help of God.” Huge crowds, including some insurgents, packed the historic Umayyad Mosque in the capital's old city, many waving the rebel opposition flag — with its three red stars — which has swiftly replaced the Assad-era flag with with its two green stars. Syrian state television reported that the sermon was delivered by Mohammed al-Bashir, the interim prime minister installed by HTS this week. The scene resonated on multiple levels. The mosque, one of the world's oldest dating back some 1,200 years, is a beloved symbol of Syria, and sermons there like all mosque sermons across Syria were tightly controlled under Assad's rule. Also, in the early days of the anti-government uprising in 2011, protesters would leave Friday prayers to march in rallies against Assad before he launched a brutal crackdown that turned the uprising into a long and bloody civil war. “I didn’t step foot in Umayyad Mosque since 2011," because of the tight security controls around it, said one worshipper, Ibrahim al-Araby. “Since 11 or 12 years, I haven’t been this happy.” Another worshipper, Khair Taha, said there was “fear and trepidation for what’s to come. But there is also a lot of hope that now we have a say and we can try to build.” Blocks away in Damascus' biggest roundabout, named Umayyad Square, thousands gathered, including many families with small children — a sign of how, so far at least, the country's transformation has not caused violent instability. “Unified Syria to build Syria,” the crowd chanted. Some shouted slurs against Assad and his late father, calling them pigs, an insult that would have previously led to offenders being hauled off to one of the feared detention centers of Assad’s security forces. One man in the crowd, 51-year-old Khaled Abu Chahine — originally from the southern province of Daraa, where the 2011 uprising first erupted — said he hoped for “freedom and coexistence between all Syrians, Alawites, Sunnis, Shiites and Druze.” The interim prime minister, al-Bashir, had been the head of a de facto administration created by HTS in Idlib, the opposition's enclave in northwest Syria. The rebels were bottled up in Idlib for years before fighters broke out in a shock offensive and marched across Syria in 10 days. Similar scenes of joy unfolded in other major cities, including in Aleppo, Homs, Hama, Latakia and Raqqa. Al-Sharaa, HTS' leader, has promised to bring a pluralistic government to Syria, seeking to dispel fears among many Syrians — especially its many minority communities — that the insurgents will impose a hard-line, extremist rule. Another key factor will be winning international recognition for a new government in a country where multiple foreign powers have their hands in the mix. The Sunni Arab insurgents who overthrew Assad did so with vital help from Turkey, a longtime foe of the U.S.-backed Kurds . Turkey controls a strip of Syrian territory along the shared border and backs an insurgent faction uneasily allied to HTS — and is deeply opposed to any gains by Syria's Kurds. In other developments, Turkish Foreign Minister Hakan Fidan said Turkey’s Embassy in Damascus would reopen Saturday for the first time since 2012, when it closed due to the Syrian civil war. The U.S. has troops in eastern Syria to combat remnants of the Islamic State group and supports Kurdish-led fighters who rule most of the east. Since Assad's fall, Israel has bombed sites all over Syria, saying it is trying to prevent weapons from falling into extremist hands. It has also seized a swath of southern Syria along the border with the Israeli-occupied Golan Heights, calling it a buffer zone. After talks with Fidan, Blinken said there was “broad agreement” between Turkey and the U.S. on what they would like to see in Syria. That starts with an "interim government in Syria, one that is inclusive and non-sectarian and one that protects the rights of minorities and women” and does not “pose any kind of threat to any of Syria’s neighbors,” Blinken said. Fidan said the priority was “establishing stability in Syria as soon as possible, preventing terrorism from gaining ground, and ensuring that IS and the PKK aren’t dominant” — referring to the Islamic State group and the Kurdistan Workers Party. Ankara considers the PKK within Turkey's borders a terrorist group, as it does the Kurdish-backed forces in Syria backed by the U.S. A U.S. official said that in Ankara, President Recep Tayyip Erdogan and Fidan both told Blinken that Kurdish attacks on Turkish positions would require a response. The official spoke to reporters on condition of anonymity to discuss private diplomatic talks. The U.S. has been trying to limit such incidents in recent days and had helped organize an agreement to prevent confrontations around the northern Syrian town of Manbij, which was taken by Turkey-backed opposition fighters from the U.S.-backed Kurdish forces earlier this week. In Baghdad, Blinken met with Iraqi Prime Minister Mohammed al-Sudani, saying both countries wanted to ensure the Islamic State group — also known by its Arabic acronym Daesh — doesn't exploit Syria's transition to re-emerge. “Having put Daesh back in its box, we can’t let it out, and we’re determined to make sure that that doesn’t happen," Blinken said. The U.S. official who briefed reporters said that Blinken had impressed upon al-Sudani the importance of Iraq exercising its full sovereignty over its territory and airspace to stop Iran from transporting weapons and equipment to Syria, either for Assad supporters or onward to the militant Hezbollah group in Lebanon. Lee reported from Ankara, Turkey. Associated Press writers Suzan Fraser in Ankara and Sally Abou AlJoud in Beirut contributed to this report.

The acquired outfielder in exchange for third baseman , pitcher and prospect Cam Smith, the teams announced on Friday. Tucker, 27, has a career .870 OPS over seven seasons with the Astros. He's entering his final year of team control -- which means he'll be a free agent after next season -- and is likely to make around $18 million through the arbitration process. He'll become the Cubs starting right fielder with relegated to designated hitter duty -- at least for now. The team still employs INF/OF , but he's likely to be moved in a separate trade, sources told ESPN. Tucker played in only 78 games last season due to a shin injury -- but will still be the Cubs' best player. The team has been searching for star-quality production on offense, and they might have found it in the three-time All-Star, who finished fifth in AL MVP voting in 2023. Paredes, 25, spent a half season with the Cubs after being acquired from the Rays in July. He'll likely serve as a replacement for at third base if he leaves Houston via free agency. Paredes is a dead pull hitter, useful for the short left field fences at Minute Maid Park. He hit 19 home runs last season and has a career .755 OPS over five big league seasons. Wesneski, 27, has appeared in 68 career games for the Cubs, including 22 as a starter. He has a career 3.93 ERA pitching as a swingman over the past three seasons. He was acquired from the Yankees at the summer trade deadline in 2022. Smith, 21, was the 14th overall pick out of Florida State in last year's amateur draft. He made headlines during his short pro debut, hitting home runs in six straight games for Single-A Myrtle Beach in August. He played mostly third base in college.Copper: The Driving Force Behind the Clean Energy Revolution

Social critic and documentary filmmaker Michael Moore said in a Substack post that he wants to "pour gasoline" on the anger Americans have expressed against the nation's health insurance industry. Moore wrote Friday that fury directed at the US health insurance industry was "1000 percent justified." Following the fatal shooting of UnitedHealthcare CEO Brian Thompson in Manhattan last week, some Americans have taken to social media and other outlets to express their frustration with the state of private health insurance in the nation. Moore — whose documentaries include criticisms of the US war on terror, gun violence, and health care, among other topics — was mentioned by name in the manifesto of Luigi Mangione, the man police believe killed Thompson. Mangione allegedly described Moore as someone who "illuminated the corruption and greed" in the health care industry in his 2007 film Sicko . “It’s not often that my work gets a killer five-star review from an actual killer,” Moore wrote in his Substack piece. He noted that he had been receiving media requests, including some that were essentially asking him to "condemn murder." “Do I condemn murder? That’s an odd question. In Fahrenheit 9/11, I condemned the murder of hundreds of thousands of innocent Iraqi people and the senseless murder of our own American soldiers at the hands of our American government,” Moore wrote. He went on to argue that his body of work made it very clear that he expressly does not and has never condoned murder. But believing murder is wrong is not saying that the wave of anger toward the health insurance industry is unwarranted, he added. “After the killing of the CEO of United HealthCare, the largest of these billion-dollar insurance companies, there was an immediate OUTPOURING of anger toward the health insurance industry.” He added: “Some people have stepped forward to condemn this anger. I am not one of them. The anger is 1000 percent justified. It is long overdue for the media to cover it. It is not new. It has been boiling. And I’m not going to tamp it down or ask people to shut up. I want to pour gasoline on that anger.” Moore said that Thompson's killing opened the door for Americans to express their long-simmering fury toward private, profit-driven health insurance companies. “Yes, I condemn murder, and that’s why I condemn America’s broken, vile, rapacious, bloodthirsty, unethical, immoral health care industry and I condemn every one of the CEOs who are in charge of it and I condemn every politician who takes their money and keeps this system going instead of tearing it up, ripping it apart, and throwing it all away. We need to replace this system with something sane, something caring and loving — something that keeps people alive,” he wrote. Even Andrew Witty, the CEO of UnitedHealth Group — the parent company of UnitedHealthcare — called the US insurance system "flawed" in a recent New York Times op-ed. “We know the health system does not work as well as it should, and we understand people’s frustrations with it,” Witty said. “No one would design a system like the one we have.” He also mourned the loss of Thompson, calling the CEO a "brilliant, kind man." Moore has a suggestion for what changing that "flawed" system might look like — state-run health care akin to the system used in Canada and other nations. “The solution is simple,” he wrote. “Throw this entire system in the trash,” he wrote. “Dismantle this immoral business that profits off the lives of human beings and monetizes our deaths, that murders us or leaves us to die, destroy it all, and instead, in its place, give us all the same health care that every other civilized country on Earth has: Universal, free, compassionate, and full of life.”

Kyle Shanahan Provides Brock Purdy Update After Packers BlowoutWith only weeks to go until the FIFA Intercontinental Cup Qatar 2024 kicks off, Al Ahly legend Wael Gomaa sees his former club’s participation in the competition as an important milestone for the Egyptian club. “Taking part in a tournament of this calibre is a source of great pride for Al Ahly. It is another achievement in the club’s illustrious history. I hope the team does well and gets a chance to play against European giants Real Madrid,” said Gomaa, speaking from Stadium 974 in Qatar, which will host two of three matches scheduled to take place between 11 - 18 December. The FIFA Intercontinental Cup Qatar 2024 is a club competition that brings together continental club champions from around the world for a riveting showdown to crown the best club in the world. “It is very important for the growth of football in the Arab world. High profile competitions such as this provide clubs in the region with the incentive to compete at the highest level in front of a home crowd,” added Gomaa. Al Ahly legend Wael Gomaa is regarded as one of Africa’s best all-time defenders. His accolades with the Egyptian giants include six CAF Champions League and seven domestic league titles. His tenacious style earned him the nickname, “The Rock.” Gomaa is regarded as one of the greatest talents of his generation. “Al Ahly is more than a club. It’s a social phenomenon that encapsulates so many cultural dynamics for millions of fans in Egypt and across the Arab world. It’s the people’s club and it is everything beautiful in my life,” said Gomaa. Al Ahly first qualified to the FIFA Intercontinental Cup Qatar 2024 after claiming its 12th CAF Champions League title. The Egyptian side then beat Al Ain of the UAE to lay claim to the African-Asian-Pacific Cup, one of four trophies up for grabs at the FIFA Intercontinental Cup competition. Three trophies remain in the mix when four clubs compete in Qatar. They are the FIFA Derby of the Americas, FIFA Challenger Cup and the FIFA Intercontinental Cup. The final match will feature Spanish giants and current UEFA Champions League champions, Real Madrid, and will be held on 18 December in Lusail Stadium, two years to the day since the 89,000-seater hosted a historic FIFA World Cup final. “Qatar has cemented itself as a world class-sports destination after hosting a World Cup tournament that will be seared in the memory of football fans forever,” said Gomaa. Al Ahly will play for the FIFA Challenger Cup on Saturday 14 December at Stadium 974 in Qatar. The African champions will play the winner of the Derby of the Americas, between Mexican side CF Pachuca and the yet to be determined winner of the Copa Libertadores, taking place three days earlier on 11 December at the same venue. “Al Ahly has a massive fan base in Qatar and our fans are ready to support our club with everything they have. Our support base will be the fuel that powers the team on the pitch and will be a differentiating factor in the tournament overall,” added Gomaa who currently lives in Qatar and works as a popular sports pundit. Tickets for the FIFA Intercontinental Cup are available online at fic24.qa. They include several accessible options for disabled fans. @FICQatar on X and Instagram may be followed and fic24.qa may be visited for all tournament related information. Related Story Qatar joins Global Coalition for Digital Safety 61 countries to compete in 8th Katara Award for Reciting Holy Qur’an

Supreme Court may free Catholic Charities from paying state unemployment taxes for their employeesLauren Boebert Quickly Deletes Cameo Account After Experts Point Out It May Be Breaking Ethics Rules

TORONTO, Dec. 13, 2024 (GLOBE NEWSWIRE) -- Edesa Biotech, Inc. EDSA , a clinical-stage biopharmaceutical company focused on developing host-directed therapeutics for immuno-inflammatory diseases, today reported financial results for the fiscal year ended September 30, 2024 and provided an update on its business. During the fiscal year, the company pivoted the in-house development of its anti-TLR4 drug candidate, EB05 (paridiprubart), to a U.S. government-funded study investigating novel threat-agnostic host-directed therapeutics in patients with Acute Respiratory Distress Syndrome (ARDS). Given this opportunity, Edesa is also amending a development and drug manufacturing project for the same asset that is supported by the Government of Canada. The company said that the goal is to maximize synergies between the two government-funded projects. For its anti-CXCL10 program, Edesa intends to manufacture EB06 and submit related data to the U.S. Food and Drug Administration as part of an investigational new drug (IND) application. The manufacturing of clinical-grade drug batches and initiation of the patient enrollment is subject to funding. Edesa anticipates topline results for this Phase 2 study could be available within as few as 12 to 18 months following regulatory clearance in the U.S. The study is currently approved in Canada. "This year, Edesa maintained its momentum despite the headwinds in the drug development sector, and we once again validated our TLR4 technology with a third competitive government award," said Par Nijhawan, MD, Chief Executive Officer of Edesa Biotech. "I have maintained my strategic support financially and I believe that our team can continue to advance and expand our development pipeline and partnerships." Edesa's Chief Financial Officer Stephen Lemieux reported that financial results for the fiscal year benefited from prudent use of working capital and effective financial management, including a more than 20% decrease in operating expenses. "Following the end of the fiscal year, we strengthened our balance sheet, and with two governments now funding the advancement of our anti-TLR4 technology, we have improved our position for future financing, potential strategic arrangements as well as other opportunities to advance our pipeline." Financial Results for the Fiscal Year Ended September 30, 2024 Total operating expenses decreased by $2.2 million to $7.0 million for the year ended September 30, 2024 compared to $9.2 million for the prior year: Research and development expenses decreased by $1.9 million to $2.9 million for the year ended September 30, 2024 compared to $4.8 million for the prior year primarily due to decreased external research expenses related to the company's completed dermatitis study and a reduction in labor costs and noncash share-based compensation, which were partially offset by an increase in expenses related to manufacturing of paridiprubart. General and administrative expenses decreased by $0.3 million to $4.1 million for year ended September 30, 2024 compared to $4.4 million for the prior year primarily due to a decrease in noncash share-based compensation, which was partially offset by an increase salaries and related costs. Total other income was unchanged at $0.8 million for the years ended September 30, 2024 and September 30, 2023 as a $0.1 million increase in reimbursement funding from the Canadian government's Strategic Innovation Fund was offset by a $0.1 million decrease in interest income. For the year ended September 30, 2024, Edesa reported a net loss of $6.2 million, or $1.93 per common share, compared to a net loss of $8.4 million, or $2.93 per common share, for the year ended September 30, 2023. Working Capital At September 30, 2024, Edesa had cash and cash equivalents of $1.0 million and negative working capital of $0.2 million. Subsequent to the fiscal year end, the company received $1.5 million in gross proceeds under a securities purchase agreement with an entity affiliated with Edesa's Chief Executive Officer and Founder, and $0.6 million in net proceeds, after deducting sales agent commissions, from common shares sold under an at-the-market offering program. Calendar Edesa management plans to participate in one-on-one meetings during JP Morgan week, which begins on January 13, 2025, in San Francisco, California. Attendees interested in meeting with management can request meetings through the conference organizers or by contacting Edesa directly at investors@edesabiotech.com . About Edesa Biotech, Inc. Edesa Biotech, Inc. EDSA is a clinical-stage biopharmaceutical company developing innovative ways to treat inflammatory and immune-related diseases. Its clinical pipeline is focused on two therapeutic areas: Medical Dermatology and Respiratory. In Medical Dermatology, Edesa is developing EB06, an anti-CXCL10 monoclonal antibody candidate, as therapy for vitiligo, a common autoimmune disorder that causes skin to lose its color in patches. Its medical dermatology assets also include EB01 (1.0% daniluromer cream), a Phase 3-ready asset developed for use as a potential therapy for moderate-to-severe chronic Allergic Contact Dermatitis (ACD), a common occupational skin condition. The company's most advanced Respiratory drug candidate is EB05 (paridiprubart), which is being evaluated in a U.S. government-funded platform study as a treatment for Acute Respiratory Distress Syndrome (ARDS), a life-threatening form of respiratory failure. The EB05 program has been the recipient of two funding awards from the Government of Canada to support the further development of this asset. In addition to EB05, Edesa is preparing an investigational new drug application (IND) in the United States for EB07 (paridiprubart) to conduct a future Phase 2 study in patients with pulmonary fibrosis. Sign up for news alerts . Connect with us on X and LinkedIn . Edesa Forward-Looking Statements This press release may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements may be identified by the use of words such as "anticipate," "believe," "plan," "estimate," "expect," "intend," "may," "will," "would," "could," "should," "might," "potential," or "continue" and variations or similar expressions, including statements related to: Edesa's ability to pivot the in-house development of its anti-TLR4 drug candidate; the company's plans to amend its contribution agreement with the Government of Canada; the company's goal to maximize synergies between two government-funded projects; Edesa plans to manufacture EB06 and submit related data to the FDA as part of an IND application; the company's plans to manufacture clinical-grade drug and initiate patient enrollment; the company's plans to finance clinical and manufacturing activities; the company's estimate that topline results for its Phase 2 vitiligo study could be available within as few as 12 to 18 months following regulatory clearance; the company's belief that in 2024 it maintained its momentum despite the headwinds in the drug development sector and once again validated its TLR4 technology with a third competitive government award; the company's belief that its team can continue to advance and expand its development pipeline and partnerships; the company's belief that its fiscal year financial results benefited from prudent use of working capital and effective financial management; the company's belief that with two governments funding the advancement of its anti-TLR4 technology, it has improved its position for future financing, potential strategic arrangements and alternatives as well as other opportunities to advance its pipeline; and the company's timing and plans regarding its clinical studies in general. Readers should not unduly rely on these forward-looking statements, which are not a guarantee of future performance. There can be no assurance that forward-looking statements will prove to be accurate, as all such forward-looking statements involve known and unknown risks, uncertainties and other factors which may cause actual results or future events to differ materially from the forward-looking statements. Such risks include: the ability of Edesa to obtain regulatory approval for or successfully commercialize any of its product candidates, the risk that access to sufficient capital to fund Edesa's operations may not be available or may be available on terms that are not commercially favorable to Edesa, the risk that Edesa's product candidates may not be effective against the diseases tested in its clinical trials, the risk that Edesa fails to comply with the terms of license agreements with third parties and as a result loses the right to use key intellectual property in its business, Edesa's ability to protect its intellectual property, the timing and success of submission, acceptance and approval of regulatory filings, and the impacts of public health crises. Many of these factors that will determine actual results are beyond the company's ability to control or predict. For a discussion of further risks and uncertainties related to Edesa's business, please refer to Edesa's public company reports filed with the U.S. Securities and Exchange Commission and the British Columbia Securities Commission. All forward-looking statements are made as of the date hereof and are subject to change. Except as required by law, Edesa assumes no obligation to update such statements. Consolidated Statements of Operations Years Ended September 30, 2024 September 30, 2023 Expenses: Research and development $ 2,881,967 $ 4,794,549 General and administrative 4,132,777 4,428,209 Loss from operations (7,014,744 ) (9,222,758 ) Other Income (Loss): Reimbursement grant income 698,277 581,039 Other income (loss) 147,222 268,104 Income tax expense 800 800 Net loss (6,170,045 ) (8,374,415 ) Exchange differences on translation (27,965 ) (1,046 ) Net comprehensive loss $ (6,198,010 ) $ (8,375,461 ) Weighted average number of common shares 3,197,423 2,858,929 Loss per common share - basic and diluted $ (1.93 ) $ (2.93 ) Consolidated Balance Sheets September 30, 2024 September 30, 2023 Assets: Cash and cash equivalents $ 1,037,320 $ 5,361,397 Other current assets 638,302 1,075,455 Non-current assets 2,138,360 2,453,585 Total Assets $ 3,813,982 $ 8,890,437 Liabilities and shareholders' equity: Current liabilities $ 1,832,827 $ 1,821,864 Non-current liabilities - 19,773 Shareholders' equity 1,981,155 7,048,800 Total liabilities and shareholders' equity $ 3,813,982 $ 8,890,437 Consolidated Statements of Cash Flows Years Ended September 30, 2024 September 30, 2023 Cash flows from operating activities: Net loss $ (6,170,045 ) $ (8,374,415 ) Adjustments for non-cash items 708,775 1,429,928 Change in working capital items 571,065 308,004 Net cash used in operating activities (4,890,205 ) (6,636,483 ) Net cash provided by financing activities 592,031 4,830,111 Effect of exchange rate changes on cash and cash equivalents (25,903 ) 76,850 Net change in cash and cash equivalents (4,324,077 ) (1,729,522 ) Cash and cash equivalents, beginning of year 5,361,397 7,090,919 Cash and cash equivalents, end of year $ 1,037,320 $ 5,361,397 © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.CHICAGO (AP) — N.J. Benson had 22 points and 17 rebounds in DePaul's 84-65 victory over Loyola Maryland on Saturday. Benson added 17 rebounds for the Blue Demons (9-4). Jacob Meyer added 12 points while shooting 4 for 11 (0 for 3 from 3-point range) and 4 of 4 from the free-throw line while they also had five rebounds. CJ Gunn went 4 of 11 from the field (1 for 5 from 3-point range) to finish with 11 points. The Greyhounds (5-6) were led in scoring by Jacob Theodosiou, who finished with 22 points. Milos Ilic added 13 points, six rebounds and two steals for Loyola (MD). Jordan Stiemke had 10 points. DePaul took the lead with 18:45 left in the first half and did not relinquish it. Benson led their team in scoring with 14 points in the first half to help put them up 44-26 at the break. DePaul extended its lead to 64-36 during the second half, fueled by an 8-0 scoring run. Isaiah Rivera scored a team-high 10 points in the second half as his team closed out the win. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .

NFL Hall of Fame WR Randy Moss announces battle with cancer outside of bowel duct on Instagram Live NFL Hall of Fame wide receiver Randy Moss announced that he has been battling a cancer found in his bowel duct between his pancreas and liver on Instagram live. Moss, aided by a cane, introduced himself as a cancer survivor and thanked his “prayer warriors” for their support. He had a Whipple procedure to put a stent on his liver on Thanksgiving after experiencing urine discoloration. Moss spent the last six days in the hospital before getting out on Friday and said he’s nursing himself back to full health with chemotherapy and radiation. Lindsey Vonn to enter World Cup ski races next weekend in Switzerland in her comeback at age 40 BEAVER CREEK, Colo. (AP) — Lindsey Vonn will return to World Cup ski racing next weekend for a pair of super-G events in St. Moritz, Switzerland, as she continues her comeback at 40 years old. Vonn teased her return in an Instagram post through her sponsor, Red Bull, on Friday morning. She said “I hear St. Moritz is pretty nice this time of year.” The U.S. Ski Team then confirmed she will race in St. Moritz. She’s won five of her 82 World Cup races on the venue at St. Moritz. Picabo Street, a two-time Olympic medalist and Vonn’s former teammate, says “it’s the coolest thing ever.” De'Vondre Campbell won't be part of the 49ers after his refusal to enter a game, Kyle Shanahan says SANTA CLARA, Calif. (AP) — San Francisco coach Kyle Shanahan said linebacker De’Vondre Campbell won’t be part of the 49ers moving forward after he refused to enter a game after losing his starting job. Shanahan said the team is still working through the options of how to deal with Campbell after he walked to the locker room in the middle of a 12-6 loss to the Los Angeles Rams. Shanahan says the team is weighing its options, which could include a suspension or release, but that Campbell won't be part of the team for the final three weeks of the season. Saudi Arabia's plans to host the men's World Cup 2034 will be harmful for the climate, experts say Saudi Arabia says that to host the 2034 World Cup in men’s soccer, it will build or renovate 15 stadiums, create a futuristic city and expand airports and public transport in a massive buildout to accommodate millions of athletes, coaches and spectators. That will emit tons of planet-warming greenhouse gases as concrete and steel are manufactured and transported, diesel-powered excavators and trucks move material and new buildings are powered and cooled. The buildings and construction sector, taken together, is the largest emitter of greenhouse gases globally. Because of the scale of the building plans and travel needed for the event, experts say the toll on the climate could be enormous. Yankees get closer Devin Williams from Brewers for Nestor Cortes, Caleb Durbin NEW YORK (AP) — The New York Yankees have acquired All-Star closer Devin Williams from the Milwaukee Brewers for left-hander Nestor Cortes and infield prospect Caleb Durbin. The Yankees also will send $2 million to the Brewers as part of the trade. A 30-year-old right-hander, Williams and his signature “Airbender” changeup are eligible for free agency after the 2025 season. He was diagnosed during spring training with two stress fractures in his back and didn’t make his season debut until July 28. Williams was 14 for 15 in save chances with a 1.25 ERA, striking out 38 and walking 11 in 21 2/3 innings. Cubs acquiring All-Star outfielder Kyle Tucker in trade with the Astros, AP source says CHICAGO (AP) — The Chicago Cubs are acquiring All-Star outfielder Kyle Tucker in a trade with the Houston Astros, paying a big price for one of baseball’s best hitters, a person familiar with the situation said. The person spoke to the AP on condition of anonymity because the move was pending a review of medical reports. The Cubs are sending third baseman Isaac Paredes, right-hander Hayden Wesneski and Cam Smith, one of their top infield prospects, to the Astros for Tucker, who is eligible for free agency after the 2025 season. Tucker was limited to 78 games this year because of a fractured right shin, but he hit .289 with 23 homers and 49 RBIs for the AL West champions. US Olympic and Paralympic officials put coach on leave after AP reports sexual abuse allegations The U.S. Olympic & Paralympic Committee has placed an employee on administrative leave after The Associated Press reported that one of its coaches was accused of sexually abusing a young biathlete, causing her so much distress that she attempted suicide. USOPC officials sent an email to the U.S. Biathlon national team saying it wanted to commend the athletes who came forward with the “concerning allegations of abuse." The email, which did not name the employee, said officials were conducting an internal investigation. USOPC spokesperson Jon Mason said no further information would be released while the inquiry is underway. New West Virginia coach Rich Rodriguez says leaving for Michigan 17 years ago was a 'mistake' MORGANTOWN, W.Va. (AP) — Rich Rodriguez says he regrets leaving West Virginia 17 years ago. Rodriguez was introduced as the coach at his alma mater on Friday. Based on the welcome he got from the thousands of West Virginia fans in attendance, much seems to be forgiven. Rodriguez told the crowd that he never should have left his home state. The 61-year-old coach says he's grown both as a person and a coach throughout his long career, and that his departure at the end of the 2007 season for a head coaching job at Michigan was a mistake. Rodriguez went 60-26 at West Virginia from 2001 to 2007. Woman who falsely accused Duke lacrosse players of rape in 2006 publicly admits she lied RALEIGH, N.C. (AP) — The woman who in 2006 falsely accused three Duke University lacrosse players of raping her has admitted publicly for the first time that she made up the story. The accusations made national headlines at the time, stirring tensions about race, class and the privilege of college athletes. Crystal Mangum, who is Black, said in an interview with the “Let’s Talk with Kat” podcast that she “made up a story that wasn’t true” about the white players who attended a party where she was hired to perform as a stripper “because I wanted validation from people and not from God.” The former Duke players were declared innocent in 2007 after Mangum’s story fell apart under legal scrutiny. Analysis: Only LeBron James knows what's happening right now, and what's in his future LAS VEGAS (AP) — LeBron James was starring in Las Vegas at this time last year, the headline attraction while he and the Los Angeles Lakers were about to win the inaugural version of the event now known as the NBA Cup. That's not the case this year. “Personal reasons ... he’s taking some time” is what Lakers coach JJ Redick said this week when detailing why James was missing from practice. “Left foot soreness” is the reason why the Lakers have ruled him out of Friday’s game in Minnesota. There’s been trade speculation in recent days. It's all very different than a year ago at Cup time.AH Real Deal: Samsung 2TB Portable SSD drops to $197.67

University system sets enrollment record