FDA Accepts Ascendis Pharma’s Supplemental Biologics License Application for TransConTM hGH for ...Leftist Congresswoman Says 'The Death Penalty Is Racist' as She Cheers on Biden's CommutationsEAGAN, Minn. (AP) — The game had suddenly gone sideways for the Minnesota Vikings , their 11-point lead on the Chicago Bears having evaporated in the closing seconds. They straightened it out in overtime, no sweat, because Sam Darnold simply hasn't been fazed. Save for his occasional rash of turnovers, in games the Vikings still managed to win, Darnold proved again on Sunday in defeating the Bears that he's directing a passing attack with the potential to be one of the NFL 's most potent. “I think he’s a mentally tough guy. I think he’s a physically tough guy. I think he’s confident in the guys around him, and I think he’s confident in our system,” coach Kevin O'Connell said after the 30-27 victory. “I think when he just continues to play quarterback at a high level, I think we’re a tough team.” After the defense forced the Bears to punt on the opening possession of overtime, Darnold led the Vikings on a 68-yard drive to set up the game-ending field goal while overcoming a 7-yard sack on the first play and two subsequent setbacks with a false start and a holding penalty. On third-and-10 from the 21, he hit Jordan Addison near the sideline for 13 yards. On first-and-15 from the 29, Darnold threaded a throw to Justin Jefferson for 20 yards after he'd muscled his way through Bears cornerback Jaylon Johnson on a post route for the clutch catch after he'd been all but silenced all afternoon by a defense determined to constantly bracket him with double coverage. On second-and-11 from the 48, Darnold connected with a wide-open T.J. Hockenson underneath for 12 yards. Then two plays later off a second-and-8 play-action fake, he found Hockenson again on a deep corner route for 29 yards to put Parker Romo in prime position for the walk-off winner. “Just execute. It’s as simple as that. Just one play at a time," said Darnold, who went 22 for 34 for 330 yards and two touchdowns without a turnover. “I think I tell the guys that every single time in the huddle, but that’s my mindset every single time I’m out there on the field, especially in that situation.” Even when Jefferson continues to draw an extraordinary amount of coverage , the Vikings with Addison, Hockenson, Aaron Jones and the rest of their crew running O'Connell's system have proven they have an offense that can go win a game when it's required. That wouldn't be possible without Darnold, whose career rebirth has helped spark the Vikings (9-2) become one of the league's biggest surprises in what's now its most difficult division. “He’s cool, calm, collected,” Hockenson said. "That’s what you want as the leader of the huddle.” The Vikings' defense ranks ninth in the league on third downs, allowing a conversion rate of 34.5% after limiting the Bears to a 6-for-17 performance. The Vikings are tied for first on fourth downs with an allowance of 36.4% after the Bears went 2 for 3. Both conversions came in the fourth quarter during touchdown drives. The Vikings also rank fourth in the NFL in opponent points per drive (1.52). The Vikings had seven possessions that crossed the 20-yard line in Chicago, but only three of them yielded touchdowns. Their lone turnover was the type of game-altering giveaways they've struggled to eliminate this month, a fumble by Aaron Jones at the 1-yard line that ruined a promising first drive. The Vikings are tied for 20th in the league in red zone touchdown rate (53.9%) and are 17th in goal-to-go touchdowns (72%). Addison had eight catches for 162 yards, both career highs, and a touchdown on nine throws from Darnold. The second-year wide receiver has had a quieter season than his rookie year, but he stepped up in a significant way on an afternoon when Jefferson was as smothered by the opposing secondary as ever. TE Johnny Mundt had the onside kick glance off his shin as he charged toward the coverage, and the first kicking team recovery in the NFL this season helped the Bears extend the game. Mundt also had the false start on the overtime drive. His lone catch was a 7-yard gain when he was stopped short of the goal line, one play before the lost fumble. Mundt played 33 of 71 snaps and Hockenson took 48 snaps with Oliver out. The Vikings lost LT Cam Robinson (foot) and LB Ivan Pace (hamstring) to injuries in the first quarter against the Bears, and O'Connell said on Monday those players were still in "evaluation mode." Oliver (ankle) will have an opportunity to return after being sidelined last week. 101.7 — Darnold's passer rating, which ranks ninth in the NFL. Darnold has posted a 100-plus passer rating in nine of 11 games this season. He had only 12 such performances in 56 career starts before joining the Vikings. The Vikings have four of their next five games at home, starting with Arizona (6-5) this week, Atlanta (6-5) on Dec. 8 and a rematch with Chicago (4-7) in a Monday night game on Dec. 16. AP NFL: https://apnews.com/hub/NFL
Global Master Data Management PDS Software Market Size, Share and Forecast By Key Players-Pimcore, Riversand, Oracle, Talend, SAPBEIRUT — Israel's military launched airstrikes across Lebanon on Monday, unleashing explosions throughout the country and killing at least 31 while Israeli leaders appeared to be closing in on a negotiated ceasefire with the Hezbollah militant group. Israeli strikes hit commercial and residential buildings in Beirut as well as in the port city of Tyre. Military officials claimed they targeted areas known as Hezbollah strongholds. They issued evacuation orders for Beirut's southern suburbs, and strikes landed across the city, including meters from a Lebanese police base and the city's largest public park. The barrage came as officials indicated they were nearing agreement on a ceasefire, while Israeli Prime Minister Benjamin Netanyahu's Security Cabinet prepared to discuss an offer on the table. Bulldozers remove the rubble of a destroyed building Monday that was hit in an Israeli airstrike in Dahiyeh, in the southern suburb of Beirut, Lebanon. Foreign ministers from the world’s leading industrialized nations also expressed cautious optimism Monday about possible progress on a ceasefire. “Knock on wood,” Italian Foreign Minister Antonio Tajani said as he opened the Group of Seven meeting outside Rome. “We are perhaps close to a ceasefire in Lebanon," he said. "Let's hope it's true and that there's no backing down at the last-minute.” A ceasefire in Gaza and Lebanon was foremost on the agenda of the G7 meeting in Fiuggi, outside Rome, that gathered ministers from Canada, France, Germany, Italy, Japan, the United Kingdom and the United States, in the last G7 encounter of the Biden administration. For the first time, the G7 ministers were joined by their counterparts from Saudi Arabia, Egypt, Jordan, the United Arab Emirates and Qatar, as well as the Secretary General of the Arab League. Thick smoke, flames and debris erupt Monday from an Israeli airstrike that targeted a building in Tayouneh, Beirut, Lebanon. Meanwhile, massive explosions lit up Lebanon's skies with flashes of orange, sending towering plumes of smoke into the air as Israeli airstrikes pounded Beirut's southern suburbs Monday. The blasts damaged buildings and left shattered glass and debris scattered across nearby streets. Some of the strikes landed close to central Beirut and near Christian neighborhoods and other targets where Israel issued evacuation warnings, including in Tyre and Nabatiyeh province. Israeli airstrikes also hit the northeast Baalbek-Hermel region without warning. Lebanon's Health Ministry said Monday that 26 people were killed in southern Lebanon, four in the eastern Baalbek-Hermel province and one in Choueifat, a neighborhood in Beirut's southern suburbs that was not subjected to evacuation warnings on Monday. The deaths brought the total toll to 3,768 killed in Lebanon throughout 13 months of war between Israel and Hezbollah and nearly two months since Israel launched its ground invasion. Many of those killed since the start of the war between Israel and Hezbollah have been civilians, and health officials said some of the recovered bodies were so severely damaged that DNA testing would be required to confirm their identities. Israel claims to have killed more than 2,000 Hezbollah members. Lebanon's Health Ministry says the war has displaced 1.2 million people. Destroyed buildings stand Monday in the area of a village in southern Lebanon as seen from northern Israel. Israeli ground forces invaded southern Lebanon in early October, meeting heavy resistance in a narrow strip of land along the border. The military previously exchanged attacks across the border with Hezbollah, an Iran-backed militant group that began firing rockets into Israel the day after the war in Gaza began last year. Lebanese politicians have decried the ongoing airstrikes and said they are impeding ceasefire negotiations. The country's deputy parliament speaker accused Israel of ramping up its bombardment to pressure Lebanon to make concessions in indirect ceasefire negotiations with Hezbollah. Elias Bousaab, an ally of the militant group, said Monday that the pressure has increased because "we are close to the hour that is decisive regarding reaching a ceasefire." Israeli officials voiced similar optimism Monday about prospects for a ceasefire. Mike Herzog, the country's ambassador to Washington, earlier in the day told Israeli Army Radio that several points had yet to be finalized. Though any deal would require agreement from the government, Herzog said Israel and Hezbollah were "close to a deal." "It can happen within days," he said. Israeli officials have said the sides are close to an agreement that would include withdrawal of Israeli forces from southern Lebanon and a pullback of Hezbollah fighters from the Israeli border. But several sticking points remain. A member of the Israeli security forces inspects an impact site Sunday after a rocket fired from Lebanon hit an area in Rinatya, outskirts of Tel Aviv, Israel. After previous hopes for a ceasefire were dashed, U.S. officials cautioned that negotiations were not yet complete and noted that there could be last-minute hitches that either delay or destroy an agreement. "Nothing is done until everything is done," White House national security spokesman John Kirby said Monday. The proposal under discussion to end the fighting calls for an initial two-month ceasefire during which Israeli forces would withdraw from Lebanon and Hezbollah would end its armed presence along the southern border south of the Litani River. The withdrawals would be accompanied by an influx of thousands more Lebanese army troops, who have been largely sidelined in the war, to patrol the border area along with an existing U.N. peacekeeping force. Western diplomats and Israeli officials said Israel demands the right to strike in Lebanon if it believes Hezbollah is violating the terms. The Lebanese government says such an arrangement would authorize violations of the country's sovereignty. On paper, being more sustainable and eco-friendly while shopping sounds great—so why don't more people do it? There is growing consumer consciousness about the environmental impact of where people choose to shop and the sustainability of the products they buy. According to McKinsey, over 60% of individuals surveyed in 2020 said they would be willing to pay more for a product that is packaged in an eco-friendly way. Since 2019, products marketed as being environmentally sustainable have seen a 28% growth in revenue compared to 20% for products with no such marketing, a 2023 McKinsey and NielsenIQ report found. Much of this is thanks to the preferences and attitudes of Gen Z, who, on average, care more than their older counterparts about being informed shoppers. The younger generation also has more social justice and environmental awareness altogether. Shoppers are willing to spend around 9.7% more on a product they know is sourced or manufactured sustainably, with 46% saying they would do so explicitly because they want to reduce their environmental footprint, according to a 2024 PwC report. Sustainable practices consumers look for from companies include production methods, packaging, and water conservation. But despite the growing consciousness around being more environmentally responsible, consumer actions don't always align with their values. In psychology, this is defined as the "say-do gap": the phenomenon wherein people openly express concern and intention around an issue, but fail to take tangible action to make a change. According to the Harvard Business Review in 2019, most consumers (65%) say they want to buy from brands that promote sustainability, but only 1 in 4 follow through. So why don't people actually shop sustainably, despite how much they express a preference for eco-friendly products—and how can we close the gap? The RealReal examined reports from the Harvard Business Review and other sources to explore why some shoppers want to buy sustainably but struggle to follow through. This lack of action isn't due to a lack of caring—in many cases, it's hard to know how to be a sustainable consumer and other factors are often outside of shoppers' control. But the more people shop sustainably, the easier and more accessible that market will be for everyone—making it much easier for folks to buy aligned with their values. There are many obstacles preventing shoppers from upholding eco-friendly habits as much as they may want to—but not all of these barriers are necessarily real, or accurately understood. Shopping sustainably simply isn't convenient or accessible for many. Those who live in apartment buildings are 50% less likely to recycle , according to Ipsos. Reasons for this can vary from lack of space to buildings being excluded altogether because of recycling contamination issues. Many believe that sustainable products are too expensive or of a lower quality. The former is often true, which does create a hurdle for many: The manufacturing processes and materials for sustainable products are pricey. For instance, organic cotton requires an intensive production process free of certain chemicals or pesticides; by definition, true eco-friendly products can't be mass-produced, further upping their price tag. Using recycled materials for packaging, or obtaining an eco certification, can also be expensive. However, although the narrative of eco-friendly products being more expensive is true, there is often more of an effort to use better quality materials that last longer than their noneco-friendly counterparts. This could end up saving consumers money in the long run: By paying more upfront, they can get more wear out of sustainable fashion, for instance. There is also undeniable political rhetoric surrounding eco-friendly products—however, despite many Conservative politicians decrying sustainable products, members of all generations are increasingly choosing to prioritize shopping sustainably regardless of their political affiliation, according to research from NYU Stern Center for Sustainable Business . This finding shows a trend toward seeing sustainability as a nonpartisan subject everyone can benefit from, no matter where they lie on the political spectrum. Some might think eco-friendly clothing, in particular, is not fashion-forward; after all, many of the top clothing retailers in the world partake in fast fashion. However, brands are increasingly being recognized as 'cool' and 'trendy' for supporting environmentally ethical practices, particularly as younger generations prioritize sustainability, as noted before. Many increasingly popular online stores are taking advantage of this paradigm shift by offering secondhand shopping options that are not only fashionable, but also more affordable, like ThredUp or Poshmark. Additionally, many legacy large-name brands are hopping on the sustainability movement and are gaining appreciation from loyal customers. Amazon's Climate Pledge Friendly program partners with third-party certification bodies to make it easier for shoppers to identify eco-friendly products as they browse the website. H&M's newly launched H&M Rewear program debuts a resale platform that allows the resale of all clothing brands—not just their own. Similarly, Patagonia's Worn Wear program allows shoppers to trade in and buy used gear and clothing. The federal government is also working to close this gap. The Environmental Protection Agency's Safer Choice program is attempting to make sustainable shopping easier for consumers and companies alike. It includes a directory of certified products, a list of safer chemicals to look out for on labels, a "Safer Choice" label that products can earn to denote they are eco-friendly, and resources for manufacturers looking to adopt more sustainable practices. Most of all, though, the biggest way shoppers can shift toward sustainable shopping is through their behaviors and attitudes amongst their peers and communities. Studies show that humans largely care what others think of their actions; the more shoppers make environmentally conscious shopping the norm, the more others will follow suit. From an economic perspective, the more consumers shop eco-friendly, the more affordable and accessible these products will become, too: Sustainable products are currently more expensive because they are not in high demand. Once demand rises, production rates and prices can lower, making these products more accessible for all. Story editing by Carren Jao. Additional editing by Kelly Glass. Copy editing by Kristen Wegrzyn. This story originally appeared on The RealReal and was produced and distributed in partnership with Stacker Studio. Get local news delivered to your inbox!Police arrested a 26-year-old man on Monday in the Manhattan killing of UnitedHealthcare’s CEO after they say a Pennsylvania McDonald's worker alerted authorities to a customer who resembled the suspected gunman. The suspect, identified by police as Luigi Nicholas Mangione, had a gun believed to be the one used in Wednesday’s attack on Brian Thompson , as well as writings expressing anger at corporate America, police said. Here are some of the latest developments in the investigation: Mangione was taken into custody at around 9:15 a.m. after police received a tip that he was eating at a McDonald’s in Altoona, Pennsylvania, about 85 miles (137 kilometers) east of Pittsburgh, police said. Mangione was being held in Pennsylvania on gun charges and will eventually be extradited to New York to face charges in connection with Thompson’s death , said NYPD Chief of Detectives Joseph Kenny. In addition to a three-page, handwritten document that suggests he harbored “ill will toward corporate America,” Kenny said Mangione also had a ghost gun, a type of weapon that can be assembled at home and is difficult to trace. Officers questioned Mangione, who was acting suspiciously and carrying multiple fraudulent IDs, as well as a U.S. passport, New York Police Commissioner Jessica Tisch said at a news conference. Officers also found a sound suppressor, or silencer, “consistent with the weapon used in the murder,” the commissioner said. He had clothing and a mask similar to those worn by the shooter and a fraudulent New Jersey ID matching one the suspect used to check into a New York City hostel before the shooting, Tisch said. Kenny said Mangione was born and raised in Maryland, has ties to San Francisco and that his last known address is in Honolulu. Mangione, who was valedictorian of his Maryland prep school, earned undergraduate and graduate degrees in computer science in 2020 from the University of Pennsylvania, a university spokesman told The Associated Press on Monday. He learned to code in high school and helped start a club at Penn for people interested in gaming and game design, according to a 2018 story in Penn Today, a campus publication. His social media posts also suggest that he belonged to the fraternity Phi Kappa Psi. They also show him taking part in a 2019 program at Stanford University, and in photos with family and friends at the Jersey Shore and in Hawaii, San Diego, Puerto Rico, and other destinations. The Gilman School, from which Mangione graduated in 2016, is one of Baltimore’s elite prep schools. Some of the city’s wealthiest and most prominent people, including Orioles legend Cal Ripken Jr., have had children attend the school. Its alumni include sportswriter Frank Deford and former Arizona Gov. Fife Symington. In his valedictory speech, Luigi Mangione described his classmates’ “incredible courage to explore the unknown and try new things,” according to a post on the school website. He praised their collective inventiveness and pioneering mindset. Mangione took a software programming internship after high school at Maryland-based video game studio Firaxis, where he fixed bugs on the hit strategy game Civilization 6, according to a LinkedIn profile. Firaxis parent company Take-Two Interactive said Monday it would not comment on former employees. He more recently worked at the car-buying website TrueCar, according to the head of the Santa Monica, California-based company. “While we generally don’t comment on personnel matters, we confirm that Luigi Mangione has not been an employee of our company since 2023,” TrueCar CEO Jantoon Reigersman said by email. Mangione comes from a prominent Maryland family. His grandfather Nick Mangione, who died in 2008, was a successful real estate developer. One of his best-known projects was Turf Valley Resort, a sprawling luxury retreat and conference center outside Baltimore that he purchased in 1978. The father of 10 children, Nick Mangione prepared his five sons — including Luigi Mangione’s father, Louis Mangione — to help manage the family business, according to a 2003 Washington Post report. The Mangione family also purchased Hayfields Country Club north of Baltimore in 1986. On Monday, Baltimore County police officers blocked off an entrance to the property, which public records link to Luigi Mangione’s parents. Reporters and photographers gathered outside the entrance. Luigi Mangione is one of 37 grandchildren of Nick Mangione, according to the grandfather's obituary. Luigi Mangione's grandparents donated to charities through the Mangione Family Foundation, according to a statement from Loyola University commemorating Nick Mangione’s wife’s death in 2023. They donated to various causes ranging from Catholic organizations to colleges and the arts. One of Luigi Mangione’s cousins is Republican Maryland state legislator Nino Mangione, a spokesman for the lawmaker's office confirmed Monday. Police said the person who killed Thompson left a hostel on Manhattan's Upper West Side at 5:41 a.m. on Wednesday. Just 11 minutes later, he was seen on surveillance video walking back and forth in front of the New York Hilton Midtown, wearing a distinctive backpack. At 6:44 a.m., he shot Thompson at a side entrance to the hotel, fled on foot, then climbed aboard a bicycle and within four minutes had entered Central Park. Another security camera recorded the gunman leaving the park near the American Museum of Natural History at 6:56 a.m. still on the bicycle but without the backpack. After getting in a taxi, he headed north to a bus terminal near the George Washington Bridge, arriving at around 7:30 a.m. From there, the trail of video evidence runs cold. Police have not located video of the suspect exiting the building, leading them to believe he likely took a bus out of town. Police said they are still investigating the path the suspect took to Pennsylvania. “This just happened this morning," Kenny said. "We’ll be working, backtracking his steps from New York to Altoona, Pennsylvania,” Kenny said. Associated Press reporters Lea Skene in Baltimore, Matt O'Brien in Providence, Rhode Island, and Cedar Attanasio in New York contributed to this report.
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