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HUNTSVILLE, Dec. 02, 2024 (GLOBE NEWSWIRE) -- Serina Therapeutics, Inc. (“Serina”) (NYSE American: SER), a clinical-stage biotechnology company, today announced a $10 million equity financing with strategic shareholder JuvVentures (UK) Limited. The transaction provides Serina with funding to continue advancing SER-252 (POZ-apomorphine), enabled by its proprietary POZ Platform TM drug optimization technology, into a Phase 1 clinical trial in advanced Parkinson's disease patients in the second half of 2025. Under the terms of the funding agreement, Serina will issue one million shares of common stock at $10 per share, a 120% premium to the closing price on November 26, 2024. The financing will be delivered in two tranches: the first $5.0 million tranche was received November 27, 2024, and the second $5.0 million tranche by January 31, 2025. Serina filed a Form 8-K with the SEC on December 2, 2024 that provides additional information regarding this transaction. About SER-252 (POZ-apomorphine) SER 252 is an investigational apomorphine therapy developed with Serina’s POZ platform and designed to provide continuous dopaminergic stimulation (CDS). CDS has been shown to reduce the severity of levodopa-related motor complications (dyskinesia) and enable greater on time, with reduced off time, in advanced Parkinson’s patients. SER-252 leverages strategic partner Enable Injections’ enFuse TM wearable drug delivery platform to enhance patient comfort and convenience, providing CDS to patients via an easy-to-administer, long-acting subcutaneous injection without skin reactions. About the POZ Platform TM Serina’s proprietary POZ technology is based on a synthetic, water soluble, low viscosity polymer called poly(2-oxazoline). Serina’s POZ technology is engineered to provide greater control in drug loading and more precision in the rate of release of attached drugs delivered via subcutaneous injection. The therapeutic agents in Serina’s product candidates are typically well-understood and marketed drugs that are effective but are limited by pharmacokinetic profiles that can include toxicity, side effects and short half-life. Serina believes that by using POZ technology, drugs with narrow therapeutic windows can be designed to maintain more desirable and stable levels in the blood. Serina’s POZ platform delivery technology has potential for use across a broad range of payloads and indications. Serina intends to advance additional applications of the POZ platform via out-licensing, co-development, or other partnership arrangements, including the non-exclusive license agreement with Pfizer, Inc. to use Serina’s POZ polymer technology for use in lipid nanoparticle drug (LNP) delivery formulations. About Serina Therapeutics Serina is a clinical-stage biotechnology company developing a pipeline of wholly owned drug product candidates to treat neurological diseases and other indications. Serina’s POZ Platform TM provides the potential to improve the integrated efficacy and safety profile of multiple modalities including small molecules, RNA-based therapeutics and antibody-based drug conjugates (ADCs). Serina is headquartered in Huntsville, Alabama on the campus of the HudsonAlpha Institute of Biotechnology. For more information, please visit https://serinatherapeutics.com . Cautionary Statement Regarding Forward-Looking Statement This release contains forward-looking statements within the meaning of federal securities laws. These statements are based on management’s current expectations, plans, beliefs or forecasts for the future, and are subject to uncertainty and changes in circumstances. Any express or implied statements in this press release that are not statements of historical fact, including statements about the potential of Serina’s POZ polymer technology, are forward-looking statements that involve substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Risks and uncertainties include, among other things, the uncertainties inherent in research and development, including the ability to meet anticipated clinical endpoints, commencement and/or completion dates for clinical trials, regulatory submission dates, regulatory approval dates and/or launch dates, as well as the possibility of unfavorable new clinical data and further analyses of existing clinical data; the risk that clinical trial data are subject to differing interpretations and assessments by regulatory authorities; whether regulatory authorities will be satisfied with the design of and results from our clinical studies; whether and when any applications may be filed for any drug or vaccine candidates in any jurisdictions; whether and when regulatory authorities may approve any potential applications that may be filed for any drug or vaccine candidates in any jurisdictions, which will depend on a myriad of factors, including making a determination as to whether the product’s benefits outweigh its known risks and determination of the product’s efficacy and, if approved, whether any such drug or vaccine candidates will be commercially successful; decisions by regulatory authorities impacting labeling, manufacturing processes, safety and/or other matters that could affect the availability or commercial potential of any drug or vaccine candidates; and competitive developments. These risks as well as other risks are more fully discussed in the company’s Annual Report on Form 10-K for the year ended December 31, 2023, the company’s Current Report on Form 8-K that was filed with the SEC on April 1, 2024, and the company’s other periodic reports and documents filed from time to time with the SEC. The information contained in this release is as of the date hereof, and Serina assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments. For inquiries, please contact: Investor.relations@serinatherapeutics.com (256) 327-9630White House says at least 8 US telecom firms, dozens of nations impacted by China hacking campaign

Opelousas High quarterback Zack Malveaux, right, and Da’Shaun Ford, middle, continue to lead the Tigers' offensive attack. Facebook Twitter WhatsApp SMS Email Print Copy article link Save For the sixth time over the past two postseasons, the Opelousas Tigers are taking the show on the road in the football state playoffs. Coach Jimmy Zachery's team is 5-0 in those games, which include four upsets of higher seeds during the 2023 run to the state crown. Then last week, the No. 14-seeded Tigers took down No. 3 Jennings 30-19 in the Division II nonselect regional round. "We're playing decently," said Zachery, whose 8-3 Tigers travel to No. 6 Plaquemine in the state quarterfinals on Friday. "But it's never enough for the coach." The Tigers, who defeated district rival Cecilia to win last year's title, have won seven straight games since a 1-3 start that included close losses to Alexandria (11-0) and Teurlings Catholic (10-1) and a road loss at Zachary High where quarterback Zack Malveaux exited the game early. "No doubt about it," Zachery said. "Our non-district schedule got us ready by playing the Zacharys of the world and facing the doggone Teurlings Catholic's of the world." Under the new LHSAA playoff rules, the higher seed hosts every round. Although the Tigers would love to play a home game, Zachery says they're comfortable as road warriors. "I'm not going to lie. We're better on the road," he admitted. "It's something we're used to. The guys understand what's at stake, whether we're on the road or at home." Plaquemine (11-1), which has won 11 straight games since a 49-14 loss to Zachary in Week 1, eliminated No. 27 Grant and No. 11 Northwest, which reached the 2023 semifinals. Green Devils quarterback Nico Victorian passed for 1,570 yards during the regular season with 23 touchdowns and four interceptions. Tailback Tyrese Mosby was sixth in the state in rushing (159-1,762 yards, 27 TDs). "They're really good," Zachery said of the Green Devils, who scored at least 48 points in seven wins. "No. 14 (sophomore John Walker) is a good receiver. They have good skill players. Defensively, they're big up front with athletes on the back end." Opelousas will counter with size and speed of its own. The Tigers' defense, headlined by Jacobian Ardoin, Jonathan Ford, Travis Esprit, Kylen Young and Jaylon Breaux, was able to neutralize Jennings' running attack. Tailback D'Shaun Ford ran for over 265 yards against Jennings, Zachery said. The 6-foot-0, 220-pound senior also gained over 200 yards in a one-point district win over Cecilia. "Offensively, we had a few miscues," Zachery said. "We turned the ball over three times. But the offensive line opened holes for Ford. He had two touchdowns." The winner will face the No. 22 Cecilia/No. 7 North DeSoto winner in the semifinals. "There's nobody left who isn't good," Zachery said. "We can't take (Plaquemine) lightly. They're in their hometown. (Mosby) runs downhill and breaks tackles. The quarterback can scramble and throw it a country mile."Saudi Arabia grants operator license for 1st international marina to Jeddah yacht clubTikTok CEO sought Musk's input ahead of Trump administration

Liberty gains 419 on the ground with 4 touchdowns in a 38-21 victory over Western KentuckyAlan Moore and Dave Gibbons' Watchmen is considered one of the most seminal works of superhero fiction ever created, and the definitive collected edition, Absolute Watchmen, is on sale on Amazon for one of the best Cyber Monday comic book deals we've dug up. At just $70 , the price is actually more than 50% off Absolute Watchmen's usual MSRP of $150. In fact, $70 is the lowest price it's ever reached on Amazon, making this one hell of a bargain. For those who aren't as familiar with DC's Absolute line of collected editions (not to be confused with the newly minted Absolute DC Universe comic reality), DC's Absolute editions are oversized slipcover collections that present the entire original comic in a single volume, along with as many extras and behind-the-scenes snippets as they can cram in. This makes Absolute Watchmen the definitive physical edition of the comic. At $70, there's really no reason to wait to add Absolute Watchmen to your collection. Don't let Cyber Monday slip you by without snapping up this spectacular deal - especially if you're looking for a nice gift for the comic reader in your life. Even if they've already got a copy of Watchmen, the Absolute edition's backmatter and wealth of extra material means that there's plenty of new stuff to enjoy with the upgraded collection. Should you buy the Absolute Watchmen Hardcover Collection? Watchmen is considered one of the seminal works of comic book fiction, and while the original story has been adapted into a movie and a sequel TV series along with other comic spin-offs, the original 12-issue series remains a classic. So if you like comics, or if you enjoy the adaptations of Watchmen, this is the best possible physical version to own. In short, don't let Cyber Monday pass you by without snagging Absolute Watchmen at $70, which is the lowest price it's ever reached. For more Cyber Monday savings, check out our guide to Cyber Monday gaming laptop deals and Cyber Monday gaming PC deals .

C3.ai Inc. stock underperforms Monday when compared to competitors

NoneReal Life Don't miss out on the headlines from Real Life. Followed categories will be added to My News. Harrowing video shows a beauty influencer being swept to her death in a flash flood in Brazil as onlookers desperately try to rescue her with a ladder. Jennifer Soares Martins — a 28-year-old influencer known as Jhei Soares — and her husband, Wallison Lima, were spotted clinging to a car in waist-deep water in Uberlândia, Minas Gerais, during the early hours Sunday, CNN Brazil reported. Video of the tragedy shows several people leaning out a window and holding an extended ladder, which is not quite long enough to reach the pair. Martins and Lima — who had leapt out of the car after crashing during the flash flood — initially try to use the vehicle to shield them from the torrent as the ladder remains painfully out of reach. Jennifer Soares Martins — a 28-year-old influencer known as Jhei Soares – drowned after being swept away by a flood in Uberlandia, Brazil. Picture: NF/Newsx She had been driving in a car with her husband Wallison Lima when their vehicle crashed, putting them in the torrent of water. Picture: NF/Newsx But the flow is so strong, it eventually moves their car, which is seen drifting out of view as the couple desperately try to cling on. Martins was later found dead, while her husband somehow managed to survive, officials said, according to the New York Post . “I just wanted her back,” he wrote with several crying emojis on social media later Sunday. Lima and Martins had been married for eight years and together for over 14. The two frequently made posts about their trips and family celebrations. Onlookers tried to help the couple with a ladder that was painfully out of reach. Picture: NF/Newsx But the beauty influencer lost her battle and was eventually dragged away. Picture: NF/Newsx Martins has over 82,000 followers on Instagram and often posted videos of her outfits, shopping hauls, and life in Brazil. Her comments have since been full of users grieving her sudden, tragic death. Despite the rain and flooding that led the young beauty influencer to her death, the government insists the conditions in Uberlandia are under control and the rain in the region has been closely monitored. “We inform you that the situation in the city of Uberlândia is under control. Electricity, water supply, internet, and telephone services have not been affected. There are no isolated communities or blocked highways,” the government told the outlet. This article originally appeared on the New York Post and was reproduced with permission More Coverage Beloved Sydney make-up artist dies age 27 ‘World first’ Macca’s item lands in Australia Claudia Poposki Originally published as Video shows horror moment influencer swept to death in flash flood More related stories Real Life Huge cost of vegan’s bizarre rant A notorious vegan activist must pay hundreds of thousands of dollars in damages after accusing a suburban vet of eating her animal patients. Read more Real Life If your boyfriend does this, leave him now Experts are warning that a worrying relationship “red flag” has become normalised after new data revealed it’s on the rise in Australia. Read more