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Pair of original MLS clubs to play for Cup title

The first new treatment for asthma attacks in 50 years has been hailed as a "game-changer" by doctors and patients. A clinical trial of the drug benralizumab showed it was far more effective than conventional steroid tablets at treating life-threatening breathing difficulties in people with a severe form of the disease. The monoclonal antibody specifically targets white blood cells that can invade the lungs of people with so-called eosinophilic asthma and cause the airways to swell and close up. The form of asthma accounts for around half of all emergency flare-ups of the disease. The same biological mechanism also underlies a third of all severe exacerbations of chronic obstructive pulmonary disease (COPD). But researchers at King's College London found asthma or COPD patients who were given an injection of the smart drug during their attack were less likely to suffer from wheezing, breathlessness and other symptoms four weeks later. There was also a marked improvement in their quality of life, according to results published in the journal The Lancet Respiratory Medicine. Professor Mona Bafadhel, the lead investigator for the study, said: "This could be a game-changer for people with asthma and COPD. "We hope this study will change how exacerbations are treated for the future, ultimately improving the health of over a billion people living with asthma and COPD across the world." An average of four people with asthma and 85 with COPD die in the UK every day. Steroid tablets have been the mainstay of treatment during flare-ups for decades, reducing inflammation in the lungs. But they don't always work so patients have to have repeated courses of the drugs, with a risk of re-admission to hospital and sometimes death. Regular use also increases the risk of diabetes and the bone-weakening disease osteoporosis. Follow our channel and never miss an update. 'An amazing turnaround' Sheraz Hussein, 36, developed eosinophilic asthma 13 years ago. His condition spiralled out of control, with asthma attacks almost every day. But the benralizumab injection he had in hospital helped stabilise his disease. He told Sky News he can scarcely believe his renewed health and vitality. He said: "I was going into that gloomy kind of state that nothing seems to be working for me, how am I going to survive my whole life? "The exacerbations I was getting, the chest infections, the shortness of breath - my normal lifestyle was completely distorted. "But since the drug, it has been an amazing turnaround." Read more from Sky News: Abandoned Cold War military base rediscovered New data reveals impact of war on civilians in Lebanon Be the first to get Breaking News Install the Sky News app for free 'It's appalling this is the first new treatment in 50 years' Benralizumab can be used at a lower dose to manage symptoms in people with eosinophilic asthma. But the finding that a higher dose injection during an attack leads to better outcomes is significant. Dr Samantha Walker of the charity Asthma + Lung UK said: "It's great news for people with lung conditions. "But it's appalling that this is the first new treatment in 50 years, and an indication of how desperately underfunded lung health research is."

In the last year, with most Israelis focused on the post-Oct. 7 war in Gaza, settlement construction in the West Bank has ballooned alongside new roads and infrastructure, including a dramatic increase in the establishment of unauthorized settler outposts. In a new report, Israeli human rights groups describe what they say are significant structural and legal changes by the Israeli government, the most religious and right-wing in the nation’s history, that “alter the face of the West Bank.” The day after Donald Trump won the U.S. presidential election, Israel’s hard-right finance minister, Bezalel Smotrich, posted a comment on the social platform X that reflected the delight of the pro-settlement camp. Using the biblical terms for the occupied West Bank, he wrote, “2025 is the year of Israeli sovereignty over Judea and Samaria.” Yisrael Medad, a spokesperson for an umbrella group of West Bank settlements, says he is encouraged by Mr. Trump’s victory, noting that in his first term as president, settlements were declared not to be a violation of international law, reversing longstanding U.S. policy. “The brave man is the one who seizes the opportunity, and that is what we have to do now and do the best we can,” says Mr. Medad. Bezalel Smotrich, Israel’s hard-right finance minister, posted a comment on the social platform X the day after Donald Trump won the U.S. presidential election that reflected the delight of the pro-settlement camp. Using the biblical terms for the occupied West Bank, he wrote, “2025 is the year of Israeli sovereignty over Judea and Samaria.” Bitter responses followed from some Israelis, who berated him for not wishing instead for more consensus outcomes: the end of the multifront war that the country has been battling since coming under Hamas attack in October 2023, and the bringing home of the 101 hostages still held in Gaza – an ongoing national trauma. But the pro-settlement movement in Israel – including Mr. Smotrich, its main advocate in the government – is exulting at what it perceives as a possible green light from the incoming Trump Middle East team to pursue annexation of the West Bank, even without the support of the broader Israeli public. In constructing the current government coalition, the most religious and far-right in the country’s history, two years ago, Prime Minister Benjamin Netanyahu granted Mr. Smotrich unprecedented power to oversee Israel’s settlement enterprise and civil administration in the West Bank. So much so that many experts say annexation of the part of the West Bank where most Jewish settlers live has already become a reality, sparking ire both regionally and internationally. For decades the existence and growth of settlements have been an obstacle to forging a two-state solution for Israelis and Palestinians. In the last year, with most Israelis’ focus on the post-Oct. 7 war in Gaza, settlement construction in the West Bank has ballooned alongside new roads and infrastructure, including a dramatic increase in the establishment of unauthorized settler outposts. In a new report, Israeli human rights groups describe what they say are significant structural and legal changes by the government that “alter the face of the West Bank and the structure of Israeli control there.” The government, the report says, is “methodically implementing a strategy designed to achieve the political vision of applying full Israeli sovereignty to the West Bank, while establishing a reality of Jewish supremacy and forcing the Palestinians living in the area into to the smallest possible geographical space.” Yael Berda, a legal scholar and professor of sociology at The Hebrew University of Jerusalem, says the recent spike in settler violence is not haphazard, but fits into a plan to transfer Palestinian residents from what is known as “Area C,” the 60% of the West Bank that has both Jewish and Palestinian communities. “They are [de facto] annexing where there are Jews living, which is why the fight is so intense to get Palestinians who live there off the land,” says Dr. Berda, author of “The Bureaucracy of the Occupation in the West Bank.” Palestinians have long claimed all areas of the West Bank as part of their own future state, while settlers see the territory as their biblical birthright. For them, Palestinian statehood is not only a security threat, but also an anathema to historic Jewish claims. The violence in Area C, which has included deadly settler rampages, led the Biden administration to impose sanctions on a key settler group – a development that Israel’s right-wing is hoping a Trump White House will undo. According to Dr. Berda, the main goal of the government’s controversial judicial overhaul plan, which elicited months of massive pro-democracy demonstrations in Israel in the months before the Israel-Hamas war, was West Bank annexation. By weakening the Supreme Court and the state’s legal advisers, she argues, the government had hoped to stymie the very institutions that have served as the primary check on the settlement project. Under Finance Minister Smotrich, almost 6,000 acres of West Bank land have been declared state land and 50 new settler outposts have been established with organizational and funding support from the government, according to Hagit Ofran, who leads Peace Now’s Settlement Watch division. With these outposts, “Small groups of settlers take over huge amounts of land and on a daily basis kick out Palestinians from their land, not allowing them to go there with their flocks or cultivate their land,” says Ms. Ofran. “They are taking hill after hill, and the government puts $75 million into their development – something we had not seen before. ... What I suspect we will see under Trump is the expulsion of Palestinians will be even more organized.” The most recent example of one kind of rule for Jewish settlers and another for Palestinians in the West Bank is the decision last week by new Defense Minister Israel Katz to end administrative detention only for settlers – a step the Biden administration condemned. Administrative detention is a tool used by Israel to detain terror suspects without trial. In an act of brazenness Friday, Jewish settlers even attacked senior Israeli military officers, including a general in charge of the army’s command in the West Bank. Yisrael Medad, a spokesperson for The Yesha Council, an umbrella group of West Bank settlements, condemned violence of any kind carried out by settlers, saying its perpetrators were outside the movement’s mainstream. He says he is encouraged by Mr. Trump’s victory, noting that in his first term as president, settlements were declared not to be a violation of international law, reversing longstanding U.S. policy and opening the door to annexation. “The brave man is the one who seizes the opportunity, and that is what we have to do now and do the best we can,” says Mr. Medad. According to Eitay Mack, an Israeli human rights lawyer who has represented Palestinians in the West Bank, “If full annexation happens, there will no longer be a hybrid regime of democracy within the Green Line [the official borders of Israel] and authoritarianism in the West Bank – but just an authoritarian regime based on race.” Mr. Smotrich, who says there is no such thing as a Palestinian people, said following Trump’s election, “We will apply the sovereignty, together with our American friends.” Among those friends is Mike Huckabee, named by Mr. Trump as his pick for U.S. ambassador to Israel. The former Arkansas governor and evangelical minister has said he doesn’t view the West Bank as occupied land, nor the half-million settlers there as occupiers. Signaling the opportunity he sees in Mr. Trump’s return to power, Mr. Netanyahu has appointed Yechiel Leiter, a former settler leader and an advocate of annexation, as Israel’s ambassador to the United States.

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BY MATT GLYNN Nov. 27, 2024 The Buffalo Niagara Partnership is moving its offices to 79 Perry St. in the space formerly used by Labatt USA. Partnership sees new home as a 'hub' The Buffalo Niagara Partnership's offices will soon have a new location. But it won't be your typical corporate offices. The region's largest business group is moving to 79 Perry St., a Pegula-owned building in the Cobblestone District, next door to KeyBank Center. "The office space is going to be a whole lot more than just office space for our team," said Dottie Gallagher, the Buffalo Niagara Partnership's president and CEO. Its offices will branded as BNP @ The Cobblestone, designed as a hub for businesses and their employees. "Our members will have access to premium co-working spaces, from a cozy cafe to semi-private desks," Gallagher said. There will also be conference rooms and event spaces. About 4,500 people a year attend Partnership events, she said. "That audience of local business professionals and executives is really second to none." Rendering of the planned new Buffalo Niagara Partnership offices. Pete Guelli, chief operating officer of the Buffalo Bills and Buffalo Sabres, said the Partnership is an ideal fit for the neighborhood. "It's incredibly active on game days and around events, but we want more in that area, and the BNP coming down to 79 Perry, to me, just gives some more credibility about why businesses should be a part of it," Guelli said. "They're the perfect tenant. They're going to bring business to businesses down there on a daily basis, and that's exactly what we need to see." The Partnership earlier this year exited its space at the former Highmark BlueCross BlueShield building on Genesee Street, and is temporarily operating from Evans Bank's headquarters in Amherst. Evans has allowed the Partnership to use the space rent free. At 79 Perry St., the Partnership is renovating office space formerly used by Labatt USA. The organization hopes to move into its new offices in February or March. Microbusinesses sign up Gallagher said 351 microbusinesses have signed up for free memberships with the Partnership. "We're thrilled to have that level of entrepreneurship represented in our membership," Gallagher said. The business group earlier this year launched BNP Pro Free, allowing businesses with five employees or fewer – plus locally owned and operated restaurants of any size – to join the business group at no cost. The initiative was funded by a grant from National Grid. Modernizing the power grid There is a great deal of attention on ensuring the state's electric power grid will be able to handle the rising demand for electricity. Gov. Kathy Hochul announced that $22 million is available for projects that strengthen and modernize the grid. The funds come from a U.S. Department of Energy grant. The New York State Energy Research and Development Authority will administer the program. The deadline for submitting proposals is Feb. 12. "We look forward to working with future partners to deliver projects that help provide clean energy to New Yorkers and support the state’s transition to a modern, zero-emission electric grid," said Doreen Harris, NYSERDA's president and CEO. Small businesses reap tech rewards Four Western New York businesses were among 35 recipients statewide of Innovation Matching grants. The grants were awarded by Empire State Development's Division of Science, Technology, and Innovation. The 35 grants were worth a combined $4.6 million. The four local recipients were: Graphenix Development, IBEX Materials, Atrevida Science and Immunotolerx Therapeutics. Ascending in accounting Mark Koziel, a Depew native and a 1991 Canisius University graduate, is about to take the reins of the world's largest accounting membership organization. Mark Koziel has been named CEO of the Association of International Certified Public Accountants. Koziel will serve as CEO of the Association of International Certified Public Accountants, effective in January. He started his career with Lumsden McCormick in Buffalo. He now lives in North Carolina and is president and CEO of Allinial Global, an association of independent accounting advisory firms. "Mark's appointment is a proud moment for Canisius University," said Ian Redpath, chair of the accounting program. "His journey from a Canisius accounting student to leading the world's premier accounting organization demonstrates the exceptional preparation and opportunities a Canisius education provides." Worksport's growing workforce Worksport, the company producing truck bed covers at a plant in West Seneca, said it has grown its workforce to 50 full-time hourly workers and 10 part-time salaried workers. "We are working our rear ends off," said Steve Rossi, the CEO, in a recent conference call with analysts. "We’re building a real business. We went from $1 million in a year to $1 million a month. Next stop is $1 million a week." Worksport said it is continuing to expand its production capacity and expects to meet its next production target of making more than 200 tonneau covers per day within 2025. THE LATEST Two of Buffalo's top development officials have been ousted . New solar project starts construction in Great Valley. Scanlon, Poloncarz criticize land bank for delays and cost of homes on projects in Buffalo and Cheektowaga. How do the Bills believe they will ever get to the more than 5,000 potential season ticket holder accounts on their waitlist for the new stadium and why advertise for more of them? Developers battle over Tonawanda Island site but sewer capacity may hinder projects. What went wrong at Tonawanda's Sumitomo tire plant ? And why did Sumitomo's Japan-based parent decide to pull the plug now? Work has begun on venture studio built to fill void in Buffalo's entrepreneurial space . Artisans report as much as 50% of their annual revenue comes from the holiday shopping season. Now valued at $5 billion, Odoo welcomes Google parent company venture fund as co-lead investor. An incentive package containing $11.6 million in sales and property tax breaks could help Wells Enterprises bring 270 jobs to Dunkirk. Local startup Rookery Labs will move into a space at the Northland Center. Family Promise of Western New York wants to build a second emergency shelter for homeless . StoreCash , one of five $1 million winners in last year’s 43North competition, has completed a $3.7 million seed funding round. The Buffalo Niagara region's jobless rate has risen to 3.6%. A report says the Buffalo Bills are ready to sell an about 20% minority stake in team. The cost of the new Buffalo Bills stadium is going up by almost 25% . A downtown golf project is getting a boost from a new investor . ICYMI Five reads from Buffalo Next: 1. Locally owned stores are pulling out all the stops to attract customers who may otherwise be lured in by the convenience of major retailers and online shopping. 2. Get the story behind Evans Bank's hunt for a merger , which ended with the Amherst-based bank's acquisition by NBT Bank. 3. A lot goes into getting local grocery stores ready for the Thanksgiving shopping rush . 4. Buffalo officials are considering whether to impose more restrictions on short-term rentals. 5. How retailers try to entice shoppers to do their holiday buying early . The Buffalo Next team gives you the big picture on the region’s economic revitalization. Email tips to buffalonext@buffnews.com or reach Buffalo Next Editor David Robinson at 716-849-4435. Was this email forwarded to you? Sign up to get the latest in your inbox five days a week . Email tips to buffalonext@buffnews.com . 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Support our high school sports coverage by becoming a digital subscriber. Subscribe now The suspension of Edison running back Julius Gillick for the CIF-SS Division 3 final against Simi Valley is one of the biggest storylines heading into the championships on Friday. Here’s what four Orange County coaches familiar with Simi Valley said about the Chargers’ chances to compete or win the section title without the 2,000-yard rusher: Frank Mazzotta, La Habra (lost to Simi Valley 41-34 in playoffs) “Edison is very well coached and they are physical. They have played and beaten a lot of good teams.” Jeff Bailey, Yorba Linda (beat Simi Valley 38-21 last season in regular season) “Well, it’s hard to say because I have not seen Simi Valley this year. But I’m sure Edison can compete because they have a quality team around the running back. And I’m sure their backup is pretty good. Next man up mentality. And their style of football would be conducive to keeping the game close and giving them a chance to win at the end. Big opportunity for a team win. Win on special teams, which they are good at.” Rick Curtis, Crean Lutheran (lost to Simi Valley 27-7 last season in playoffs) “Jeff Grady was my offensive coordinator while I was at Santa Margarita, so I am partial to my good friend. However, I was able to see Edison play North Torrance in the first round and I was impressed with their defense and with how Jeff’s quarterback (Sam Thomson) managed the game. During that game, Edison’s backup running back (Sam Edmisten) played, as Julius was nursing an injury. I believe he’s a sophomore and he impressed me. I haven’t seen Simi Valley play this year, but we saw them last year and as you know, Jim Benkert is a great coach. With Troy Thomas dialing up the defense and with Jeff’s creativity on offense, I think they have a good chance of bringing home the championship. I think it will be a great game. To me, Edison is a Division 2 team. Edison by 10 is my call.” Brett Brown, Huntington Beach (lost to Simi Valley 32-29 last season in playoffs and lost to Edison 47-20 in regular season last season) “Edison has played really well defensively all year and they have depth at RB. Obviously it is a big loss with Gillick being out, but I think they will definitely compete. Both teams are well coached, play hard, and it should be a really good game.” Related Articles

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