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$7EY'O FMDz V'<ΜHWMkZMN驢X`BB餢iM *eHgTӎףNoneUnderstand the questionsSyrian government forces withdraw from central city of Homs as insurgent offensive accelerates BEIRUT (AP) — A Syrian opposition war monitor and a pro-government media outlet say government forces have withdrawn from much of the central city of Homs. The pro-government Sham FM reported that government forces took positions outside Syria’s third-largest city, without elaborating. Rami Abdurrahman who heads the Britain-based Syrian Observatory for Human Rights, said Syrian troops and members of different security agencies have withdrawn from the city, adding that rebels have entered parts of it. Losing Homs is a potentially crippling blow for Syria’s embattled leader, Bashar Assad. An archbishop's knock formally restores Notre Dame to life as winds howl and heads of state look on PARIS (AP) — France’s iconic Notre Dame Cathedral has formally reopened its doors for the first time since a devastating fire nearly destroyed the 861-year-old landmark in 2019. The five-year restoration is widely seen as a boost for French President Emmanuel Macron, who championed the ambitious timeline, and brings a welcome respite from his domestic political woes. World leaders, dignitaries, and worshippers gathered on Saturday evening for the celebrations under the cathedral's soaring arches. The celebration was attended by 1,500 dignitaries, including President-elect Donald Trump, Britain’s Prince William, and Ukrainian President Volodymyr Zelenskyy. For Catholics, Notre Dame’s rector said the cathedral “carries the enveloping presence of the Virgin Mary, a maternal and embracing presence.′′ Trump is welcomed by Macron to Paris with presidential pomp and joined by Zelenskyy for their talks PARIS (AP) — French President Emmanuel Macron has welcomed Donald Trump to Paris with a full dose of presidential pomp. And they held a hastically-arranged meeting with Ukraine’s Volodymyr Zelenskyy on a day that's mixing pageantry with attention to pressing global problems. The president-elect's visit to France is part of a global a celebration of the reopening of Notre Dame Cathedral five years after a devastating fire. Macron and other European leaders are trying to win Trump’s favor and persuade him to maintain support for Ukraine in its defense against Russia’s invasion. Trump isn't back in office but he's already pushing his agenda and negotiating with world leaders NEW YORK (AP) — Donald Trump is making threats, traveling abroad, and negotiating with world leaders. He has more than a month-and-a-half to go before he’s sworn in for a second term. But the president-elect is already moving aggressively to not only fill his Cabinet and outline policy goals, but also to try to achieve his priorities. In recent days, Trump has threatened to impose a 25% tariff on goods from Canada and Mexico, two of the country’s largest trading partners. That led to emergency calls and a visit. And he's warned of “ALL HELL TO PAY” if Hamas doesn't release the hostages still being held captive in Gaza. South Korea's president avoids an impeachment attempt over short-lived martial law SEOUL, South Korea (AP) — South Korea’s embattled President Yoon Suk Yeol has avoided an opposition-led attempt to impeach him over his short-lived imposition of martial law. Most of Yoon's ruling party lawmakers boycotted a parliamentary vote Saturday to deny a two-thirds majority needed to suspend his presidential powers. The scrapping of the motion is expected to intensify protests calling for Yoon’s ouster and deepen political chaos in South Korea. A survey suggests a majority of South Koreans support the president’s impeachment. Yoon’s martial law declaration drew criticism from his own ruling conservative People Power Party. But the party also apparently fears losing the presidency to liberals. Days after gunman killed UnitedHealthcare's CEO, police push to ID him and FBI offers reward NEW YORK (AP) — Nearly four days after the shooting of UnitedHealthcare CEO Brian Thompson, police still do not know the gunman’s name or whereabouts or have a motive for the killing. But they have made some progress in their investigation into Wednesday's killing of the leader of the largest U.S. health insurer, including that the gunman likely left New York City on a bus soon after fleeing the scene. The also found that the gunman left something behind: a backpack that was discovered in Central Park. Police are working with the FBI, which on Friday night announced a $50,000 reward for information leading to an arrest and conviction. UnitedHealthcare CEO's shooting opens a door for many to vent frustrations over insurance The fatal shooting of UnitedHealthcare's CEO has opened the door for many people to vent their frustrations and anger over the insurance industry. The feelings of exasperation, anger, resentment, and helplessness toward insurers aren’t new. But the shooting and the headlines around it have unleashed a new wave of patients sharing such sentiments and personal stories of interactions with insurance companies. Conversations at dinner tables, office water coolers, social gatherings and on social media have pivoted to the topic. Many say they hope the new amplified voices can bring about change for companies often accused of valuing profits over people. 2 Pearl Harbor survivors, ages 104 and 102, return to Hawaii to honor those killed in 1941 attack PEARL HARBOR, Hawaii (AP) — The bombing of Pearl Harbor 83 years ago launched the United States into World War II. Two survivors returned to the Hawaii military base on Saturday for a remembrance ceremony on the attack's anniversary. Both are over 100 years old. They joined active-duty troops, veterans and members of the public for an observance hosted by the Navy and the National Park Service. A third survivor was planning to join them but had to cancel due to health issues. The bombing killed more than 2,300 U.S. servicemen. An explosion destroys an apartment block in a Dutch city, killing at least 3 and injuring others THE HAGUE, Netherlands (AP) — An explosion and fire has rocked a neighborhood in the Dutch city of The Hague, killing three people and injuring other people and destroying several apartments. The cause of the disaster is unclear. Emergency authorities said four people were rescued from the rubble and taken to the hospital. The mayor said rescuers were no longer looking for survivors but for eventual bodies, but could not specify how many people might still be unaccounted for. Residents of the northeastern neighborhood of Mariahoeve in The Hague heard a huge bang and screams before dawn. Dutch authorities have deployed a specialized urban search and rescue team to find victims. How 'Mufasa' rose with Aaron Pierre and Blue Ivy's voices along with new Lin-Manuel Miranda music SAN DIEGO (AP) — When Aaron Pierre was cast as Mufasa, the weight of following in the late James Earl Jones’ legendary footsteps was enough to rattle any actor. But instead of letting the pressure roar too loudly, he harnessed his nerves to breathe fresh life into his young lion character. Pierre found parallels between himself and his character while filming his leading role in “Mufasa: The Lion King,” which opens in theaters Dec. 20. He took the reigns as the new voice of Mufasa after Jones played the iconic King Mufasa in both the 1994 and 2019 versions of Disney’s “The Lion King.” The prequel offers a fresh exploration into Mufasa’s origin story.
"Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum." Section 1.10.32 of "de Finibus Bonorum et Malorum", written by Cicero in 45 BC "Sed ut perspiciatis unde omnis iste natus error sit voluptatem accusantium doloremque laudantium, totam rem aperiam, eaque ipsa quae ab illo inventore veritatis et quasi architecto beatae vitae dicta sunt explicabo. Nemo enim ipsam voluptatem quia voluptas sit aspernatur aut odit aut fugit, sed quia consequuntur magni dolores eos qui ratione voluptatem sequi nesciunt. Neque porro quisquam est, qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit, sed quia non numquam eius modi tempora incidunt ut labore et dolore magnam aliquam quaerat voluptatem. Ut enim ad minima veniam, quis nostrum exercitationem ullam corporis suscipit laboriosam, nisi ut aliquid ex ea commodi consequatur? Quis autem vel eum iure reprehenderit qui in ea voluptate velit esse quam nihil molestiae consequatur, vel illum qui dolorem eum fugiat quo voluptas nulla pariatur?" 1914 translation by H. Rackham "But I must explain to you how all this mistaken idea of denouncing pleasure and praising pain was born and I will give you a complete account of the system, and expound the actual teachings of the great explorer of the truth, the master-builder of human happiness. No one rejects, dislikes, or avoids pleasure itself, because it is pleasure, but because those who do not know how to pursue pleasure rationally encounter consequences that are extremely painful. Nor again is there anyone who loves or pursues or desires to obtain pain of itself, because it is pain, but because occasionally circumstances occur in which toil and pain can procure him some great pleasure. To take a trivial example, which of us ever undertakes laborious physical exercise, except to obtain some advantage from it? But who has any right to find fault with a man who chooses to enjoy a pleasure that has no annoying consequences, or one who avoids a pain that produces no resultant pleasure?" 1914 translation by H. Rackham "But I must explain to you how all this mistaken idea of denouncing pleasure and praising pain was born and I will give you a complete account of the system, and expound the actual teachings of the great explorer of the truth, the master-builder of human happiness. No one rejects, dislikes, or avoids pleasure itself, because it is pleasure, but because those who do not know how to pursue pleasure rationally encounter consequences that are extremely painful. Nor again is there anyone who loves or pursues or desires to obtain pain of itself, because it is pain, but because occasionally circumstances occur in which toil and pain can procure him some great pleasure. To take a trivial example, which of us ever undertakes laborious physical exercise, except to obtain some advantage from it? But who has any right to find fault with a man who chooses to enjoy a pleasure that has no annoying consequences, or one who avoids a pain that produces no resultant pleasure?" To keep reading, please log in to your account, create a free account, or simply fill out the form below.India's exports to Australia surge 14% since ECTA, trade momentum strong
DIDWW brings advanced voice and SMS solutions to ITW Asia 2024BGBA-445 is under clinical development by BeiGene and currently in Phase II for Non-Small Cell Lung Cancer. According to GlobalData, Phase II drugs for Non-Small Cell Lung Cancer have a 38% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. BGBA-445 overview BGBA-445 is under development for the treatment of advanced malignancies, metastatic solid tumors, recurrent head and neck cancer squamous cell carcinoma, non-small cell lung cancer, squamous non-small cell lung cancer, metastatic urothelial carcinoma, renal cell carcinoma, nasopharyngeal carcinoma (NPC), bladder cancer and melanoma. The drug candidate is administered through intravenous route. It acts by targeting OX40 (CD134) receptor. BeiGene overview BeiGene is a biotechnology company. It specializes in the development and commercialization of immuno-oncology medicines to treat cancers. The company offers Zanubrutinib, a small molecule inhibitor to treat various blood cancers and Sonrotoclax, a small molecule Bcl-2 inhibitor for treating chronic lymphocytic leukemia. BeiGene also provides Tislelizumab (BGB-A317), a monoclonal antibody targeting solid tumors and hematologic cancer; and Pamiparib (BGB-290) against solid tumor malignancies. The company has operations in the US, Australia, Germany, Spain, Canada, Switzerland and Italy. BeiGene is headquartered in the Cayman Islands. For a complete picture of BGBA-445’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .
Family blames fiery I-55 deaths of mom, daughters on lumber truck in St. Louis County suit
Trump's tariff threat a grim reminder of turbulent trade in first administrationM/I Homes CEO Robert Schottenstein sells $573,404 in stockAn online debate over foreign workers in tech shows tensions in Trump's political coalitionCheck out a collection of videos featuring people and places from the Thomastown, Kells & Bennettsbridge along with parts of the south and the wider mid-section of the County Kilkenny . FOR MORE LOCAL NEWS, CLICK HERE If you have any photos or videos of County Kilkenny from days gone by, get in touch with Kilkenny Live across social media!
Povetacicept is under clinical development by and currently in Phase II for Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis). According to GlobalData, Phase II drugs for Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) have a 74% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Povetacicept overview Povetacicept is under development for the treatment of myasthenia gravis, systemic lupus erythematosus, membranous glomerulonephritis, Sjogren's syndrome, proteinuria in IgA nephropathy (Berger's Disease), lupus nephritis, immune thrombocytopenia, acquired (autoimmune) hemolytic anemia, cold agglutinin disease, unspecified antibody-related neurological diseases, ANCA-associated vasculitides and autoimmune encephalitis (post-infectious). It is administered through intravenous and subcutaneous route. The drug candidate is an engineered B-cell modulator. It acts by targeting BAFF and APRIL. It was also under development for pemphigus foliaceus, pemphigus vulgaris and bullous pemphigoid. Alpine Immune Sciences overview (Alpine), a subsidiary of Vertex Pharmaceuticals Inc. is a clinical-stage biopharmaceutical company that discovers and develops protein-based immunotherapies. The company’s main activities involve the use of unique protein engineering strategies, including the directed evolution of immune proteins into novel, multi-targeted therapeutics. Alpine’s pipeline products include povetacicept (ALPN-303) is a dual antagonist of the B cell activating factor (BAFF) and a proliferation-inducing ligand that targets systemic lupus erythematosus, glomerulonephritis and cytopenia; and acazicolcept (ALPN-101) is a first-in-class, dual inhibitor of the CD28 and ICOS T-cell costimulatory pathways that treat systemic lupus erythematosus (SLE). Alpine is headquartered in Seattle, Washington, the US. For a complete picture of Povetacicept’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .New research shows restaurant chains and food concepts are helping shopping malls regain their footing, driving consumers to the once-struggling spaces. The data from Yelp shows restaurants have become a driving force in this ever-changing retail landscape, helping to catapult visitor numbers above pre-pandemic levels at malls. Shoppers grab a bite to eat and then spend their money at various businesses before and after they dine out — creating a bounce-back effect for what has often been dubbed a "struggling industry." Days of packed shopping malls are beginning to return, but they look a bit different than what we were used to in the 1990s and early 2000s. RELATED STORY | Retailers say they're ready for potential Trump tariffs Take a drive past or step foot near Great Northern Mall in Ohio and you'll be greeted by one restaurant after the next. More are on the way, including a Texas Roadhouse in the near future. "Five times more traffic," Tony Ke, the owner of TJ Hibachi and Sushi said. Ke said through the ups and downs of the coronavirus pandemic, and many folks opting for online shopping over the years, things are finally turning around. He said business is booming with five times more traffic in the mall food court than in years past. "It's really getting better and better," Ke said. And he's not alone. Scripps News Cleveland followed through and spoke with Beverly Bolton, owner of Fortune's Cookies. The self-proclaimed community baker and Cleveland-area mom took a gamble, opening her first brick-and-mortar inside Great Northern a year ago. "It's been an adventure, but better than I expected," Bolton said. The local cookie shop has become so popular that she's been scouted to fill that nostalgic mall cookie void. "We've had some other malls approach us. Actually, use the space where Mrs. Fields used to be in," Bolton said. RELATED STORY | Big Lots continues some store closures as its bankruptcy proceeds Placer.AI reports shopping malls — whether it be open-air concepts or traditional malls like Great Northern — are on the rise again in 2024. The organization that tracks retail foot traffic reports the primary reason is restaurants and food concepts in malls. They are up 7% from 2019 to 2024. Yelp recently released a report of the top 25 mall brands, and 17 of the top 25 mall brands are restaurant chains: Food concepts are a driving force as well. This includes Filipino, Vegan and specifically Bubble Teas —which are up 100% over the last five years, according to Yelp. Michael Goldberg, a professor in the Department of Design Innovation at the Weatherhead School of Management at Case Western Reserve University, said a generation that has virtually lived online plays a critical role in the process. "Many Americans, particularly younger Americans, are focused on experiences and nothing is better than sharing food with friends," Goldberg said. Young social media influencers are eating food on camera, providing reviews and driving people to dive in and try the food. The TikTok generation has given a major boost to once-struggling brands and revived them tenfold. Case in point: Chili's Triple Dipper. "The thought that Chili's is back and being driven by influencer videos on TikTok is quite fascinating and, you know, I mean, there is a nostalgia for brands," Goldberg said. Localized community programming and holiday events like pictures with Santa are a mainstay at malls like Great Northern. Lori Weidleman, who has been cranking out pretzels at Auntie Anne's since 1997, said change is constant. However, she added it's become apparent people will pay for a quality product that takes them back to a special moment in life. "Ohio's doing really good. We're strong and beating our goals and our targets. And it's multi-generational interest," Weidleman said. This story was originally published by Mike Holden at Scripps News Cleveland .Talavera Solutions Launches to Transform Technical Excellence in the Americas
AGNC Investment Corp. ( NASDAQ:AGNCM – Get Free Report ) announced a quarterly dividend on Wednesday, December 11th, NASDAQ Dividends reports. Investors of record on Wednesday, January 1st will be paid a dividend of 0.5904 per share on Wednesday, January 15th. This represents a $2.36 annualized dividend and a yield of 9.25%. The ex-dividend date of this dividend is Tuesday, December 31st. AGNC Investment has increased its dividend payment by an average of 72.4% per year over the last three years. AGNC Investment Stock Performance Shares of AGNC Investment stock opened at $25.52 on Friday. The stock’s 50 day simple moving average is $25.19 and its 200-day simple moving average is $25.19. AGNC Investment has a 1-year low of $23.51 and a 1-year high of $25.85. AGNC Investment Company Profile AGNC Investment Corp. provides private capital to housing market in the United States. It invests in residential mortgage pass-through securities and collateralized mortgage obligations for which the principal and interest payments are guaranteed by the United States government-sponsored enterprise or by the United States government agency. Further Reading Receive News & Ratings for AGNC Investment Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for AGNC Investment and related companies with MarketBeat.com's FREE daily email newsletter .
Goderich woman’s 'passion' for Christmas on display for all to enjoy
