China has unveiled its next-generation high-speed train, the CR450 prototype, which has set a new global benchmark by reaching test speeds of 450 km/h. The train surpasses the current CR400 Fuxing trains, which operate at 350 km/h, making it the fastest train in the world, according to state media reports. About the High-speed train The CR450 was developed following extensive research and development that began in 2021, focusing on safety, energy efficiency, and passenger comfort. It features significant advancements, including a streamlined design that reduces energy consumption by over 20% and an optimized braking system to ensure stability and safety at high speeds. Two prototype models, the CR450AF and CR450BF, have been revealed, each featuring an eight-car formation with advanced technologies such as water-cooled permanent magnet traction systems and high-stability bogies. These innovations improve the train’s energy efficiency and performance. According to the China State Railway Group, the CR450 is expected to shorten travel times significantly. For example, the Beijing-Shanghai journey, which currently takes 4.5 hours, could be reduced to just over three hours. Further testing and refinement are underway to ensure the train’s readiness for commercial service, with a launch anticipated as early as next year. In addition to speed and efficiency, the CR450 prioritizes passenger experience with features such as increased cabin space, noise reduction technologies, and adjustable storage for bicycles and wheelchairs. Advanced materials like carbon fiber contribute to its reduced weight and superior energy efficiency, aligning with China’s sustainability goals. The unveiling of the CR450 reinforces China’s position as a global leader in high-speed rail technology. The country currently boasts the world’s largest high-speed rail network, with 47,000 kilometers of operational tracks connecting major cities. While not all routes are profitable, the network has significantly boosted economic and social development. China’s high-speed rail expertise has also been exported globally, with projects in countries like Thailand, Indonesia, and Serbia. ALSO READ: Mysterious Water Flow In Jaisalmer Forces Evacuations As Tubewell Digging In Taragarh VillageLONDON -- Many of us have felt it, and now it’s official: “brain rot” is the Oxford dictionaries’ word of the year. Oxford University Press said Monday that the evocative phrase “gained new prominence in 2024,” with its frequency of use increasing 230% from the year before. Oxford defines brain rot as “the supposed deterioration of a person’s mental or intellectual state, especially viewed as the result of overconsumption of material (now particularly online content) considered to be trivial or unchallenging.” The word of the year is intended to be “a word or expression that reflects a defining theme from the past 12 months.” “Brain rot” was chosen by a combination of public vote and language analysis by Oxford lexicographers. It beat five other finalists: demure , slop, dynamic pricing , romantasy and lore. While it may seem a modern phenomenon, the first recorded use of “brain rot” was by Henry David Thoreau in his 1854 ode to the natural world, “Walden.” Oxford Languages President Casper Grathwohl said that in its modern sense, “’brain rot’ speaks to one of the perceived dangers of virtual life, and how we are using our free time.” “It feels like a rightful next chapter in the cultural conversation about humanity and technology. It’s not surprising that so many voters embraced the term, endorsing it as our choice this year,” he said. Last year’s Oxford word of the year was “rizz,” a riff on charisma , used to describe someone’s ability to attract or seduce another person. Collins Dictionary’s 2024 word of the year is “brat” – the album title that became a summer-living ideal.The world is experiencing more catastrophic weather events with greater frequency. As vulnerable populations continue to face the consequences of climate change, world leaders are faced with the challenge of finding innovative solutions to protect their citizens, adapt their economies, and build resilient infrastructure. The CSIS Sustainable Development and Resilience Initiative recently hosted an event with representatives from the United States government, developing country partners, and the private sector to discuss the growing need to prioritize a systems-oriented development approach to climate-resilient infrastructure investments in developing countries. The U.S. Agency for International Development (USAID) and the U.S. Millenium Challenge Corporation (MCC), in partnership with other U.S. government agencies, used the event to launch the Resilience at Scale: A Systems Approach to Climate-Resilient Infrastructure Planning report which analyzes the opportunities and challenges associated with applying a systems approach to strategically plan for infrastructure investments. Additionally, at COP29 in Baku, Azerbaijan, the U.S. Center convened a related event for that international forum. As representatives from governments, the private sector, and multilateral organizations look for ways to bolster climate-resilient investments in their countries and regions, rethinking how the United States approaches protecting both the monetary and physical value of these investments will be important. Q1: What is the “Resilience at Scale” report? A1: The Resilience at Scale report calls for a “paradigm shift” toward system resilience as opposed to the resilience of individual investment assets. A systems approach looks holistically at how individual infrastructure projects work together to build resilience; brings governments, private sector actors, and multilateral organizations into partnership with one another to support a strategic pipeline of investments in support of adaptation as a whole; and necessitates agreement on resilience standards for long-term development. Historically, U.S. government agencies have addressed climate risk through the lens of individual investments (a road, a bridge, or a school) without thoroughly acknowledging the full picture. If the school is only accessible by road via a bridge, and the bridge gives out in a flood, the value of both the road and the school is negated. Instead, by looking at the system as a whole (the road, the bridge, and the school), the U.S. government and its many partners are better able to identify vulnerabilities and target specific projects to increase the overall resilience of a community or region. A systems approach necessitates assessing current vulnerabilities to the system, integrating climate resilience across development projects, building out country capacity, and coordinating with other donors to financially target adaptation priorities. The Resilience at Scale report is divided into three main sections: This report was an interagency effort led by USAID and the MCC in support of the President’s Emergency Plan for Adaptation and Resilience (PREPARE) and was informed by the work of the PREPARE Infrastructure Working Group, which included representatives from the U.S. Army Corp of Engineers, the U.S. Development Finance Corporation, the U.S. Department of Transportation, U.S. Department of State, U.S. Department of the Treasury, and the U.S. Trade and Development Agency. Through two years of research and convening, the effort sought to address the gap in the literature on the benefits of, and current appetite for, a systems approach to climate-resilient infrastructure planning. Q2: Why would a shift to a more systematic approach to resilient infrastructure planning be significant? A2: Infrastructure encompasses both the physical assets and the services they provide; building resilient infrastructure means building resilient communities with reliable water, energy, sanitation, communications, and transportation systems. If one piece of infrastructure fails, it can have a domino effect. A systems approach can enable infrastructure to be built strategically to benefit competing priorities , including health, gender equality, and digital connectivity. During the historic flooding in Pakistan in 2022, over one-third of the country was submerged in water and it was estimated that the cost of the damage would exceed $30 billion. Approximately 33,000 schools were either destroyed or damaged, delaying education for millions of children for nearly a year. Because the infrastructure failed, there were ripple effects across a range of public services from education to health care. Adapting to the changing climate requires a comprehensive approach to resilience because climate change impacts are far-reaching. The United States has been screening its international development investments for climate resilience since 2014 in accordance with Executive Order 13677 , which makes it a requirement to take into consideration the impacts of climate change for all projects. But transitioning to a more systems-oriented approach has the potential to improve reliability and cost-effectiveness, while also working to protect multiple assets at once. For example, in 1999 the Japan International Cooperation Agency developed a plan to address flood risk in Ho Chi Minh City, Vietnam, based on previous rainfall patterns, without taking into account future risks such as increased urbanization. This ultimately led to increased flood vulnerability. Ho Chi Minh City has since worked with the World Bank to rethink its approach to drainage infrastructure, which has allowed the city to create an investment pipeline that plans for future risks. By incorporating a systems approach , governments should be able to plan more effectively. Implementing a systems approach faces many challenges , as it requires investors, governments, and multilateral organizations to think through the long-term impacts of different projects, work in conjunction with each other throughout the project’s lifespan, and agree on the same standards of risk, resilience, and feasibility. A lack of strong organizational planning diminishes a government’s ability to effectively implement a long-term strategy to build resilient societies. In addition, taking a systems approach requires upfront private sector involvement. The lack of sufficient funding for climate-oriented projects does not encourage governments to strategically plan for and implement investments that work in tandem to build resilient systems. However, a systems approach to development investments could allow for the U.S. taxpayer dollar to be spent more strategically both in terms of impact and pursuit of U.S. foreign policy objectives. Q3: How does a systems approach to resilient infrastructure relate to the emerging resilience economy? A3: Industries are being forced to rethink their approach to acquisition, production, warehousing, and transportation as extreme weather events are altering agricultural seasons, impacting people’s ability to work, and interfering with supply chains. The economic benefits of adaptation are straightforward: the global economy risks losing 4 percent of its GDP without adaptation; but for every $1 invested in adaptation efforts the economic benefits returned could reach approximately $2–10. Resilience efforts stretch across sectors from enhancing the usability and accuracy of early warning systems to boosting sustainable infrastructure and health systems. As the world works to adapt to the consequences of climate change, a resilience-oriented economy is emerging through the creation of new investment asset classes, insurance solutions, and technology-enabled climate information services. Financing for adaptation efforts crosses sectoral divides that bring a variety of stakeholders together ranging from insurance firms to agricultural companies to technology startups, and it has already produced innovative approaches to building resilience across the world. In Mongolia, one of the nations most impacted by climate change, a joint U.S.-Mongolia study in 2016 found that the country’s water shortage was one of the key constraints for national economic growth. In partnership with the MCC, Mongolia entered into a $462 million investment compact focused on water infrastructure to increase the country’s water supply by up to 80 percent. The compact is to build new groundwater wells and a water purification plant to enable the usage of wastewater for power generation, reducing the demand for fresh water. In addition to the physical infrastructure projects, the compact is working to strengthen institutional, operational, and human resource capacity for water utilities and introduce a self-sustaining financial framework into the system. The water purification plant is the first of its kind in Mongolia, bringing with it new avenues for construction and skills training. The compact is set to end in 2026, but the government of Mongolia is already thinking through the next steps to further incentivize the use of recycled water by updating its existing regulatory framework on wastewater usage and through financial incentives. As the government looks at ways to apply a similar framework to air pollution issues, the resilience economy will continue to grow in Mongolia. Q4: How does this connect to the President’s Emergency Plan for Adaptation and Resilience? A4: The PREPARE initiative was launched in 2021 at COP26 in Glasgow, Scotland with the goal to “help more than half a billion people in developing countries adapt to and manage the impacts of climate change by 2030.” It is based on three principles: knowledge sharing, integrating adaptation into project planning and preparation, and resource mobilization. The following year, the PREPARE Call to Action to the private sector was announced. This prong of the initiative has since mobilized 40 companies to make commitments collectively valued at approximately $3 billion while projecting to reach more than 118 million people around the world by 2030. The private sector invests in what will protect their capital. As supply chains shift, private actors make investments in climate-resilient infrastructure to protect their assets from extreme weather events. The Resilience at Scale report identifies opportunities for partnerships between governments, private sector actors, and multilateral institutions that will mobilize resources to be a catalyst for further investment. The report was published in support of the PREPARE initiative, but it also provides a roadmap for industries that are looking to make investments in climate-vulnerable regions. The report seeks to inform the first pillar of PREPARE, “ Knowledge is Power ,” by articulating a way of thinking about climate-resilient infrastructure investments. As governments, private actors, and multilateral institutions work toward building more resilient communities, taking a systems approach to climate-resilient infrastructure investments wherever possible could help expand the reach of current capital pools while building longevity into those investments. Noam Unger is the director of the Sustainable Development and Resilience Initiative at the Center for Strategic and International Studies (CSIS) in Washington, D.C. Madeleine McLean is a program manager and research associate with the Sustainable Development and Resilience Initiative at CSIS.

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Britain should follow Australia’s lead and ban young people from social media, according to a leading campaigner for the protection of childhood. The Australian Parliament last week backed the world’s toughest measures to stop under-16s using social media – and tech companies could fines of nearly £26million if they do not enforce new rules. Former Conservative MP Miriam Cates, a senior fellow at the Centre for Social Justice and GB News presenter, hopes Australia will blaze a trail for Britain to follow. She wants children denied access to “dreadful” content which encourages suicide, self-harm and misogyny and exposes them to pornography – and she is concerned they can be “contacted by people they don’t know” and “bullied by people they do know”. Ms Cates is also alarmed that algorithms encourage young people to spend hours staring at screens. “They are not being outside, they are not making face to face contact, they are not reading, they are not studying they are not doing sport – all those things that children really need to grow into competent adults,” she said. A further goal is encouraging smartphone manufacturers to produce phones which allow children to make calls, send texts, use digital train tickets and access maps – but not download apps. “I think that’s the answer really but Government will have to incentivise that to make it happen,” she said. Her call comes as Labour MP Josh MacAlister works to change the law so headteachers will have a legal requirement to make schools “mobile-free zones”. His draft law would raise the age of “internet adulthood” from 13 to 16 – making it harder for companies to use children’s data to “push addictive content”. Children’s Commissioner for England Dame Rachel de Souza said: “Too many children are still routinely exposed to significant and damaging online harms including violence, pornography and other material that promotes harmful behaviour. We have heard too many stories of children causing harm to themselves, or others, on the back of material they have been exposed to online.” Dame Rachel said she was “really impressed” by the action in Australia, adding that “we need to start here with holding the social media companies properly to account for their laissez faire approach to children’s safety”. Sir Peter Wanless, the chief executive of the NSPCC children’s charity, did not favour a “blanket ban”, saying this would “penalise children for the failures of tech companies to make their sites properly safe for young users”. A Government spokeswoman said there are “no current plans to implement a smartphone or social media ban for children,” adding: “We are focused on finding the best way of ensuring young people are kept safe while also benefiting from the latest technology. By next summer, the Online Safety Act will bring in protections for children to make sure their experiences online are appropriate for their age. “We have recently set out new priorities on online safety, including ensuring safety is baked into platforms from the start, and launched a research project looking at the links between social media and children’s wellbeing. This will help build the evidence base to inform future action.”AMESBURY, Mass. , Dec. 2, 2024 /PRNewswire/ -- Provident Bancorp, Inc. (the "Company") (Nasdaq:PVBC), the holding company for BankProv (the "Bank"), today announced that its Board of Directors has adopted a new stock repurchase program. Under the repurchase program, the Company may repurchase up to 883,366 shares of its common stock, or approximately five percent of the current outstanding shares. The repurchase program was adopted following the receipt of non-objection from the Federal Reserve Bank of Boston . The repurchase program permits shares to be repurchased in open market or private transactions, through block trades, and pursuant to any trading plan that may be adopted in accordance with Rule 10b5-1 of the Securities and Exchange Commission. Repurchases will be made at management's discretion at prices management considers to be attractive and in the best interests of both the Company and its stockholders, subject to the availability of stock, general market conditions, the trading price of the stock, alternative uses for capital, and the Company's financial performance. Open market purchases will be conducted in accordance with the limitations set forth in Rule 10b -18 of the Securities and Exchange Commission and other applicable legal requirements. The repurchase program may be suspended, terminated or modified at any time for any reason, including market conditions, the cost of repurchasing shares, the availability of alternative investment opportunities, liquidity, and other factors deemed appropriate. These factors may also affect the timing and amount of share repurchases. The repurchase program does not obligate the Company to purchase any particular number of shares. About Provident Bancorp, Inc. Provident Bancorp, Inc. (NASDAQ:PVBC) is the holding company for BankProv, a full-service commercial bank headquartered in Massachusetts . With retail branches in the Seacoast Region of Northeastern Massachusetts and New Hampshire , as well as commercial banking offices in the Manchester / Concord market in Central New Hampshire , BankProv delivers a unique combination of traditional banking services and innovative financial solutions to its markets. Founded in Amesbury, Massachusetts in 1828, BankProv holds the honor of being the 10th oldest bank in the nation. The Bank insures 100% of deposits through a combination of insurance provided by the Federal Deposit Insurance Corporation (FDIC) and the Depositors Insurance Fund (DIF). For more information, visit bankprov.com . Forward-Looking Statements This news release may contain certain forward-looking statements, such as statements of the Company's or the Bank's plans, objectives, expectations, estimates and intentions. Forward-looking statements may be identified by the use of words such as, "expects," "subject," "believe," "will," "intends," "may," "will be" or "would." These statements are subject to change based on various important factors (some of which are beyond the Company's or the Bank's control), and actual results may differ materially. Accordingly, readers should not place undue reliance on any forward-looking statements (which reflect management's analysis of factors only as of the date on which they are given). These factors include: general economic conditions; interest rates; inflation; levels of unemployment; legislative, regulatory and accounting changes; monetary and fiscal policies of the U.S. Government, including policies of the U.S. Treasury and the Board of Governors of the Federal Reserve Bank; deposit flows; our ability to access cost-effective funding; changes in liquidity, including the size and composition of our deposit portfolio and the percentage of uninsured deposits in the portfolio; changes in consumer spending, borrowing and savings habits; competition; our ability to successfully shift the balance sheet to that of a traditional community bank; real estate values in the market area; loan demand; the adequacy of our level and methodology for calculating our allowance for credit losses; changes in the quality of our loan and securities portfolios; the ability of our borrowers to repay their loans; our ability to retain key employees; failures or breaches of our IT systems, including cyberattacks; the failure to maintain current technologies; the ability of the Company or the Bank to effectively manage its growth; global and national war and terrorism; the impact of the COVID-19 pandemic or any other pandemic on our operations and financial results and those of our customers; and results of regulatory examinations, among other factors. The foregoing list of important factors is not exclusive. Readers should carefully review the risk factors described in other documents that the Company files from time to time with the Securities and Exchange Commission, including Annual and Quarterly Reports on Forms 10-K and 10-Q, and Current Reports on Form 8-K. Investor contact: Joseph Reilly President and Chief Executive Officer Provident Bancorp, Inc. jreilly@bankprov.com View original content to download multimedia: https://www.prnewswire.com/news-releases/provident-bancorp-inc-adopts-stock-repurchase-program-302320082.html SOURCE Provident Bancorp, Inc.

AppLovin (NASDAQ:APP) Shares Down 4.2% – Time to Sell?

THOUSAND OAKS, Calif. , Dec. 2, 2024 /PRNewswire/ -- Amgen (NASDAQ:AMGN) will present at Citi's 2024 Global Healthcare Conference at 9:30 a.m. ET on Thursday , Dec. 5, 2024. Peter Griffith , executive vice president and chief financial officer at Amgen, Jay Bradner , executive vice president of Research and Development and chief scientific officer at Amgen, and Susan Sweeney , executive vice president of Obesity and Related Conditions at Amgen, will participate in a fireside chat at the conference. The webcast will be broadcast over the internet simultaneously and will be available to members of the news media, investors and the general public. The webcast, as with other selected presentations regarding developments in Amgen's business given by management at certain investor and medical conferences, can be found on Amgen's website, www.amgen.com , under Investors. Information regarding presentation times, webcast availability and webcast links are noted on Amgen's Investor Relations Events Calendar. The webcast will be archived and available for replay for at least 90 days after the event. About Amgen Amgen discovers, develops, manufactures and delivers innovative medicines to help millions of patients in their fight against some of the world's toughest diseases. More than 40 years ago, Amgen helped to establish the biotechnology industry and remains on the cutting-edge of innovation, using technology and human genetic data to push beyond what's known today. Amgen is advancing a broad and deep pipeline that builds on its existing portfolio of medicines to treat cancer, heart disease, osteoporosis, inflammatory diseases and rare diseases. In 2024, Amgen was named one of the "World's Most Innovative Companies" by Fast Company and one of "America's Best Large Employers" by Forbes, among other external recognitions . Amgen is one of the 30 companies that comprise the Dow Jones Industrial Average ® , and it is also part of the Nasdaq-100 Index ® , which includes the largest and most innovative non-financial companies listed on the Nasdaq Stock Market based on market capitalization. Amgen is one of the 30 companies that comprise the Dow Jones Industrial Average and is also part of the Nasdaq-100 index. In 2023, Amgen was named one of "America's Greatest Workplaces" by Newsweek, one of "America's Climate Leaders" by USA Today and one of the "World's Best Companies" by TIME. For more information, visit Amgen.com and follow us on X (formerly known as Twitter), LinkedIn , Instagram , TikTok , YouTube and Threads . Amgen Forward-Looking Statements This news release contains forward-looking statements that are based on the current expectations and beliefs of Amgen. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including any statements on the outcome, benefits and synergies of collaborations, or potential collaborations, with any other company (including BeiGene, Ltd. or Kyowa Kirin Co., Ltd.), the performance of Otezla ® (apremilast) (including anticipated Otezla sales growth and the timing of non-GAAP EPS accretion), our acquisitions of Teneobio, Inc., ChemoCentryx, Inc., or Horizon Therapeutics plc (including the prospective performance and outlook of Horizon's business, performance and opportunities, any potential strategic benefits, synergies or opportunities expected as a result of such acquisition, and any projected impacts from the Horizon acquisition on our acquisition-related expenses going forward), as well as estimates of revenues, operating margins, capital expenditures, cash, other financial metrics, expected legal, arbitration, political, regulatory or clinical results or practices, customer and prescriber patterns or practices, reimbursement activities and outcomes, effects of pandemics or other widespread health problems on our business, outcomes, progress, and other such estimates and results. Forward-looking statements involve significant risks and uncertainties, including those discussed below and more fully described in the Securities and Exchange Commission reports filed by Amgen, including our most recent annual report on Form 10-K and any subsequent periodic reports on Form 10-Q and current reports on Form 8-K. Unless otherwise noted, Amgen is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise. No forward-looking statement can be guaranteed and actual results may differ materially from those we project. Our results may be affected by our ability to successfully market both new and existing products domestically and internationally, clinical and regulatory developments involving current and future products, sales growth of recently launched products, competition from other products including biosimilars, difficulties or delays in manufacturing our products and global economic conditions. In addition, sales of our products are affected by pricing pressure, political and public scrutiny and reimbursement policies imposed by third-party payers, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international trends toward managed care and healthcare cost containment. Furthermore, our research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. We or others could identify safety, side effects or manufacturing problems with our products, including our devices, after they are on the market. Our business may be impacted by government investigations, litigation and product liability claims. In addition, our business may be impacted by the adoption of new tax legislation or exposure to additional tax liabilities. If we fail to meet the compliance obligations in the corporate integrity agreement between us and the U.S. government, we could become subject to significant sanctions. Further, while we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors, or we may fail to prevail in present and future intellectual property litigation. We perform a substantial amount of our commercial manufacturing activities at a few key facilities, including in Puerto Rico , and also depend on third parties for a portion of our manufacturing activities, and limits on supply may constrain sales of certain of our current products and product candidate development. An outbreak of disease or similar public health threat, such as COVID-19, and the public and governmental effort to mitigate against the spread of such disease, could have a significant adverse effect on the supply of materials for our manufacturing activities, the distribution of our products, the commercialization of our product candidates, and our clinical trial operations, and any such events may have a material adverse effect on our product development, product sales, business and results of operations. We rely on collaborations with third parties for the development of some of our product candidates and for the commercialization and sales of some of our commercial products. In addition, we compete with other companies with respect to many of our marketed products as well as for the discovery and development of new products. Discovery or identification of new product candidates or development of new indications for existing products cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate or development of a new indication for an existing product will be successful and become a commercial product. Further, some raw materials, medical devices and component parts for our products are supplied by sole third-party suppliers. Certain of our distributors, customers and payers have substantial purchasing leverage in their dealings with us. The discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. Our efforts to collaborate with or acquire other companies, products or technology, and to integrate the operations of companies or to support the products or technology we have acquired, may not be successful. There can be no guarantee that we will be able to realize any of the strategic benefits, synergies or opportunities arising from the Horizon acquisition, and such benefits, synergies or opportunities may take longer to realize than expected. We may not be able to successfully integrate Horizon, and such integration may take longer, be more difficult or cost more than expected. A breakdown, cyberattack or information security breach of our information technology systems could compromise the confidentiality, integrity and availability of our systems and our data. Our stock price is volatile and may be affected by a number of events. Our business and operations may be negatively affected by the failure, or perceived failure, of achieving our environmental, social and governance objectives. The effects of global climate change and related natural disasters could negatively affect our business and operations. Global economic conditions may magnify certain risks that affect our business. Our business performance could affect or limit the ability of our Board of Directors to declare a dividend or our ability to pay a dividend or repurchase our common stock. We may not be able to access the capital and credit markets on terms that are favorable to us, or at all. CONTACT: Amgen, Thousand Oaks Elissa Snook , 609-251-1407 (media) Justin Claeys , 805-313-9775 (investors) View original content to download multimedia: https://www.prnewswire.com/news-releases/amgen-to-present-at-citis-2024-global-healthcare-conference-302319891.html SOURCE Amgen

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Shares of AppLovin Co. ( NASDAQ:APP – Get Free Report ) traded down 4.2% during mid-day trading on Friday . The company traded as low as $326.69 and last traded at $332.13. 869,744 shares were traded during trading, a decline of 81% from the average session volume of 4,590,855 shares. The stock had previously closed at $346.73. Analyst Upgrades and Downgrades APP has been the topic of several research analyst reports. Wells Fargo & Company upped their price objective on AppLovin from $250.00 to $360.00 and gave the company an “overweight” rating in a research report on Wednesday, November 20th. UBS Group raised shares of AppLovin from a “neutral” rating to a “buy” rating and raised their price target for the stock from $100.00 to $145.00 in a research note on Tuesday, September 17th. BTIG Research boosted their price objective on shares of AppLovin from $202.00 to $291.00 and gave the company a “buy” rating in a research report on Thursday, November 7th. Benchmark reaffirmed a “sell” rating and set a $66.00 target price on shares of AppLovin in a research report on Thursday, November 7th. Finally, Oppenheimer reissued an “outperform” rating and issued a $480.00 price objective on shares of AppLovin in a research note on Tuesday, December 10th. One equities research analyst has rated the stock with a sell rating, four have assigned a hold rating, thirteen have issued a buy rating and one has issued a strong buy rating to the company. According to data from MarketBeat.com, the stock has an average rating of “Moderate Buy” and a consensus target price of $310.71. View Our Latest Research Report on AppLovin AppLovin Stock Performance AppLovin ( NASDAQ:APP – Get Free Report ) last released its earnings results on Wednesday, November 6th. The company reported $1.25 EPS for the quarter, topping analysts’ consensus estimates of $0.92 by $0.33. The company had revenue of $1.20 billion during the quarter, compared to analysts’ expectations of $1.13 billion. AppLovin had a net margin of 26.85% and a return on equity of 122.24%. AppLovin’s revenue for the quarter was up 38.6% on a year-over-year basis. During the same period last year, the business earned $0.30 EPS. Equities research analysts predict that AppLovin Co. will post 4.06 EPS for the current fiscal year. Insider Buying and Selling In other news, insider Victoria Valenzuela sold 15,971 shares of the firm’s stock in a transaction that occurred on Thursday, December 19th. The shares were sold at an average price of $313.07, for a total transaction of $5,000,040.97. Following the sale, the insider now owns 372,205 shares of the company’s stock, valued at $116,526,219.35. This trade represents a 4.11 % decrease in their position. The sale was disclosed in a document filed with the Securities & Exchange Commission, which is available through this link . Also, CMO Katie Kihorany Jansen sold 59,876 shares of the stock in a transaction on Tuesday, November 12th. The stock was sold at an average price of $286.14, for a total transaction of $17,132,918.64. Following the sale, the chief marketing officer now directly owns 1,017,388 shares in the company, valued at $291,115,402.32. This trade represents a 5.56 % decrease in their ownership of the stock. The disclosure for this sale can be found here . Insiders sold 888,867 shares of company stock worth $284,773,062 in the last 90 days. Insiders own 14.69% of the company’s stock. Institutional Inflows and Outflows A number of large investors have recently modified their holdings of APP. Capital Performance Advisors LLP purchased a new position in shares of AppLovin in the 3rd quarter valued at about $25,000. DT Investment Partners LLC purchased a new stake in shares of AppLovin in the third quarter valued at approximately $27,000. Meeder Asset Management Inc. acquired a new position in shares of AppLovin during the 3rd quarter worth approximately $27,000. Raleigh Capital Management Inc. purchased a new position in shares of AppLovin during the 3rd quarter valued at approximately $29,000. Finally, Quest Partners LLC acquired a new stake in AppLovin in the 2nd quarter valued at $33,000. Institutional investors and hedge funds own 41.85% of the company’s stock. About AppLovin ( Get Free Report ) AppLovin Corporation engages in building a software-based platform for advertisers to enhance the marketing and monetization of their content in the United States and internationally. It operates through two segments, Software Platform and Apps. The company's software solutions include AppDiscovery, a marketing software solution, which matches advertiser demand with publisher supply through auctions; MAX, an in-app bidding software that optimizes the value of a publisher's advertising inventory by running a real-time competitive auction; Adjust, a measurement and analytics marketing platform that provides marketers with the visibility, insights, and tools needed to grow their apps from early stage to maturity; and Wurl, a connected TV platform, which distributes streaming video for content companies and provides advertising and publishing solutions through its AdPool, ContentDiscovery, and Global FAST Pass products. Further Reading Receive News & Ratings for AppLovin Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for AppLovin and related companies with MarketBeat.com's FREE daily email newsletter .Ulta Beauty Inc. stock underperforms Friday when compared to competitors

ATLANTA (AP) — Ethan Vasko threw three touchdown passes and ran for a fourth as Coastal Carolina became bowl eligible by beating Georgia State 48-27 for its sixth win of the season in the regular season finale on Saturday. The Chanticleers evened their season record at 6-6 with the win and finished 3-5 in the Sun Belt East. The loss leaves Georgia State (3-9) with just one win in eight conference games. Vasko threw 10 yards to Senika McKie for the game's first score midway through the first quarter, but the Panthers got a Liam Rickman 28-yard field goal and a 19-yard touchdown run by Freddie Brock to take a 10-7 second-quarter lead. Vasko threw his second TD pass, this one a five-yard strike to Zach Courtney to take the lead and Kade Hensley booted a 43-yard field goal as time expired to put Coastal Carolina up 17-10 at halftime. Christian Washington ran 18-yards for a touchdown to open up a 24-10 lead four minutes into the third quarter. Vasko hit McKie for their second touchdown, this one from 31-yards out and Vasko ran 10 yards for a fourth-quarter touchdown to make it 38-10 with under 10 minutes to play. Vasko was 13 of 17 passing for 200 yards and carried 13 times for another 68. Washington carried 20 times for 124 yards. McKie caught five passes for 81 yards Georgia State amassed 428 yards of offense, but the Panthers turned the ball over six times. Christian Veilleux completed 15 of 26 passes for 205 yards but was picked off four times and fumbled. Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-footballMarxist Seminar Explores Similarities Between Old and New FascismThe Gophers football program is on the verge of signing the state’s top-rated high school prospect to headline its recruiting class for a second straight year. The U hasn’t done that since 2017-18. Robbinsdale Cooper linebacker Emmanuel Karmo is set to join Minnesota when the early signing period opens Wednesday, just like Esko safety Koi Perich did a year ago. The U fought off fellow Big Ten schools in both recruiting battles. “It feels amazing,” Karmo told the Pioneer Press this week. “I’ve waited a long time for this.” Karmo, a four-star prospect, said his other top contenders were Wisconsin, Nebraska and, to a lesser degree, Ohio State. His more than 15 scholarship offers also included Southern California, Penn State, Oregon, with some interest from Michigan. The 6-foot-3, 235-pound athlete, who is also the U’s overall No. 1 recruit in the 2025 class, played nearly everywhere in high school and committed to Minnesota in April, but that didn’t stop others from pursuing him and seeing if he would be willing to visit their campuses. “When coaches come in, they just see his build and his film speaks for itself,” said Robbinsdale Cooper head coach Tony Patterson. “The recruiting process was a little bit stressful for him. He wanted to make sure that he was making the right decision and not really basing it on when the big-time schools come in. “Some kids can get glamor and glitz in their eyes, but I think he did it his way. He spoke with his family. He made the best decision for him and his family to stay home in Minnesota.” Karmo is close with his large family, especially his mother, and was looking for a close-knit connection in a college. The Gophers weren’t among the first to offer Karmo, but he found a bond with U defensive line coach Winston DeLattiboudere. “He showed how invested he was in his family, and also Emmanuel as a person,” Patterson said. “So, I think that’s what drew him to Minnesota.” Karmo played four years on varsity and started the final three for the Class 5A school a few miles west of Minneapolis. He played everywhere — safety (as an underclassman) and linebacker/edge rusher (as upperclassman), wide receiver, tight end, running back, wildcat quarterback and punter. In 10 games as a senior, Karmo had five rushing touchdowns and five receiving touchdowns, along with 64 tackles, two sacks, one interception and one fumble recovery. Other teams ran away from his side of the field, but he worked to track ball carriers down. The Hawks finished 8-2, but fell short of the state tournament. The Gophers see Karmo’s skills best translating at linebacker in college. “They told me I would be useful on third-down situations and stuff like that,” Karmo said. “They want me to come in and play early.” The Gophers nearly had the top-rated in-state recruit sign with the U in three straight classes, but Cooper defensive lineman Jaxon Howard went to Louisiana State for a year before transferring back to Minnesota. He played 118 snaps for the Gophers as a redshirt freshman this fall. Howard gave Karmo the space to make his own college decision but was instrumental in showing Karmo how to lead in high school. “He just passed down the torch when he left (Cooper),” Karmo said. “I took over and now I’m on the way.” Karmo, who spent part of his youth in St. Louis, said he had a “pretty rocky start” at Cooper, but began to lead by example during his junior year. “He’s invested in Cooper,” Patterson said. “... His play on the field spoke for itself, but it’s the off-the-field things that, sometimes, they get unnoticed. He’s encouraging guys, giving (car) rides to guys, making sure that the young guys understand what it means to be a Cooper Hawk.” Patterson sees Karmo as a no-nonsense worker with twitchy athleticism. “Emmanuel is a special guy. He’s one of those kids that coaches kind of just salivate over,” Patterson said. “He has all the intangibles: great GPA, smart player, size, frame. He has the ability to get even bigger, faster, stronger in college, under their weight program. “He’s one of those guys that just show up and go to work, no complaints about anything. He doesn’t have kind of a look-at-me attitude; he wants a team to succeed. This year I saw that, putting the team on his back and trying to do everything in his power to have us reach that next level.”

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Three long days of counting in the General Election finished late on Monday night when the final two seats were declared in the constituency of Cavan-Monaghan. Fianna Fail was the clear winner of the election, securing 48 of the Dail parliament’s 174 seats. Sinn Fein took 39 and Fine Gael 38. Labour and the Social Democrats both won 11 seats; People Before Profit-Solidarity took three; Aontu secured two; and the Green Party retained only one of its 12 seats. Independents and others accounted for 21 seats. The return of a Fianna Fail/Fine Gael-led coalition is now highly likely. However, their combined seat total of 86 leaves them just short of the 88 needed for a majority in the Dail. While the two centrist parties that have dominated Irish politics for a century could look to strike a deal with one of the Dail’s smaller centre-left parties, such as the Social Democrats or Labour, a more straightforward route to a majority could be achieved by securing the support of several independent TDs. For Fianna Fail leader Micheal Martin and current taoiseach and Fine Gael leader Simon Harris, wooing like-minded independents would be likely to involve fewer policy concessions, and financial commitments, than would be required to convince another party to join the government benches. Longford-Westmeath independent TD Kevin “Boxer” Moran, who served in a Fine Gael-led minority government between 2017 and 2020, expressed his willingness to listen to offers to join the new coalition in Dublin. “Look, my door’s open,” he told RTE. “Someone knocks, I’m always there to open it.” Marian Harkin, an independent TD for Sligo-Leitrim, expressed her desire to participate in government as she noted that Fianna Fail and Fine Gael were within “shouting distance” of an overall majority. “That means they will be looking for support, and I certainly will be one of those people who will be speaking to them and talking to them and negotiating with them, and I’m looking forward to doing that, because that was the reason that I ran in the first place,” she said. Meanwhile, the Social Democrats and Irish Labour Party both appear cautious about the prospect of an alliance with Fianna Fail and Fine Gael. They will no doubt be mindful of the experience of the Green Party, the junior partner in the last mandate. The Greens experienced near wipeout in the election, retaining only one of their 12 seats. Sinn Fein appears to currently have no realistic route to government, given Fianna Fail and Fine Gael’s ongoing refusal to share power with the party. Despite the odds being stacked against her party, Sinn Fein president Mary Lou McDonald contacted the leaders of the Social Democrats and Labour on Monday to discuss options. Earlier, Fianna Fail deputy leader and outgoing Finance Minister Jack Chambers predicted that a new coalition government would not be in place before Christmas. Mr Chambers said planned talks about forming an administration required “time and space” to ensure that any new government will be “coherent and stable”. After an inconclusive outcome to the 2020 election, it took five months for Fianna Fail, Fine Gael and the Greens to strike the last coalition deal. Mr Chambers said he did not believe it would take that long this time, as he noted the Covid-19 pandemic was a factor in 2020, but he also made clear it would not be a swift process. He said he agreed with analysis that there was no prospect of a deal before Christmas. “I don’t expect a government to be formed in mid-December, when the Dail is due to meet on December 18, probably a Ceann Comhairle (speaker) can be elected, and there’ll have to be time and space taken to make sure we can form a coherent, stable government,” he told RTE. “I don’t think it should take five months like it did the last time – Covid obviously complicated that. But I think all political parties need to take the time to see what’s possible and try and form a stable government for the Irish people.” Fine Gael minister of state Peter Burke said members of his parliamentary party would have to meet to consider their options before giving Mr Harris a mandate to negotiate a new programme for government with Fianna Fail. “It’s important that we have a strong, stable, viable government, whatever form that may be, to ensure that we can meet the challenges of our society, meet the challenges in terms of the economic changes that are potentially going to happen,” he told RTE. Despite being set to emerge with the most seats, it has not been all good news for Fianna Fail. The party’s outgoing Health Minister Stephen Donnelly became one of the biggest casualties of the election when he lost his seat in Wicklow in the early hours of Monday morning. Mr Donnelly was always predicted to face a fight in the constituency after boundary changes saw it reduced from five to four seats. If it is to be a reprise of the Fianna Fail/Fine Gael governing partnership of the last mandate, one of the major questions is around the position of taoiseach and whether the parties will once again take turns to hold the Irish premiership during the lifetime of the new government. The outcome in 2020 saw the parties enter a coalition on the basis that the holder of the premier position would be exchanged midway through the term. Fianna Fail leader Mr Martin took the role for the first half of the mandate, with Leo Varadkar taking over in December 2022. Current Fine Gael leader Mr Harris succeeded Mr Varadkar as taoiseach when he resigned from the role earlier this year. However, this time Fianna Fail has significantly increased its seat lead over Fine Gael, compared with the last election when there were only three seats between the parties. The size of the disparity in party numbers is likely to draw focus on the rotating taoiseach arrangement, raising questions as to whether it will be re-run in the next coalition and, if it is, on what terms. On Sunday, Simon Coveney, a former deputy leader of Fine Gael, said a coalition that did not repeat the rotating taoiseach arrangement in some fashion would be a “difficult proposition” for his party. Meanwhile, Fine Gael minister Paschal Donohoe said he would be making the case for Mr Harris to have another opportunity to serve as taoiseach. On Monday, Mr Chambers said while his party would expect to lead the government it would approach the issue of rotating the taoiseach’s role on the basis of “mutual respect” with Fine Gael. “I think the context of discussions and negotiations will be driven by mutual respect, and that’s the glue that will drive a programme for government and that’s the context in which we’ll engage,” he said. On Monday, Labour leader Ivana Bacik reiterated her party’s determination to forge an alliance with fellow centre-left parties with the intention of having a unified approach to the prospect of entering government. Asked if Labour was prepared to go into government with Fianna Fail and Fine Gael on its own, she told RTE: “No, not at this stage. We are absolutely not willing to do that. “We want to ensure there’s the largest number of TDs who share our vision and our values who want to deliver change on the same basis that we do.” The Social Democrats have been non-committal about any potential arrangement with Fianna Fail and Fine Gael, and have restated a series of red lines they would need to achieve before considering taking a place in government. Leader Holly Cairns, who gave birth to a daughter on polling day on Friday, said in a statement: “The party is in a very strong position to play an important role in the next Dail. In what position, government or opposition, remains to be seen.” Fianna Fail secured the most first preference votes in Friday’s proportional representation election, taking 21.9% to Fine Gael’s 20.8%. Sinn Fein came in third on 19%. While Sinn Fein’s vote share represented a marked improvement on its disappointing showing in June’s local elections in Ireland, it is still significantly down on the 24.5% poll-topping share it secured in the 2020 general election. The final breakdown of first preferences also flipped the result of Friday night’s exit poll, which suggested Sinn Fein was in front on 21.1%, with Fine Gael on 21% and Fianna Fail on 19.5%.

Capital Increase in Genmab as a Result of Employee Warrant ExerciseDLA Exploring Use of Digital Twins for OT Systems SecuritySchneider National stock hits all-time high at $32.25 11-30-2024 03:06 PM CET | Business, Economy, Finances, Banking & Insurance Press release from: ABNewswire Schneider National Inc., stock soared to an all-time high this week, reaching a peak of $32.25. The transportation and logistics services company has seen a remarkable 37.38% increase in its stock price over the past year, reflecting strong performance and investor confidence. This milestone underscores the company's robust growth trajectory and its ability to navigate the complex logistics landscape effectively, even amid the challenges posed by global economic conditions. The all-time high represents a significant achievement for Schneider National, marking a period of sustained value creation for its shareholders. In other recent news, Schneider National experienced a series of financial adjustments following its third-quarter earnings report. The transportation and logistics services company saw Benchmark raise its stock price target from $30.00 to $32.00, maintaining a Buy rating. This adjustment comes after Schneider National's third-quarter earnings fell short of expectations, with an adjusted operating income of $44.3 million. Meanwhile, BofA Securities upgraded Schneider National's rating from Underperform to Buy and increased its price target to $34.00. This revised stance reflects a positive outlook following recent developments. However, BofA Securities also lowered its earnings per share estimates for 2024 and 2025 due to weaker than expected performance in the third quarter. Evercore ISI reduced Schneider National's price target from $27.00 to $26.00, retaining an In Line rating, following the company's third-quarter earnings report. Schneider National reported steady revenues of $1.2 billion, despite a slight dip in adjusted diluted earnings per share from $0.20 to $0.18. Among these recent developments, Schneider National continued its share repurchase program with $4 million in purchases. These adjustments and actions highlight Schneider National's commitment to shareholder returns, strategic growth, and operational efficiency in the face of recent financial challenges. Media Contact Company Name: ABC Private Limited Contact Person: Media Relations Email:Send Email [ https://www.abnewswire.com/email_contact_us.php?pr=schneider-national-stock-hits-alltime-high-at-3225 ] Country: India Website: https://www.se.com/in/en/ This release was published on openPR.Van Nistelrooy returned to Old Trafford as Erik ten Hag’s assistant in the summer and had a four-game interim spell in charge following his compatriot’s sacking in October. He left the club in the wake of Ruben Amorim’s appointment but was only out of work for two weeks after being appointed Leicester’s new manager on a deal until 2027. The 48-year-old had a glittering playing career with United and was disappointed his return had to end so soon. “The moment I took over the interim job what I said was I’m here to help United and to stay to help United, and I meant it,” he said. “So I was disappointed, yeah, very much so, and it hurt I had to leave. “The only job I would take as an assistant was at United because of the bond that I have with the people in the club and the fans. “But in the end I got my head around it because I also understand the new manager. I’m in football long enough, and I’ve managed myself, that you can think of a situation, me being there, I understand. “I spoke to Ruben about it, fair enough to him, the conversation was grateful, man to man, person to person, manager to manager, and that helped a lot to move on and straightaway get into talks with new possibilities which of course lifted my spirits.” The Dutchman takes on a difficult job at the King Power Stadium as he is tasked with keeping Leicester in the Premier League. He inherits an influential dressing room, which has seen a number of managers come and go over the last few years. Ruud's here for his first press conference as our Manager 😃 pic.twitter.com/A4Juixvorb — Leicester City (@LCFC) December 2, 2024 Van Nistelrooy revealed he has done his due diligence and also let the players know as well. “It’s the only way you can work. It’s mutual respect. I also mentioned to the players yesterday that I looked at the squad and started to make phone calls about players, because in football everyone knows everyone,” he said. “With two or three phone calls you hear stories about 20 players and for me it was important that you hear there are good characters there. That’s important, that there are good people there. “I look at the players how they play. I obviously don’t know them but I got general information and the individuals that they are a good bunch of people. That was important for me to get in.”