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Sowei 2025-01-12
TOKYO and CAMBRIDGE, Mass. , Dec. 4, 2024 /PRNewswire/ -- Eisai Co., Ltd. (Headquarters: Tokyo , CEO: Haruo Naito , "Eisai") and Biogen Inc. (Nasdaq: BIIB, Corporate headquarters: Cambridge, Massachusetts , CEO: Christopher A. Viehbacher , "Biogen") announced today that the Federal Commission for the Protection Against Sanitary Risk (COFEPRIS) in Mexico has approved humanized anti-soluble aggregated amyloid-beta (Aβ) monoclonal antibody "LEQEMBI ® " (lecanemab) for the treatment of early Alzheimer's disease (AD)*. LEQEMBI selectively binds to soluble Aβ aggregates (protofibrils**), as well as insoluble Aβ aggregates (fibrils) which are a major component of Aβ plaques, thereby reducing both Aβ protofibrils and Aβ plaques in the brain. LEQEMBI is the first approved treatment shown to reduce the rate of disease progression and to slow cognitive and functional decline through this mechanism. LEQEMBI is also approved and being marketed in the U.S., Japan , China , South Korea , Hong Kong , Israel , the United Arab Emirates, and Great Britain . LEQEMBI's approval is based on the large global Phase 3 Clarity AD study. In the Clarity AD study, LEQEMBI met its primary endpoint and all key secondary endpoints with statistically significant results. 1,2 Approximately 1.3 million people in Mexico are estimated to suffer from AD, accounting for 60-70% of all dementia diagnoses. 3 AD most commonly affects individuals over the age of 65. 3 Eisai serves as the lead of LEQEMBI development and regulatory submissions globally with both Eisai and Biogen co-commercializing and co-promoting the product and Eisai having final decision-making authority. Eisai and Biogen will co-commercialize and co-promote LEQEMBI in Mexico . * Collectively referred to mild cognitive impairment due to AD or mild AD dementia. ** Protofibrils are believed to contribute to the brain injury that occurs with AD and are considered to be the most toxic form of Aβ, having a primary role in the cognitive decline associated with this progressive, debilitating condition. 4 Protofibrils cause injury to neurons in the brain, which in turn, can negatively impact cognitive function via multiple mechanisms, not only increasing the development of insoluble Aβ plaques but also increasing direct damage to brain cell membranes and the connections that transmit signals between nerve cells or nerve cells and other cells. It is believed the reduction of protofibrils may prevent the progression of AD by reducing damage to neurons in the brain and cognitive dysfunction. 5 Notes to Editors 1. About lecanemab (LEQEMBI ® ) Lecanemab is the result of a strategic research alliance between Eisai and BioArctic. It is a humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble (protofibril) and insoluble forms of amyloid-beta (Aβ). Lecanemab is approved and being marketed in the U.S., Japan , China , South Korea , Hong Kong , Israel , the United Arab Emirates and Great Britain for the treatment of Alzheimer's disease (AD) in patients with Mild Cognitive Impairment (MCI) or mild dementia stage of disease (collectively referred to as early AD). The treatment's approvals in these countries was based on Phase 3 data from Eisai's global Clarity AD clinical trial, in which it met its primary endpoint and all key secondary endpoints with statistically significant results. 1,2 The most common adverse events (>10%) in the lecanemab group were infusion reactions, ARIA-H (combined cerebral microhemorrhages, cerebral macrohemorrhages, and superficial siderosis), ARIA-E (edema/effusion), headache, and fall. Lecanemab is under regulatory review in 16 countries and regions, including the European Union. In November 2024 , the treatment received a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) recommending approval. Since July 2020 the Phase 3 clinical study (AHEAD 3-45) for individuals with preclinical AD, meaning they are clinically normal and have intermediate or elevated levels of amyloid in their brains, is ongoing. AHEAD 3-45 is conducted as a public-private partnership between the Alzheimer's Clinical Trial Consortium that provides the infrastructure for academic clinical trials in AD and related dementias in the U.S, funded by the National Institute on Aging, part of the National Institutes of Health, Eisai and Biogen. Since January 2022 , the Tau NexGen clinical study for Dominantly Inherited AD (DIAD), that is conducted by Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU), led by Washington University School of Medicine in St. Louis , is ongoing and includes lecanemab as the backbone anti-amyloid therapy. 2. About the Collaboration between Eisai and Biogen for AD Eisai and Biogen have been collaborating on the joint development and commercialization of AD treatments since 2014. Eisai serves as the lead of lecanemab development and regulatory submissions globally with Eisai and Biogen co-commercializing and co-promoting the product and Eisai having final decision-making authority. 3. About the Collaboration between Eisai and BioArctic for AD Since 2005, Eisai and BioArctic have had a long-term collaboration regarding the development and commercialization of AD treatments. Eisai obtained the global rights to study, develop, manufacture and market lecanemab for the treatment of AD pursuant to an agreement with BioArctic in December 2007 . The development and commercialization agreement on the antibody lecanemab back-up was signed in May 2015 . 4. About Eisai Co., Ltd. Eisai's Corporate Concept is "to give first thought to patients and people in the daily living domain, and to increase the benefits that health care provides." Under this Concept (also known as human health care ( hhc ) Concept), we aim to effectively achieve social good in the form of relieving anxiety over health and reducing health disparities. With a global network of R&D facilities, manufacturing sites and marketing subsidiaries, we strive to create and deliver innovative products to target diseases with high unmet medical needs, with a particular focus in our strategic areas of Neurology and Oncology. In addition, we demonstrate our commitment to the elimination of neglected tropical diseases (NTDs), which is a target (3.3) of the United Nations Sustainable Development Goals (SDGs), by working on various activities together with global partners. For more information about Eisai, please visit www.eisai.com (for global headquarters: Eisai. Co., Ltd.), us.eisai.com (for U.S. headquarters: Eisai, Inc.) or www.eisai.eu (for Europe , Middle East , Africa , Russia , Australia and New Zealand headquarters: Eisai Europe Ltd.), and connect with us on X ( global and U.S ), LinkedIn (for global , U.S. and EMEA ) and Facebook ( global ). 5. About Biogen Founded in 1978, Biogen is a leading biotechnology company that pioneers innovative science to deliver new medicines to transform patients' lives and to create value for shareholders and our communities. We apply deep understanding of human biology and leverage different modalities to advance first-in-class treatments or therapies that deliver superior outcomes. Our approach is to take bold risks, balanced with return on investment to deliver long-term growth. The company routinely posts information that may be important to investors on its website at www.biogen.com . Follow Biogen on social media – Facebook , LinkedIn , X , YouTube . Biogen Safe Harbor This news release contains forward-looking statements, about the potential clinical effects of lecanemab; the potential benefits, safety and efficacy of lecanemab; potential regulatory discussions, submissions and approvals and the timing thereof; the treatment of Alzheimer's disease; the anticipated benefits and potential of Biogen's collaboration arrangements with Eisai; the potential of Biogen's commercial business and pipeline programs, including lecanemab; and risks and uncertainties associated with drug development and commercialization. These statements may be identified by words such as "aim," "anticipate," "believe," "could," "estimate," "expect," "forecast," "intend," "may," "plan," "possible," "potential," "will," "would" and other words and terms of similar meaning. Drug development and commercialization involve a high degree of risk, and only a small number of research and development programs result in commercialization of a product. Results in early-stage clinical studies may not be indicative of full results or results from later stage or larger scale clinical studies and do not ensure regulatory approval. You should not place undue reliance on these statements. These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected in such statements, including without limitation unexpected concerns that may arise from additional data, analysis or results obtained during clinical studies; the occurrence of adverse safety events; risks of unexpected costs or delays; the risk of other unexpected hurdles; regulatory submissions may take longer or be more difficult to complete than expected; regulatory authorities may require additional information or further studies, or may fail or refuse to approve or may delay approval of Biogen's drug candidates, including lecanemab; actual timing and content of submissions to and decisions made by the regulatory authorities regarding lecanemab; uncertainty of success in the development and potential commercialization of lecanemab; failure to protect and enforce Biogen's data, intellectual property and other proprietary rights and uncertainties relating to intellectual property claims and challenges; product liability claims; and third party collaboration risks, results of operations and financial condition. The foregoing sets forth many, but not all, of the factors that could cause actual results to differ from Biogen's expectations in any forward-looking statement. Investors should consider this cautionary statement as well as the risk factors identified in Biogen's most recent annual or quarterly report and in other reports Biogen has filed with the U.S. Securities and Exchange Commission. These statements speak only as of the date of this news release. Biogen does not undertake any obligation to publicly update any forward-looking statements. References View original content to download multimedia: https://www.prnewswire.com/news-releases/leqembi-lecanemab-approved-for-the-treatment-of-early-alzheimers-disease-in-mexico-302322515.html SOURCE Eisai Inc.646 lodi

EAGAN, Minn. (AP) — Justin Jefferson might be weary of all the safeties shadowing his every route, determined not to let the Minnesota Vikings go deep, but he's hardly angry. The double and triple coverage he continually faces, after all, is a sign of immense respect for his game-breaking ability. The strategy also simply makes sense. “I would do the same," Jefferson said. "It’s either let everybody else go off or let Justin go off. I’m going to let everybody else go off. That would be my game plan.” When the Vikings visit Chicago on Sunday, they're expecting the usual heavy dose of split-safety coverage designed to put a lid on the passing attack and force them to operate primarily underneath. “We see that every week: Teams just have different tendencies on film, and then when we go out on the field they play us totally different,” Jefferson said, later adding: “I don’t really feel like anyone else is getting played how I’m getting played.” Jefferson nonetheless is second in the NFL in receiving yards (912) behind Cincinnati's Ja'Marr Chase, his former college teammate at LSU. Last week, Jefferson set yet another all-time record by passing Torry Holt for the most receiving yards over the first five seasons of a career. Holt logged 80 regular-season games and accumulated 6,784 yards for St. Louis. Jefferson has 6,811 yards — in just 70 games. “I want to go up against those single coverages. I want to go have my opportunities to catch a deep pass downfield, just one-on-one coverage, like a lot of these other receivers get," Jefferson said. "It’s definitely difficult going up against an extra person or an extra two people, but it is what it is and the concepts that we’re drawing up and the ways that we’re trying to get me open, it definitely helps.” With fellow tight end Josh Oliver ruled out of the game on Sunday because of a sprained ankle, T.J. Hockenson is certain to have his heaviest workload since returning from knee surgery four weeks ago. He's also certain that Jefferson will continue to see persistent double-teams. “It puts it on us to make some plays and do some things to get them out of that,” Hockenson said. Vikings coach Kevin O'Connell has been forced to dig deeper into the vault of play designs and game plans to help keep quarterback Sam Darnold and the offense on track. O'Connell said after Minnesota's 12-7 win at Jacksonville, when Darnold threw three interceptions to precipitate a safer strategy down the stretch, that he superseded his play-calling role with the wisdom of a head coach to help win that game. "Not just the egomaniac of wanting to score points and constantly show everybody how smart we are. There was a mode that I think you have to go into sometimes to ensure a victory,” O'Connell said on his weekly show on KFAN radio. Taking what the defense gives is usually the shrewdest strategy. “You’ve got to really implement some new things and some things that maybe you didn’t come across during your early coaching years whether as a coordinator or position coach or even when you’re responsible for a small area of the game plan as a younger coach," O'Connell said. "You really have to kind of look outside the lens of always what you see on tape.” AP NFL: https://apnews.com/hub/NFL

Bettie Gean Littles MinorBlues supporters also sang the name of head coach Maresca during the closing stages of an emphatic success sealed by goals from Axel Disasi, Christopher Nkunku, Noni Madueke, Cole Palmer and substitute Jadon Sancho. Bottom club Southampton briefly levelled through Joe Aribo but were a man down from the 39th minute after captain Jack Stephens was sent off for pulling the hair of Marc Cucurella. Chelsea, who have endured an underwhelming period since Todd Boehly’s consortium bought the club in 2022, climbed above Arsenal and into second place on goal difference, seven points behind leaders Liverpool. “It was a very good feeling, especially because you can see that they are happy, that is our target,” Maresca said of the atmosphere in the away end. “We work every day to keep them happy and tonight was a very good feeling, especially the one that they can see that Chelsea’s back. This is an important thing.” Maresca rotated his squad in Hampshire, making seven changes following Sunday’s impressive 3-0 win over Aston Villa. Following a sloppy start, his side, who stretched their unbeaten run to six top-flight games, could easily have won by more as they hit the woodwork three times, in addition to squandering a host of chances. “I’m very happy with the five we scored,” said the Italian. “I’m not happy with the first 15, 20 minutes, where we struggled. The reason why we struggled is because we prepared the game to press them man to man and the first 15, 20 minutes we were not pressing them man to man. “After 15, 20 minutes we adjust that and the game was much better. For sure we could score more but five goals they are enough.” Southampton manager Russell Martin rued a costly “moment of madness” from skipper Stephens. The defender’s ridiculous red card was the headline mistake of a catalogue of errors from the beleaguered south-coast club as they slipped seven points from safety following an 11th defeat of a dismal season. “I don’t think anyone will be as disappointed as Jack,” Martin said of Stephens, who was sent off for the second time this term after tugging the curls of Cucurella as Saints prepared to take a corner. “I haven’t got to sit down and talk with him about that at all. He will be hurt more than anyone and it’s changed the game for us tonight, which is disappointing. “I think they have to describe it as violent conduct; it’s not violent really but there’s no other explanation for that really. It’s a moment of madness that’s really cost us and Jack.” Southampton repeatedly invited pressure with their risky attempts to play out from defence, with goalkeeper Joe Lumley gifting Chelsea their second goal, scored by Nkunku. While Saints were booed off at full-time, Martin, who was missing a host of key players due to injuries and suspensions, praised the effort of his depleted team. “When they see such a big scoreline and a couple of the goals we concede, I understand it (the jeers),” he said. “It’s football, it’s emotive, people feel so much about it, it’s why it’s such a special sport in this country and so big. “I understand it but I feel really proud of the players tonight, some of the football we played at 11 v 11 was amazing. “For an hour with 10 men we’ve dug in so deep, there were some big performances. I’m proud of them for that and I’m grateful for that because that’s not easy in that circumstance.”

American trust in medical institutions and vaccine technology has been plunging the past several years, and though the media treats this as a "troubling" and dangerous development for our society the shift might represent a positive change. The activities of Big Pharma have gone largely unchecked and unchallenged for many decades. The FDA has a revolving door policy, allowing pharmaceutical executives to exit their companies and work at the agency with impunity, then leave again and return to their former jobs. It not hard to understand how this creates a serious conflict of interest at the FDA. This problem of corruption was never more clear than it was during the covid pandemic. Since that event, the US population has been losing faith in the ability of the government to scrutinize pharmaceutical products and protect people from potentially disastrous experimental medications and vaccines. When the love affair between government and Big Pharma was put on blatant display, the American people rightly began to question everything. Recently, CNN unveiled a poll which proves that US faith in vaccines is in steep decline. #6 - CNN shares a devastating poll, revealing that a growing number of parents no longer believe the government’s or media’s lies about vaccines. Video: @Inversionism pic.twitter.com/uulexk7Iq2 The reality is that the vaccines were largely unnecessary. Infections and fatalities were dropping rapidly well before the first vaccines were introduced to the public, likely because of natural immunity. Later spikes only prove that the vaccines had minimal effect on the spread of the virus. At the height of the pandemic frenzy, the average Infection Fatality Rate of the Covid virus was a tiny 0.23% . Meaning, 99.8% of the public was under no threat from the illness. Furthermore those that did become dangerously sick were often elderly people with preexisting conditions. This fact was reinforced by data showing that the vast majority of deaths from covid were among people with at least one comorbidity. If a person died after years of diabetes or cardiovascular disease, but they also had covid, the default of the medical establishment was to list the death as covid related. That is to say, deaths from covid and deaths from preexisting conditions were mixed together without regard for how this might affect public statistics. It should also be noted that the IFR of covid did not change from pre-vaccination conditions to post-vaccination conditions. The death rate was the same regardless of vaccination status, though CDC, WHO and Big Pharma analysis often failed to use unvaccinated people as a control group. This was likely done deliberately to hide the bigger picture from the public. Instead, the establishment would use stats like CFR (Case Fatality Rate) or "Mortality Odds", which discount asymptomatic cases and greatly overestimate the true rate of death . Few establishment media outlets ever mentioned the real Infection Fatality Rate through the entirety of the pandemic. The goal was to pump up the covid death count as high as possible in order to frighten the public into accepting experimental mRNA vaccinations that were rushed into production under FDA emergency approval. The average vaccine is tested for many years (sometimes a decade or more) in order to meet safety standards. Covid vaccines were slapped together and shipped out in less than 12 months. The action was hailed as a "medical miracle" , but the truth is that it was a massive gamble at best, and a draconian con at worst. Governments around the world exploited pandemic fears and used unprecedented leverage to force the public into taking the jab. Keep in mind that the Biden Administration almost gained the power to penalize companies employing workers without proof of vaccination (vaccine passports). That is to say, the government under Biden tried to erase constitutional protections and take people's jobs away unless they submitted to regular vaccines. It was an epic authoritarian sprint. They were only thwarted because of the Supreme Court and the courage of conservative red states defying the agenda. The covid event has created a culture of distrust when it comes to vaccine science. Now, the public wants independent investigations and assurances on vaccines to prove safety rather than simply taking the FDA and Big Pharma at their word. It's not so much a movement against vaccines - It's a movement to demand transparency, something which Americans should have had to begin with.The crash happened at 10.45am in crowded downtown Delray Beach, multiple news outlets reported. The Brightline train was stopped on the tracks, its front destroyed, about a block away from the Delray Beach fire rescue truck, its ladder ripped off and strewn in the grass several yards away, The Sun-Sentinel newspaper reported. The Delray Beach Fire Rescue said in a social media post that three Delray Beach firefighters were in stable condition at a hospital. Palm Beach County Fire Rescue took 12 people from the train to the hospital with minor injuries. Emmanuel Amaral rushed to the scene on his golf cart after hearing a loud crash and screeching train brakes from where he was having breakfast a couple of blocks away. He saw firefighters climbing out of the window of their damaged truck and pulling injured colleagues away from the tracks. One of their helmets came to rest several hundred feet away from the crash. “The front of that train is completely smashed, and there was even some of the parts to the fire truck stuck in the front of the train, but it split the car right in half. It split the fire truck right in half, and the debris was everywhere,” Mr Amaral said. Brightline officials did not immediately comment on the crash. A spokesperson for the National Transportation Safety Board said it was still gathering information about the crash and had not decided yet whether it will investigate. The NTSB is already investigating two crashes involving Brightline’s high-speed trains that killed three people early this year at the same crossing along the railroad’s route between Miami and Orlando. More than 100 people have died after being hit by trains since Brightline began operations in July 2017 – giving the railroad the worst death rate in the United States. But most of those deaths have been either suicides, pedestrians who tried to run across the tracks ahead of a train or drivers who went around crossing gates instead of waiting for a train to pass. Brightline has not been found to be at fault in those previous deaths.

LUANDA, Angola (AP) — long-delayed trip to Africa had many of the hallmarks of a traditional state visit: There was a 12-shot cannon salute. A series of warm handshakes with Angolan President João Lourenço. Celebratory music. Photo opportunities. But another issue overshadowed the visit. When reporters tried to question the president about why he after repeatedly saying he would not do so, Biden tried to brush aside the questions. He gestured toward Lourenço and laughed, declaring, “Welcome to America.” Biden saluted Lourenço for his efforts to bolster stronger U.S. relations, declared that would shape the world's future and even indulged his love of trains by championing a major railway project that his administration says could change the way the entire continent does business. Some takeaways from the president's visit: (Don't) meet the press Biden offered the joke about America before his meeting with Lourenço, and he answered a question on Tuesday about the political situation in South Korea, saying only that he'd not been briefed — something that was rectified moments later when advisers filled him in on what was happening as the motorcade sped away from a site where he'd given a speech. Other than that, Biden went the entire trip, which began Sunday night and included two brief stopovers in Cape Verde in addition to Angola, dodging reporters. He did similar during last month's . Biden's press secretary tried to explain the pardon decision Since Biden announced his pardon decision shortly before climbing aboard Air Force One bound for Africa, it fell to White House press secretary Karine Jean-Pierre to spend nearly half an hour offering long and awkward answers to uncomfortable questions aboard the aircraft hours later. Biden said in a statement explaining the pardon that, while he believed in the justice system, he also felt that politics had infected the cases against his son and “enough was enough.” Jean-Pierre maintained that he wasn't trying to have it both ways. “I don’t think it’s a contradiction,” she said. “Two things could be true. You can believe in the Department of Justice system, and you could also believe that the process was infected politically.” She also bristled when it was suggested that such complaints about the Department of Justice smacked of President-elect Donald Trump's of federal bureaucrats that he's said for years are out to unfairly undermine him and fellow top Republicans. ‘All in on Africa’ — with time running out During his meeting with Lourenço at the presidential palace, Biden said, and extolled how strong Angolan relations were with Washington. His administration has invested billions in Angola, with the centerpiece being promoting the Lobito Corridor, a vast project to revitalize supply chains by refurbishing 800 miles (1,300 kilometers) of train lines in Angola, Zambia and Congo. Given where Angola was barely a generation ago, the alliance is in many ways remarkable. An oil-rich nation on Africa's southwest coast, Angola achieved independence from Portugal in 1975, but spent subsequent years embroiled in civil war, which often featured proxy fighting between U.S.-backed forces and those allied with the Soviet Union. Even today, the country's red and black flag features a yellow machete and half-cog, an insignia resembling the Soviet hammer and sickle. But Biden leaves office on Jan. 20, and Lourenço, like many leaders of African nations, has already begun suggesting that he's looking toward a Trump-dominated future. Biden administration officials say they're hopeful Trump and top Republicans will continue a business-friendly approach to investing in Africa that includes continuing to support the Lobito Corridor. Now the Africa policy will be up to Trump Biden lauded Lourenço for helping boost his country's relationship with the United States, and he said the youth of Africa would change the world. He also visited the country’s national slavery museum, stressing how Angola and the United States — which were once linked by the horrors of enslaved human beings, now could increasingly be linked by economic opportunity. But if Biden came to Angola hoping to cement his foreign policy legacy in this country and throughout Africa, it will actually fall to Trump — the man he and spent much of 2024 running against before in July — to see it through. ___ Will Weissert, The Associated PressUnai Emery feels confidence returning after Aston Villa end winless runThe crash happened at 10.45am in crowded downtown Delray Beach, multiple news outlets reported. The Brightline train was stopped on the tracks, its front destroyed, about a block away from the Delray Beach fire rescue truck, its ladder ripped off and strewn in the grass several yards away, The Sun-Sentinel newspaper reported. The Delray Beach Fire Rescue said in a social media post that three Delray Beach firefighters were in stable condition at a hospital. Palm Beach County Fire Rescue took 12 people from the train to the hospital with minor injuries. Emmanuel Amaral rushed to the scene on his golf cart after hearing a loud crash and screeching train brakes from where he was having breakfast a couple of blocks away. He saw firefighters climbing out of the window of their damaged truck and pulling injured colleagues away from the tracks. One of their helmets came to rest several hundred feet away from the crash. “The front of that train is completely smashed, and there was even some of the parts to the fire truck stuck in the front of the train, but it split the car right in half. It split the fire truck right in half, and the debris was everywhere,” Mr Amaral said. Brightline officials did not immediately comment on the crash. A spokesperson for the National Transportation Safety Board said it was still gathering information about the crash and had not decided yet whether it will investigate. The NTSB is already investigating two crashes involving Brightline’s high-speed trains that killed three people early this year at the same crossing along the railroad’s route between Miami and Orlando. More than 100 people have died after being hit by trains since Brightline began operations in July 2017 – giving the railroad the worst death rate in the United States. But most of those deaths have been either suicides, pedestrians who tried to run across the tracks ahead of a train or drivers who went around crossing gates instead of waiting for a train to pass. Brightline has not been found to be at fault in those previous deaths.

After Iranian arrest tied to U.S. military murders, town advances sanctuary policiesVoters want more US involvement on world stage despite isolationist talk, Ronald Reagan Institute survey findsHong Kong police issue arrest warrants and bounties for six activists including two Canadians

After starting 2-0 in its inaugural Atlantic Coast Conference schedule, SMU looks to make the month even more special on Sunday, hosting Longwood in Dallas, Texas. The Mustangs seek a seven-game win streak in their final nonconference test before welcoming No. 4 Duke to Dallas on Jan. 4. In recent victories over Alabama State, Virginia, LSU, and Boston College, SMU (10-2) averaged 85.3 points per game, allowed just 66.0 ppg, and climbed to No. 30 in the NET rankings. "We're a different team right now than we were earlier in the season," SMU head coach Andy Enfield said at the beginning of December, his words ringing even truer as the season progresses. "They'd never been under pressure together until recently, so they're starting to learn and figure things out." Longwood (11-3) enters its third consecutive road game, having won five of its last six overall. That includes a major 82-67 win at North Carolina Central on Dec. 20. It was only the sixth nonconference home loss for NCC since 2016, and Longwood head coach Griff Aldrich saw it as a result of his team's growing cohesiveness. "We got great contributions from so many players," Aldrich said. "We have been working to play more and more connected, and this team has really taken positive steps this week." The Mustangs' Matt Cross is among the biggest threats to Longwood's defense, which allows just 66.6 points per game. A 6-foot-7 forward, Cross had 36 points over SMU's last two wins, including a 16-point, 16-rebound double-double against LSU. What Cross does with the ball in his hands is impressive -- he is averaging 13.5 ppg in December -- but it is also what he does off the ball that increases his value. "He's extremely tough," Enfield said after Cross' performance against LSU. "His wall up in transition, where (Corey) Chest came down, was going to dunk the ball, and he stood there and took the contact. ...That's a big-time basketball play." Longwood is paced by Michael Christmas, a veteran forward in his fourth year in the program. A hard-nosed wing who can score at all three levels, Christmas is Longwood's only returner who started at least 30 games on last year's NCAA Tournament team. He is averaging a team-high 11.9 points per game. "(He) loves this university, loves this town and community," Aldrich said of Christmas. "He opted to come back here to really invest in the program." --Field Level MediaU.S. Department of the Treasury Releases Final Rules on Investment Tax Credit to Produce Clean Power, Strengthen Clean Energy Economy - Treasury

Sebastian Zapeta, 33, who federal immigration officials said is a Guatemalan citizen who entered the US illegally, was arraigned in Brooklyn criminal court. He appeared briefly before a judge and wore a white jumpsuit over a weathered black hooded sweatshirt. He did not speak. He will remain jailed ahead of his next court date on Friday. The apparently random attack occurred on Sunday morning on a stationary F train at the Coney Island station in Brooklyn. Police said on Tuesday that identification of the victim was still “pending at this time”. Authorities say Zapeta approached the woman, who was sitting motionless in the train car and may have been sleeping, and used a lighter to set her clothing on fire. The woman quickly became engulfed in flames, while the suspect then sat at a bench on the subway platform and watched, according to police. Video posted to social media appeared to show the woman standing inside the train ablaze as some people look on from the platform, and at least one officer walks by. NYPD chief of transit Joseph Gulotta said that several officers had responded to the fire and one stayed to keep the crime scene “the way it’s supposed to be” while the others went to get fire extinguishers and transit workers. They were eventually able to douse the fire, but “unfortunately, it was too late”, Police Commissioner Jessica Tisch said — the woman was pronounced dead at the scene. During Zapeta’s court hearing on Tuesday, Assistant District Attorney Ari Rottenberg said Zapeta at one point fanned the flames on the woman using his shirt. He said a 911 call from a subway rider helped identify Zapeta. Mr Rottenberg added that under interrogation Zapeta claimed he did not know what happened, noting that he consumes alcohol. But he alleged that Zapeta identified himself to interrogators in images related to the attack. Zapeta was taken into custody on Sunday afternoon while riding a train on the same subway line after police got a tip from some teenagers who recognised him from images circulated by the police. A Brooklyn address for Zapeta released by police matches a shelter that provides housing and substance abuse support. The shelter did not immediately respond to a request for comment. Federal immigration officials said Zapeta had been previously deported in 2018 but at some point reentered the US illegally. The crime — and the graphic video of it that ricocheted across social media — deepened a growing sense of unease among some New Yorkers about the safety of the subway system in a city where many residents take the subway multiple times each day.

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