Luca Guadagnino Slams Turkish ‘Queer’ Ban As “Obtuse Censorship”Title: Expert Analysis Indicates High Possibility of Infighting Among Anti-Government Armed Groups as Battlefield Situation Dramatically Changes

Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.Simmons scores 19 as Gardner-Webb takes down SE Louisiana 73-69

However, others suggest that Nvidia's situation may be more complex and connected to the broader geopolitical tensions between the United States and China. As the trade war between the two superpowers intensifies, technology companies are increasingly caught in the crossfire, facing restrictions on doing business with Chinese firms and heightened scrutiny of their strategic investments. Nvidia's proposed acquisition of Arm Holdings, which has close ties to Chinese tech companies, has raised red flags in Washington and fueled suspicions about potential national security risks.A 44-year-old Butte man pleaded not guilty Thursday to nine counts of sexual abuse of children for allegedly having numerous videos of children engaged in sexual acts. Adam Lee McPhie was escorted from the Butte jail to District Judge Kurt Krueger’s courtroom and with lawyer Mark Johnson by his side, pleaded not guilty to each count. Krueger accepted the pleas and set the next hearing for Jan. 18. Adam Lee McPhie talks with his attorney, Mark Johnson, prior to appearing before District Judge Kurt Krueger on Thursday, Nov. 21, 2024 in the Butte-Silver Bow Courthouse. Johnson said he would seek a bail reduction, but it remains at $1 million for now as requested by prosecutors. McPhie has been jailed since his arrest on Oct. 3. Prosecutors and police believe the children in the images are all under age 16 and some are likely 12 or younger. Adam Lee McPhie appears before District Judge Kurt Krueger on Thursday, Nov. 21, 2024 in the Butte-Silver Bow Courthouse. Under Montana law, sexual abuse of children tied to child pornography carries a maximum of 10 years in prison and a fine of up to $50,000. But if the offender was 18 or older and the victims are 12 or under, a conviction carries a 100-year-prison term and the first 25 years cannot be suspended. The offender is also not eligible for parole until at least 25 years are served. The charges allege that McPhie possessed videos of children on various dates in 2023. Investigators received cyber tips from the National Center for Missing and Exploited Children that were reported by the cloud-based storage provider for cell phone company Verizon Wireless. Adam Lee McPhie appears before District Judge Kurt Krueger on Thursday, Nov. 21, 2024 in the Butte-Silver Bow Courthouse. An agent with the Montana Department of Criminal Investigation obtained a search warrant to review the files and matched them with call logs and other information tied to McPhie’s cell phone number. Some of the videos show nude, pre-pubescent children in sex acts, some with adults and some with other children, prosecutors say. In one, a female child appears to be in pain and is crying. The cyber tips all took place in 2023, with the earliest reported in February that year and the latest on May 30. In the agent’s investigation, “it has been discovered that there are potentially hundreds of additional CSAM (child sexual abuse material) files connected to McPhie,” prosecutors said in an affidavit. “The investigation continues into these files.” Mike Smith is a reporter at the Montana Standard with an emphasis on government and politics. Get the latest in local public safety news with this weekly email. Government and Politics Reporter {{description}} Email notifications are only sent once a day, and only if there are new matching items.As Xiaomi continues to expand its product offerings, the launch of the YU7 marks a new chapter in the company's journey. With a focus on quality, innovation, and affordability, Xiaomi is poised to disrupt the automotive industry in a way that only a company of its caliber can.

Reuniting with Evans is none other than Robert Downey Jr., who portrayed the beloved genius, billionaire, playboy, philanthropist Tony Stark aka Iron Man. Downey Jr.'s portrayal of the character was widely praised and helped cement Iron Man as a fan-favorite in the Marvel Cinematic Universe. The dynamic between Evans' noble and patriotic Captain America and Downey Jr.'s charismatic and witty Iron Man was a highlight of the Avengers films, and fans are thrilled to see them team up once again.Moreover, Nvidia's struggles may also reflect a larger trend of tech companies becoming pawns in the US-China tech war, as both countries seek to gain a competitive edge in key technological fields. The escalating tensions have led to increased scrutiny of foreign investments, stricter regulations on technology transfers, and growing concerns about the security implications of cross-border collaborations. Nvidia, as a prominent player in the semiconductor industry with global operations, finds itself at the center of these challenges and must navigate a complex web of regulatory, political, and economic considerations.

Title: "Controversy Erupts as Elderly Woman Sets Mountain Ablaze While Collecting Plastic Bottles: Incites Debate on Environment and Responsibility"Missing trees, misleading ornaments, mini inflatables: Holiday decor scams leave shoppers less jolly

NEW YORK (AP) — A slide for market superstar Nvidia on Monday knocked Wall Street off its big rally and helped drag U.S. stock indexes down from their records. The S&P 500 fell 0.6%, coming off its 57th all-time high of the year so far. The Dow Jones Industrial Average dipped 240 points, or 0.5%, and the Nasdaq composite pulled back 0.6% from its own record. Nvidia’s fall of 2.5% was by far the heaviest weight on the S&P 500 after China said it’s investigating the company over suspected violations of Chinese anti-monopoly laws. Nvidia has skyrocketed to become one of Wall Street’s most valuable companies because its chips are driving much of the world’s move into artificial-intelligence technology. That gives its stock’s movements more sway on the S&P 500 than nearly every other. Nvidia’s drop overshadowed gains in Hong Kong and for Chinese stocks trading in the United States on hopes that China will deliver more stimulus for the world’s second-largest economy. Roughly three in seven of the stocks in the S&P 500 also rose. The week’s highlight for Wall Street will arrive midweek when the latest updates on inflation arrive. Economists expect Wednesday’s report to show the inflation that U.S. consumers are feeling remained stuck at close to the same level last month. A separate report on Thursday, meanwhile, could show an acceleration in inflation at the wholesale level. They’re the last big pieces of data the Federal Reserve will get before its meeting next week on interest rates. The widespread expectation is still that the central bank will cut its main interest rate for the third time this year. The Fed has been easing its main interest rate from a two-decade high since September to offer more help for the slowing job market, after bringing inflation nearly all the way down to its 2% target. Lower interest rates can ease the brakes off the economy, but they can also offer more fuel for inflation. Expectations for a series of cuts from the Fed have been a major reason the S&P 500 has set so many all-time highs this year. “Investors should enjoy this rally while it lasts—there’s little on the horizon to disrupt the momentum through year-end,” according to Mark Hackett, chief of investment research at Nationwide, though he warns stocks could stumble soon because of how overheated they’ve gotten. On Wall Street, Interpublic Group rose 3.6% after rival Omnicom said it would buy the marketing and communications firm in an all-stock deal. The pair had a combined revenue of $25.6 billion last year. Omnicom, meanwhile, sank 10.2%. Macy’s climbed 1.8% after an activist investor, Barington Capital Group, called on the retailer to buy back at least $2 billion of its own stock over the next three years and make other moves to help boost its stock price. Super Micro Computer rose 0.5% after saying it got an extension that will keep its stock listed on the Nasdaq through Feb. 25, as it works to file its delayed annual report and other required financial statements. Earlier this month, the maker of servers used in artificial-intelligence technology said an investigation found no evidence of misconduct by its management or by the company’s board following the resignation of its public auditor . All told, the S&P 500 fell 37.42 points to 6,052.85. The Dow dipped 240.59 to 4,401.93, and the Nasdaq composite lost 123.08 to 19,736.69. In the oil market, a barrel of benchmark U.S. crude rallied 1.7% to settle at $68.37 following the overthrow of Syrian leader Bashar Assad, who sought asylum in Moscow after rebels. Brent crude, the international standard, added 1.4% to $72.14 per barrel. The price of gold also rose 1% to $2,685.80 per ounce amid the uncertainty created by the end of the Assad family’s 50 years of iron rule. In stock markets abroad, the Hang Seng jumped 2.8% in Hong Kong after top Chinese leaders agreed on a “moderately loose” monetary policy for the world’s second-largest economy. That’s a shift away from a more cautious, “prudent” stance for the first time in 10 years. A major planning meeting later this week could also bring more stimulus for the Chinese economy. U.S.-listed stocks of several Chinese companies climbed, including a 12.4% jump for electric-vehicle company Nio and a 7.4% rise for Alibaba Group. Stocks in Shanghai, though, were roughly flat. In Seoul, South Korea’s Kospi slumped 2.8% as the fallout continues from President Yoon Suk Yeol ’s brief declaration of martial law last week in the midst of a budget dispute. In the bond market, the yield on the 10-year Treasury rose to 4.19% from 4.15% late Friday. AP Business Writers Matt Ott and Elaine Kurtenbach contributed.

Baltimore (7-4) at Los Angeles Chargers (7-3) Monday, 8:15 p.m. EST, ESPN/ABC BetMGM NFL odds: Ravens by 3. Against the spread: Ravens 5-5-1; Chargers 7-3. Series record: Ravens lead 9-5. Last meeting: Ravens beat Chargers 20-10 in Inglewood, Calif., on Nov. 26, 2023. Last week: Ravens lost to Pittsburgh 18-16; Chargers beat Cincinnati 34-27. Ravens offense: overall (1), rush (2), pass (3), scoring (2). Ravens defense: overall (3), rush (26), pass (2), scoring (23). Chargers offense: overall (18), rush (12), pass (19), scoring (18). Chargers defense: overall (11), rush (11), pass (12), scoring (1). Turnover differential: Ravens plus-2; Chargers plus-8. K Justin Tucker missed two field goals last week and is under pressure after spending most of his career beyond reproach. He’s missed six field goals on the season and is 4 for 12 from 50-plus yards since the start of last season. WR Ladd McConkey had a career-high 123 yards on six receptions against Cincinnati. The rookie came up with clutch catches of 28 and 27 yards to set up the game-winning touchdown. Chargers RB J.K. Dobbins vs. Ravens’ run defense. Dobbins showed promise during his time in Baltimore, but he never was able to live up to that potential because of injuries. Now in Los Angeles on a one-year “prove it” contract, Dobbins has nearly matched his most productive season as a professional with 726 yards and eight touchdowns in 10 games. After seeing Pittsburgh run the ball 34 times last week, the Chargers will be glad to copy that bruising approach with Dobbins. The Ravens are allowing 77.5 rushing yards per game, but even the sturdiest defense can buckle against that volume of work, so getting off the field will be critical. Baltimore’s defense has a couple of significant injury concerns. LB Roquan Smith (hamstring) left last weekend’s game, and S Kyle Hamilton has been nursing an ankle problem, although he played against the Steelers. ... Chargers OLB Khalil Mack (groin) didn’t play against Cincinnati. If the veteran pass rusher remains out this week, it would be a big loss to the chances of containing the Ravens' multi-faceted offense. The Ravens have won four straight over the Chargers in the regular season, but Los Angeles did earn a 23-17 AFC wild-card round upset in January 2019. ... Baltimore cruised to a 34-6 win over the Chargers in its first visit to SoFi Stadium on Oct. 17, 2021. Ravens RB Derrick Henry leads the NFL with 1,185 yards rushing and 15 total TDs (13 rushing and two receiving). He’s also run for a league-high 52 first downs. ... Henry is one rushing TD shy of the Ravens’ single-season record, set by Jamal Lewis in 2003. ... Baltimore QB Lamar Jackson is 6-2 on “Monday Night Football” with 20 TD passes and no interceptions. ... Henry is one of four players in the Super Bowl era to score a TD in each of the first 11 games of a season. The others are O.J. Simpson (1975), John Riggins (1983) and Jerry Rice (1987). ... The Ravens have scored touchdowns on a league-best 77.8% of their red zone trips. ... Jackson needs 124 yards passing and 16 yards rushing for a second consecutive season with 3,000 passing and 600 rushing. Since the AFL-NFL merger, only Randall Cunningham (1988-1990), Cam Newton (2011-12), Josh Allen (2021-22) and Jalen Hurts (2021-23) have accomplished that feat. ... Dobbins ran for two touchdowns against Cincinnati, giving him multiple scores in two of his past three games. He did it twice in 24 games as a Raven. ... OLB Tuli Tuipulotu had 1 1/2 sacks of Bengals QB Joe Burrow, his third straight game with more than one. All seven of Tuipulotu’s sacks this season have come in the past four games, and six of his eight tackles for loss have come in that span. ... The Chargers allowed a season-worst 27 points to Cincinnati after holding each of their previous nine opponents to 20 points or fewer. ... QB Justin Herbert has thrown one interception in 277 attempts this season. That lone pick came in Week 2 at Carolina. ... The Chargers lost their fifth turnover of the season when Herbert fumbled to start the fourth quarter. It was their first turnover at home. ... Los Angeles does not have a takeaway in its past two games. Herbert has heated up after a slow start in terms of fantasy production, having thrown for multiple touchdowns in three of his past four games. He is likely to keep that success going this week. Baltimore has allowed 22 scores through the air, which is tied with Houston for second most in the league, and Herbert should have plenty of chances to add to that total in what could be another high-scoring matchup. AP NFL: https://apnews.com/hub/NFL

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The Apple Watch is a technological marvel that seamlessly integrates into our daily lives, providing us with a plethora of features and functionalities right at our wrist. However, one peculiar phenomenon that many Apple Watch users have undoubtedly encountered is its tendency to inexplicably stick to glass surfaces. This seemingly magical occurrence can be attributed to the intriguing properties of optically clear adhesive (OCA) that is used in the construction of the Apple Watch, which we will delve into in this article.

Prudential Financial, Inc. (NYSE:PRU) Shares Purchased by PNC Financial Services Group Inc.10 Famous People Who Actually Admitted To Using Ozempic And 9 Who Flat-Out Denied It