Wall St closes lower at end of holiday-shortened weekJimmy Carter: A brief bio— BIRTH NAME: James Earl Carter, Jr. — BORN: Oct. 1, 1924, at the Wise Clinic in Plains, Georgia, the first U.S. president born in a hospital. He would become the first president to live for an entire century . — EDUCATION: Plains High School, Plains, Georgia, 1939-1941; Georgia Southwestern College, Americus, Georgia, 1941-1942; Georgia Institute of Technology, Atlanta, 1942-1943; U.S. Naval Academy, Annapolis, Maryland, 1943-1946 (class of 1947); Union College, Schenectady, New York, 1952-1953. — PRESIDENCY: Sworn-in as 39th president of the United States at the age of 52 years, 3 months and 20 days on Jan. 20, 1977, after defeating President Gerald R. Ford in the 1976 general election. Left office on Jan. 20, 1981, following 1980 general election loss to Ronald Reagan. — POST-PRESIDENCY: Launched The Carter Center in 1982. Began volunteering at Habitat for Humanity in 1984. Awarded Nobel Peace Prize in 2002. Taught for 37 years at Emory University, where he was granted tenure in 2019, at age 94. — OTHER ELECTED OFFICES: Georgia state senator, 1963-1967; Georgia governor, 1971-1975. — OTHER OCCUPATIONS: Served in U.S. Navy, achieved rank of lieutenant, 1946-53; Farmer, warehouseman, Plains, Georgia, 1953-77. — FAMILY: Wife, Rosalynn Smith Carter , married July 7, 1946 until her death Nov. 19, 2023. They had three sons, John William (Jack), James Earl III (Chip), Donnel Jeffrey (Jeff); a daughter, Amy Lynn; and 11 living grandchildren and 14 great-grandchildren. Source: Jimmy Carter Library & Museum
ROCK HILL, S.C. (AP) — Nick Johnson had 22 points in Winthrop's 102-97 win over Mercer on Saturday. Johnson had five rebounds for the Eagles (10-4). Kasen Harrison shot 7 of 11 from the field, including 1 for 3 from 3-point range, and went 5 for 8 from the line to add 20 points. Kelton Talford shot 4 of 9 from the field and 10 of 14 from the free-throw line to finish with 18 points. The Bears (6-6) were led in scoring by Ahmad Robinson, who finished with 27 points and seven assists. Tyler Johnson added 19 points for Mercer. Angel Montas finished with 17 points. Winthrop plays Sunday against Indiana on the road, and Mercer visits Georgia State on Saturday. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .
ATLANTA (AP) — The Atlanta Falcons are back in first place in the NFC South and again in control of their playoff hopes. Rookie quarterback Michael Penix Jr. showed the poise in his first NFL start the Falcons will need to take advantage of their opportunity to end a six-year playoff drought. Powered by a big-play defense that produced two pick-6s, a solid starting debut by Penix and two rushing touchdowns by Bijan Robinson, the Falcons cruised past the hapless New York Giants 34-7 on Sunday. On Sunday night, the Falcons (8-7) received the assist they needed when Tampa Bay lost at Dallas . Because the Falcons swept the Buccaneers, they hold the tiebreaker advantage if they remain tied atop the division. The Falcons have games remaining at Washington on Sunday night and at home against Carolina to close the regular season. If Atlanta wins both games, it would win the division and have a home playoff game. The Falcons are assured of their best record since a 10-6 finish under coach Dan Quinn in 2017, their most recent playoff season. Quinn is in his first season as Washington's coach and has led the Commanders (10-5) to three straight wins, including Sunday's 36-33 victory over Philadelphia. Penix, the No. 8 overall pick in this year's NFL draft, was promoted after coach Raheem Morris benched Kirk Cousins. Penix completed 18 of 27 passes for 202 yards with one interception on a pass that should have been caught by tight end Kyle Pitts. Penix is not a dual-threat quarterback, but he showed the ability to escape pressure in the pocket that Cousins lacks following his 2023 Achilles tendon injury. The left-hander's superior arm strength also was immediately obvious. What’s working Robinson's production provided a safety net for the offense which helped make for a smooth transition to Penix. Robinson had scoring runs of 2 and 4 yards. Robinson has rushed for 10 touchdowns this season. He's the first Atlanta player with 10 more more rushing touchdowns since Devonta Freeman during the 2016 Super Bowl season. Robinson ran for 94 yards on 22 carries and had 103 yards from scrimmage. His 11th game this season with at least 100 yards from scrimmage are the most for the Falcons since Warrick Dunn's 11 in 2005. Morris said Robinson deserves to be considered with Philadelphia's Saquon Barkley in discussions regarding the league's top running backs. “Bijan has been outstanding all year in the things that he’s able to do," Morris said. “He’s special. If it wasn’t for this other guy out in Philly, he’d get a lot more recognition across the league. But that guy is having a special year, and Bijan’s not far behind him.” What needs help With kicker Younghoe Koo on injured reserve and watching from the sideline, Riley Patterson was wide left on his first field-goal attempt from 43 yards. Patterson rebounded to make attempts from 52 and 37 yards. Stock up Jessie Bates III and Matthew Judon each had a pick-6 to highlight a day of big plays for the defense. Arnold Ebiketie had his fifth sack of the season and added a fumble recovery. Kaden Ellis added a strip-sack. He also has five sacks this season, including sacks in four consecutive games. It is the longest streak for Atlanta since Patrick Kerney had sacks in five straight games in 2001. Stock down There was some thought that a change at quarterback could be good news for Pitts, who often seemed to be missing in action with Cousins running the offense. After all, a tight end often is a natural target for quick passes from a rookie making his first start. Instead, Pitts had a poor start to the Penix era when he bobbled his first pass from the left-hander, creating an interception by cornerback Cor’Dale Flott. Pitts caught a 7-yard pass on his only other target. For the season, Pitts has 41 catches for 543 yards and three touchdowns. Injuries There will be much interest in this week's injury report after WR Drake London (hamstring) was hurt in the second half. Morris provided an optimistic postgame outlook on London. CB Antonio Hamilton (quad) did not return after leaving the game in the first half. Key number 8: Bates has four interceptions and four forced fumbles. His combined eight forced turnovers lead the NFL. Next steps The game against Jayden Daniels and the Commanders is a reminder Penix was only the fourth of six quarterbacks selected in the first round of the NFL draft. Daniels, from LSU, was the No. 2 overall pick behind Caleb Williams by Chicago. AP NFL: https://apnews.com/hub/nfl
Dragons fans left fuming after Mark Gasnier joins Jason Ryles and Zac Lomax at Parramatta
Officials have positively identified the remains of a girl whose body was found hidden in brush under a plastic tarp in 1973, Pennsylvania authorities said this week. The remains belong to Ruth Elizabeth Brenneman, 14, Pennsylvania State Police Sgt. Josh Lacey told reporters at a news conference Wednesday. Two game wardens found the decomposed remains of a young girl in a wooded area of Lebanon County on Oct. 10, 1973, approximately 47 miles from Brenneman's home in York County, Lacey said. It couldn't be determined how she died. Officials have spent the last 50 years attempting to identify the girl, Lacey said. In another effort to identify her, officials, with the help of the National Center for Missing and Exploited Children, exhumed the girl's body from Mount Lebanon Cemetery in May 2016. Finally, the positive identification was made last month after her remains were examined at Lehigh Valley Hospital. Lacey said she was identified using genealogy. "As a result of their efforts, this young female will no longer be known as Jane Doe," Lacey said. Identifying the body is a "huge step in this investigation," State Trooper Ian Keck said. "We have to know about the victim and their everyday life, who they associated with and their different activities." Brenneman was last seen "after she left for school and never returned home," Lacey said. Officials are looking into whether she made it to school that day. They are also trying to determine whether Brenneman was considered missing and on what day she went missing, Keck said. "Just because we identified her today that doesn't end our investigation," Keck said. "We're going to do our best and put our best foot forward here to come to a conclusion." Anyone who knew Brenneman or knows anything about her is asked to contact Pennsylvania State Police. Lacey declined to say whether there is a person of interest in the case and couldn't say for sure whether it was a homicide, as that is still "pending" with the coroner's office. He did say there was "some level of suspicion" to Brenneman's death "given the fact she was found underneath a tarp in some brush." Brenneman's family, in a statement read by Lacey, said her identification "has provided us with some closure on questions that have lingered for the past 51 years."
TRC in a mess; public driven from pillar to postPhase 3 Study Results Demonstrated Three Year, Disease-Free Survival of 96% THOUSAND OAKS, Calif. , Dec. 7, 2024 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced new data demonstrating that adding BLINCYTO ® (blinatumomab) to chemotherapy significantly improves disease-free survival (DFS) in newly diagnosed pediatric patients with National Cancer Institute (NCI) standard risk (SR) B-cell acute lymphoblastic leukemia (B-ALL) of average or higher risk of relapse. The data are from a Phase 3 study (AALL1731) conducted by the Children's Oncology Group. The results were simultaneously published in the New England Journal of Medicine and will be presented during the plenary session on Sunday, Dec. 8 , at 2 p.m. PT at the 66 th American Society of Hematology (ASH) Annual Meeting & Exposition in San Diego . "Over the last decade, BLINCYTO has reshaped the treatment landscape for B-ALL, offering a critical lifeline for thousands of adult and pediatric patients," said Jay Bradner , M.D., executive vice president of Research and Development and chief scientific officer at Amgen. "These powerful new data leave us little doubt about the profound impact of this medicine for a large number of children affected by this disease. We are grateful to the Children's Oncology Group, along with the patients, families and clinical teams, for their dedication and partnership in advancing this critical study to improve the lives of children with cancer." Based on the results of the first pre-specified interim analysis for efficacy, the study met its primary endpoint of DFS and study randomization was terminated early based on the recommendation from the data and safety monitoring committee due to the benefit observed in the BLINCYTO arm compared to the chemotherapy-only arm. Overall, the 3-year DFS was 96.0% for patients treated with chemotherapy plus BLINCYTO compared to 87.9% for those treated with only chemotherapy. The hazard ratio (HR) was 0.39 [95% confidence interval (CI) 0.24-0.64], indicating a 61% reduction in the risk of disease relapse, secondary malignant neoplasm or remission death with BLINCYTO. At 3 years, more patients remained alive and cancer free when treated with BLINCYTO plus chemotherapy compared to chemotherapy alone. "The AALL1731 study results are truly practice-changing, further solidifying blinatumomab's role as the standard of care for a large number of children with B-ALL," said Sumit Gupta , M.D., Ph.D., FRCPC, co-chair of the Children's Oncology Group AALL1731 study and oncologist and clinician investigator, Division of Haematology/Oncology at The Hospital for Sick Children (SickKids) and associate professor of pediatrics at the University of Toronto . "These breakthrough data showing a significant improvement in disease-free survival are poised to bring substantial clinical value to children with newly diagnosed B-ALL." The addition of BLINCYTO to chemotherapy in standard risk patients resulted in outcomes similar to those previously achieved in only the most favorable pediatric risk subsets. Among SR-Average patients, 3-year DFS was 97.5% for patients treated with BLINCYTO compared to 90.2% for those treated with only chemotherapy (HR 0.33, CI 0.15-0.69). For SR-High patients, 3-year DFS was 94.1% for those treated with BLINCYTO compared to 84.8% for those treated with only chemotherapy (HR 0.45, 95% CI 0.24-0.85). "Relapsed ALL remains a major cause of pediatric cancer mortality, with nearly half of the relapses occurring in children with standard-risk B-ALL," said Rachel E. Rau , M.D., co-chair of the Children's Oncology Group AALL1731 study, pediatric hematologist-oncologist at Seattle Children's Hospital and associate professor of pediatrics at the University of Washington . "These findings underscore the progress made with blinatumomab in preventing relapse and support its role as a critical addition to current therapeutic strategies." Safety results are consistent with the known safety profile of BLINCYTO. BLINCYTO has demonstrated a positive balance of benefits and risks, with only 0.3% of first courses associated with Grade 3+ cytokine release syndrome (CRS) and 0.7% with seizures. A higher risk of infections was observed in the BLINCYTO arm. These results provide the first evidence supporting BLINCYTO for use in the consolidation phase in newly diagnosed pediatric Philadelphia chromosome-negative (Ph-) B-ALL patients. This groundbreaking first-in-class Bispecific T-cell Engager (BiTE ® ) therapy is now backed by additional evidence reinforcing its role in redefining a standard of care for both adult and pediatric patients, starting from one month old, regardless of measurable residual disease (MRD) status. The findings further establish BLINCYTO as a versatile first-line consolidation therapy across all ages and treatment backbones. The NCI's Cancer Therapy Evaluation Program (CTEP), which sponsored the study will share data with the U.S. Food and Drug Administration as part of their ongoing communications relating to the trial. About The Children's Oncology Group The Children's Oncology Group (childrensoncologygroup.org), a member of the NCI National Clinical Trials Network (NCTN), is the world's largest organization devoted exclusively to childhood and adolescent cancer research. The Children's Oncology Group unites over 10,000 experts in childhood cancer at more than 200 leading children's hospitals, universities and cancer centers across North America , Australia , New Zealand and Saudi Arabia in the fight against childhood cancer. Today, more than 80% of the 15,000 children and adolescents diagnosed with cancer each year in the United States are cared for at Children's Oncology Group member institutions. Research performed by Children's Oncology Group institutions over the past 50 years has transformed childhood cancer from a virtually incurable disease to one with a combined 5-year survival rate of 86%. The Children's Oncology Group's mission is to improve the cure rate and outcomes for all children with cancer. About AALL1731 (NCT03914625) The AALL1731 study was a Phase 3 randomized trial to determine if two non-sequential cycles of BLINCYTO added to chemotherapy improved disease-free survival (DFS) in children with newly diagnosed pediatric National Cancer Institute (NCI) standard risk (SR) B-cell acute lymphoblastic leukemia (B-ALL). The study enrolled 4,264 newly diagnosed NCI SR B-ALL patients, of whom 2,334 were risk stratified at the end of induction therapy as either SR-Average or SR-High. At the first planned interim efficacy analysis (data cutoff June 30, 2024 ), 1,440 of the eligible and evaluable patients had been randomized. The AALL1731 study was designed and conducted independently from industry. The Cancer Therapy Evaluation Program (CTEP) of the NCI sponsored the trial and provided funding to the Children's Oncology Group to conduct the study. NCI is part of the National Institutes of Health (NIH). In addition, Amgen provided BLINCYTO and support through an NCI Cooperative Research and Development Agreement. About Acute Lymphoblastic Leukemia (ALL) ALL, also known as acute lymphoblastic leukemia, is a fast-growing type of blood cancer that develops in the bone marrow and can sometimes spread to other parts of the body, including the lymph nodes, liver, spleen and central nervous system. ALL is a rare disease, with an estimated 6,550 new cases, affecting both children and adults, diagnosed in the U.S. in 2024. 1 B-ALL begins in immature cells that would normally develop into B-cell lymphocytes, which are white blood cells that grow in bone marrow. 2,3 B-ALL is the most common type of ALL, constituting approximately 75% of cases in adults and approximately 88% in children, the most common cancer in children. 4,5 About BLINCYTO ® (blinatumomab) BLINCYTO is the first globally approved Bispecific T-cell Engager (BiTE ® ) immuno-oncology therapy that targets CD19 surface antigens on B cells. BiTE ® molecules fight cancer by helping the body's immune system detect and target malignant cells by engaging T cells (a type of white blood cell capable of killing other cells perceived as threats) to cancer cells. By bringing T cells near cancer cells, the T cells can inject toxins and trigger cancer cell death (apoptosis). BiTE ® immuno-oncology therapies are currently being investigated for their potential to treat a wide variety of cancers. BLINCYTO was granted Breakthrough Therapy and Priority Review designations by the U.S. FDA and is approved in the U.S. for the treatment of: In the European Union (EU), BLINCYTO is indicated as monotherapy for the treatment of: BLINCYTO ® IMPORTANT SAFETY INFORMATION WARNING: CYTOKINE RELEASE SYNDROME and NEUROLOGICAL TOXICITIES including IMMUNE EFFECTOR CELL-ASSOCIATED NEUROTOXICITY SYNDROME Contraindications BLINCYTO ® is contraindicated in patients with a known hypersensitivity to blinatumomab or to any component of the product formulation. Warnings and Precautions Adverse Reactions Dosage and Administration Guidelines INDICATIONS BLINCYTO ® (blinatumomab) is indicated for the treatment of CD19-positive B-cell precursor acute lymphoblastic leukemia (ALL) in adult and pediatric patients one month and older with: Please see BLINCYTO ® full Prescribing Information , including BOXED WARNINGS. About Bispecific T-Cell Engager (BiTE ® ) Technology BiTE technology is a targeted immuno-oncology platform that is designed to engage a patient's own T cells to any tumor-specific antigen, activating the cytotoxic potential of T cells to eliminate detectable cancer. The BiTE immuno-oncology platform has the potential to treat different cancer types through tumor-specific antigens. The BiTE platform has a goal of leading to off-the-shelf solutions, which have the potential to make innovative T-cell treatment available to all providers when their patients need it. For more than a decade, Amgen has been advancing this innovative technology, which has demonstrated strong efficacy in hematological malignancies and now a solid tumor with the approval of IMDELLTRA. Amgen remains committed to progressing multiple BiTE molecules across a broad range of hematologic and solid tumor malignancies, paving the way for additional applications in more tumor types. Amgen is further investigating BiTE technology with the goal of enhancing patient experience and therapeutic potential. To learn more about BiTE technology, visit BiTE ® Technology 101 . About Amgen Amgen discovers, develops, manufactures and delivers innovative medicines to help millions of patients in their fight against some of the world's toughest diseases. More than 40 years ago, Amgen helped to establish the biotechnology industry and remains on the cutting-edge of innovation, using technology and human genetic data to push beyond what's known today. Amgen is advancing a broad and deep pipeline that builds on its existing portfolio of medicines to treat cancer, heart disease, osteoporosis, inflammatory diseases and rare diseases. In 2024, Amgen was named one of the "World's Most Innovative Companies" by Fast Company and one of "America's Best Large Employers" by Forbes, among other external recognitions . Amgen is one of the 30 companies that comprise the Dow Jones Industrial Average ® , and it is also part of the Nasdaq-100 Index ® , which includes the largest and most innovative non-financial companies listed on the Nasdaq Stock Market based on market capitalization. For more information, visit Amgen.com and follow Amgen on X , LinkedIn , Instagram , TikTok , YouTube and Threads . Amgen Forward-Looking Statements This news release contains forward-looking statements that are based on the current expectations and beliefs of Amgen. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including any statements on the outcome, benefits and synergies of collaborations, or potential collaborations, with any other company (including BeiGene, Ltd. or Kyowa Kirin Co., Ltd.), the performance of Otezla ® (apremilast) (including anticipated Otezla sales growth and the timing of non-GAAP EPS accretion), Amgen's acquisitions of Teneobio, Inc., ChemoCentryx, Inc., or Horizon Therapeutics plc (including the prospective performance and outlook of Horizon's business, performance and opportunities, any potential strategic benefits, synergies or opportunities expected as a result of such acquisition, and any projected impacts from the Horizon acquisition on Amgen's acquisition-related expenses going forward), as well as estimates of revenues, operating margins, capital expenditures, cash, other financial metrics, expected legal, arbitration, political, regulatory or clinical results or practices, customer and prescriber patterns or practices, reimbursement activities and outcomes, effects of pandemics or other widespread health problems on Amgen's business, outcomes, progress, and other such estimates and results. Forward-looking statements involve significant risks and uncertainties, including those discussed below and more fully described in the Securities and Exchange Commission reports filed by Amgen, including its most recent annual report on Form 10-K and any subsequent periodic reports on Form 10-Q and current reports on Form 8-K. Unless otherwise noted, Amgen is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise. No forward-looking statement can be guaranteed and actual results may differ materially from those Amgen projects. Discovery or identification of new product candidates or development of new indications for existing products cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate or development of a new indication for an existing product will be successful and become a commercial product. Further, preclinical results do not guarantee safe and effective performance of product candidates in humans. The complexity of the human body cannot be perfectly, or sometimes, even adequately modeled by computer or cell culture systems or animal models. The length of time that it takes for Amgen to complete clinical trials and obtain regulatory approval for product marketing has in the past varied and Amgen expects similar variability in the future. Even when clinical trials are successful, regulatory authorities may question the sufficiency for approval of the trial endpoints Amgen has selected. Amgen develops product candidates internally and through licensing collaborations, partnerships and joint ventures. Product candidates that are derived from relationships may be subject to disputes between the parties or may prove to be not as effective or as safe as Amgen may have believed at the time of entering into such relationship. Also, Amgen or others could identify safety, side effects or manufacturing problems with its products, including its devices, after they are on the market. Amgen's results may be affected by its ability to successfully market both new and existing products domestically and internationally, clinical and regulatory developments involving current and future products, sales growth of recently launched products, competition from other products including biosimilars, difficulties or delays in manufacturing its products and global economic conditions. In addition, sales of Amgen's products are affected by pricing pressure, political and public scrutiny and reimbursement policies imposed by third-party payers, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international trends toward managed care and healthcare cost containment. Furthermore, Amgen's research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. Amgen's business may be impacted by government investigations, litigation and product liability claims. In addition, Amgen's business may be impacted by the adoption of new tax legislation or exposure to additional tax liabilities. If Amgen fails to meet the compliance obligations in the corporate integrity agreement between Amgen and the U.S. government, Amgen could become subject to significant sanctions. Further, while Amgen routinely obtains patents for its products and technology, the protection offered by its patents and patent applications may be challenged, invalidated or circumvented by its competitors, or Amgen may fail to prevail in present and future intellectual property litigation. Amgen performs a substantial amount of its commercial manufacturing activities at a few key facilities, including in Puerto Rico, and also depends on third parties for a portion of its manufacturing activities, and limits on supply may constrain sales of certain of its current products and product candidate development. An outbreak of disease or similar public health threat, such as COVID-19, and the public and governmental effort to mitigate against the spread of such disease, could have a significant adverse effect on the supply of materials for Amgen's manufacturing activities, the distribution of Amgen's products, the commercialization of Amgen's product candidates, and Amgen's clinical trial operations, and any such events may have a material adverse effect on Amgen's product development, product sales, business and results of operations. Amgen relies on collaborations with third parties for the development of some of its product candidates and for the commercialization and sales of some of its commercial products. In addition, Amgen competes with other companies with respect to many of its marketed products as well as for the discovery and development of new products. Further, some raw materials, medical devices and component parts for Amgen's products are supplied by sole third-party suppliers. Certain of Amgen's distributors, customers and payers have substantial purchasing leverage in their dealings with Amgen. The discovery of significant problems with a product similar to one of Amgen's products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on its business and results of operations. Amgen's efforts to collaborate with or acquire other companies, products or technology, and to integrate the operations of companies or to support the products or technology Amgen has acquired, may not be successful. There can be no guarantee that Amgen will be able to realize any of the strategic benefits, synergies or opportunities arising from the Horizon acquisition, and such benefits, synergies or opportunities may take longer to realize than expected. Amgen may not be able to successfully integrate Horizon, and such integration may take longer, be more difficult or cost more than expected. A breakdown, cyberattack or information security breach of Amgen's information technology systems could compromise the confidentiality, integrity and availability of Amgen's systems and Amgen's data. Amgen's stock price may be volatile and may be affected by a number of events. Amgen's business and operations may be negatively affected by the failure, or perceived failure, of achieving its environmental, social and governance objectives. The effects of global climate change and related natural disasters could negatively affect Amgen's business and operations. Global economic conditions may magnify certain risks that affect Amgen's business. Amgen's business performance could affect or limit the ability of the Amgen Board of Directors to declare a dividend or its ability to pay a dividend or repurchase its common stock. Amgen may not be able to access the capital and credit markets on terms that are favorable to it, or at all. Any scientific information discussed in this news release relating to new indications for Amgen's products is preliminary and investigative and is not part of the labeling approved by the U.S. Food and Drug Administration for the products. The products are not approved for the investigational use(s) discussed in this news release, and no conclusions can or should be drawn regarding the safety or effectiveness of the products for these uses. CONTACT: Amgen, Thousand Oaks Elissa Snook , 609-251-1407 (media) Justin Claeys , 805-313-9775 (investors) References View original content to download multimedia: https://www.prnewswire.com/news-releases/blincyto-blinatumomab-added-to-chemotherapy-significantly-improves-survival-in-newly-diagnosed-pediatric-patients-with-b-cell-precursor-acute-lymphoblastic-leukemia-b-all-302325381.html SOURCE Amgen
ROCK HILL, S.C. (AP) — Nick Johnson had 22 points in Winthrop's 102-97 win over Mercer on Saturday. Johnson had five rebounds for the Eagles (10-4). Kasen Harrison shot 7 of 11 from the field, including 1 for 3 from 3-point range, and went 5 for 8 from the line to add 20 points. Kelton Talford shot 4 of 9 from the field and 10 of 14 from the free-throw line to finish with 18 points. The Bears (6-6) were led in scoring by Ahmad Robinson, who finished with 27 points and seven assists. Tyler Johnson added 19 points for Mercer. Angel Montas finished with 17 points. Winthrop plays Sunday against Indiana on the road, and Mercer visits Georgia State on Saturday. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .
Jimmy Carter: a challenged presidency, a life of moral courageUNLV beats UC Riverside 66-53
ATLANTA (AP) — Jimmy Carter, the peanut farmer who tried to restore virtue to the White House after the Watergate scandal and Vietnam War, then rebounded from a landslide defeat to become a global advocate of human rights and democracy, has died. He was 100 years old . The Carter Center said the 39th president died Sunday afternoon, roughly 22 months after entering hospice care , at his home in Plains, Georgia, where he and his wife, Rosalynn, who died in November 2023, lived most of their lives. The center said he died peacefully, surrounded by his family. President Joe Biden mourned Carter’s death, saying the world lost an “extraordinary leader, statesman and humanitarian” and he also lost a dear friend. Biden cited Carter’s work to eradicate disease, forge peace, advance civil and human rights, promote free and fair elections and house the homeless as an example for others. Biden spoke later Sunday evening about Carter, calling it a “sad day” but one that “brings back an incredible amount of good memories." “I’ve been hanging out with Jimmy Carter for over 50 years,” Biden said in his remarks. He recalled the former president being a comfort to him and his wife Jill when their son Beau died in 2015 of cancer. The president remarked how cancer was a common bond between their families, with Carter himself having cancer later in his life. “Jimmy knew the ravages of the disease too well,” said Biden. The president has ordered a state funeral for Carter in Washington. A moderate Democrat, Carter ran for president in 1976 as a little-known Georgia governor with a broad grin, effusive Baptist faith and technocratic plans for efficient government. His promise to never deceive the American people resonated after Richard Nixon’s disgrace and U.S. defeat in southeast Asia. “If I ever lie to you, if I ever make a misleading statement, don’t vote for me. I would not deserve to be your president,” Carter said. Carter’s victory over Republican Gerald Ford, whose fortunes fell after pardoning Nixon, came amid Cold War pressures, turbulent oil markets and social upheaval over race, women’s rights and America’s role in the world. His achievements included brokering Mideast peace by keeping Egyptian President Anwar Sadat and Israeli Prime Minister Menachem Begin at Camp David for 13 days in 1978. But his coalition splintered under double-digit inflation and the 444-day hostage crisis in Iran. His negotiations ultimately brought all the hostages home alive, but in a final insult, Iran didn’t release them until the inauguration of Ronald Reagan, who had trounced him in the 1980 election. Humbled and back home in Georgia, Carter said his faith demanded he keep doing whatever he could, for as long as he could, to try to make a difference. He and Rosalynn co-founded The Carter Center in 1982 and spent the next 40 years traveling the world as peacemakers, human rights advocates and champions of democracy and public health. Awarded the Nobel Peace Prize in 2002, Carter helped ease nuclear tensions in North and South Korea, avert a U.S. invasion of Haiti and negotiate cease-fires in Bosnia and Sudan. By 2022, the center had monitored at least 113 elections around the world. Carter was determined to eradicate guinea worm infections as one of many health initiatives. Swinging hammers into their 90s, the Carters built homes with Habitat for Humanity. The common observation that he was better as an ex-president rankled Carter. His allies were pleased he lived long enough to see biographers and historians revisit his presidency and declare it more impactful than many understood at the time. Propelled in 1976 by voters in Iowa and then across the South, Carter ran a no-frills campaign. Americans were captivated by the earnest engineer, and while an election-year Playboy interview drew snickers when he said he “had looked on many women with lust. I’ve committed adultery in my heart many times,” voters weary of political cynicism found it endearing. The first family set an informal tone in the White House, carrying their own luggage, trying to silence the Marine Band’s traditional “Hail to the Chief" and enrolling daughter Amy in public schools. Carter was lampooned for wearing a cardigan and urging Americans to turn down their thermostats. But Carter set the stage for an economic revival and sharply reduced America's dependence on foreign oil by deregulating the energy industry along with airlines, trains and trucking. He established the departments of Energy and Education, appointed record numbers of women and nonwhites to federal posts, preserved millions of acres of Alaskan wilderness and pardoned most Vietnam draft evaders. Emphasizing human rights , he ended most support for military dictators and took on bribery by multinational corporations by signing the Foreign Corrupt Practices Act. He persuaded the Senate to ratify the Panama Canal treaties and normalized relations with China, an outgrowth of Nixon’s outreach to Beijing. But crippling turns in foreign affairs took their toll. When OPEC hiked crude prices, making drivers line up for gasoline as inflation spiked to 11%, Carter tried to encourage Americans to overcome “a crisis of confidence.” Many voters lost confidence in Carter instead after the infamous address that media dubbed his “malaise" speech, even though he never used that word. After Carter reluctantly agreed to admit the exiled Shah of Iran to the U.S. for medical treatment, the American Embassy in Tehran was overrun in 1979. Negotiations to quickly free the hostages broke down, and then eight Americans died when a top-secret military rescue attempt failed. Carter also had to reverse course on the SALT II nuclear arms treaty after the Soviets invaded Afghanistan in 1979. Though historians would later credit Carter's diplomatic efforts for hastening the end of the Cold war, Republicans labeled his soft power weak. Reagan’s “make America great again” appeals resonated, and he beat Carter in all but six states. Born Oct. 1, 1924, James Earl Carter Jr. married fellow Plains native Rosalynn Smith in 1946, the year he graduated from the Naval Academy. He brought his young family back to Plains after his father died, abandoning his Navy career, and they soon turned their ambitions to politics . Carter reached the state Senate in 1962. After rural white and Black voters elected him governor in 1970, he drew national attention by declaring that “the time for racial discrimination is over.” Carter published more than 30 books and remained influential as his center turned its democracy advocacy onto U.S. politics, monitoring an audit of Georgia’s 2020 presidential election results. After a 2015 cancer diagnosis, Carter said he felt “perfectly at ease with whatever comes.” “I’ve had a wonderful life,” he said. “I’ve had thousands of friends, I’ve had an exciting, adventurous and gratifying existence.” Sanz is a former Associated Press reporter.Will This DealShare Cofounder’s Bold Plan Be A Game-Changer For Youth Sports Training?Insurgents reach gates of Syria’s capital, threatening to upend decades of Assad rule
The Darnold-Jefferson connection is thriving for the surging Vikings
Share Tweet Share Share Email The Google Play Store is filled with endless games of different categories. Gamers visit it to get the game they like. Some gamers like racing games, while others like action and adventure games. Every gamer visits the Google Play Store to get their favorite games, but our article is helpful for those gamers who love the open-world category. Many games in this category are available on the Google Play Store, but which one would be the best game is still the question whose answer will be given in today’s article. Today, we’ll brief you about the 3 Best Open World Games on The Google Play Store. These games are outstanding and top-rated. Many gamers have downloaded, installed, and played these games and have positively reviewed them. Indeed, you’ll give a positive review about these 3 games after playing them. Therefore, let us brief you about them without any further ado. 3 Best Open World Games on The Google Play Store We’ll start our article by revealing the names. Gamers who are reading our article might be curious about knowing the names. Therefore, let us reveal the names. Here are the 3 Best Open World Games on The Google Play Store: Gangstar Vegas: World of Crime Dude Theft Wars Grand City Thug Crime Gamers will dislike the other games in this category after playing these 3 games. These 3 games have eye-catching visuals and fantastic gameplay. The number of downloads the developers have witnessed on these 3 games is incredible. Every gamer has given positive reviews about these 3. Hence, we have recommended these 3 games because they are outstanding. We’ll review these 3 games to help you pick your favorite one. Reading the reviews will help you pick the game of your choice. Therefore, please continue reading the article because you will learn useful things about these 3 games we mentioned here. Gangstar Vegas: World of Crime Many open-world games have been released and played, but gamers who played the Gangstar Vegas: World of Crime game have never gotten bored because of its outstanding features. We have listed this game in the top spot because of its outstanding features and fantastic gameplay. Indeed, the gameplay of the Gangstar Vegas: World of Crime game is outstanding. Gamers who have tried this game have never complained about its gameplay because its developer has added endless features that gamers love. Gameloft Montreal developed this game, and Gameloft released it for Android and iOS. Gameloft Brazil, Gameloft Hanoi, and Gameloft Kharkiv are the 3 other developers who provided additional help to develop this game. The additional help these developers provided proved helpful because Gangstar Vegas: World of Crime game has earned more than 100 Million downloads on the Google Play Store. Gameloft is a well-known publisher on the Google Play Store, but the features gamers witnessed while playing this game are endless and outstanding. Hence, we can say that Gameloft isn’t lucky that it has witnessed over 100 million downloads on this game because the features added to it are outstanding. We’re about to brief you about this game’s gameplay and features, but let us brief you about its downloading process. We have listed the Gangstar Vegas: World of Crime game on the top spot. If you want to download it, visit the website we’re about to recommend. Gangstar Vegas APK 25 is the website you must visit to download the Gangstar Vegas MOD APK game. This trustworthy website provides this game in a 100% working format. Therefore, please visit this website if you have decided to download this game. We have given you your destination. Now, let us brief you about this game’s gameplay. Gangstar Vegas: World of Crime is an open-world game whose gameplay features a very famous city of America, Las Vegas. It was released on 7 June 2013. Las Vegas wasn’t as eye-catching in 2013 as it is now, but the developer has created eye-catching buildings and roads. Gamers who play this game are impressed by the visuals because they are outstanding. You’re given complete freedom to explore Las Vegas and perform different activities. You can roam freely and perform any activity you want. Some gamers are interested in clearing the missions, while others want the freedom to roam freely. It depends on the gamer’s perspective, but Gameloft has given you a game that contains 80 different missions. These missions include combat, theft, robbery, and other activities that gamers love. You’re given heavy weapons to clear these missions. This is what every gamer loves, and Gameloft has given everything you want. You’ll love to play this game after installing it on your Android Phone if playing the open world games is your favorite activity. Dude Theft Wars Dude Theft Wars is another famous open-world game developed by Poxel Studios. This game has also earned over 100 Million downloads on the Google Play Store, but its characters are cartoonish. It is an open-world sandbox game that was released in 2018. It is an outstanding game containing 2 modes, Single Player and Multiplayer. Its gameplay is outstanding, but most gamers get bored after playing the same thing repeatedly. Poxel Studios has given those gamers an option to play this game online. They have added an outstanding multiplayer to this game. In Multiplayer, you compete with your opponents and defeat them to earn rewards. Your name will become famous, and you will earn more rewards after a certain time. This progression system motivates gamers to work hard to compete more. This feature has impressed many gamers, and they want to play the Dude Theft Wars game on their Android Phone. This game is released for Android and iOS. Hence, you don’t have to worry if you have an iOS phone in your hands. You can play this game on your iOS device. We’ve briefed you about this game’s multiplayer, but its single-player mode is also considered best because you perform different activities in it. In open-world games, gamers are given complete freedom to do whatever comes to their minds. You can do whatever you want, but Poxel Studios’ development team has added outstanding missions to this game. You’re given a variety of weapons and big vehicles to drive. You use those quality weapons and drive big cars to complete difficult and different missions. Many missions of different categories are available, but the bank heists and police chase missions are outstanding. I love playing such missions when playing any open-world game. Indeed, you’ll love such missions when playing the Dude Theft Wars game on your Android Phone. Dude Theft Wars is available on the Google Play Store, but gamers who want complete features in this game must visit the Dude Theft APK 72 website to download the Dude Theft Wars MOD APK on their Android Phones. We recommend this website because it delivers complete information, and the download link given to gamers contains complete features. Every gamer wants full features in the beginning. For them, we are recommending this website. This website will be your best helper when downloading this game. Therefore, please visit it if you want to download, install, and play the Dude Theft Wars game on your Android Phone. Grand City Thug Crime Grand City Thug Crime is the last game on our list, and its visuals are eye-catching. We have mentioned this game in the last spot, but that doesn’t mean it lacks features. Grand City Thug Crime is packed with endless features, but gamers love its visuals. No gamer expects such visuals whenever they play any open-world game, but the visuals added inside the Grand City Thug Crime are impressive. Multi-Robot Games developed and published this game, which witnessed over 50 million downloads on the Google Play Store. Witnessing this number isn’t easy. It is only possible when your game delivers things that gamers want. Fortunately, Multi-Robot Games has provided gamers with those things that they love. This developer has given outstanding action and adventure to this game. Grand City Thug Crime is full of action and adventure. I would say again that the visuals of this game are eye-catching and impressive. The way our character is controlled is also easy. Gamers who have never played any open-world game will easily control the character because of simple options. The controls are displayed on your Android Phone’s screen and are easy to follow. You perform various activities, including Fighting, Shooting, Heists and Police Chases. Our player runs a gang and fights with different gangsters. He faces difficulties but defeats his opponents in the end. You’ll love this game’s story after playing it. Therefore, I am leaving this to you. Download this game from the Google Play Store and play it to explore the open-world given by the Multi-Robot Games. These are the 3 Best Open World Games on The Google Play Store. You’ll love to play these games because many gamers have already played them and given positive feedback about them. You won’t install any other game when you have these 3 games installed on your Android Phone. Playing these games after 10 years won’t make you feel bored because you will experience new things each time you run these games on your Android Phone. Therefore, please follow our suggestion and try any of these 3 games on your Android Phone. Hopefully, you’ll love the open-world action and adventure of these 3 games . Conclusion How was our article? I hope you will love our article because we highlighted the 3 Best Open World Games on The Google Play Store. We’ll show up with more games like these in the upcoming days. Therefore, please visit our website to find information about the best games that are available to download from the Google Play Store. Also, drop a comment if you have questions about this topic. We’ll answer your question as doing it is our duty. That’s all for now. Take Care! Related Items: Games , technology Share Tweet Share Share Email Recommended for you The Intersection of Technology and Sustainability in EV Charging Embedded Payments in E-commerce: Driving Smooth Checkout Experiences Why Technology Is Important in Our Life and Its Impact on Modern Society CommentsNoneIn a significant move to address the growing menace of digital financial frauds, the Department of Financial Services (DFS) has directed banks to adopt advanced technologies, including artificial intelligence (AI) and machine learning (ML), to safeguard customers from fraudsters. The decision was taken during a high-level meeting chaired by the Secretary of DFS with representatives from the Reserve Bank of India ( RBI ), public sector banks, private banks, and payment banks. The meeting focused on tackling digital frauds , especially the increasing number of mule accounts used to facilitate illegal transactions. Department of Financial Services in a social media post stated that "Banks were directed to adopt advanced technologies, including AI/ML solutions, for real-time detection of mule accounts, training & upskilling bank staff on fraud detection & prevention, greater advocacy & awareness for common citizen for not to fall prey to the fraudsters" The secretary of Department of Financial Services, emphasized the need for proactive measures to protect citizens' hard-earned money and highlighted the importance of leveraging cutting-edge tools and practices to combat these challenges effectively. Astrology Vastu Shastra Course By - Sachenkumar Rai, Vastu Shashtri View Program Web Development Java 21 Essentials for Beginners: Build Strong Programming Foundations By - Metla Sudha Sekhar, IT Specialist and Developer View Program Entrepreneurship Building Your Winning Startup Team: Key Strategies for Success By - Dr. Anu Khanchandani, Startup Coach with more than 25 years of experience View Program Marketing Future of Marketing & Branding Masterclass By - Dr. David Aaker, Professor Emeritus at the Haas School of Business, UC Berkeley, Author | Speaker | Thought Leader | Branding Consultant View Program Data Analysis Learn Power BI with Microsoft Fabric: Complete Course By - Prince Patni, Software Developer (BI, Data Science) View Program Web Development Advanced C++ Mastery: OOPs and Template Techniques By - Metla Sudha Sekhar, IT Specialist and Developer View Program Artificial Intelligence(AI) Java Programming with ChatGPT: Learn using Generative AI By - Metla Sudha Sekhar, IT Specialist and Developer View Program Web Development Intermediate Java Mastery: Method, Collections, and Beyond By - Metla Sudha Sekhar, IT Specialist and Developer View Program Web Development A Comprehensive ASP.NET Core MVC 6 Project Guide for 2024 By - Metla Sudha Sekhar, IT Specialist and Developer View Program Marketing Digital Marketing Masterclass by Pam Moore By - Pam Moore, Digital Transformation and Social Media Expert View Program Finance A2Z Of Money By - elearnmarkets, Financial Education by StockEdge View Program Leadership Business Storytelling Masterclass By - Ameen Haque, Founder of Storywallahs View Program Artificial Intelligence(AI) AI-Powered Python Mastery with Tabnine: Boost Your Coding Skills By - Metla Sudha Sekhar, IT Specialist and Developer View Program Artificial Intelligence(AI) Tabnine AI Masterclass: Optimize Your Coding Efficiency By - Metla Sudha Sekhar, IT Specialist and Developer View Program Artificial Intelligence(AI) Basics of Generative AI: Unveiling Tomorrow's Innovations By - Metla Sudha Sekhar, IT Specialist and Developer View Program Artificial Intelligence(AI) Mastering C++ Fundamentals with Generative AI: A Hands-On By - Metla Sudha Sekhar, IT Specialist and Developer View Program Web Development C++ Fundamentals for Absolute Beginners By - Metla Sudha Sekhar, IT Specialist and Developer View Program Legal Complete Guide to AI Governance and Compliance By - Prince Patni, Software Developer (BI, Data Science) View Program Office Productivity Advanced Excel Course - Financial Calculations & Excel Made Easy By - Anirudh Saraf, Founder- Saraf A & Associates, Chartered Accountant View Program Finance Financial Literacy i.e Lets Crack the Billionaire Code By - CA Rahul Gupta, CA with 10+ years of experience and Accounting Educator View Program Entrepreneurship Startup Fundraising: Essential Tactics for Securing Capital By - Dr. Anu Khanchandani, Startup Coach with more than 25 years of experience View Program Office Productivity Microsoft Word Mastery: From Beginner to Expert By - CA Raj K Agrawal, Chartered Accountant View Program Finance Crypto & NFT Mastery: From Basics to Advanced By - CA Raj K Agrawal, Chartered Accountant View Program Finance Tally Prime & GST Accounting: Complete Guide By - CA Raj K Agrawal, Chartered Accountant View Program Artificial Intelligence(AI) Master in Python Language Quickly Using the ChatGPT Open AI By - Metla Sudha Sekhar, IT Specialist and Developer View Program Web Development JavaScript Essentials: Unlock AI-Driven Insights with ChatGPT By - Metla Sudha Sekhar, IT Specialist and Developer View Program Web Development Django & PostgreSQL Mastery: Build Professional Web Applications By - Metla Sudha Sekhar, IT Specialist and Developer View Program Notably, they were encouraged to explore MuleHunter.AI , an AI/ML-driven solution developed by the RBI, which offers enhanced capabilities in detecting fraudulent activities and tracking suspicious accounts. Discover the stories of your interest Blockchain 5 Stories Cyber-safety 7 Stories Fintech 9 Stories E-comm 9 Stories ML 8 Stories Edtech 6 Stories In addition to deploying advanced technologies, banks were instructed to prioritize the training and upskilling of their staff in fraud detection and prevention. The secretary also emphasized the importance of spreading awareness among customers about common fraud tactics, urging citizens to stay vigilant and not fall prey to fraudsters. The meeting underscored the importance of inter-bank collaboration and sharing of good practices to ensure a unified approach to curbing digital financial frauds. Banks were encouraged to foster partnerships and exchange ideas to strengthen the overall security framework of the financial system. This directive comes as part of the government's broader commitment to safeguarding the financial ecosystem and ensuring citizens' trust in digital banking channels. By integrating advanced technologies and fostering collective efforts, the banking sector aims to build a robust defense mechanism against evolving financial frauds.