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(Azacitidine + cedazuridine) is under clinical development by Taiho Oncology and currently in Phase III for Refractory Anemia With Excess Blasts. According to GlobalData, Phase III drugs for Refractory Anemia With Excess Blasts have a 67% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. (Azacitidine + cedazuridine) overview ASTX-030, a fixed dose combination of azacitidine and cedazuridine is under development for the treatment of myelodysplastic syndromes (MDS), chronic myelocytic leukemia (CML), refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, chronic myelomonocytic leukemia (CMML), and acute myeloid leukemia (AML). It is administered by oral route. It acts by targeting DNA (cytosine 5) methyltransferase 1 and cytosine deaminase (CDA). The drug candidate is being developed based on Pyramid technology. Taiho Oncology overview Taiho Oncology, a subsidiary of Taiho Pharmaceutical Co Ltd, is a provider of cancer treatments and solutions. The company manufactures and markets cancer anti-metabolites as well as targeted small molecule inhibitors. Its products portfolio includes oral drugs for the treatment of gastric cancer, colorectal cancer and a variety of solid tumours. Taiho Oncology’s pipeline products includes anti metabolic agents and selectively targeted agents. The company’s LONSURF is an anti-cancer drug for the treatment of metastatic colorectal cancer. Taiho Oncology is headquartered in Princeton, New Jersey, the US. For a complete picture of (Azacitidine + cedazuridine)’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .Canada Post strike: Key issues in the dispute that's holding up mail delivery
Showing 1 to 10 of 10 results (window.adq = window.adq || []).push((api) => api.addSlot({"key":"card","index":"1","searchTerm":null,"fullSearchTerm":null})); Playing Nice Drama Summary: Two couples discover that their toddlers were switched at birth in a hospital mix-up. Psychological thriller adapted from the best-selling novel by JP Delaney, starring James Norton, Niamh Algar, James McArdle and Jessica Brown Findlay RT says:: The response any domestic thriller hopes to receive from an audience is: what if this happened to me? And thanks to a concept that’s just about plausible enough to pull at something primal, viewers are sure to be asking themselves just that very question within the first five minutes of Playing Nice. Two couples discover that their toddlers were swapped at birth in a hospital mix-up and the dilemma now is whether they should stick, switch or share. It’s a thorny issue, but one made more problematic by the spikiness of one protagonist. For dad Miles (James McArdle) is already giving off villain-of-the-piece vibes, his surface kindness laced with a hint of menace, the compliments he offers wife Lucy (Jessica Brown Findlay) decidedly double-edged. Pete (James Norton) and Maddie (Niamh Algar), on the other hand, possess both relatability and likeability, and it feels as though our allegiances ought to lie with them. But in this type of drama, seemingly run-of-the-mill people are often pushed to extremes, so might our sympathies shift after episode two airs tomorrow at 9pm? DAVID BROWN How to watch 7/7: The London Bombings 2025 Documentary and factual News and current affairs Summary: Documentary looking at the 2005 attack in which four bombs were detonated on London's transport system and telling the story of the ensuing police investigation and the three-week hunt to catch the bombers RT says:: The Underground and bus bombings of 7 July 2005 killed 52 people and injured hundreds more. It remains the worst terrorist atrocity committed on British soil, and this fourpart documentary tells the tale in often harrowing detail. At times it’s almost too difficult to watch, but it’s a remarkable testimony to the best of human spirit in moments too terrible to contemplate. The first episode concentrates on the response of the authorities, rescue workers and victims to what was happening. It was, if you’ll recall, the morning after London had been awarded the 2012 Olympics and the city was slightly giddy, and, in the case of marketing manager Martine Wright, slightly hungover and late for work. Her life would be irrevocably altered after she ran up a Tube escalator to find a Circle Line train waiting: “I thought, ‘What a result...’ ” JOHN AIZLEWOOD How to watch SAS Rogue Heroes Season 2 2025 Season 2 6 episodes War Drama Summary: The SAS have to reinvent themselves as they spearhead war into civilian-populated Europe. RT says:: Jack O’Connell struts around wonderfully as lead SAS renegade Paddy Mayne. He makes grand gestures, he growls threats, he quotes poetry and he blows things up — all in a day’s work. Mayne’s air of suppressed rage is offset by Gwilym Lee as his suave senior officer. In Lee’s previous drama, The Great, he was also the (relatively) straight guy: he is excellent at playing the sane voice in a crazy situation. We’ve reached September 1943, as the temporarily renamed SRS is fighting its way through Italy, where their exploits unfold against beautiful town squares and rolling countryside (supplied by Croatia). And they generally manage to find a few bottles of looted wine to enjoy. DAVID BUTCHER How to watch Walk the Line Documentary and factual Drama 2005 James Mangold 123 mins 12A Summary: Oscar-winning musical biographical drama starring Joaquin Phoenix and Reese Witherspoon. John R Cash emerges from humble farm beginnings to become country-and-western legend Johnny Cash. But the road to stardom for the "Man in Black" is not without hardship and heartbreak, although salvation appears in his dependable soulmate, June Carter. RT says:: In adapting both of Johnny Cash’s autobiographies in 2005, director/co-screenwriter James Mangold succeeded in crafting a music biopic that feels truthful, despite its moments of cliché. To play Cash and June Carter, Joaquin Phoenix and Reese Witherspoon trained so that they could perform all their own music, and they bounce off each other beautifully throughout. Mangold returns to similar territory with his new film, A Complete Unknown, which stars Timothée Chalamet as Bob Dylan and hits cinemas on 17 January. CALUM BAKER How to watch (window.adq = window.adq || []).push((api) => api.addSlot({"key":"card","index":"2","searchTerm":null,"fullSearchTerm":null})); No Time to Die Action Romance 2020 Cary Fukunaga 157 mins 12 Summary: Spy adventure starring Daniel Craig, Rami Malek and Léa Seydoux. After narrowly surviving an attempt on his life, James Bond believes his lover, Madeleine Swann, has betrayed him. Five years later, he is drawn out of retirement and back into her life when a new global threat - a deadly biological weapon - emerges. But with Bond's nemesis, Blofeld, behind bars, who is the mysterious figure intent on using this terrifying new technology? RT says:: The campaign to find a new Bond began the second Daniel Craig announced his retirement from the role with this 2020 adventure. While it’s fun to debate just who could take over the tux to become the eighth cinematic 007 (everybody from Aaron Taylor-Johnson to Paul Mescal has been mentioned as a contender), let’s take a moment to appreciate Craig’s gritty yet vulnerable portrayal, which began with 2012’s excellent Skyfall and ends spectacularly — not to mention emotionally — here. This time, Bond gives up retirement to track down the creator of a bioweapon that could wipe out life on Earth. JOSH WINNING How to watch The Good Fight 2017 Drama Crime/detective 15 Summary: Spin-off from legal drama The Good Wife. It follows the life of Diane Lockhart, who after losing her life savings must start from scratch at a new law firm. Christine Baranski stars. How to watch Celebrity Hunted 2017 Entertainment Documentary and factual Summary: Pairs of celebs take part in a special version of the reality series. They become fugitives as they go on the run from the 'hunters', a group of former police and intelligence officers. RT says:: Having left Strictly under a cloud earlier in 2024, Giovanni Pernice returns to TV, competing in the reality thriller alongside his 2022 dance partner, Radio 2’s Richie Anderson. They’re the headline act as six pairs of celebrities go on the run across mainland UK, while an elite team of police and military personnel track them down. As the clock starts ticking, the fugitives make a daring escape from a train in rural Norfolk. One bickering pair hide in a barn, while another team are firmly in the hunters’ sights already. Can they evade an early capture? MICHAEL HOGAN How to watch Call the Midwife Season 14 2025 Season 14 8 episodes Drama Summary: Expect miracles. A heartwarming tale of life in London's impoverished East End. Midwives welcome new lives and care for the community in the changing times of the 50s and 60s. RT says:: Events depicted in this series must often leave viewers wondering whether they ever really happened — one prime example here being activists on the Isle of Dogs plunging the community into disarray by blockading access to the island. To save you the time searching online, it transpires that, yes, there was once a ten-day “unilateral declaration of independence”, and its inclusion in tonight’s drama is another reason why Call the Midwife (having now charted London’s social history from 1957 through to this point at the start of the 1970s) ought really to be put in a time capsule of postwar life. Yes, it can, at times, be sentimental, but there’s no denying its rich evocation of times past. DAVID BROWN How to watch Wuthering Heights: The Read with Vinette Robinson 2025 Arts and culture Documentary and factual Summary: Bradford born actor Vinette Robinson performs as the narrator for one of Bronte's most loved novels - Wuthering Heights. Seen through the eyes of housekeeper Nelly Dean, the story takes shape around the intense and destructive love between Heathcliff and Catherine Earnshaw, set against the backdrop of the Yorkshire moors RT says:: BBC4’s classy The Read series (a sort of Bedtime Stories for adults) continues with actor Vinette Robinson’s dramatic reading of Emily Brontë’s timeless classic. Sitting at a kitchen table, hands cradled around a cup of tea, Robinson channels narrator Nelly Dean, the nosey housekeeper whose story of Heathcliff and Catherine Earnshaw is one of literature’s great romances. The effect is intimate, like a friend who has popped around to share the wildest gossip you’ve ever heard. Ditto her ability to switch masterfully from narration to gut-wrenching dialogue. Literature has rarely felt so alive. STEPHEN KELLY How to watch One Hundred Ways of Listening Documentary and factual News and current affairs Summary: Sound anthropologist Tom Rice opens up how ways of listening shape each person's relationship to the world around them, and how a busy world places more demand on our ears. With the pace at which technology is developing, can we even be sure of what it is we're listening to? Recognising the vast scope and extraordinary complexity of listening can sharpen perception, making it easier to thrive in the complex sound world of the 21st century RT says:: As one would expect, the soundscape for a programme with a title like this is extraordinary and it’s definitely worth using headphones for the full effect. From eavesdropping to unconscious bias, via semantic, ecstatic, palimpsestic and even “visual listening”, Dr Tom Rice presents a fascinating guide to the 100 ways in which we (and other animals, plants and even inanimate objects) react, respond to and process the vibrations that create sound waves. He’s been researching this for 20 years. And Rice’s favourite way to listen? In the warm water of a bath where you fall into what is known as a “sound state.” Just don’t take the radio in with you. ANNA JONES How to listenTaylor Swift and Travis Kelce had a post-holiday night out in New York City with Jack Antonoff and Margaret Qualley on Friday night (Dec. 27), based on photos that circulated Saturday. Photographer @josiahwphotos (on Instagram) posted images of Swift and Kelce’s arrival to NoHo restaurant BondST, and their departure after dinner. Additional photos showed Antonoff, Swift’s close friend and longtime producer, and wife Qualley joining the couple. Swift’s dinner look (seen in pictures here ) was led by an oversized wool blazer with padded shoulders by Stella McCartney , a piece with cage paneling along the hem that’s hand-embroidered with lead-free crystals ( Crystal Cage Oversize Blazer , $5,500). The shape of the blazer nods to menswear, while its embellishment, and its styling with tights and heeled boots, gives it a glimmer of femininity. BondST is a hot spot known for its Japanese-inspired cuisine with two locations in NYC, the one in NoHo (where Swift has been seen dining with friends before) and another in Hudson Yards. The superstar wrapped her record-breaking, $2 billion-grossing Eras Tour on Dec. 8 in Vancouver. On Dec. 12, she was named the winner of 10 Billboard Music Awards , including Top Artist. With 49 total wins collected throughout her career, she’s now the most celebrated artist in the history of the BBMAs. “Thank you to the fans, because Billboard is counting your stuff. They’re counting what you listen to, the albums that you’re passionate about,” she shared in a video message that aired during the telecast. “I count these as fan-voted awards because you’re the ones who care about the albums and come see us in concert. Everything that’s happened with the Eras Tour and The Tortured Poets Department , I just have to say thank you. It means the world to me that you guys embraced the things I’ve made, and the fact that you care so much about my music ... This is the nicest early birthday present you could have given me. So, thank you very much. I love it. It’s exactly what I wanted.” Swift, who turned 35 on Dec. 13, made an appearance at the Dec. 21 Chiefs game at Arrowhead Stadium in Kansas City, Mo., to support Kelce. Since wrapping her tour, she’s also been seen visiting patients at Kansas City’s Children’s Mercy Hospital; though she didn’t publicize her visit, patients and their families posted about her generosity online. Swift additionally made a substantial donation to Kansas City children’s non-profit Operation Breakthrough, according to the organization.Preview: Walsall vs. Doncaster Rovers - prediction, team news, lineups
South Africa seals place in World Test Championship final with a tense 2-wicket win against Pakistan
