Expion360 Announces Departure of Chief Financial OfficerBlues supporters also sang the name of head coach Maresca during the closing stages of an emphatic success sealed by goals from Axel Disasi, Christopher Nkunku, Noni Madueke, Cole Palmer and substitute Jadon Sancho. Bottom club Southampton briefly levelled through Joe Aribo but were a man down from the 39th minute after captain Jack Stephens was sent off for pulling the hair of Marc Cucurella. Chelsea, who have endured an underwhelming period since Todd Boehly’s consortium bought the club in 2022, climbed above Arsenal and into second place on goal difference, seven points behind leaders Liverpool. “It was a very good feeling, especially because you can see that they are happy, that is our target,” Maresca said of the atmosphere in the away end. “We work every day to keep them happy and tonight was a very good feeling, especially the one that they can see that Chelsea’s back. This is an important thing.” Maresca rotated his squad in Hampshire, making seven changes following Sunday’s impressive 3-0 win over Aston Villa. Following a sloppy start, his side, who stretched their unbeaten run to six top-flight games, could easily have won by more as they hit the woodwork three times, in addition to squandering a host of chances. “I’m very happy with the five we scored,” said the Italian. “I’m not happy with the first 15, 20 minutes, where we struggled. The reason why we struggled is because we prepared the game to press them man to man and the first 15, 20 minutes we were not pressing them man to man. “After 15, 20 minutes we adjust that and the game was much better. For sure we could score more but five goals they are enough.” Southampton manager Russell Martin rued a costly “moment of madness” from skipper Stephens. The defender’s ridiculous red card was the headline mistake of a catalogue of errors from the beleaguered south-coast club as they slipped seven points from safety following an 11th defeat of a dismal season. “I don’t think anyone will be as disappointed as Jack,” Martin said of Stephens, who was sent off for the second time this term after tugging the curls of Cucurella as Saints prepared to take a corner. “I haven’t got to sit down and talk with him about that at all. He will be hurt more than anyone and it’s changed the game for us tonight, which is disappointing. “I think they have to describe it as violent conduct; it’s not violent really but there’s no other explanation for that really. It’s a moment of madness that’s really cost us and Jack.” Southampton repeatedly invited pressure with their risky attempts to play out from defence, with goalkeeper Joe Lumley gifting Chelsea their second goal, scored by Nkunku. While Saints were booed off at full-time, Martin, who was missing a host of key players due to injuries and suspensions, praised the effort of his depleted team. “When they see such a big scoreline and a couple of the goals we concede, I understand it (the jeers),” he said. “It’s football, it’s emotive, people feel so much about it, it’s why it’s such a special sport in this country and so big. “I understand it but I feel really proud of the players tonight, some of the football we played at 11 v 11 was amazing. “For an hour with 10 men we’ve dug in so deep, there were some big performances. I’m proud of them for that and I’m grateful for that because that’s not easy in that circumstance.”
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Phosphorylation and dephosphorylation enzyme groups regulate sleep and wakefulness in mammals December 3, 2024 Japan Science and Technology Agency A research group has discovered that in mammals, a protein kinase A (PKA) promotes wakefulness, while protein phosphatase 1 (PP1) and calcineurin promote sleep. This study revealed that the balance between sleep and wakefulness is regulated by the action of multiple enzymes, which is an important finding when considering how to control sleep duration and sleepiness at the molecular level. Facebook Twitter Pinterest LinkedIN Email Recent research has observed that chemical modifications called phosphorylation of various proteins *1) in brain neurons dynamically regulates in controlling sleep and wakefulness. On the other hand, it has not been fully elucidated the protein kinases that suppress sleep and the dephosphorylation enzymes that control sleep and wakefulness. Animals, including humans, require a certain amount of sleep daily. When this sleep requirement is not met, humans experience "sleep deprivation." However, the molecular mechanisms involved in sleep regulation remain unclear. A research group, Professor Hiroki Ueda, Doctoral Student Yimeng Wang, Doctoral Student Siyu Cao, and Lecturer Koji Ode et al. at the Graduate School of Medicine of the University of Tokyo, has discovered that protein kinase A (PKA) *2) promotes wakefulness, while protein phosphatase 1 (PP1) and calcineurin *3) , dephosphorylation enzymes, promote sleep in mammals. Focusing on PKA and dephosphorylation enzymes, the research group created comprehensive gene knockout mice and conducted further experiments inducing the expression of functionally modified enzymes using viral vectors *4) . Consequently, they found that PKA activation decreased sleep duration and delta power, and indicator of sleep needs. On the other hand, PP1 and calcineurin activation conversely increased sleep duration and delta power. In these sleep-wake promoting activities, it is essential that PKA, PP1, and calcineurin act at post-synapses responsible for information transmission between neurons. In addition, they demonstrated that PKA and PP1/calcineurin may work competitively to regulate the daily sleep duration. This study has revealed that the balance between sleep and wakefulness is regulated by the action of multiple enzymes, which is an important finding when considering how to control sleep duration and sleepiness on the molecular level. This result was achieved in the Ueda Biological Timing Project, a research area of the Exploratory Research for Advanced Technology (ERATO) by the Japan Science and Technology Agency (JST). Under this project, JST is developing "systems biology for understanding humans" using sleep-wake rhythms as a model system in this project, aiming to understand "biological time" information that runs from molecules to individual humans living in society. (*1) Protein phosphorylation After proteins are produced by transcription and translation, their activity may be adjusted by various chemical modifications. Phosphorylation is the most ubiquitous modification found in cells. Enzymes that catalyze the reaction of transferring phosphate groups to proteins using adenosine triphosphate as a substrate are called protein kinases, and enzymes that catalyze the reaction of removing phosphorylation modifications from phosphoproteins are called protein phosphatases. (*2 ) Protein kinase A (PKA) A protein kinase activated by cyclic adenosine monophosphate, an intracellular signaling molecule. PKA consists of a catalytic subunit responsible for kinase activity and a regulatory subunit that inhibits enzyme activity. (*3 ) Protein phosphatase 1 (PP1) and calcineurin Among the protein phosphatases, PP1, PP2A, and calcineurin are expressed at high levels in the brain. This study revealed that PP1 and calcineurin have sleep-regulating functions. These dephosphorylation enzymes consist of a catalytic subunit responsible for dephosphorylation activity and a regulatory subunit controlling the enzyme's subcellular localization and enzyme activity. Unlike other dephosphorylation enzymes, calcineurin is characterized by its activation by calcium. (*4) Viral vectors A tool for introducing a gene into a cell, taking advantage of the viral ability of cellular infection adeno-associated virus (AAV)-PHP.eB, a type of viral vector modified from AAV, was used in this study. This viral vector allows for highly efficient gene transfer, especially to the central nervous system. Story Source: Materials provided by Japan Science and Technology Agency . Note: Content may be edited for style and length. Journal Reference : Cite This Page :GENEVA (AP) — World Cup sponsor Bank of America teamed with FIFA for a second time Tuesday, signing for the Club World Cup that still has no broadcast deals just over six months before games start. Read this article for free: Already have an account? To continue reading, please subscribe: * GENEVA (AP) — World Cup sponsor Bank of America teamed with FIFA for a second time Tuesday, signing for the Club World Cup that still has no broadcast deals just over six months before games start. Read unlimited articles for free today: Already have an account? GENEVA (AP) — World Cup sponsor Bank of America teamed with FIFA for a second time Tuesday, signing for the Club World Cup that still has no broadcast deals just over six months before games start. Bank of America became FIFA’s first global banking partner in August and sealed a separate deal for a second event also being played in the United States, two days before the group-stage draw in Miami for the revamped 32-team club event. It features recent European champions Real Madrid, Manchester City and Chelsea. “FIFA is going to take America by storm and we’re going to be right at their side,” the bank’s head of marketing, David Tyrie, said in a telephone interview Tuesday. Bank of America joins 2026 World Cup sponsors Hisense and Budweiser brewer AB InBev in separately also backing the club event, and more deals are expected after Saudi Arabia is confirmed next week as the 2034 World Cup host. While games at the next World Cup, co-hosted with Canada and Mexico, will be watched by hundreds of millions globally mostly on free-to-air public networks, the Club World Cup broadcast picture is unclear. FIFA has promised hundreds of millions of dollars in prize money for the 32 clubs to share but is yet to announce any broadcast deals for the month-long tournament. It is expected to land on a streaming service. “You have to think about how you are going to connect with these fans,” Tyrie told the Associated Press from Boston. “TV is one, sure, social media is a big avenue. “The smart marketing capabilities are able to say ‘Hey, we need to tilt this one a little bit more away from TV-type marketing into social-type marketing.’ We have got a pretty decent strategy that we’re putting in place to do activation.” Engaging Bank of America’s customers and 250,000 employees are key to that strategy, Tyrie said. “It’s going to be for our clients, and entertainment, it’s going to be for our employees in creating excitement. All of the above.” The Club World Cup will be played in 12 stadiums across 11 cities, including Bank of America Stadium in Charlotte, N.C, and Lumen Field where the hometown Seattle Sounders play three group-stage games. European powers Madrid, Man City and Bayern Munich lead a 12-strong European challenge. Teams qualified by winning continental titles or posting consistently good results across four years of those competitions. The exception is Lionel Messi’s Inter Miami, who FIFA gave the entry reserved for a host nation team in October based on regular season record without waiting for the MLS Cup final. LA Galaxy hosts New York Red Bulls playing for that national title Saturday. Winnipeg Jets Game Days On Winnipeg Jets game days, hockey writers Mike McIntyre and Ken Wiebe send news, notes and quotes from the morning skate, as well as injury updates and lineup decisions. Arrives a few hours prior to puck drop. Messi’s team opens the FIFA tournament June 15 in the Miami Dolphins’ Hard Rock Stadium and will play its three group games in Florida. “The more brand players you bring in, the bigger the following you have got,” Tyrie acknowledged, though adding Messi being involved was “not a make or break for the event.” The Club World Cup final is July 13 at Met Life Stadium near New York, which also will host the World Cup final one year later. ___ AP soccer: https://apnews.com/hub/soccer Advertisement Advertisement
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NoneStanley Black & Decker Inc. stock underperforms Wednesday when compared to competitorsNoneSupermicro, a leading technology company renowned for its high-performance server and storage solutions, has recently captivated the gaming industry’s attention with its burgeoning foray into AI-driven technologies. This pivot signifies a promising yet complex direction for the company, warranting a closer look at its stock performance and future prospects within the gaming sector. AI and Gaming: A Lucrative Convergence The application of artificial intelligence in gaming is reshaping the landscape, offering more immersive and intelligent gaming experiences. Supermicro’s strategic investments in AI capabilities aim to cater to this growing demand. The integration of AI with gaming holds the potential to substantially boost Supermicro’s stock value, as investors are keen on technologies that fuel enhanced gaming performance and user engagement. Current Stock Analysis With the announcement of AI-focused enhancements, Supermicro’s stock has experienced fluctuations, sparking debates among analysts. The stock’s short-term volatility might deter risk-averse investors, but long-term prospects remain promising due to AI’s increasing prominence in gaming. The company’s commitment to innovation could lead to significant profitability, positioning it as a major player in the gaming hardware domain. The Road Ahead Supermicro’s vision of intertwining AI with gaming hardware could usher in a new era of competitive gaming. While challenges exist, such as technology adoption rates and market competition, the company’s robust R&D efforts help mitigate potential setbacks. Investors and gaming enthusiasts alike have much to anticipate as Supermicro navigates this promising yet challenging venture. In summary, Supermicro’s advancements in AI technology offer exciting prospects for the gaming industry, with the potential to dramatically influence both the company’s stock trajectory and the broader gaming ecosystem. How Supermicro’s AI Innovations Could Revolutionize Gaming and Influence Market Trends Exploring AI’s Role in Transforming Gaming Experiences Supermicro’s expansion into AI-driven technologies represents a strategic move to capture the burgeoning demand for more advanced gaming experiences. By leveraging AI, Supermicro aims to create more adaptive, intelligent gaming hardware capable of enhancing performance and user engagement. This development could revolutionize gaming, making it more immersive and tailored to individual player preferences, thus attracting wider audiences and enhancing the gaming industry’s appeal globally. Insights into Supermicro’s Market Position and Competitive Edge As Supermicro delves deeper into AI, its innovation sets the stage for significant industry shifts. By aligning its offerings with AI capabilities, Supermicro gains a competitive edge over traditional gaming hardware companies. This alignment not only attempts to secure its position within the technology sector but also drives new trends focusing on smart gaming solutions. The gaming community stands at the forefront of technological evolution, making it ripe for AI integration—a factor Supermicro seems poised to capitalize on. AI-Driven Features that Enhance Gaming Hardware Supermicro’s focus on AI entails a multitude of potential features poised to redefine gaming hardware. These features may include real-time performance optimization, advanced analytics for improved gameplay insights, and adaptive graphics rendering for richer visuals. Additionally, AI could enhance security protocols within gaming systems, ensuring safer online gameplay environments. These developments are expected to resonate well with both casual and professional gamers, offering varied use cases from recreational gaming to competitive esports environments. Challenges and Innovations in AI Gaming Sector Despite the promising outlook, Supermicro faces several challenges, such as bridging the gap between AI advancements and consumer accessibility. Innovating at scale while maintaining affordability and user-friendliness remains a critical hurdle. However, Supermicro’s commitment to extensive R&D could pave the way for overcoming these obstacles, allowing the company to deliver high-performance yet cost-efficient products. In conclusion, Supermicro’s push into AI not only places the company at the forefront of gaming technology but also sets a new precedent for how AI can enhance user experience in this domain. For investors and gaming enthusiasts alike, the company’s journey presents a fascinating opportunity to witness the evolution of gaming through the lens of cutting-edge technology. For more information about Supermicro’s advancements, visit Supermicro .
