( MENAFN - GetNews) International Process Solutions (IPS), a trusted leader in calibration and compliance services, is proud to announce the expansion of its offerings with Lab Installation Services now available across Southern and Northern California. This strategic move aims to meet the growing demand for high-quality laboratory setup solutions for businesses and research facilities in California's bustling biotech, pharmaceutical, and industrial sectors. With more than two decades of expertise in calibration, validation, and compliance, IPS has built a reputation for precision, efficiency, and reliability. The introduction of lab installation services demonstrates the company's commitment to providing end-to-end solutions for its clients, enabling laboratories to operate at optimal performance from the moment they are established. Meeting a Critical Industry Need Modern laboratories demand precision and attention to detail, from the placement of specialized equipment to the configuration of utilities and compliance with stringent regulatory standards. International Process Solutions' Lab Installation Services aim to address these challenges by offering comprehensive support for: 1. Equipment Installation: Placement and setup of essential lab tools, ensuring precision and adherence to industry standards. 2. Utility Integration: Connection and optimization of utilities such as gas lines, electrical systems, and HVAC to meet the specific needs of laboratory operations. 3. Regulatory Compliance: Ensuring installations meet ISO and GMP standards, as well as local and federal safety guidelines. 4. Customized Solutions: Tailored installations designed to meet the unique requirements of biotech, pharmaceutical, and research facilities. Expertise You Can Trust “We understand the critical role a well-installed laboratory plays in advancing science, innovation, and business operations,” said IPS spokesperson.“By launching our Lab Installation Services, we're empowering our clients with the tools and infrastructure they need to achieve precision and reliability from day one.” IPS's team of certified professionals leverages their deep knowledge of calibration and compliance to deliver turnkey solutions for new and expanding laboratories. From initial planning and design to final installation and certification, IPS ensures a seamless and stress-free experience. Serving California's Leading Innovation Hubs The launch of Lab Installation Services is tailored to meet the needs of California's diverse industries, including biotechnology hubs in the Bay Area and rapidly growing pharmaceutical sectors in Los Angeles, Orange County, and San Diego. The company's dual presence in Northern and Southern California ensures timely and responsive service for businesses statewide. IPS's long-standing relationships with local and global clients further position the company as a trusted partner in advancing science and innovation. Whether it's a startup building its first lab or an established company expanding its research capabilities, IPS provides a comprehensive solution to meet their needs. Commitment to Sustainability In addition to offering cutting-edge services, International Process Solutions is committed to sustainability. The company integrates energy-efficient technologies and environmentally friendly practices in its installations, helping laboratories reduce their carbon footprint while maintaining peak efficiency. About International Process Solutions Based in San Carlos, California, International Process Solutions specializes in calibration, validation, and compliance services for biotech, pharmaceutical, and industrial sectors. As an ISO-certified company, IPS delivers exceptional quality and expertise, helping clients meet the highest standards of accuracy and reliability. The addition of Lab Installation Services further reinforces IPS's position as a one-stop solution provider for laboratory needs. MENAFN18122024003238003268ID1109009571 Legal Disclaimer: MENAFN provides the information “as is” without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the provider above.France faces political turmoil as confidence vote topples PM Barnier's govt
Wayne Gretzky's wife backs Trump's endorsement of hubby to replace Trudeau as PMThe Securities and Exchange Commission of Pakistan (SECP) has announced that despite extensive advocacy and engagement, the annual accounts of listed companies revealed very limited adherence to the gender pay gap disclosure requirements. SECP through Circular 10 of 2024 in April this year directed the board of directors of listed companies to disclose gender pay gap data in their annual reports and on their websites with effect from June 30, 2024. The directive was issued in compliance with Prime Minister’s Women Empowerment Package (PM-WEP) 2024, said a press release issued here on Monday. Furthermore, the SECP advocated compliance through social media and by disseminating notices to listed companies for compliance through Pakistan Stock Exchange vide notice PSX/N-1140 dated November 26, 2024. In order to facilitate compliance with the disclosure requirement, a suggested format and calculation method was provided along with the Circular. Additionally, an advocacy session was organized in collaboration with the Federation of Pakistan Chambers of Commerce and Industry (FPCCI) to further emphasize the importance of gender pay gap disclosure and to promote gender inclusive practices among businesses. The SECP is once again urging all listed companies to fully comply with the requirement to include gender pay gap data in their annual reports and on their websites. Failure to comply with the Circular may lead to enforcement actions against non-compliant companies. The SECP is committed to promoting transparency, gender equality and facilitating PM WEP 2024 to foster a more gender inclusive business environment in Pakistan.
Computational biologists from the National University of Singapore (NUS) have uncovered how RNA splicing—a crucial process for isoform expression and protein diversity—is regulated across different cell types in the peripheral blood. This important discovery helps explain how individuals' genetic differences contribute to their predisposition to complex diseases such as systemic lupus erythematosus (SLE) and Graves' disease (GD). This project was conducted as part of the Asian Immune Diversity Atlas (AIDA) consortium, which uses population-scale single-cell gene expression profiling of over one million immune cells (PBMCs) from over 600 Asian donors in five countries to understand how genes and environment make us different from each other and influence our health. The study was a research collaboration with A*STAR Genome Institute of Singapore (GIS), Samsung Genome Institute, RIKEN Center for Integrative Medical Sciences, and Nanyang Technological University. This study was published as a cover article in the journal Nature Genetics on 3 December 2024. Alternative splicing (AS) is a fundamental regulatory mechanism in messenger RNA (mRNA) processing, and abnormal splicing is a major cause of genetic disorders. To understand the genetic regulation of splicing, previous efforts such as the Genotype-Tissue Expression (GTEx) project have primarily focused on tissue-level measurements, and these efforts have shown that different tissues have distinct patterns of splicing regulation. However, this raised an intriguing question: does disease-relevant genetic regulation of splicing occur only in one or a few cell types? To answer this research question, the main bottleneck is the lack of a large population-scale cell-type-resolved dataset suitable for splicing analysis and corresponding analytical pipelines. Furthermore, Asian populations have been notably underrepresented in large-scale genetic studies. For instance, Asians account for only 1.3% of the GTEx dataset, while individuals of European descent make up 84.6%. A recent study showed that ancestry could be a main factor that affects the findings of genetic regulation, mostly due to differences in allele frequencies. This highlights an urgent need for genetic studies that better represent diverse ancestries. To address these research gaps, a research team led by Assistant Professor Liu Boxiang, with lead authors Tian Chi, Zhang Yuntian, and Tong Yihan, from the Department of Pharmacy and Pharmaceutical Sciences at the NUS Faculty of Science utilized the AIDA single-cell RNA-seq dataset to analyze cell-type-specific splicing. This work represents the first comprehensive analysis of splicing regulation in a population-scale and genetics-coupled single-cell dataset. Asst Prof Liu holds a joint appointment with the Department of Biomedical Informatics and Precision Medicine Translational Research Programme at the NUS Yong Loo Lin School of Medicine and is an Adjunct Principal Scientist at GIS. The Asian Immune Diversity Atlas (AIDA) single-cell RNA-seq dataset The AIDA Data Freeze v.1 includes up to 21 immune cell subtypes for context-dependent alternative splicing and splicing quantitative trait loci (sQTL) analysis. The blood samples in this dataset were collected from a cohort of 503 healthy donors of diverse Asian ancestries, spanning East, Southeast, and South Asian populations. This diversity allows the observation of Asian-specific genetic regulation of splicing. For example, an sQTL of the TCHP gene has been identified to possibly influence the risk of Graves' disease in East Asian populations. Owing to the high average sequencing depth and the "exon painting" effect (incomplete reverse transcription along with stochastic mRNA cleavage and recapping that creates multiple 5' ends) captured by 5' library preparation, the AIDA scRNA-seq data preserved a substantial portion of mRNA sequences, making it particularly well-suited for splicing analysis. Cell-type-specificity in splicing regulation This study uncovered widespread context-dependent splicing events that were often specific to a particular cell type. Notably, an ancestry-biased mRNA isoform of SPSB2, likely driven by cross-population allele frequency differences in rs11064437, was found to be unannotated in canonical gene annotation. This highlighted the lack of ancestral diversity in a widely used annotation database. Not only is splicing cell-type-specific, but its genetic regulation is also cell-type-specific. Terminologically, an sQTL is a genetic variant that influences the splicing of RNA transcript. This study revealed 11,577 independent cis-sQTLs and 607 trans-sQTLs across 19 PBMC subtypes, and many of these were cell-type-specific and disease-associated. Implication in diseases and experimental validation These findings provided a unique resource for identifying genetic variants and molecular mechanisms underlying complex traits and diseases. The researchers demonstrated that diseases could be linked to splicing by showing the significant contributions of cis-sQTL effects to autoimmune and inflammatory disease. They also identified 563 putative risk genes. For example, an Asian-specific sQTL was found to disrupt the 5' splice site of TCHP exon four to putatively modulate the risk of Graves' disease in East Asian populations. The sQTL effect has been validated using a minigene experiment in K562 cells. Asst Prof Liu said, "Our study established a roadmap for population-scale single-cell splicing regulation analysis and provided insights into the development of splice-modifying therapeutics." This cell-type-specific sQTL map is a milestone in human genetics and drug target discovery for complex diseases related to splicing. Meanwhile, the examples provided in the analysis strongly suggest the importance of ancestral diversity in human genetics research. To take the research further, the team plans to leverage single-cell technology to investigate more tissues such as muscle and adipose. The ongoing research holds great promise in revealing more detailed molecular mechanisms in complex diseases at single-cell resolution. More information: Chi Tian et al, Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases, Nature Genetics (2024). DOI: 10.1038/s41588-024-02019-8
NEW DELHI: In July 2008, then Prime Minister Manmohan Singh rose in Parliament to defend his embattled government in the face of a no-confidence motion. “Whatever I have done in this high office, I have done so with a clear conscience and the best interests of my country and our people at heart,” he said. The motion fell, and Singh completed two full terms in office. Sixteen years later, political and ideological boundaries collapsed as leaders united in tribute to Singh. Allies, opponents, world leaders, intellectuals, sportspersons and millions of common Indians paid homage to the two-time prime minister and former finance minister on Friday, hailing him as a “visionary” and an “outstanding statesman”. Flags flew at half-mast across the national capital on a gloomy, overcast day and scores poured into Singh’s 3, Motilal Nehru Road residence, where his body was kept in state. His wife Gursharan Kaur and other family members stood by his body, which was draped in the Tricolour, as people of all hues, including President Droupadi Murmu, Prime Minister Narendra Modi, former Congress chief Sonia Gandhi, party chief Mallikarjun Kharge and Leader of Opposition in the Lok Sabha Rahul Gandhi paid their last respects. Sonia Gandhi, who heads the Congress Parliamentary Party, called him her “friend, philosopher and guide”. “A luminous and beloved guiding light for the Congress party, his compassion and vision transformed and empowered the lives of millions of Indians,” she said. Several, including Andhra Pradesh chief minister Chandrababu Naidu, left notes in a condolence book in the drawing room of his house, where he spent the final decade of his life after moving out of the official prime minister’s residence in 2014. Tributes also poured in from across the globe, as former presidents, prime ministers and diplomats recollected their interactions with the soft-spoken economist, who died aged 92 of age-related ailments. Social media was awash with images of Singh in his unmistakable powder-blue turban as people celebrated his transformative effect on the Indian economy after he broke the shackles of the Licence Raj as finance minister in 1991 and lay down social security measures for India’s poorest classes as prime minister between 2004 and 2014. Singh’s body will be taken from his residence to the Congress’s Akbar Road headquarters at 8am on Saturday, where the public will be allowed to pay their condolences. At 9.30am, a funeral procession will proceed to Nigambodh Ghat. There, he will be laid to rest with full State honours at 11.45am. The Union cabinet led by Prime Minister Narendra Modi met at 11am and paid tributes to “an eminent statesman, renowned economist and a distinguished leader” who “left his imprint on our national life.” The Centre had on Thursday declared a week of national mourning. Separately, in a video eulogy, Modi remembered Singh as a remarkable human being whose journey from Partition-era displacement to India’s highest office embodied the nation’s resilient spirit. “His humility, gentleness, and intellectualism became the hallmark of his parliamentary life. I remember that earlier this year when his term in the Rajya Sabha came to an end, I said that his dedication as a parliamentarian was an inspiration to all. Despite his age, he would attend important sessions in a wheelchair and fulfil his parliamentary duties,” Modi said. He later laid a wreath at Singh’s residence and offered condolences to his wife, Kaur. Union ministers Amit Shah, Nirmala Sitharaman, Rajnath Singh and Hardeep Puri also visited the residence, as did BJP chief JP Nadda. Chief ministers MK Stalin (Tamil Nadu), Sukhwinder Singh Sukhu (Himachal Pradesh) and Revanth Reddy (Telangana) also reached Delhi to pay their respects. Vice-president Jagdeep Dhankhar met Singh’s family and “acknowledged his enduring legacy”, his office said in a statement, while former president Ram Nath Kovind called Singh “a modern reformer for the Indian economy”. A raft of foreign leaders and statesmen articulated their memories of the Cambridge- and Oxford-educated technocrat and underscored the efforts Singh made to establish India as a force on the global stage. Singh was “a remarkable man” who made a “major personal contribution to strengthening friendly ties” between the two countries, Russian President Vladimir Putin said in a statement. “As Prime Minister and when serving in other high-ranking positions, he accomplished a lot in promoting India’s economic development and asserting its interests on the world stage. He also made a major personal contribution to strengthening friendly ties between our two countries by elevating them to the level of a special privileged strategic partnership... I had the occasion of talking with this remarkable man several times. We will cherish the memory of him,” he said. French President Emmanuel Macron said “India has lost a great man” and France a true friend. “He had devoted his life to his country. Our thoughts are with his family and the people of India,” Macron said on X. Malaysian Prime Minister Anwar Ibrahim offered a moving tribute to his former Indian counterpart, calling him, “my mitra (friend), my bhai (brother)”. “During the years of my incarceration, he extended a kindness that he didn’t have to — one that was neither politically expedient nor, as one can imagine, appreciated by the Malaysian government at that time... He offered scholarships for my children, particularly my son, Ihsan. Although I had declined the gracious offer, such a gesture undoubtedly showed his extraordinary humanity and generosity,” said Ibrahim, who was imprisoned between 1999 and 2004, and then from 2015 to 2018. United States secretary of state Antony Blinken called Singh “one of the greatest champions of the bilateral strategic partnership”. “Dr Singh was one of the greatest champions of the US-India strategic partnership, and his work laid the foundation for much of what our countries have accomplished together in the past two decades,” he said. Sri Lankan President Anura Kumara Dissanayake called him “a visionary leader”. Tributes also arrived from the leaders of Afghanistan, Maldives, Mauritius, and Nepal, underscoring the indelible footprint that Singh’s legacy left on southeast Asia in particular. Former Canadian prime minister Stephen Harper said he was saddened to learn of the passing. “He was an individual of exceptional intelligence, integrity, and wisdom. Laureen and I wish to convey our condolences to all his family and friends,” Harper said. Several business leaders hailed Singh’s legacy that snapped government control of business and allowed private enterprises to flourish. Aditya Birla Group Chairman Kumar Mangalam Birla said the nation lost one of its tallest leaders and finest economists. “His most defining contribution — the epochal 91 reforms spurred a multi-decadal economic boom and more importantly reshaped the calculus of possibilities for India and Indians,” Birla said in a statement. Indian industry, economy, and entrepreneurs in particular, owe a debt of gratitude to the liberalisation reforms that were ushered in the early 90s under Manmohan Singh’s leadership, Bharti Enterprises Founder and Chairman Sunil Mittal said. Economists across the world also paid their respects to a luminary in their field, who was also deputy chief of the erstwhile Planning Commission and governor of the Reserve Bank of India (RBI). Former World Bank chief economist Kaushik Basu said Singh’s modesty came from “a deep sense of courage and self-confidence.” “He was a combination of sharp intellect, innate modesty and personal integrity, which is rare in politics,” the former chief economic advisor to the Indian government told news agency PTI. Gita Gopinath, first deputy managing director of the International Monetary Fund (IMF), credited Singh with “significantly enhancing the economic prospects for hundreds of millions of Indians”. “His visionary reforms inspired countless young economists like me. Rest in peace, Dr Manmohan Singh,” she said. Cricket legend Sachin Tendulkar led the sporting world in paying homage. “Dr Manmohan Singh ji’s demise is a profound loss for India. His contributions to our nation shall always be remembered. My prayers are with his family and loved ones as we mourn his passing away,” he said on X.Romanian president tasks incumbent PM with forming new government
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