baccarat app Cal staves off Sacramento State for third straight winSAN DIEGO (AP) — Syracuse coach Fran Brown and Washington State acting coach Pete Kaligis shared a heartfelt hug after their Holiday Bowl news conference on Thursday. Kaligis can certainly use all the support he can get, especially an embrace and some encouraging words from the opposing coach. No. 22 Syracuse (9-3, No. 21 CFP), led by national passing leader Kyle McCord, is a 17-point favorite according to BetMGM in Friday night's Holiday Bowl against the depleted Cougars (8-4), whose season has nosedived since mid-November. After beating future Pac-12 opponent San Diego State 29-26 on Oct. 26 at Snapdragon Stadium, coach Jake Dickert, quarterback John Mateer and the rest of the Cougars were 7-1 and about to jump into The Associated Press Top 25. Now the Cougars are barely recognizable as they return to Snapdragon. Dickert was hired away by Wake Forest, Mateer transferred to Oklahoma and running back Wayshawn Parker left for Utah. Numerous coaches, including the offensive and defensive coordinators, are gone, and more than 20 players have entered the transfer portal. The Cougars, who lost their last three games, are a prime example of how college football's rapidly changing landscape can dramatically affect a program. “Going into the ins-and-outs of the game tomorrow doesn’t matter,” Kaligis said. “We are who we are, we have what we have. I know that’s for both of us.” Kaligis said players who entered the portal after Dickert left can suit up Friday night. “I know we came here with 98 guys. That's who we’re going to show up on the field with.” Kaligis said relationships between players and coaches are more important than ever, even if there's less time to develop trust “and coach them the right way.” “When a staff (member) leaves and guys get in the portal, it’s because of the relationships they have garnered with their position coaches. When that position coach isn’t guaranteed he’s going to be there, that’s who that young man trusts,” Kaligis said. “I’ve been doing this for a long time," he added. "What’s been hard for me, I spent 13 years at Wyoming, I saw three graduating classes. I remember I was the longest-tenured coach there. To see them all the way through. When I came to Wazzu, I was their fourth D-line coach." The Cougs improved to 8-1 by beating Utah State 49-28 on Nov. 9 but then lost three straight, including to Oregon State in the de facto championship game between the two teams left in the Pac-12. They also lost to New Mexico and Wyoming, two of the Mountain West teams that weren't invited to join the reconstituted Pac-12 starting in 2026. McCord, who transferred from Ohio State, rewrote the Orange's record book this season with 4,326 yards passing, 29 touchdowns and 367 completions. He's well within range of breaking Deshaun Watson's ACC single-season record of 4,593, which he set in 15 games in 2016. A win will give Syracuse 10 wins for the first time since 2018 and just the third time since 2000. Brown can become the second Syracuse coach since World War II to record 10 wins in his first season, joining Paul Pasqualoni, who did it in 1991. In their final regular-season game, the Orange rallied from a 21-0 deficit for a 42-38 win against then-No. 6 Miami that knocked the Hurricanes out of ACC title contention and ended their College Football Playoff hopes. McCord threw for 380 yards and three touchdowns. “We want to go out and have a good game,” Brown said. “We have an opportunity of winning 10 games, which means you’re starting to become a successful program, right? Our players haven’t had a chance of winning a bowl game. So there’s a lot of things that are on the line for us to really be able to build our program and being able to move forward.” This will be the teams' second meeting. Syracuse beat Washington State 52-25 in 1979. Get poll alerts and updates on the AP Top 25 throughout the season. Sign up . AP college football: and

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No. 22 Syracuse looking for 10 wins in 1st year under Fran Brown against depleted Washington StateBack in its second-quarter earnings report in August, Target ( TGT 2.81% ) gave investors hope that it was finally turning the corner. Since the pandemic began to wind down, the retailer has struggled with inflation, weak consumer discretionary spending , and an increase in theft. However, Target's shares plunged on Wednesday after its latest update indicated that the recovery trend didn't last, and the company is still struggling on both sides of the income statement. Comparable sales rose 0.3% in the quarter as traffic was up 2.4%, but its average transaction fell. The company's sales shifted to the digital channel, with digital comps up 10.8%, but in-store comparable sales fell 1.9%. Overall revenue rose 1.1% to $25.7 billion, which missed the consensus of $25.9 billion. The retailer continued to face margin pressure as gross margin fell from 27.4% to 27.2%, due to higher inventory levels and increased fulfillment and supply chain costs. Management stocked up on and rerouted inventory ahead of the October port strike, which should be a one-time headwind. Higher wages and benefits led to an increase in selling, general, and administrative expenses from 20.9% to 21.4%; as a result, operating margin fell from 5.2% to 4.6%. That led to a decline in earnings per share (EPS) from $2.10 to $1.85, which badly missed estimates of $2.30. Target also offered disappointing guidance for the key holiday quarter: It sees flat comparable sales growth and earnings per share of $1.85 to $2.45, which was well below the consensus of $2.64. It also cut its full-year EPS guidance from $9.00-$9.70 to $8.30-$8.90. What's ailing Target The company trotted out familiar excuses. Management said that "We encountered some unique challenges and cost pressures that impacted our bottom-line performance"; on the earnings call, it said that consumers are continuing to be selective about spending, and patiently waiting for deals. However, Target's struggles came as rival Walmart continued to dominate. Walmart captured comparable-sales growth of 5% in its third quarter at U.S. stores, driven by its core grocery business. It trimmed inventory in the third quarter and was able to increase gross margin, driving overall profitability. Walmart also reported mid-single-digit deflation in its general merchandise category, showing that it's lowering prices across its product range. And it called out market-share gains across all income cohorts, a sign that it's taking market share from Target, among other retailers. Target did have some bright spots, including 6% comparable-sales growth in beauty, and double-digit growth in Drive Up and same-day delivery. But overall, inventory challenges, consumer sluggishness, and competitive weakness continued to weigh on the business. Can Target bounce back? While Target stock deserves to be down sharply on the news and had fallen 21% as of early Wednesday afternoon, there are some reasons it could bounce back sooner than you think. Target has a lot of operating leverage in its business model, and a modest improvement in gross margin can lead to a surge in operating profits. First, better inventory management might have enabled the company to expand gross margin to 29%, an improvement of 180 basis points. Those gains would flow directly down to operating margin, which was just 4.6%. If its operating margin was instead 6.4% -- 180 basis points higher, and within Target's historical guidance for an operating margin of at least 6% -- operating income would have jumped 39%, a huge difference. Getting there isn't as hard as it looks, especially as management expects categories that have been under pressure, like home, to eventually recover. Second, shares are cheap compared to those of peers like Walmart: Target now trades at a price-to-earnings (P/E) ratio of 14 based on this year's EPS estimates. Of course, the company needs to make some fundamental improvements before investors can capitalize on the discounted valuation, but the opportunity is there. After the third-quarter update, however, a recovery in the stock looks even further away.

No. 5 UCLA snaps No. 1 South Carolina's 43-game win streakFrom pagans to pansexuals... how civil servants are being encouraged to mark an array of 'woke weeks' at work By MARTIN BECKFORD Published: 23:03, 26 December 2024 | Updated: 23:09, 26 December 2024 e-mail View comments Civil servants are being encouraged to mark a baffling array of ‘ woke weeks’ at work. Diversity and inclusion calendars produced by Whitehall departments and quangos include the dates of everything from Pansexual Visibility Day and Stress Awareness Month to the pagan festivals of Samhain and Yule. NHS England’s calendar marks more than 350 awareness events including gender-fluid visibility week and transgender parent day. Staff support groups often hold talks or put up displays in offices to coincide with the dates although the Government insists that employees do not have to commemorate them. Earlier this year the Mail told how the Foreign Office was flying the flag for bisexuality awareness week outside its grand headquarters. Last night Elliot Keck, head of campaigns at the TaxPayers’ Alliance, said: ‘The extent to which the diversity demagogues have taken over Whitehall is truly alarming. ‘While there are key religious and national dates that the public sector should be aware of, the focus of internal calendars should be on driving home deadlines for delivering improvements to public services. ‘Ministers should remind civil servants that their duty is to the public as a whole.’ Obscure: Pagan festivals, such as last week’s Winter Solstice at Stonehenge, are marked in internal calendars Diversity and inclusion calendars produced by Whitehall departments and quangos include the dates of everything from Pansexual Visibility Day and Stress Awareness Month to the pagan festivals of Samhain and Yule Caroline Ffiske from Conservatives for Women said: 'Whoever put Pansexual Visibility Day in this calendar should be invited to write up the history of this day and would be shown to struggle to cover half of the back of a small envelope' And Caroline Ffiske from Conservatives for Women said: ‘It’s offensive, and illustrates a lack of judgement and courage from the organisers, to see recently made-up woke nonsense treated with the same degree of seriousness as important days for Christians and those of other faiths. ‘Whoever put Pansexual Visibility Day in this calendar should be invited to write up the history of this day and would be shown to struggle to cover half of the back of a small envelope.’ The Forestry Commission, which manages publicly owned woodland, said in a recent equality report: ‘A Diversity and Inclusion calendar has been published for 2024, which has helped to inform our communications plan for internal and external engagement. It also raises awareness of key dates affecting our stakeholders and wider society.’ Details of the calendar obtained by the Mail reveal that it includes Latinx Heritage Month, a gender-neutral term for people of South American background which is mainly used in the USA, and the birthday of Rastafarian divinity Haile Selassie. So crowded is the Forestry Commission’s calendar that Men’s Health Awareness Month, Islamophobia Awareness Month and Disability History Month are all included in November while June is Pride Month as well as Gypsy, Roma and Travellers History Month. A Forestry Commission spokesman said: ‘The dates are not automatically added to staff calendars – they are available to access as an e-resource as part of our commitment to fostering an inclusive culture in our workplaces and understanding the people we serve.’ The Ministry of Justice meanwhile issues a list of ‘core awareness’ dates containing events not included by the Forestry Commission. April is Stress Awareness Month as well as containing Intergenerational Week, but National Stress Awareness Day is in November along with Inter Faith Week. In the shadow of the stones a group of revellers go through ultra stretches and bends during the Winter Solstice celebrations Carers Week takes place in June as does Social Mobility Awareness Day. The Ministry of Justice said: ‘Religious holidays and other notable occasions, like Holocaust Memorial Day, Carers Week and Black History Month are widely marked and these events are recognised across government. ‘Recognising them helps tackle discrimination and supports our drive to build a workforce that reflects the diverse communities we serve across England and Wales.’ The Crown Commercial Service, a procurement quango within the Cabinet Office, lists hundreds of events in its inclusion and diversity calendars. They range from World Braille Day and International Mother Language Day to Pansexual Visibility Day. As well as major religious holidays such as Easter and Ramadan, it includes the Declaration of Bab celebrated by the Baha’i faith and even the Beltane and Yule festivals sacred to pagans. Christmas Day is not mentioned in the diversity calendar but the Government insisted this is because it is already included in the main calendars seen by all staff on their computer systems. A Cabinet Office spokesman said: ‘As you would expect, Christmas and other public holidays are all rightly marked in teams’ calendars by default. ‘These optional, shared calendars provide additional dates for awareness only. Inclusion in the calendar does not mean they are officially marked by CCS.’ All three public bodies highlight the National Day for Staff Networks, the support groups for employees of different races, faiths and sexualities that have sprung up across the public sector in recent years. Share or comment on this article: From pagans to pansexuals... how civil servants are being encouraged to mark an array of 'woke weeks' at work e-mail Add comment

Caprock Group LLC increased its position in Dimensional Emerging Markets Core Equity 2 ETF ( NYSEARCA:DFEM – Free Report ) by 118.4% during the third quarter, Holdings Channel reports. The firm owned 16,401 shares of the company’s stock after buying an additional 8,891 shares during the quarter. Caprock Group LLC’s holdings in Dimensional Emerging Markets Core Equity 2 ETF were worth $462,000 as of its most recent filing with the SEC. Several other hedge funds have also bought and sold shares of DFEM. Bessemer Group Inc. acquired a new position in Dimensional Emerging Markets Core Equity 2 ETF during the first quarter worth approximately $372,000. CreativeOne Wealth LLC bought a new stake in Dimensional Emerging Markets Core Equity 2 ETF in the 1st quarter valued at $282,000. Jane Street Group LLC lifted its holdings in Dimensional Emerging Markets Core Equity 2 ETF by 365.2% during the 1st quarter. Jane Street Group LLC now owns 1,723,162 shares of the company’s stock valued at $43,923,000 after purchasing an additional 1,352,755 shares during the last quarter. EverSource Wealth Advisors LLC boosted its position in Dimensional Emerging Markets Core Equity 2 ETF by 42.4% during the first quarter. EverSource Wealth Advisors LLC now owns 56,764 shares of the company’s stock worth $1,459,000 after purchasing an additional 16,894 shares during the period. Finally, Mosaic Family Wealth Partners LLC boosted its position in Dimensional Emerging Markets Core Equity 2 ETF by 12.9% during the first quarter. Mosaic Family Wealth Partners LLC now owns 877,660 shares of the company’s stock worth $22,372,000 after purchasing an additional 100,473 shares during the period. Dimensional Emerging Markets Core Equity 2 ETF Price Performance Shares of DFEM opened at $26.58 on Friday. The company’s 50-day moving average is $27.46 and its 200-day moving average is $26.98. The firm has a market capitalization of $3.72 billion, a PE ratio of 10.39 and a beta of 0.83. Dimensional Emerging Markets Core Equity 2 ETF has a fifty-two week low of $23.49 and a fifty-two week high of $28.86. Dimensional Emerging Markets Core Equity 2 ETF Profile The Dimensional Emerging Markets Core Equity 2 ETF (DFEM) is an exchange-traded fund that mostly invests in total market equity. The fund actively selects emerging markets securities of all sizes with a tilt toward small-cap companies, seeking to provide long-term capital appreciation. DFEM was launched on Apr 27, 2022 and is managed by Dimensional. Read More Want to see what other hedge funds are holding DFEM? Visit HoldingsChannel.com to get the latest 13F filings and insider trades for Dimensional Emerging Markets Core Equity 2 ETF ( NYSEARCA:DFEM – Free Report ). Receive News & Ratings for Dimensional Emerging Markets Core Equity 2 ETF Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Dimensional Emerging Markets Core Equity 2 ETF and related companies with MarketBeat.com's FREE daily email newsletter .No. 5 UCLA snaps No. 1 South Carolina's 43-game win streak

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Ravens’ running game was crucial in a big win over the Chargers, especially on 4th downThe South Carolina women's basketball team has been defeated for the first time since March 31, 2023. The No. 1 Gamecocks fell Sunday in Los Angeles as Lauren Betts posted a double-double effort to lead No. 5 UCLA to a 77-62 triumph. The Gamecocks (5-1) suffered their first defeat after 43 consecutive victories, dating back to the loss to Iowa 77-73 in the NCAA Tournament semifinals. South Carolina defeated Iowa last season for the national championship. Betts finished with 11 points, a game-high 14 rebounds, four assists and four blocks to power the Bruins (5-0) to a historic victory. UCLA also got 15 points from Londynn Jones on 5-of-5 shooting from 3-point range, 13 points from Elina Aarnisalo and 11 each from Kiki Rice and Gabriela Jacquez. It's the first time UCLA has beaten South Carolina since 1981. The Bruins lost twice to the Gamecocks in the 2022-23 season, including in the Sweet 16 of the NCAA Tournament. Te-Hina Paopao had 18 points for South Carolina on 4-of-4 3-point shooting, while Tessa Johnson had 14 points. UCLA won the rebounding battle 41-34, marking the second time this season the Gamecocks have been outrebounded. South Carolina also got outscored in the paint 26-18. It's rare that a Dawn Staley-coached team -- units that typically revolve around dominant centers from A'ja Wilson to Aaliyah Boston to Kamilla Cardoso -- gets beat in the paint and on the glass, but with 6-foot-7 Betts, UCLA had the recipe to outmuscle the Gamecocks in those areas of the game. South Carolina never led after UCLA began the game with an 18-5 run, capped off by back-to-back 3-pointers from Jones. The Gamecocks cut the deficit to nine points in the second quarter, but the Bruins responded with a 17-5 run and entered halftime ahead by 21 points. Aarnisalo scored seven points during that run. From there, the Gamecocks never got within single digits of the lead in the second half. It's the first time in 21 tries that UCLA has beaten an AP-ranked No. 1 team. And it's the first time South Carolina lost a true road game since 2021, a streak of 33 games. The schedule doesn't get any easier for South Carolina. While UCLA faces UT Martin next on Friday, the Gamecocks play No. 8 Iowa State on Thursday. --Field Level MediaLG Energy Solution Hosts 'Battery Innovation Contest (BIC) 2025' to Foster Breakthrough Battery TechnologiesThe South Carolina women's basketball team has been defeated for the first time since March 31, 2023. The No. 1 Gamecocks fell Sunday in Los Angeles as Lauren Betts posted a double-double effort to lead No. 5 UCLA to a 77-62 triumph. The Gamecocks (5-1) suffered their first defeat after 43 consecutive victories, dating back to the loss to Iowa 77-73 in the NCAA Tournament semifinals. South Carolina defeated Iowa last season for the national championship. Betts finished with 11 points, a game-high 14 rebounds, four assists and four blocks to power the Bruins (5-0) to a historic victory. UCLA also got 15 points from Londynn Jones on 5-of-5 shooting from 3-point range, 13 points from Elina Aarnisalo and 11 each from Kiki Rice and Gabriela Jacquez. It's the first time UCLA has beaten South Carolina since 1981. The Bruins lost twice to the Gamecocks in the 2022-23 season, including in the Sweet 16 of the NCAA Tournament. Te-Hina Paopao had 18 points for South Carolina on 4-of-4 3-point shooting, while Tessa Johnson had 14 points. UCLA won the rebounding battle 41-34, marking the second time this season the Gamecocks have been outrebounded. South Carolina also got outscored in the paint 26-18. It's rare that a Dawn Staley-coached team -- units that typically revolve around dominant centers from A'ja Wilson to Aaliyah Boston to Kamilla Cardoso -- gets beat in the paint and on the glass, but with 6-foot-7 Betts, UCLA had the recipe to outmuscle the Gamecocks in those areas of the game. South Carolina never led after UCLA began the game with an 18-5 run, capped off by back-to-back 3-pointers from Jones. The Gamecocks cut the deficit to nine points in the second quarter, but the Bruins responded with a 17-5 run and entered halftime ahead by 21 points. Aarnisalo scored seven points during that run. From there, the Gamecocks never got within single digits of the lead in the second half. It's the first time in 21 tries that UCLA has beaten an AP-ranked No. 1 team. And it's the first time South Carolina lost a true road game since 2021, a streak of 33 games. The schedule doesn't get any easier for South Carolina. While UCLA faces UT Martin next on Friday, the Gamecocks play No. 8 Iowa State on Thursday. --Field Level Media

Equity Residential stock underperforms Tuesday when compared to competitors despite daily gainsSuper Football Conference: National Red All-Division teams, 2024None

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US to send $1.25 billion in weapons to Ukraine, pushing to get aid out before Biden leaves office WASHINGTON (AP) — U.S. officials say the United States is expected to announce it will send another $1.25 billion in military assistance to Ukraine. It's part of a push by the Biden administration to get as much aid to Kyiv as possible before leaving office on Jan. 20. Officials say the large package of aid includes a significant amount of munitions, including for the National Advanced Surface-to-Air Missile Systems and the HAWK air defense system. It also will provide Stinger missiles and 155 mm- and 105 mm artillery rounds. The officials say they expect the announcement will be made on Monday. They spoke on condition of anonymity to provide details not yet made public. An online debate over foreign workers in tech shows tensions in Trump's political coalition WEST PALM BEACH, Fla. (AP) — An online spat between factions of Donald Trump’s supporters over immigration and the tech industry has thrown internal divisions in the president-elect’s political movement into public display. The argument previews fissures and contradictory views his coalition could bring to the White House. The rift laid bare tensions between the newest flank of Trump’s movement — that is, wealthy members of the tech world who want more highly skilled workers in their industry — and people in Trump’s Make America Great Again base who championed his hardline immigration policies. A 9th telecoms firm has been hit by a massive Chinese espionage campaign, the White House says WASHINGTON (AP) — A top White House official says a ninth U.S. telecoms firm has been confirmed to have been hacked as part of a sprawling Chinese espionage campaign that gave officials in Beijing access to private texts and phone conversations of an unknown number of Americans. Administration officials said this month that at least eight telecommunications companies, as well as dozens of nations, had been affected by the Chinese hacking blitz known as Salt Typhoon. But Anne Neuberger, a deputy national security adviser, said Friday that a ninth victim had been identified after the administration released guidance to companies about how to hunt for Chinese culprits in their networks. Warren Upton, the oldest living survivor of the attack on Pearl Harbor, dies at 105 HONOLULU (AP) — The oldest living survivor of the 1941 Japanese attack on Pearl Harbor and the last remaining survivor of the USS Utah has died. He was 105. Warren Upton died Wednesday at a hospital in Los Gatos, California. Kathleen Farley, the California state chair of the Sons and Daughters of Pearl Harbor Survivors, says he suffered a bout of pneumonia. The Utah was moored at Pearl Harbor when Japanese planes began bombing the Hawaii naval base in the early hours of Dec. 7, 1941. The attack propelled the U.S. into World War II. Israeli troops forcibly remove staff and patients from northern Gaza hospital, officials say DEIR AL-BALAH, Gaza Strip (AP) — Gaza's Health Ministry says Israeli troops have stormed one of the last hospitals operating in the territory's north and forced many of the staff and patients outside. Then they had to remove their clothes in winter weather. Friday's incident was the latest assault on Kamal Adwan Hospital. Staff say it has been hit multiple times in the past three months by Israeli troops waging an offensive against Hamas fighters in the surrounding neighborhoods. Israel's military says Hamas uses the hospital as a base. It did not provide evidence, and hospital officials have denied it. Azerbaijani and U.S. officials suggest plane that crashed may have been hit by weapons fire U.S. and Azerbaijani officials have said weapons fire may have brought down an Azerbaijani airliner that crashed on Wednesday, killing 38 people. The statements from Rashad Nabiyev and White House national security spokesman John Kirby on Friday raised pressure on Russia. Officials in Moscow have said a drone attack was underway in the region that the Azerbaijan Airlines flight was destined for but have not addressed statements from aviation experts who blamed the crash on Russian air defenses responding to a Ukrainian attack. The plane was flying from Azerbaijan’s capital of Baku to Chechnya on Wednesday when it crashed, killing 38 people and leaving all 29 survivors injured. Court rules Georgia lawmakers can subpoena Fani Willis for information related to her Trump case ATLANTA (AP) — A judge has ruled that the Georgia state Senate can subpoena Fulton County District Attorney Fani Willis. It's part of a inquiry into whether Willis has engaged in misconduct during her prosecution of President-elect Donald Trump. But Fulton County Superior Court Judge Shukura Ingram is giving Willis the chance to contest whether lawmakers’ demands are overly broad before Willis responds. A Republican-led committee was formed earlier this year and sent subpoenas to Willis in August seeking to compel her to testify during its September meeting and to produce scores of documents. Willis argued that the committee didn’t have the power to subpoena her. US homelessness up 18% as affordable housing remains out of reach for many people Federal officials say the United States saw an 18.1% increase in homelessness, a dramatic rise driven mostly by a lack of affordable housing as well as devastating natural disasters and a surge of migrants in several parts of the country. The U.S. Department of Housing and Urban Development said that federally required tallies taken across the country in January found that more than 770,000 people were counted as homeless. That increase comes on top of a 12% increase in 2023, which HUD blamed on soaring rents and the end of pandemic assistance. Among the most concerning trends was a nearly 40% rise in family homelessness. What Snoop wants: Arizona Bowl gives NIL opportunities to players for Colorado State, Miami (Ohio) TUCSON, Ariz. (AP) — When Snoop Dogg agreed to become the sponsor of the Arizona Bowl, he had a demand: It must have a NIL component. Other bowls have provided NIL chances for single players the past few years, but the Arizona Bowl is believed to be the first to offer NIL compensation to every player on both Colorado State and Miami (Ohio). The players participated in youth clinics before Saturday's game and will be compensated for their time. Alex Ovechkin is on track to break Wayne Gretzky's NHL career goals record Alex Ovechkin of the Washington Capitals is chasing the NHL career goals record of 894 held by Wayne Gretzky. Ovechkin entered the season 42 goals short of breaking a record that long seemed unapproachable. He is set to play again Saturday at the Toronto Maple Leafs after missing more than a month with a broken left fibula. Ovechkin was on pace to get to 895 sometime in February before getting injured. At 868, he his 27 goals away from passing Gretzky.( MENAFN - Investor Brand Network) Clene (NASDAQ: CLNN) and its wholly owned subsidiary, Clene Nanomedicine Inc., a late clinical-stage biopharmaceutical company focused on improving mitochondrial health and protecting neuronal function to treat neurodegenerative diseases, including amyotrophic lateral sclerosis (“ALS”) and multiple sclerosis (“MS”), recently received additional written guidance and a roadmap from the U.S. Food and Drug Administration's (“FDA”) Division of Neurology 1 regarding a potential accelerated approval pathway for lead drug candidate CNM-Au8 in ALS.“The FDA guidance on a potential path to meet the regulatory standard for substantial evidence of effectiveness supporting accelerated approval came following an in-person Nov. 1 Type C meeting with the DN1 where the company presented additional clinical trial data and analyses. The FDA recommended that Clene leverage additional Neurofilament Light ('NfL') data from its three Expanded Access Programs ('EAPs') to support earlier findings,” reads an article discussing the guidance. “Together with the survival and supportive biomarker data generated thus far, the drug's benign safety profile, and the emerging EAP NfL data, we look forward to continued discussions with the Agency,” said Clene's CEO and President, Rob Etherington.“Clene plans to include the additional data in an NDA submission under the accelerated approval pathway in mid-2025. We remain dedicated to the ALS community and honored to help critically ill patients and their families.” To view the full article, visit About Clene Inc. Clene (along with its subsidiaries,“Clene”) and its wholly owned subsidiary Clene Nanomedicine Inc., is a late clinical-stage biopharmaceutical company focused on improving mitochondrial health and protecting neuronal function to treat neurodegenerative diseases, including amyotrophic lateral sclerosis, Parkinson's disease and multiple sclerosis. CNM-Au8® is an investigational first-in-class therapy that improves central nervous system cells' survival and function via a mechanism that targets mitochondrial function and the NAD pathway while reducing oxidative stress. CNM-Au8® is a federally registered trademark of Clene Nanomedicine, Inc. The company is based in Salt Lake City, Utah, with R&D and manufacturing operations in Maryland. For more information, please visit . NOTE TO INVESTORS: The latest news and updates relating to CLNN are available in the company's newsroom at About BioMedWire BioMedWire (“BMW”) is a specialized communications platform with a focus on the latest developments in the Biotechnology (BioTech), Biomedical Sciences (BioMed) and Life Sciences sectors. It is one of 70+ brands within the Dynamic Brand Portfolio @ IBN that delivers : (1) access to a vast network of wire solutions via InvestorWire to efficiently and effectively reach a myriad of target markets, demographics and diverse industries ; (2) article and editorial syndication to 5,000+ outlets ; (3) enhanced press release enhancement to ensure maximum impact ; (4) social media distribution via IBN to millions of social media followers ; and (5) a full array of tailored corporate communications solutions . With broad reach and a seasoned team of contributing journalists and writers, BMW is uniquely positioned to best serve private and public companies that want to reach a wide audience of investors, influencers, consumers, journalists and the general public. By cutting through the overload of information in today's market, BMW brings its clients unparalleled recognition and brand awareness. BMW is where breaking news, insightful content and actionable information converge. To receive SMS alerts from BioMedWire,“Biotech” to 888-902-4192 (U.S. Mobile Phones Only) For more information, please visit Please see full terms of use and disclaimers on the BioMedWire website applicable to all content provided by BMW, wherever published or re-published: /Disclaimer BioMedWire San Francisco, CA 415.949.5050 Office [email protected] BioMedWire is powered by IBN MENAFN26122024000224011066ID1109033808 Legal Disclaimer: MENAFN provides the information “as is” without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the provider above.SACRAMENTO – The Sacramento Kings have parted ways with head coach Mike Brown, according to a league source. Doug Christie, who has been an assistant with the Kings since 2021-22 and played five seasons in Sacramento, is expected to take over as the interim head coach, sources say. The departure of Brown comes after the Kings started the 2024-25 season with a 13-18 record, currently sitting as the 12th seed in the Western Conference. It comes less than 24 hours after the Kings blew a 19-point lead in the second half against the Detroit Pistons , extending the team's losing streak to five games, the longest losing streak since Brown took over as head coach in 2022. Brown was at practice Friday and spoke with reporters. About 10 minutes after speaking with the media, reports came down that the Kings were parting ways with Brown. The Kings had playoff expectations coming into the season after adding six-time All-Star DeMar DeRozan . Brown signed a three-year extension through 2027 in June. He was named the 2022-23 NBA Coach of the Year, leading the Kings back to the playoffs for the first time since 2006. He held a 107-88 record at the helm for the Kings. The Kings take on the Los Angeles Lakers at Crypto.com Arena on Saturday at 7:30 p.m. They return home to take on the Dallas Mavericks Monday at 7 p.m.