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"z>csVz`խ 9M7ថ#وAD{CK :y/ ܀8N&_=!M cɳ3_lGlufosfamide is under clinical development by Eleison Pharmaceuticals and currently in Phase III for Metastatic Adenocarcinoma of The Pancreas. According to GlobalData, Phase III drugs for Metastatic Adenocarcinoma of The Pancreas have a 38% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Glufosfamide overview Glufosfamide is under development for the treatment of metastatic pancreatic adenocarcinoma. The drug candidate is administered intravenously. Glufosfamide is beta-D-glucosyl-isophosphoramide mustard and a glucose-conjugated prodrug. It is an analogue of ifosfamide. It acts as an alkylating agent and stops tumor growth by cross-linking bases in DNA double-helix strands, directly attacking DNA. The drug candidate was also under development for the treatment of recurrent sensitive small-cell lung cancer, soft tissue sarcoma, epithelial ovarian cancer, peritoneal serous cancer, or carcinoma of the fallopian tube.It was under development for the treatment of metastatic pancreatic adenocarcinoma. Eleison Pharmaceuticals overview Eleison Pharmaceuticals is a drug development company that acquires, develops, and commercializes clinical stage drug candidates for orphan cancers. The company’s pipeline products include glufosfamide and inhaled lipid-complexed cisplatin. Its glufosfamide is an analog of chemotherapeutic agent for treatment of metabolically active tumors and hypoxic tumor regions. Eleison Pharmaceuticals’ inhaled lipid-complexed cisplatin is a sustained release formulation of cisplatin in a nanoscale lipid based complex used for pediatric osteosarcoma – bone cancer. The company provides clinical trials for pancreatic cancer and osteosarcoma. Eleison Pharmaceuticals is headquartered in Princeton, New Jersey, the US. For a complete picture of Glufosfamide’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .Rangers making wild Chris Kreider lineup decision vs. Devils
El Salvador's Congress on Monday approved a bill promoted by President Nayib Bukele to roll back a ban on the mining of gold and other metals, dismaying environmentalists. The small Central American nation became the world's first country to outlaw metal mining in 2017, warning of the harmful effects of the chemicals used, like cyanide and mercury. The move by Bukele's predecessor, former left-wing rebel Salvador Sanchez Ceren, reflected a growing rejection of mining by rural communities in the region. But last month, Bukele, who is popular at home for his crackdown on street gangs, signaled that he wanted to change course. The bill to bring back metal mining was approved by 57 deputies out of a total of 60, said Ernesto Castro, head of the legislature -- which is dominated by the ruling party -- as environmental campaigners protested nearby. Critics fear that mining will pollute the Lempa River, which runs through a potential mining zone proposed by Bukele and supplies water to 70 percent of the inhabitants of the capital and surrounding areas. "This wretched mining will punish the people, it will contaminate our waters and rivers and that's an attack on life," activist Vidalina Morales told reporters. Bukele said last month that El Salvador, a country of 6.6 million people, had "potentially" the largest gold deposits per square kilometer in the world. "God placed a gigantic treasure underneath our feet," he wrote on social media, arguing that the mining ban was "absurd." "If we make responsible use of our natural resources, we can change the economy of El Salvador overnight," he said. The new law stipulates that the state will be the only entity authorized to search for, extract and process mined metals. However, the government may do so through companies in which it is a shareholder. The bill prohibits the use of mercury in mining operations, which may not be carried out in protected natural areas or places with important water sources. A survey by Central American University published on Monday revealed that 59 percent of respondents do not consider El Salvador "an appropriate country for metal mining." Since El Salvador dollarized its remittances-reliant economy in 2001, it has registered average annual growth of 2.1 percent. Twenty-seven percent of Salvadorans live in poverty, according to the United Nations Economic Commission for Latin America and the Caribbean, and 70 percent of the workforce operates in the informal sector. Elsewhere in the region, Costa Rica and Honduras have banned open-pit mining, and Panama declared a moratorium on new mining concessions last year after mass protests over plans for a huge copper mine. ob/fj/dr/jgc
Mackenzie Klatsky recorded 13 points for Marlboro in its 58-33 win over Toms River North in Toms River. Emily Borgen adde 11 points for Marlboro, which used a 19-7 second quarter and a 18-9 third quarter to grab control of the game. Elizabeth Stellato was also in double figures with 10 points. 12/23 - 12:00 PM Girls Basketball Final Marlboro 58 Toms River North 33 Marlboro was on fire from three-point range with six different players combining for 10 three-pointers. Klatsky had the most with three. Jordyn Brown scored a game-high 15 points for Toms River North. The N.J. High School Sports newsletter is now appearing in mailboxes 5 days a week. Sign up now! Follow us on social: Facebook | Instagram | X (formerly Twitter)Richard Parsons, prominent Black executive who led Time Warner and Citigroup, dies at 76
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SANTA CLARA, Calif. (AP) — Dan Campbell stood at the podium after Detroit blew a 17-point lead to San Francisco in last season's NFC title game and talked about how that might have been the Lions' only shot at reaching the Super Bowl. The coach knew how difficult it would be to maintain that high level of play through injuries, attrition and with a target on their back as a top contender in the NFC. Eleven months later as Campbell and the Lions prepare to return to Levi's Stadium for the first time since that loss , that has proved to be prophetic — for San Francisco instead of Detroit. The Lions (13-2) head into the rematch Monday night with the inside track at the top seed in the NFC playoffs, while the 49ers (6-9) have already been eliminated from postseason contention . The element of revenge for last season's 34-31 loss is secondary for Detroit, considering what's on the line the last two weeks of the season. The Lions can clinch the top seed in the NFC by winning their final two games or with a win against the Niners if Minnesota loses to Green Bay on Sunday. “Anytime we lose, the thought of losing is going to motivate you to not want to lose again, particularly with where you were at,” Campbell said. “So, that’s always going to bring its own level of motivation to it. But this is where we’re at in the season, we know that we need another win, we understand where we’re at in the division and the NFC, so I think it’s all encompassing.” While the Lions have no need to search for motivation, that's not the case for the 49ers, who are playing out the string of a lost season after making losing back-to-back NFC title games in 2021-22 and the Super Bowl last season. A run of injuries to key players like Christian McCaffrey, Trent Williams, Nick Bosa and Brandon Aiyuk, combined with inconsistent play all season have led to the 49ers having nothing to play for in the final two games. “It’s obviously not where you want to be this time of year,” Bosa said. "It’s different, especially watching where we’re at last year against this team. Just that feeling of December, January football is a feeling that I’ve gotten used to being really competitive and being in the mix. I think we’re doing a good job of staying engaged and obviously this is our job, so we’re going to finish it strong. Go ing deep Detroit’s faith in Jameson Williams is paying off, taking advantage of his game-breaking abilities with big plays. Jared Goff heaved an 82-yard touchdown pass over Williams’ shoulders and into his hands in last week’s win at Chicago. Earlier this season, Goff threw 70-, 64- and 52-yard passes for scores to the third-year receiver. “We work on it a ton, him and I do, and it’s a testament to him,” Goff said. “He’s asking for it. He wants that work, and I’m more than happy to give it to him during the week. It’s good. Our connection continues to grow. He’s obviously one of the best deep threats in our league, even when it’s not perfect.” Makeshift line The 49ers head into the game scrambling to put together an offensive line. Williams has been out for more than a month with an ankle injury and his backup at left tackle, Jaylon Moore, is now sidelined by a quadriceps injury. Left guard Aaron Banks injured his knee last week, while his backup Ben Bartch is already out with an ankle injury. That will leave the Niners with two third-stringers protecting Brock Purdy. But Shanahan said he isn’t thinking of sitting Purdy to protect him. “People deal with that throughout the year on other weeks, too,” he said. “I mean, we’ve got a football team. We’ve got to go out and we’ve got two games here and we’ve got to see what guys we can put out there and whatever we do we’re going to put a game plan together to, as best as we can to give us a chance to win.” Bag of tricks Lions offensive coordinator Ben Johnson, who may have a chance for the second straight offseason to be an NFL head coach, routinely pulls off trick plays and his latest was a doozy. Goff intentionally stumbled after taking a snap and Jahmyr Gibbs went to the ground as their teammates yelled, “fumble,” to fool the Bears on a 21-yard touchdown pass to Sam LaPorta. “Those make you feel good because everybody is invested in it,” Campbell said. “It’s fun. It’s different. It’s sound. “I know it sounds crazy, but it’s sound.” Just for kicks San Francisco kicker Jake Moody is having a rough second season after being drafted in the third round a year ago. Moody has missed seven field goals this season, including a 41-yarder last week at Miami. Moody is just 10 for 16 since coming back from a high ankle sprain in his kicking foot, but Shanahan said he still has confidence in him. “I still feel the same about him, that I believe he’ll be our guy,” Shanahan said. "I mean everyone’s got to perform and do things like that. I think he has had a tough year. Before his high ankle sprain, he missed one. ... I think he was 12 of 13 before that, so I thought he was doing really well." ___ AP Sports Writer Larry Lage contributed to this report. ___ AP NFL: https://apnews.com/hub/nfl Josh Dubow, The Associated Press
CALGARY, AB, Dec. 3, 2024 /CNW/ - Enbridge Inc. (TSX: ENB) (NYSE: ENB) is pleased to announce that its Board of Directors has appointed Douglas L. Foshee as a Director of Enbridge, effective January 1, 2025. Mr. Foshee has more than 40 years of energy industry experience, including as Chair, President and CEO of El Paso Corporation from 2003 to 2012, as CFO and then COO of Halliburton Company from 2001 to 2003, and as Chair, President and CEO of Nuevo Energy from 1996-2001. "On behalf of the Board of Directors of Enbridge, we are very pleased to welcome Doug to the Enbridge Board. He has extensive energy industry and business experience and will be an excellent addition to our Board," stated Pamela Carter, the Chair of the Board of Directors of Enbridge. About Enbridge Inc. At Enbridge, we safely connect millions of people to the energy they rely on every day, fueling quality of life through our North American natural gas, oil and renewable power networks and our growing European offshore wind portfolio. We're investing in modern energy delivery infrastructure to sustain access to secure, affordable energy and building on more than a century of operating conventional energy infrastructure and two decades of experience in renewable power. We're advancing new technologies including hydrogen, renewable natural gas, carbon capture and storage. Headquartered in Calgary, Alberta, Enbridge's common shares trade under the symbol ENB on the Toronto (TSX) and New York (NYSE) stock exchanges. To learn more, visit us at enbridge.com . FOR FURTHER INFORMATION PLEASE CONTACT: Media Toll Free: (888) 992-0997 Email: media@enbridge.com Investment Community Toll Free: (800) 481-2804 Email: investor.relations@enbridge.com View original content: https://www.prnewswire.com/news-releases/enbridge-appoints-new-director-to-its-board-302321529.html SOURCE Enbridge Inc.
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