7xm to inch Carter hits 5 3s, scores 23 to help LSU beat Mississippi Valley State 110-45BERLIN (AP) — Harry Kane scored a hat trick including two penalties for Bayern Munich to beat Augsburg 3-0 in the Bundesliga on Friday. The win stretched Bayern’s lead to eight points ahead of the rest of the 11th round, and Kane took his goals tally to a league-leading 14. The England forward is the fastest player to reach 50 goals in the Bundesliga in what was his 43rd game. However, coach Vincent Kompany should be concerned by his team’s ongoing difficulty of scoring in matches it dominates. Bayern previously defeated St. Pauli and Benfica only 1-0. Kompany’s team had to wait until stoppage time before Kane sealed the result with his second penalty. Two minutes later, Kane scored with a header after controlling Leon Goretzka’s cross with his first touch for a flattering scoreline. “We had to be patient,” Kane said. “And at halftime that’s what we said, to keep doing what we’re doing. We had a few chances in the first half and we just had to be a bit more clinical and obviously, thankfully, we got the penalty to kind of open the game up.” Mads Pedersen was penalized for handball following a VAR review and Kane duly broke the deadlock in the 63rd. Bayern continued as before with 80% possession, but had to wait for Keven Schlotterbeck to be penalized through VAR for a foul on Kane. Kane sealed the result in the third minute of stoppage time and there was still time for him to grab another. It’s Bayern’s seventh consecutive win without conceding a goal since it conceded four at Barcelona (4-1) on Oct. 23 in the Champions League. “You can see now that we have a solid defense and that’s the basis, also in games like today’s,” Bayern midfielder Joshua Kimmich said. “When it’s a game of patience, then it’s important for us to know that sometimes one goal will have to do. Like today we added two more before the finish, but in the end you only need to score one more than the opponent.” Bayern next hosts Paris Saint-Germain in the Champions League on Tuesday, then Borussia Dortmund away in the Bundesliga next weekend, before defending champion Bayer Leverkusen visits in the third round of the German Cup. ___ AP soccer:

GCC-4001 is under clinical development by Artiva Biotherapeutics and currently in Phase II for Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma). According to GlobalData, Phase II drugs for Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma) have a 17% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. GCC-4001 overview GCC-4001 (AB-101) is under development for the treatment of rheumatoid arthritis, systemic lupus erythematosus, pemphigus vulgaris, granulomatosis with polyangiitis and microscopic polyangiitis, B-cell non-Hodgkin lymphoma, relapsed or refractory chronic lymphocytic leukemia, diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, follicular lymphoma, Waldenstrom Macroglobulinemia, peripheral T-cell lymphomas (PTCL), angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma (ALCL), R/R classical Hodgkin lymphoma, lupus nephritis (LN) and autoimmune disorders. The therapeutic candidate is an allogeneic, non-engineered, cord blood-derived natural killer (NK) cell therapy. It is administered through intravenous route and is being developed based on AlloNK platform. Artiva Biotherapeutics overview Artiva Biotherapeutics is a biotechnology company developing allogeneic natural killer (NK) cell therapies to treat hematologic cancers or solid tumors. It is investigating AB-101, an allogeneic NK cell therapy used for the treatment of B-cell malignancies; AB-201, a CAR-NK (chimeric antigen receptor-modified natural killer) cell therapy targeting HER2 positive solid tumors; and AB-202 against CD19 positive B-cell malignancies. Artiva Biotherapeutics utilizes its proprietary CAR (chimeric antigen receptor) platform to improve NK cells’ therapeutic activity and tumor-targeting capability. Artiva Biotherapeutics is headquartered in San Diego, California, the US. For a complete picture of GCC-4001’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .

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Police appeal for information after reports of man 'being cruel to a swan'THE HAGUE, Netherlands (AP) — Alyssa Naeher ended her national team career with one last win. The stalwart goalkeeper made two critical saves in her final match for the United States, and the Americans beat the Netherlands 2-1 on Tuesday. “I definitely wasn’t thinking about it during the game, just wanted to win the game and do what I could to come away with the ‘W’ for us to close out the year,” Naeher said. Lynn Williams scored the go-ahead goal in the 71st minute for the U.S., which won its fifth Olympic gold medal in France this summer and wrapped up the year on a 20-game unbeaten streak. The Americans were coming off a scoreless draw with England on Saturday at Wembley Stadium. Naeher announced two weeks ago that the European exhibitions would be her final matches. The 36-year-old goalkeeper played in 115 games for the U.S., with 111 starts, 89 wins and 69 shutouts. Naeher is the only U.S. keeper with shutouts in both a World Cup and an Olympic final. She was in goal when the United States defeated the Netherlands 2-0 in the 2019 Women's World Cup final . “I feel like in my heart I would love to keep going. In my head, in my body and mind, I feel like it’s the right time. And I think it’s the right time with this team as well as it builds towards the future and towards 2027,” Naeher said. “This environment, this team, is an incredible team to be a part of, but it’s also really hard and really challenging in a lot of ways as well. “I feel like I’ve given everything I have to give for this team and that’s why I feel at peace with that.” The Netherlands took the lead on center back Veerle Buurman's header off a corner kick in the 15th minute. Naeher prevented a second goal when she punched away Dominique Janssen's shot in the 38th. The United States drew even at the end of the first half on an own goal that deflected off Buurman and past Dutch goalkeeper Daphne van Domselaar. Naeher slid to stop Danielle van de Donk's shot in the 69th minute before Williams, a second-half substitute, scored her fourth goal of the year and 21st of her career. “I wouldn’t say that this was our prettiest game of soccer ever. And sometimes that’s how games go. You can talk about tactics, you can talk about formations, you talk about everything, but the biggest thing was matching their intensity. Getting to the second ball, getting to the first ball. That was the shift that needed to happen,” Williams said about the team's second-half mindset. Naeher finished with six saves. She is not quite finished with soccer yet: She will continue playing next season for the Chicago Red Stars of the National Women's Soccer League. “She’s been consistent again and again. Even when she’s been questioned at times in her career, she’s always found the answer,” U.S. coach Emma Hayes said. “Not only has she been a great player in this program, but let me tell you, she’s so loved by everyone, players and staff alike. She is the best teammate you could ask for and that just speaks volumes to the person that she is.” Lily Yohannes came in as a substitute in the second half. Yohannes, who has dual citizenship, opted to play for the United States over the Netherlands last month. She plays professionally for the Dutch club Ajax. The U.S. finished the year without the trio of Mallory Swanson, Trinity Rodman and Sophia Smith, who were left off the roster for the final two matches to rest and heal nagging injuries. The U.S. is unbeaten in 15 matches under Hayes, who took over in May. AP soccer: https://apnews.com/hub/soccer

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Sports Correspondent Liverpool manager Arne Slot has urged his players to stay vigilant, reminding them that their current seven-point lead at the top of the Premier League could quickly evaporate if they become complacent. The Reds extended their advantage with a hard-fought 3-1 victory over Leicester City on Boxing Day. Despite falling behind early to a goal from Jordan Ayew in the sixth minute, Liverpool responded with goals from Cody Gakpo, Curtis Jones, and Mohamed Salah to secure the win. In reflecting on the title race, Slot pointed to Manchester City’s dramatic drop from first to seventh as a cautionary tale. “When you’ve been in this game for a long time, you know that with 20 games to go, you don’t pay attention to the table,” Slot said after the match. “Just a month ago, we were one point behind City, and look at where they are now. This can happen to any team, so it’s far too early to celebrate. We’ve all witnessed the challenges, and many of our victories haven’t come easily. It shows how tough it is to win, even with a full squad. We must continue to take it one game at a time.”All the signs Michelle Keegan was pregnant with first child - from hiding bump to cosy nights inA Chinese commercial aerospace company conducted the first test flight of a detonation ramjet engine on Tuesday, designed for an aircraft it says will be able to take passengers from Beijing to New York in two hours. Its developer Space Transportation, or Lingkong Tianxing Technology, said it had reached a speed of 5,000km/h or Mach 4 – four times the speed of sound – at altitudes exceeding 65,600 feet. The engine uses detonation combustion technology and features a modular, compact design. “This engine has significant commercial potential in the field of high-speed flight within near-space environments,” the Beijing-based company said in a statement. Unlike traditional rocket engines or jet engines, the detonation ramjet generates thrust by using shock waves from detonation combustion to compress the incoming air, eliminating the need for compressors and turbine components. This simplifies the structure, improves the thrust-to-weight ratio, and lowers costs.

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