top 464 AusperBio (PRNewsfoto/AusperBio Therapeutics Inc.) SAN FRANCISCO , Dec. 26, 2024 /PRNewswire/ -- AusperBio Therapeutics, Inc . and Ausper Biopharma Co., Ltd . (collectively AusperBio ), a privately held clinical-stage biotechnology company dedicated to advancing targeted oligonucleotide therapies to achieve a functional cure for chronic hepatitis B ( CHB ), today announced the successful completion of a USD 73 million Series B financing. The round was led by HanKang Capital , with participation from Sherpa Capital , CDH Investments , and a strategic investor, as well as continued participation from existing investors Qiming Venture Partners , InnoPinnacle Fund , and YuanBio Venture Capital . This financing followed the company's Series A round completed in July this year, demonstrating continued investor confidence in its proprietary platform and strategic direction. The proceeds will fund the continued Phase 2 development of AHB-137 , AusperBio's lead investigational therapy, supporting both clinical studies in China and global trials, as well as the development of commercial-scale manufacturing processes. The funding will also facilitate the expansion of the company's therapeutic pipeline and operational capabilities to drive sustained growth. Dr. Guofeng Cheng , co-founder and CEO of AusperBio, stated, " We are honored by our investors' confidence and support. This milestone financing recognizes our scientific and clinical accomplishments to date and enables us to accelerate our clinical programs and move closer to delivering a functional cure for CHB patients in need." Dr. Chris Yang , co-founder and CSO, added, "AHB-137 continues to attract attention from the scientific and clinical communities, particularly after the late-breaking oral presentation at the recent AASLD conference. The promising clinical data further validates our Med-OligoTM platform, strengthening our development of groundbreaking targeted oligonucleotide therapies for CHB and other serious chronic diseases." AusperBio is committed to delivering patient-centered innovations, aiming to alleviate the global health burden of CHB and transform treatment paradigms for this serious chronic disease. About AHB-137 AHB-137, a novel unconjugated antisense oligonucleotide ( ASO ) developed within AusperBio's proprietary Med-OligoTM ASO technology platform, was designed to treat chronic hepatitis B for a functional cure. Its compelling preclinical and Phase 1 clinical data were highlighted at the 2023 EASL conference and the 2024 EASL conference, respectively. Interim Phase 2a data was presented in a late-breaking oral session at the 2024 AASLD. This novel dual-mechanism ASO has completed its global Phase 1b trial and is now undergoing multiple Phase 2 trials in China . With its global development strategy, AHB-137 is advancing rapidly toward the goal of an HBV cure. About AusperBio. AusperBio is a clinical-stage biopharmaceutical company with operations in the USA and China , dedicated to advancing oligonucleotide and targeted delivery technologies for transformative therapies, with an initial focus on curing chronic hepatitis B infection. The company has developed a proprietary Med-OligoTM ASO platform which has been shown to substantially enhance the current ASO therapeutics, through novel insights into ASO design. Combining with efficient targeted delivery conjugation technologies, the modular Med-OligoTM Platform empowers ASO therapeutics to treat a broad range of diseases, including viral infections, metabolic conditions, genetic disorders, and immune diseases. For further information, please contact: Media Contact Email: info@ausperbio.com Investor Relations Contact: Tel: 650-888-1756 (US) Email: growth@ausperbio.com View original content to download multimedia: https://www.prnewswire.com/news-releases/ausperbio-secures-73-million-in-series-b-financing-to-advance-functional-cure-for-chronic-hepatitis-b-302339451.html SOURCE AusperBio Therapeutics Inc.

Additionally, an emphasis on rebounding is crucial for the team's success. Securing rebounds is a fundamental aspect of the game that can make or break a team's chances of winning. By pushing Liu to be more aggressive on the boards, the coach is ensuring that the team has a strong presence in the paint, both offensively and defensively. Rebounding is not just about grabbing the ball but also about creating second-chance opportunities and limiting the opponent’s scoring chances.BOISE, Idaho (AP) — Freshman wide receiver George Dimopoulos threw a 25-yard touchdown pass to Dane Pardridge on the first play of double overtime and Jordan Hansen ended the game on a fourth-down sack to give Northern Illinois a 28-20 victory over Fresno State on Monday in the Idaho Potato Bowl. Dimopoulos, who played quarterback in high school, also converted the two-point conversion when he passed it to quarterback Josh Holst for his second completion of the season. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.

As news of the fire spread, concerns were raised about the potential data loss and disruption to Alibaba's cloud services, which are used by millions of businesses and individuals around the world. Alibaba moved swiftly to address these concerns, providing regular updates on the status of their data center operations and assuring customers of their commitment to data security and resilience. Despite the challenges posed by the fire, Alibaba's technical teams worked around the clock to restore affected services and to minimize any disruptions to their customers' operations.The Prime Minister said the season was a time to remember the importance of “being there for one another”, including in “the more difficult times”. He also expressed hope for “peace, particularly in the Middle East as the birthplace of the Christmas story” amid spiralling conflict across the region. The message comes after a challenging first five months in office for the Labour Government and against the backdrop of a flatlining economy and rising inflation. Sir Keir said: “This Christmas, people will be travelling up and down the country. Heading home, visiting relatives and loved ones to celebrate together the hope and joy of this special season. “It’s a time to remind ourselves what’s really important. Family. Friendship. And fellowship between all people. “Being there for one another – in these celebrations, as well as the more difficult times.” To our military and veterans, the whole nation thanks you for the sacrifices you make to keep us safe. My government will serve you as you have served your country. I wish you and your families a very happy Christmas and a peaceful New Year. pic.twitter.com/LphMZog6np — Keir Starmer (@Keir_Starmer) December 22, 2024 The Prime Minister sought to strike an optimistic note following another year of political upheaval for Britain, which saw Labour win a landslide victory after a surprise election called by Rishi Sunak in the summer. After taking office in July, the new Government made a series of unpopular decisions as ministers confronted the realities of creaking public services and strained national finances. As well as dealing with the economic inheritance, Sir Keir said he needed to fix a “broken society” which manifested itself in summer riots across the country after the Southport knife attack. Sir Keir said: “This Christmas, I will be hoping for peace, particularly in the Middle East as the birthplace of the Christmas story. “I’ll be looking towards a better, brighter future for every person and celebrating the joy and wonder that Christmas brings. “So, from my family to yours, I hope you have a very merry Christmas.” The message comes after revised official figures released on Monday indicated that UK gross domestic product (GDP) showed no growth between July and September. Downing Street defended the Government’s record so far when asked about the data, telling reporters: “We had to take those tough decisions to lay the foundations of growth such that we can then deliver the higher living standards over this Parliament that people want to see.” The Prime Minister also used his message to thank those spending Christmas serving others, including in the NHS and emergency services, the armed forces, churches and charities. “I know that this is not an easy time for everyone, and my thoughts are with all those who are lonely this Christmas. “Having a tough time, missing a loved one. You are not alone,” he said. Meanwhile, Kemi Badenoch said Christmas was a time to reflect on “all that’s happened in the year” and “support all of those people who need our assistance”. “I want to take this opportunity to say thank you to everyone, not just in the Conservative Party or in my constituency, but across the country,” the Tory leader said. “For all that you have been doing in your communities, supporting each other and helping to keep all our towns, villages and places going. “I think that Christmas is a time for us to reflect on all that’s happened in the year. “Sometimes we have amazing years. “Sometimes, like when I lost my dad, we have difficult years and we’re commiserating, but we do it together. “But it’s a time for us to support all of those people who need our assistance, who need our help, who need our support.” She added: “And I’m looking forward to 2025. “I wish you all the very best for the New Year and all of the exciting things to come.” Liberal Democrat leader Sir Ed Davey said: “This year, I’ve had the chance to spend time with some amazing young carers. “Incredible young people who will spend this Christmas doing what they do all year round; looking after loved ones who are ill or disabled. “Carers embody the Christmas spirit of love, selflessness and generosity. “So I hope we can all take some time to think of them, and keep them in our hearts. “And wish them – and everyone – a Christmas full of peace, joy and love.”

Dallas Cowboys vs. Washington Commanders: This expert prediction includes our best bet of the game. AP Pat Sharyon | Special Correspondent The Dallas Cowboys will head to the nation’s capital to face the Washington Commanders in Week 12 of the NFL season at Northwest Stadium on Sunday at 1 p.m. EST. Our best bet for tomorrow’s contest is Over 44.5 points (-115). In anticipation of this NFC East matchup, the data analysts at Dimers.com have simulated the game 10,000 times, and then compared these results to current NFL betting odds to inform the data-driven betting preview provided to you below. This preview includes Dimers’ best bets and predicted scoreline for Dallas Cowboys vs. Washington Commanders. To unlock Dimers’ full suite of data-driven betting insights, which includes daily props, trends, and parlays, sign up for Dimers Pro with promo code SYRACUSE10 , which will save you 10% off your first subscription payment. Note: If you’re using this game preview to bet on NFL games, you can claim huge betting bonuses with our brand new exclusive bet365 bonus code “SYRACUSE”, while sports fans in New York State can take full advantage of our NBA League Pass FanDuel promo code. Additionally, bettors are encouraged to check out this exclusive promo offer from DraftKings and BetMGM. Cowboys vs. Commanders betting preview Utilize the interactive widget below to view the current spread, total, and moneyline odds and probabilities for the Cowboys-Commanders game at Northwest Stadium. This prediction and best bet for Sunday’s NFL matchup between the Cowboys and Commanders is from Dimers.com , a reliable source for sports betting predictions. Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country. Game details The key information you need before the Cowboys vs. Commanders NFL game. Teams: Dallas Cowboys vs. Washington Commanders Date: Sunday, November 24, 2024 Kickoff: 1 p.m. EST Location: Northwest Stadium NFL standings: Current NFL division standings NFL injuries: Check the latest updates to the official NFL injury report Odds The latest and best odds for the NFL contest between the Cowboys and Commanders. Spread: Cowboys +10.5 (-110), Commanders -10.5 (-105) Moneyline: Cowboys +450, Commanders -560 Total: Over/Under 44.5 (-115/-105) The odds and lines presented in this article are the best available from selected sports betting site at the time of publication and are subject to change. Expert prediction: Cowboys vs. Commanders Leveraging advanced data analysis and advanced algorithms, the experts at Dimers have performed 10,000 simulations of Sunday’s Cowboys vs. Commanders matchup. According to Dimers’ popular predictive analytics model, the Commanders are more likely to beat the Cowboys at Northwest Stadium. This prediction is based on the model giving the Commanders an 83% chance of winning the game. Furthermore, Dimers predicts that the bookmakers have got it right and the Cowboys and Commanders each have a 50% chance of covering the spread, while the over/under total of 44.5 points has a 53% chance of going over. As always, these predictions and probabilities are accurate at the time of publication but are subject to change. Cowboys vs. Commanders best bet Our top pick for the Cowboys vs. Commanders Week 12 NFL game is to bet on Over 44.5 points (-115) . This expert betting advice is based on world-class simulations and valuable betting intelligence, designed to help you make smarter investments. Score prediction for Cowboys vs. Commanders Dimers’ projected final score for the Dallas vs. Washington game on Sunday has the Commanders winning 27-17. This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome. NFL player props: Sunday NFL props are a popular way to wager on Sunday’s game without necessarily betting on its outcome. This article features the most likely first and anytime touchdown scorers for the Cowboys and Commanders, as well as projected player stats. Dallas Cowboys First touchdown scorer predictions Rico Dowdle: 8.3% probability CeeDee Lamb: 8.2% probability KaVontae Turpin: 5.6% probability Anytime touchdown predictions Rico Dowdle: 36.4% probability CeeDee Lamb: 36.3% probability KaVontae Turpin: 26.6% probability Projected box score leaders QB passing yards: Cooper Rush , 188 yards Receiving yards: CeeDee Lamb , 70 yards Rushing yards: Rico Dowdle , 53 yards Washington Commanders First touchdown scorer predictions Jayden Daniels: 12.3% probability Brian Robinson: 11.6% probability Terry McLaurin: 9.5% probability Anytime touchdown predictions Jayden Daniels: 49.4% probability Brian Robinson: 46.8% probability Terry McLaurin: 40.3% probability Projected box score leaders QB passing yards: Jayden Daniels , 200 yards Receiving yards: Terry McLaurin , 70 yards Rushing yards: Brian Robinson , 62 yards NFL Week 12: Cowboys vs. Commanders Get ready for Sunday’s action between the Cowboys and Commanders in Week 12 of the NFL season at Northwest Stadium, which is scheduled to start at 1 p.m. EST. We emphasize that all of the NFL best bets and NFL predictions on this page are derived from 10,000 data-driven simulations of the Cowboys vs. Commanders matchup, and they are accurate at the time of publication. They aim to help you make more informed choices when placing bets at online sportsbooks . Please remember to gamble responsibly and seek reliable sources for accurate and up-to-date information when making online betting choices. 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In the early hours of today, the moment that millions of users around the world had been eagerly awaiting finally arrived - the much-anticipated release went live! However, as excitement reached a fever pitch and users rushed to access the new platform, servers quickly became overwhelmed and struggled to keep up with the unprecedented influx of traffic.In a rapidly evolving digital landscape, Balachandar Ramalingam's leadership in implementing an AI-driven 3D Data Classification and Standardization System marks a groundbreaking achievement in component management for global product lines. In this interview, we discuss the challenges, innovations, and significant impact of this project, which has redefined intelligent manufacturing processes. Could you start by telling us what motivated you to pursue this AI-based transformation in component management? Certainly! The motivation stemmed from the complexities of managing increasingly diverse product portfolios. As operations expanded globally, legacy systems struggled to keep pace with the demand for accurate component identification. This led to inefficiencies, higher inventory costs, and longer procurement cycles. We needed a solution that could automate and standardize the way we classified and managed components, and AI was the perfect fit for this challenge. What was the core idea behind the AI-based system you developed? The core idea was to build an intelligent, shape-based component classification system powered by AI. We focused on creating a centralized repository of standardized component data, accessible across all our global operations. The AI model we developed could automatically identify, classify, and match components based on their shapes, ensuring consistency and reducing redundancies. This system also made it easier for teams to quickly find and reuse components across different product lines, which was a game-changer for us. How did the collaboration with cross-functional teams play a role in the success of this project? Collaboration was crucial. We worked closely with data scientists, design engineers, supply chain teams, and manufacturing experts. Each team brought unique insights into the classification process and its challenges. This cross-functional collaboration helped refine the AI model and ensure its successful implementation across various regions. Having a unified approach allowed us to address complex problems more effectively and align our efforts with the global strategy. What were the measurable outcomes of this initiative? The impact was substantial. We achieved a 20% reduction in inventory costs through improved component identification and reuse. Our supply chain efficiency also increased by 18%, thanks to better component standardization and streamlined procurement processes. Most importantly, overall profitability improved by 10%, which highlights the broader operational benefits of the system. The project didn’t just save costs – it also optimized our resources and accelerated product development cycles. How did this project improve time-to-market and resource utilization? By reducing procurement lead times and enabling teams to reuse components more efficiently, we could get products to market much faster. The AI system also helped identify underutilized components across product lines, improving resource allocation. This meant that manufacturing teams could focus on innovation instead of spending excessive time sourcing and managing new parts. What were some key insights you gained from this transformation process? One key insight was the importance of having high-quality training data for machine learning models. The accuracy of the system depended heavily on the data we fed it. Another important lesson was the need for continuous improvement – the AI model had to be constantly refined based on real-world feedback. We also learned that proper integration and alignment across teams were essential for successful system adoption. Looking ahead, what does the future hold for AI in manufacturing? This project has set a strong foundation for future AI applications in manufacturing. The success we’ve seen with component classification can be extended to other areas like predictive maintenance and supply chain optimization. I believe AI will continue to revolutionize manufacturing by improving efficiency, reducing costs, and driving innovation. Finally, how has this project impacted your career? This project has been a significant milestone in my career. It not only deepened my expertise in AI but also gave me invaluable experience in leading large-scale systems deployment. The success of this initiative has positioned me as an innovator in manufacturing technology, and I’m excited to continue exploring new ways AI can enhance industrial processes.

Transperson makes history by being appointed as guest lecturer in Karnataka varsityUS President-elect Donald Trump has threatened to demand control of the Panama Canal be returned to Washington, complaining of "unfair" treatment of American ships and hinting at China's growing influence. Here are five things to know about the waterway connecting the Pacific and Atlantic oceans. The 80-kilometer (50-mile) interoceanic waterway is operated by the Panama Canal Authority, an autonomous public entity. The Central American nation's constitution describes the canal as an "inalienable heritage of the Panamanian nation" that is open to vessels "of all nations." The United States is its main user, accounting for 74 percent of cargo, followed by China with 21 percent. Panama's government sets the price of tolls based on canal needs and international demand. Rates depends on a vessel's cargo capacity. "The canal has no direct or indirect control from China, nor the European Union, nor the United States or any other power," Panama's President Jose Raul Mulino said Sunday as he dismissed Trump's threat. All vessels, including warships and submarines, are given a Panama Canal pilot. Panama's independence from Colombia in 1903 is linked to the canal. Following the failure of French count Ferdinand de Lesseps to open a channel through the isthmus, the United States promoted the separation of the province of Panama and signed a treaty with the nascent country that ceded land and water in perpetuity to build it. After 10 years of construction and an investment of $380 million, the canal was inaugurated on August 15, 1914 with the transit of the steamer Ancon. Some 25,000 deaths from disease and accidents were recorded during its construction. The canal "is part of our history" and "an irreversible achievement," Mulino said. Washington's establishment of a "Canal Zone" -- an enclave with its own military bases, police and justice system -- gave rise to decades of demands by Panamanians to reunify the country and take control of the waterway. In 1977, Panamanian nationalist leader Omar Torrijos and US president Jimmy Carter signed treaties that allowed the canal to be transferred to Panama on December 31, 1999. "Any attempt to reverse this historic achievement not only dishonors our struggle, but is also an insult to the memory of those who made it possible," former president Martin Torrijos, the general's son, wrote on social media. Under the treaties, supported by more than 40 countries, the canal is deemed neutral and any ship can pass through. The only conditions are that ships must comply with safety regulations and military vessels from countries at war must not pass through at the same time. Unlike Egypt's Suez Canal, the Panama Canal operates using freshwater stored in two reservoirs. A drought led to a reduction in the number of transits in 2023, but the situation has since normalized. The canal, which has a system of locks to raise and lower vessels, transformed global shipping. Crafts can travel between the two oceans in about eight hours without having to sail all the way around Cape Horn, the southern tip of the Americas. The canal allows a ship to shave 20,300 kilometers off a journey from New York to San Francisco. Five percent of world maritime trade passes through the canal, which connects more than 1,900 ports in 170 countries. By the early 21st century, it had become too small, so it was expanded between 2009 and 2016. Today, the canal can accommodate ships up to 366 meters long and 49 meters wide (1,200 feet by 161 feet) -- equivalent to almost four football pitches. It generates six percent of Panama's national economic output and since 2000 has pumped more than $28 billion into state coffers. More than 11,200 ships transited the canal in the last fiscal year carrying 423 million tons of cargo. jjr/fj/dr/mlm

AC Milan's journey in the Champions League this season has been nothing short of thrilling. With each match, the Rossoneri have captivated fans and critics alike with their tenacity, skill, and unwavering determination to succeed on the European stage. However, as the team gears up for its upcoming fixture, an unexpected change in the lineup has sent shockwaves through the football world: Federico Chiesa is set to replace the injured Nicolo Barella, taking on the daunting task of filling the shoes of the talented Hakan Calhanoglu.An interview with an accountant - Coralie Spencer Simon Langton Girls school

As the city mourns the loss of one of its most prominent figures, the search for answers continues and the healing process begins. The capture of the suspect brings a sliver of closure to a community reeling from the shock of such a heinous crime, but the scars left by this tragedy will undoubtedly take time to fade. However, in the face of adversity, the resilience and spirit of the community remain steadfast, united in their resolve to overcome and heal from this devastating event.NAPLES, Fla. — Sophia Popov woke up at 6 a.m. Thursday fired up to get to the first tee. She wasn’t nervous about the narrow opening shot at Tiburon Golf Club, however, because this time, she didn’t have to hit it. Popov, 32, instead had on a headset as she went to work as an on-course commentator for the first time for ESPN. The 2020 AIG Women’s British Open champion is part of this week's Featured Groups coverage at the LPGA’s season-ending . She has twice commentated in the booth for other networks during the 2015 and 2024 Solheim Cups. : | “I’ve always thought about this as a career and I really want to do it,” said Popov, "and I think this is definitely where I see my future. But at the same time, I feel like my game has actually kind of come together towards the end of the year. I definitely would like to play another year and then kind of see how the year goes, and ease out of playing and more into broadcast and not make it a hard stop.” Popov gave birth to daughter Maya Mae Mehles in June 2023 and returned to the tour in March. Will Haskett and Amanda Blumenherst are in the studio for this week’s Featured Groups coverage while Chantel McCabe joins Popov on the course.

Now, the stage is set for a thrilling encounter between these two football juggernauts. Real Madrid, with their rich history and experience in the Champions League, will look to assert their dominance and continue their quest for European glory. Led by a seasoned coach and boasting a roster of world-class talent, Real Madrid will be a tough nut to crack for any team that stands in their way.However, despite their strong start to the season, Inter will need to be wary of the threat posed by Lazio. Managed by Simone Inzaghi, Lazio are a team that has been on the rise in recent years and have the quality to compete with the best teams in Italy. With players like Ciro Immobile, Luis Alberto, and Sergej Milinkovic-Savic leading the charge, Lazio are currently in the top four of the Serie A table and have shown that they are capable of beating any team on their day.

Army's 10ID mum on PH's political issuePittsburgh quarterback Eli Holstein was carted off the field with 5:32 left in the first quarter with an apparent left ankle injury during Saturday's Atlantic Coast Conference game against host Louisville. The freshman was sacked at the Panthers' 49-yard line by Louisville's Ashton Gillotte, who rolled on the quarterback's ankle. Holstein was in a walking boot as he was helped to the cart. Holstein missed last week's game against Clemson after suffering a head injury in the loss to Virginia two weeks ago. Holstein was 3-for-5 passing for 51 yards and an interception before exiting. Nate Yarnell, who threw for 350 yards in the loss to Clemson, replaced Holstein. --Field Level Media

The "Prosecutor's Open Class" series, featuring real-life prosecutors discussing legal concepts and cases in an accessible and engaging manner, has garnered widespread attention for its informative content and impactful storytelling. By addressing topics relevant to minors, such as juvenile delinquency, cyberbullying, and child protection laws, the series aims to raise awareness and promote understanding of the legal system among young viewers. Through these educational videos, minors are equipped with the necessary tools to navigate legal challenges and protect their rights effectively.

Furthermore, Huawei's commitment to environmental sustainability has had a positive impact on the islands of Zhoushan. The company has introduced energy-efficient solutions, such as solar panels and smart grids, to reduce carbon emissions and promote a greener environment. By harnessing renewable energy sources and promoting eco-friendly practices, Huawei is not only building a more sustainable future for the archipelago but is also setting an example for other regions to follow.Inside the bitter fight to become Donald Trump’s Treasury secretary