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NEW YORK, Dec. 07, 2024 (GLOBE NEWSWIRE) -- Y-mAbs Therapeutics, Inc. (the "Company" or "Y-mAbs") YMAB , a commercial-stage biopharmaceutical company focused on the development and commercialization of novel radioimmunotherapy and antibody-based therapeutic products for the treatment of cancer, today announced the presentation of CD38-SADA in Non-Hodgkin Lymphoma (NHL) preclinical data and trial in progress posters at the 66 th American Society of Hematology (ASH) Annual Meeting & Exposition being held on December 7 –10, 2024, in San Diego, California. A poster titled " CD38-SADA, a S elf- A ssembling and D is- A ssembling Bispecific Fusion Protein for Two-Step Pretargeted Radioimmunotherapy of Non-Hodgkin Lymphoma " characterizes the selective binding of CD38-SADA to DOTA-chelated lanthanide metals and high-avidity binding to CD38, a tumor specific antigen overexpressed across a range of lymphoma cells. Data from this poster demonstrate anti-tumor efficacy of CD38-SADA when used with Lutetium 177 (Lu 177 )-DOTA in a two-step approach to pre-targeted radioimmunotherapy ("PRIT"). Tumor responses in a xenograft mouse model were rapid and dose-dependent, further supporting the clinical development of CD38-SADA PRIT in patients with CD38-positive lymphoid malignancies. "This preclinical analysis provides important insights into the unique pharmacology of CD38-SADA and its therapeutic potential for NHL," said Brian H. Santich, Ph.D., the lead author and co-inventor of the SADA PRIT technology platform. "The anti-tumor efficacy positively correlated with increasing doses of Lu 177 -DOTA and CD38-SADA, which informed the study design and initial dosing regimen of our Trial 1201 in patients with NHL." In addition, Y-mAbs presents a trial-in-progress poster from its ongoing Phase 1 (Trial 1201) clinical study evaluating the safety and tolerability of CD38-SADA PRIT with Lu 177 -DOTA in adults with relapsed or refractory NHL. Trial 1201 is a first-in-human, dose-escalation, open-label, multicenter study composed of two parts. Part A includes dose escalation of the CD38-SADA bispecific fusion protein to define the optimal safe dose of the CD38-SADA protein, the administration interval between CD38-SADA and Lu 177 -DOTA, and the Lu 177 -DOTA dose for tumor imaging. In Part B, dose escalation of Lu 177 -DOTA will establish the optimal therapeutic dose of the radioactive payload. For each part, the escalation is based on a 3+3 trial design of 4 planned dose levels. "We are pleased to share the details of this Phase 1 clinical trial, which is investigating a potentially transformative approach to pre-targeted radioimmunotherapy for patients with relapsed and refractory NHL," said Vignesh Rajah, MBBS, DCH, MRCP (UK), Chief Medical Officer. "This is our second clinical program evaluating the SADA PRIT technology platform and our first in hematological malignancies." The abstract details are below: Abstract Title: " CD38-SADA, a Self-Assembling and Dis-Assembling Bispecific Fusion Protein for Two-Step Pretargeted Radioimmunotherapy of Non-Hodgkin Lymphoma" Format : Poster Presentation, ID: 1599 Date and Time: Saturday, December 7, 2024, 5:30 PM-7:30 PM Abstract Title: " CD38-SADA Pretargeted Radioimmunotherapy (PRIT) with Lutetium 177 (Lu177)-DOTA in Adult Patients with Relapsed or Refractory Non-Hodgkin Lymphoma: A First-in-Human Phase 1 Trial" Format : Poster Presentation, ID: 4434.1 Date and Time: Monday, December 9, 2024, 6:00 PM-8:00 PM Researchers at Memorial Sloan Kettering Cancer Center (MSK), including Dr. Nai-Kong Cheung, developed the SADA technology for radioimmunotherapy, which is exclusively licensed by MSK to Y-mAbs. Dr. Cheung has intellectual property rights and interests in the technology, and as a result of this licensing arrangement, MSK has institutional financial interests in the technology. About Y-mAbs Y-mAbs is a commercial-stage biopharmaceutical company focused on the development and commercialization of novel, radioimmunotherapy and antibody-based therapeutic cancer products. The Company's technologies include its investigational Self-Assembly DisAssembly ("SADA") Pretargeted Radioimmunotherapy Platform ("PRIT") and bispecific antibodies generated using the Y-BiClone platform. The Company's broad and advanced product pipeline includes the anti-GD2 therapy DANYELZA® (naxitamab-gqgk), the first FDA-approved treatment for patients with relapsed or refractory high-risk neuroblastoma in the bone or bone marrow after a partial response, minor response, or stable disease to prior therapy. About CD38-SADA PRIT CD38-SADA is a bispecific fusion protein that tightly binds to the CD38 antigen and to select radionuclides chelated to tetraxetan (or "DOTA"). CD38-SADA contains a p53-derived domain that drives the self-assembly of CD38-SADA tetramers, which possess four distinct binding sites for CD38. In the first step of pre-targeted radiotherapy, non-radiolabeled-CD38-SADA tetramers are infused and bind with high avidity to CD38-positive tumors, while unbound CD38-SADA disassembles into low molecular weight monomers that are removed by the kidney. The second infusion delivers the "radioactive payload," which binds to the CD38-SADA on tumor cells for localized irradiation. CD38-SADA PRIT with Lutetium 177 (Lu 177)-DOTA is now under clinical investigation in Trial 1201 (NCT05994157). Forward-Looking Statements Statements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such statements include, but are not limited to, statements about our business model, including financial outlook for 2024 and beyond, including estimated operating expenses, use of cash and cash equivalents and DANYELZA product revenue and sufficiency of cash resources and related assumptions; expectations with respect to the Company's future financial performance; implied and express statements regarding the future of the Company's business, including with respect to expansion and its goals; expectations with respect to the Company's plans and strategies, development, regulatory, commercialization and product distribution plans, including the timing thereof; expectations with respect to the Company's products and product candidates, including potential territory and label expansion of DANYELZA and the potential market opportunity related thereto and potential benefits thereof, and the potential of the SADA PRIT technology and potential benefits and applications thereof; expectations relating to key anticipated development milestones, including potential expansion and advancement of commercialization and development efforts, including potential indications, applications and geographies, and the timing thereof; expectations with respect to current and future clinical and pre-clinical studies and the Company's research and development programs, including with respect to timing and results; expectations regarding collaborations or strategic partnerships and the potential benefits thereof; and other statements that are not historical facts. Words such as ‘‘anticipate,'' ‘‘believe,'' "contemplate," ‘‘continue,'' ‘‘could,'' ‘‘estimate,'' ‘‘expect,'' "hope," ‘‘intend,'' ‘‘may,'' ‘‘might,'' ‘‘plan,'' ‘‘potential,'' ‘‘predict,'' ‘‘project,'' ‘‘should,'' ‘‘target,'' "will," ‘‘would',' "guidance," "goal," "objective," and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Our product candidates and related technologies are novel approaches to cancer treatment that present significant challenges. Actual results may differ materially from those indicated by such forward-looking statements as a result of various factors, including but not limited to: risks associated with the Company's financial condition and need for additional capital; the risks that actual results of the Company's restructuring plan and revised business plan will not be as expected; risks associated with the Company's development work; cost and success of the Company's product development activities and clinical trials; the risks of delay in the timing of the Company's or its partners' regulatory submissions or failure to receive approval of its drug candidates; the risks related to commercializing any approved pharmaceutical product including the rate and degree of market acceptance of product candidates; development of sales and marketing capabilities and risks associated with failure to obtain sufficient reimbursement for products; risks related to the Company's dependence on third parties including for conduct of clinical testing and product manufacture as well as regulatory submissions; the Company's ability to enter into new partnerships or to recognize the anticipated benefits from its existing partnerships; risks related to government regulation; risks related to market approval, risks associated with protection of the Company's intellectual property rights; risks related to employee matters and managing growth; risks related to the Company's common stock, risks associated with macroeconomic conditions, including the conflict between Russia and Ukraine and sanctions related thereto, the state of war between Israel and Hamas and the related risk of a larger regional conflict, inflation, increased interest rates, uncertain global credit and capital markets and disruptions in banking systems; and other risks and uncertainties affecting the Company including those described in the "Risk Factors" section included in the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2023, and the Company's Quarterly Report on Form 10-Q for the quarterly periods ended March 31, 2024, and September 30, 2024, and future filings and reports by the Company. Any forward-looking statements contained in this press release speak only as of the date hereof, and the Company undertakes no obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise. SADA®, SADA PRIT®, DANYELZA® and Y-mAbs® are registered trademarks of Y-mAbs Therapeutics, Inc. Investor Contact: Courtney Dugan VP, Head of Investor Relations cdu@ymabs.com © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.The documentary covers a $4.5 billion crypto heist A couple who stole millions of dollars in cryptocurrency are the subject of a new Netflix documentary, Biggest Heist Ever . The film covers the theft of $72 million worth of bitcoin from a virtual cryptocurrency exchange in 2016, which had a damaging effect on the entire crypto ecosystem. Over the next five years following the incident, the amount stolen grew in value to $4.5 billion. READ MORE: The 20 best films of 2024 Beyond the crime itself, Biggest Heist Ever mostly dives into the married couple responsible. Ilya Lichtenstein and Heather Morgan were nicknamed Bitcoin Bonnie and Clyde, and chased fame as well as fortune through the latter’s online rap persona Razzlekhan. Biggest Heist Ever was released on Netflix on December 6, 2024. What happened to Ilya Lichtenstein and Heather Morgan? Heather Morgan is also an influencer CREDIT: Olivier Douliery/ AFP As documented in the film, Ilya Lichtenstein and Heather Morgan were both arrested in February 2022. Lichtenstein, who has been in prison since his arrest, was sentenced to five years in prison on November 15, 2024 after pleading guilty to hacking Bitfinex’s network and conspiracy to commit money laundering. At the time of his sentencing, Lichtenstein said: “I want to take full responsibility for my actions and make amends any way I can.” Morgan, who wasn’t involved in the actual hack but pleaded guilty to one count of conspiracy to commit money laundering, was sentenced to 18 months in prison. Is there more to the story? As shown at the end of the documentary, Lichtenstein sent a statement to the film’s director Chris Smith in May 2022, suggesting there is another dynamic at play. “Chris, thank you for your kind note,” the statement read. “As you mentioned, I am unable to discuss the case at this time. I look forward to sharing my perspective when the time is right. As your instincts probably tell you, there is more to this story than meets the eye. Best of luck with your film.” Following her sentencing, Morgan, who declined to appear in Biggest Heist Ever , declared she would “soon be telling my story” across her social media channels. In a video on TikTok , she said: “It’s over, and I’m very excited that I will soon be telling my story, sharing my thoughts, and telling you more about the creative and other endeavours I’ve been working.” Related Topics Netflix99 bet ph

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The health ministry in Hamas-run Gaza said Friday hospitals have only two days' fuel left before they must restrict services, after the UN warned aid delivery to the war-devastated territory is being crippled. The warning came a day after the International Criminal Court issued arrest warrants for Israeli Prime Minister Benjamin Netanyahu and former defence minister Yoav Gallant more than a year into the Gaza war. The United Nations and others have repeatedly decried humanitarian conditions, particularly in northern Gaza where Israel said Friday it had killed two commanders involved in Hamas's October 7, 2023 attack that triggered the war. Gaza medics said an overnight Israeli raid on Beit Lahia and nearby Jabalia resulted in dozens killed or missing. Marwan al-Hams, director of Gaza's field hospitals, told reporters all hospitals in the Palestinian territory "will stop working or reduce their services within 48 hours due to the occupation's (Israel's) obstruction of fuel entry". World Health Organization chief Tedros Adhanom Ghebreyesus said he was "deeply concerned about the safety and well-being of 80 patients, including 8 in the intensive care unit" at Kamal Adwan hospital, one of just two partly operating in northern Gaza. Kamal Adwan director Hossam Abu Safia told AFP it was "deliberately hit by Israeli shelling for the second day" Friday and that "one doctor and some patients were injured". Late Thursday, the UN's humanitarian coordinator for the Palestinian territories, Muhannad Hadi, said: "The delivery of critical aid across Gaza, including food, water, fuel and medical supplies, is grinding to a halt." He said that for more than six weeks Israeli authorities "have been banning commercial imports" while "a surge in armed looting" has hit aid convoys. Vowing to stop Hamas from regrouping, Israel on October 6 began an air and ground operation in Jabalia and then expanded it to Beit Lahia. Gaza's health ministry says the operation has killed thousands. The UN says more than 100,000 have been displaced from the area, and an official told the Security Council last week that people "are effectively starving". Issuing the warrants for Netanyahu and Gallant, the Hague-based ICC said there were "reasonable grounds" to believe they bore "criminal responsibility" for the war crime of starvation as a method of warfare, and crimes against humanity including over "the lack of food, water, electricity and fuel, and specific medical supplies". A furious Netanyahu said: "Israel rejects with disgust the absurd and false actions and accusations made against it." He said the judges were "driven by anti-Semitic hatred of Israel". On Friday, he thanked his Hungarian counterpart Viktor Orban for inviting him to visit in defiance of the ICC warrant, which Orban branded "political". Hungary currently holds the rotating EU presidency. US President Joe Biden, whose country is Israel's top military supplier, called the warrants against Israeli leaders "outrageous", but other world leaders supported the court. Irish Prime Minister Simon Harris said Netanyahu would be arrested if he set foot in the country. Biden and French President Emmanuel Macron on Friday discussed efforts towards a ceasefire in Lebanon, the White House said. The ICC also issued a warrant for Hamas military chief Mohammed Deif, saying it had grounds to suspect him of war crimes and crimes against humanity over the attacks on Israel that sparked the war, and including "sexual and gender-based violence" against hostages. Israel said it killed Deif in July, but Hamas has not confirmed his death. On Thursday, a UN representative said an Israeli raid on Palmyra in Syria this week was "likely the deadliest" by Israel on the country so far. On Friday, a war monitor said the strikes killed 92 pro-Iran fighters. Israel again bombed Gaza on Friday. In Gaza City, just south of Jabalia, one man who said he took his cousins to hospital after a strike urged "the world... to put an end" to the war. Belal, who gave only his first name, said 10 members of his family had been killed. At least 44,056 people have been killed in Gaza during more than 13 months of war, most of them civilians, according to figures from Gaza's health ministry which the United Nations considers reliable. Hamas triggered the war with the deadliest attack in Israeli history, which resulted in the deaths of 1,206 people, mostly civilians, according to an AFP tally of Israeli official figures. The war expanded to Lebanon in late September when Israel escalated air strikes against Iran-backed Hezbollah and later sent ground troops into southern Lebanon, after nearly a year of tit-for-tat cross-border exchanges which Hezbollah said were in support of Hamas. Lebanon says more than 3,580 people have been killed in the country, most of them since late September. A strike on Baalbek in the east killed the director of Dar al-Amal university hospital and six colleagues, the health ministry said late Friday. Israeli strikes again targeted Hezbollah's south Beirut stronghold and south Lebanon, the official National News Agency said. UN peacekeepers in south Lebanon have reported being fired on numerous times, blaming both Israel and "non-state" actors. On Friday, Rome said Hezbollah was probably behind rocket fire that lightly wounded four Italian peacekeepers. bur-ami/srm/kirTOLEDO, Ohio (AP) — Sam Lewis' 18 points helped Toledo defeat Defiance 111-49 on Saturday. Lewis also had five rebounds for the Rockets (6-3). Javan Simmons scored 16 points while shooting 8 of 9 from the field and 0 for 3 from the line and added eight rebounds. Sonny Wilson finished 7 of 10 from the field to finish with 16 points. Jalen Brown finished with 12 points for the Yellow Jackets. Connor Bush added eight points for Defiance. Donovan Stone finished with eight points. Toledo took the lead with 19:42 remaining in the first half and did not relinquish it. The score was 55-23 at halftime, with Simmons racking up 14 points. Toledo extended its lead to 90-34 during the second half, fueled by a 16-3 scoring run. Grgur Brcic scored a team-high 10 points in the second half as their team closed out the win. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .

Canada is already examining tariffs on certain US items following Trump’s tariff threatA winter travel advisory has been issued by Environment Canada for Ottawa. The advisory was issued Saturday morning and will be in effect starting this afternoon and tonight. A local amount of snow amounting to 10 to 15 centimetres is expected for the capital this Saturday, as “an Alberta Clipper will bring snow across the area which could make for hazardous travel conditions,” says the weather agency in the advisory. "Snow will progress southeastward through the afternoon before tapering off from west to east late tonight or Sunday morning," reads the advisory. "Motorists should expect hazardous winter driving conditions and adjust travel plans accordingly." Weather forecast Environment Canada calls for a high of -5 C, which feels like minus 12 with windchill this morning and -7 this afternoon. Tonight, the weather agency calls for a low of -6 C and periods of snow beginning early this evening, 10 to 15 cm of snow. Sunday, a high of 3 C, and periods of snow ending late in the morning then mainly cloudy skies are expected. A low of - 5 C, and cloudy periods with a 30 per cent chance of flurries are anticipated for the night. The snow will continue through Monday. The weather agency says a low of -2 C and a 40 per cent chance are forecasted for Monday. A low of -2 C and periods of snow or freezing rain are forecasted for the night. Ottawa saw 12 cm of snow already this week. Shopping Trends The Shopping Trends team is independent of the journalists at CTV News. We may earn a commission when you use our links to shop. Read about us. Editor's Picks Our Guide To The Most Giftable Toys In 2024 17 Sweet Treats And Snacks That Make Great Stocking Stuffers The Best Gift Ideas From Canadian Brands For Everyone On Your List Home Our Guide To The Best Sectional Sofas You Can Get In Canada Our Guide To The Best Electric Snow Shovels In Canada In 2024 (And Where To Get Them) Our Guide To The Best Hydroponic Gardens In Canada In 2024 (And Where To Get Them) Gifts 20 Of The Best Gifts Worth Splurging On In 2024 Mary Berg's Favourite Kitchen Products To Gift This Holiday Season The Best Gifts to Give Your Dad in 2024 Beauty Our Guide To The Best Self Tanners You Can Get In Canada 20 Anti-Aging Skincare Products That Reviewers Can’t Stop Talking About 12 Budget-Friendly Makeup Brushes And Tools Worth Adding To Your Kit Deals Black Friday May Be Over, But You Can Still Take Advantage Of These Amazing Sales On Amazon Canada It's Officially Travel Tuesday: Here Are The Best Deals On Flights, Hotels, And Vacations The Waterpik Advanced Water Flosser Will Make Cleaning Your Teeth So Much Easier — And It's 40% Off For Cyber Monday Ottawa Top Stories WINTER TRAVEL ADVISORY | Winter travel advisory issued for Ottawa this Saturday OC Transpo to open Trillium Line in three stages starting Jan. 6 'The Gingerbread Man' in Manotick reopens 2 years after devastating fire Vigils held in eastern Ontario to mark 35 years since Montreal massacre Ottawa police seeking suspect in Mooney's Bay area shooting CHEO, Shriners Hospitals launch first-of-its-kind fellowship Ski season begins at Camp Fortune Christmas Cheer Breakfast raises $150K for Ottawa families CTVNews.ca Top Stories 'Shameful': Monument honouring fallen soldiers included names of living veterans Veterans are asking for answers after discovering that two sculptures in Ontario honouring fallen soldiers include the names of many people who are very much alive. 'If it ain't broke don't fix it': U.S. ambassador warns Canada against cutting Mexico out of trilateral trade deal Cutting Mexico out of the current North American free trade deal 'may not be the best path to take,' says U.S. Ambassador to Canada David Cohen. South Korean President Yoon's impeachment vote fails after ruling party boycotts it A South Korean legislative push to impeach President Yoon Suk Yeol over his short-lived imposition of martial law fell through on Saturday after most lawmakers from his conservative governing party boycotted the vote. Days after gunman killed UnitedHealthcare's CEO, police push to ID him and FBI offers reward The gunman who killed the CEO of the largest U.S. health insurer likely left New York City on a bus soon after the brazen ambush that has shaken corporate America, police officials said. But he left something behind: a backpack that was discovered in Central Park. Canada's air force took video of object shot down over Yukon, updated image released The Canadian military has released more details and an updated image of the unidentified object shot down over Canada's Yukon territory in February 2023. Cookie inflation: How much more is your holiday baking costing you this year? Estimate how much more your Christmas cookies will cost to bake this year compared to the past five years using Statistics Canada's monthly average retail price data. LGBTQ2S+ refugees languish as Kenyan government blocks Canadians from resettling them In a low-income neighbourhood on the outskirts of Nairobi, seven people gather in an air-conditioned home around a dinner table for a Ugandan stew of matoke bananas with peanut sauce. An explosion has caused several injuries and damaged apartments in a Dutch city An explosion and fire rocked a neighborhood in the Dutch city of The Hague early Saturday, destroying several apartments and injuring multiple people, according to authorities. Smash and grab: Canada sees a spike in jewelry store robberies Many cities across Canada are seeing a spike in jewelry store robberies in recent months. Atlantic Maritime weekend weather: Cold start and snowy finish Colder temperatures lie ahead for the weekend in the Maritimes with another swipe of snow and rain expected Sunday. Sister of man found dead in Kentville, N.S., speaks out The sister of a 52-year-old man found dead in a tent in Kentville, N.S., on Wednesday is speaking out on her loss. WATCH LIVE | 61st annual Christmas Daddies Telethon airs Saturday on CTV A beloved yearly tradition, the Christmas Daddies Telethon airs from 11 a.m. to 6 p.m. on Saturday, Dec. 7, on CTV. Toronto One out of 10 Canadians had packages stolen in the past year: survey One out of 10 Canadians say they have had at least one package stolen in the last year, according to a survey. Three people taken to hospital after triple shooting in downtown Toronto Toronto Police are on the scene of shooting that has sent three people to the hospital in the early hours of Saturday morning. 'They’re definitely worried:' Jewelry store robberies are on the rise in the GTHA The GTHA has seen a spike in the number of jewelry store robberies in recent months with the Toronto Police Service reporting nearly double the number of incidents this year over last. Montreal 'Duty to learn': Vigils mark 35th anniversary of Polytechnique anti-feminist killings Braving a biting winter wind, dignitaries gathered in front of Polytechnique Montréal's main campus on Friday to pay tribute to the 14 women killed at the Montreal institution in an anti-feminist attack 35 years ago. Quebec premier wants to ban praying in public Premier François Legault took advantage of the last day of the parliamentary session on Friday to announce to 'Islamists' that he will 'fight' for Quebec values and possibly use the notwithstanding clause to ban prayer in public places such as parks. Champs Sports Bar to ban dancing, karaoke after noise complaints A dive bar on St-Laurent Boulevard is halting dance and karaoke events after the neighbouring landlord filed a noise complaint, and will build a soundproof wall to resolve the issue. Northern Ontario Seniors at Sudbury apartment building haven’t had a working elevator in almost half a year Residents at Place Nolin in Sudbury haven’t had a working elevator in nearly six months. The senior’s building is a 40-unit, five-level building, run independently by its own board of directors. Northern Ontario man sentenced for killing his dog WARNING: This article contains graphic details of animal abuse which may be upsetting to some readers. A 40-year-old northern Ontario man is avoiding prison after pleading guilty to killing his dog earlier this year. How the combination of diapers and splash pads led to 10K illnesses New research is raising concerns about the safety of splash pads, which can be ground zero for germs and greatly increase the risk of spreading disease. Windsor 'I do think it is extraordinary': Law community expresses concern over notwithstanding clause threat Hundreds of professionals within the law community have expressed concern with the premier’s threat of using the notwithstanding clause to back new legislation promising a crackdown on encampments. Suspects sought after two hardware store break-ins Essex County OPP are investigating two overnight break-ins at hardware stores. Homeless encampment returns to the chagrin of residents Ashley Harrington's problem was solved for a short time, but then a homeless encampment returned behind her property. London Homeless encampments buried in snow, city hall’s response falling short The absence of a Winter Response to Homelessness this year means more Londoners endured this week’s snowstorm in tents and make-shift shelters. Running behind on your shoveling? Now's the time to hop to it. A bit more snow is on the way today – although nothing like the accumulations the region has experienced over the past week. London Knights’ win streak ends, Cowan injured after setting point streak record The London Knights’ 19 game win streak came to an end Friday night after a 5-3 loss to the Oshawa Generals at Canada Life Place. Kitchener Threat that caused school lockdowns in Guelph came from the United States Guelph Police Service is releasing more information about a call that caused two schools to go into lockdown and a third to implement hold-and-secure measures earlier this week. University of Waterloo harnessing the power of alpaca poop The University of Waterloo is trying to create an unusual type of compost. Legal experts concerned about promised encampment legislation Legal experts are raising concerns about human rights violations as the provincial government promises more powers to deal with growing encampments across the province. Barrie Driver charged after passing snow plow in front of oncoming OPP vehicle A driver was pulled over and charged after passing a snow plow in front of an oncoming OPP vehicle. Multi-vehicle crash on Highway 400 snarled traffic A three-vehicle crash on Highway 400 snarled Friday afternoon traffic. Man arrested after 16-hour standoff with Barrie police seeks to be released from custody The 43-year-old man taken to hospital in distress following a 16-hour armed standoff with Barrie police last month is seeking bail. Winnipeg Major Manitoba fossil milestones highlight the potential for future discoveries in the province A trio of fossil finds through the years helped put Manitoba on the mosasaur map, and the milestone of those finds have all been marked in 2024. Cops and taxes could be highlights of the next Winnipeg budget Higher property tax hikes and more cops could be coming in next week's city budget. Manitoba premier hints at change of location for supervised drug consumption site The Manitoba government signalled Friday it is open to changing the location of a proposed supervised drug consumption site that had been revealed two days earlier and met with criticism. Calgary Calgarians panicked as Canada Post strike enters fourth week The impacts of the Canada Post strike are ramping up as other shippers pause their pick-ups to clear growing backlogs. Calgary company steps up to help grieving family with free furnace after fatal carbon monoxide poisoning A Calgary furnace company stepped up big time Friday to help a Calgary family grieving the loss of a loved one. Calgary's Seraphina Ellen takes Taylor Swift tribute to Vancouver to mark Eras Tour arrival Seraphina Ellen, a third-year finance student at the University of Calgary, received attention online for performing Taylor Swift covers at university open mics. Edmonton Security guard killed at Edmonton apartment building Homicide detectives are investigating the death of a security guard in central Edmonton on Friday morning. 'Focus on bad guys': Albertans react to expansion of federal gun ban A local gun store owner says the new federal gun ban has left the industry shell-shocked. Markets, spirit of giving and hockey: What a weekend in Edmonton It's the first weekend in December and that means there will be plenty of holiday events for all to enjoy. Regina Bernadette McIntyre named Saskatchewan's 24th Lieutenant Governor Saskatchewan’s 24th Lieutenant Governor will be Bernadette McIntyre after being appointed to the position by Prime Minister Justin Trudeau on Friday. Roses handed out in commemoration of polytechnic massacre Members of the YWCA handed out roses at the University of Regina to bring awareness to violence against women. Sask. father who kept daughter from mom to prevent COVID-19 vaccine free from additional prison time Michael Gordon Jackson, the Saskatchewan father who withheld his then seven-year-old daughter from her mom for nearly 100 days to prevent the girl from getting a COVID-19 vaccine, was handed a 12-month prison sentence and 200 days probation on Friday, but credited with time served. Saskatoon 'You're not alone': Saskatoon woman turns the page on years of domestic violence For one Saskatoon woman, Dec. 6 was not just the national day of action on violence against women — it was the day her abusive ex-husband was sentenced for his years of physical abuse against her. Sask. man involved in Megan Gallagher's murder sentenced to life in prison Robert 'Bobby' Thomas will spend life behind bars, ineligible for parole for 18 years, for his role in Megan Gallagher's murder. Sask. special support classrooms mean segregation for neurodiverse students, critics say The Saskatchewan government is set to expand a pilot program designed to minimize disruptive behaviours in school classrooms, but some are concerned that it will segregate children with disabilities from and harm their development. Vancouver Long time coming: Taylor Swift's Eras Tour arrives at final stop in Vancouver Pop superstar Taylor Swift greeted some 55,000 eager fans in downtown Vancouver Friday with what’s become a familiar opening line. The East Van Cross could be moving to a new location The iconic East Van Cross could be getting a new home, as Vancouver councillors are set to discuss moving the artwork to a more accessible location. More cases of parasite causing deadly whirling disease in fish found in B.C. waters The British Columbia government says it has detected more cases of a parasite that Parks Canada describes as potentially devastating to young trout and salmon. Vancouver Island B.C. ombudsman to investigate delay in sending social assistance cheques amid post strike Thousands of social assistance cheques have not been distributed in British Columbia because of the Canada Post strike, prompting an investigation by provincial ombudsperson Jay Chalke. Long time coming: Taylor Swift's Eras Tour arrives at final stop in Vancouver Pop superstar Taylor Swift greeted some 55,000 eager fans in downtown Vancouver Friday with what’s become a familiar opening line. Four-year-old superhero inspires smiles at B.C. long-term care home While he’s not faster than a speeding bullet, nor more powerful than a locomotive, this four-year-old is proving to be a superhero. Kelowna Study of 2023 Okanagan wildfires recommends limiting development in high-risk areas A study into the devastating wildfires that struck British Columbia's Okanagan region in 2023 has recommended that government and industry limit development in high-fire-risk areas. Kelowna, B.C., to host the Memorial Cup in the spring of 2026 The Western Hockey League's Kelowna Rockets will host the Memorial Cup in the spring of 2026, the Canadian Hockey League said Wednesday. 545 vehicles impounded in 332 days: BC Highway Patrol pleads for drivers to slow down Mounties with the BC Highway Patrol in Kelowna say they've impounded more than 545 vehicles for excessive speed and aggressive driving so far this year. That works out to more than 1.6 per day. Stay Connected

Zelensky insists on a 'just peace' at Trump Paris meetingGanji Chudail comes to life as Neena Gupta stars in a YouTube India comedy video | Watch

NEW YORK (AP) — He's making threats, traveling abroad and negotiating with world leaders. Donald Trump has more than a month and a half to go before he's sworn in for a second term. But the Republican president-elect is already moving aggressively not just to fill his Cabinet and outline policy goals, but to achieve those priorities . Trump has threatened to impose a 25% tariff on goods from Canada and Mexico, prompting emergency calls and a visit from Canada's prime minister that resulted in what Trump claimed were commitments from both U.S. allies on new border security measures. The incoming president has warned there will be “ALL HELL TO PAY" if, before his inauguration on Jan. 20, 2025, Hamas does not release the hostages being held in Gaza . He has threatened to block the purchase of U.S. Steel by a Japanese company, warning "Buyer Beware!!!” And this weekend, Trump was returning to the global stage, joining a host of other foreign leaders for the reopening of the Notre Dame Cathedral five years after it was ravaged by a fire. On Saturday, he met with French President Emmanuel Macron — joined at the last minute by Ukrainian President Volodymyr Zelenskyy — and had plans to see Britain's Prince William also in Paris. Absent in Paris: lame duck President Joe Biden, who has largely disappeared from headlines, except when he issued a pardon of his son , Hunter, who was facing sentencing for gun crimes and tax evasion. First lady Jill Biden is attending in his place. “I think you have seen more happen in the last two weeks than you’ve seen in the last four years. And we’re not even there yet,” Trump said in an over-the-top boast at an awards ceremony Thursday night . For all of Trump's bold talk, though, it is unclear how many of his efforts will bear fruit. The pre-inauguration threats and deal-making are highly unusual, like so much of what Trump does, said Julian Zelizer, a political historian at Princeton University. “Transitions are always a little complicated in this way. Even though we talk about one president at a time," he said, “the reality is one president plus. And that plus can act assertively sometimes." Zelizer said that is particularly true of Trump, who was president previously and already has relationships with many foreign leaders such as Macron, who invited both Trump and Biden to Paris this weekend as part of the Notre Dame celebration. “Right now he’s sort of governing even though he’s not the president yet. He’s having these public meetings with foreign leaders, which aren't simply introductions. He's staking out policy and negotiating things from drug trafficking to tariffs," Zelizer said. Trump already has met with several foreign leaders, in addition to a long list of calls. He hosted Argentinian President Javier Milei in Florida at his Mar-a-Lago club in November. After the tariff threat, Canadian Prime Minister Justin Trudeau made a pilgrimage to Mar-a-Lago for a three-hour dinner meeting. Canadian officials later said the country is ready to make new investments in border security, with plans for more helicopters, drones and law enforcement officers. Last Sunday, Trump dined with Sara Netanyahu, wife of the Israeli prime minister. Incoming Trump aides have also been meeting with their future foreign counterparts. On Wednesday, several members of Trump's team, including incoming national security adviser Mike Waltz, met with Andriy Yermak, a top aide to Zelenskyy, in Washington, as Ukraine tries to win support for its ongoing efforts to defend itself from Russian invasion, according to a person familiar with the meeting. Yermak also met with Trump officials in Florida, he wrote on X . That comes after Trump's incoming Middle East envoy, Steve Witkoff, traveled to Qatar and Israel for high-level talks about a cease-fire and hostage deal in Gaza, according to a U.S familiar with the efforts, meeting with the prime ministers of both countries. There is no prohibition on incoming officials or nominees meeting with foreign officials, and it is common and fine for them to do so — unless those meetings are designed to subvert or otherwise impact current U.S. policy. Trump aides were said to be especially cognizant of potential conflicts given their experience in 2016, when interactions between Trump allies and Russian officials came under scrutiny. That included a phone call in which Trump's incoming national security adviser, Michael Flynn, discussed new sanctions with Russia’s ambassador to the United States, suggesting things would improve after Trump became president. Flynn was later charged with lying to the FBI about the conversation. Trump’s incoming press secretary Karoline Leavitt said that, “All transition officials have followed applicable laws in their interactions with foreign nationals.” She added: “World leaders recognize that President Trump is returning to power and will lead with strength to put the best interests of the United States of America first again. That is why many foreign leaders and officials have reached out to correspond with President Trump and his incoming team.” Such efforts can nonetheless cause complications. If, say, Biden is having productive conversations on a thorny foreign policy issue and Trump weighs in, that could make it harder for Biden “because people are hearing two different voices” that may be in conflict, Zelizer said. Leaders like Russia's Vladimir Putin and Netanyahu may also anticipate a more favorable incoming administration and wait Biden out, hoping for more a better deal. It also remains unclear how extensively the Biden administration has been kept apprised of Trump transition efforts. Although there is no requirement that an incoming administration coordinate calls and meetings with foreign officials with the State Department or National Security Council, that has long been considered standard practice. That is, in part, because transition teams, particularly in their early days and weeks, do not always have the latest information about the state of relations with foreign nations and may not have the resources, including interpretation and logistical ability, to handle such meetings efficiently. Still, the Biden and Trump teams have been talking, particularly on the Middle East, with the incoming and outgoing administrations having agreed to work together on efforts to free hostages who remain in held in Gaza, according to a U.S. official, who, like others, was not authorized to comment publicly about the sensitive talks and spoke on condition of anonymity. That includes conversations between Witkoff and Biden’s foreign policy team as well as Waltz and Biden national security adviser Jake Sullivan. Last month, Biden administration officials said they had kept Trump’s team closely apprised of efforts to broker a ceasefire deal between Israel and Hezbollah on the Israel-Lebanon border. “I just want to be clear to all of our adversaries, they can’t play the incoming Trump administration off of the Biden administration. I’m regularly talking to the Biden people. And so, this is not a moment of opportunity or wedges for them," Waltz said Friday in a Fox Business interview. But when it comes to immigration, Biden administration officials haven’t been entirely in the loop on discussions around how to execute on Trump’s pledge to deport millions of migrants, according to four administration officials with knowledge of the transition who spoke on condition of anonymity. That’s not terribly surprising given how differently the teams view migration. Trump’s team, meanwhile, is already claiming credit for everything from gains in the stock and cryptocurrency markets to a decision by Walmart to roll back diversity, equity and inclusion policies Trump opposes. “Promises Kept — And President Trump Hasn’t Even Been Inaugurated Yet,” read one press release that claimed, in part, that both Canada and Mexico have already pledged "immediate action” to help “stem the flow of illegal immigration, human trafficking, and deadly drugs entering the United States." Mexican President Claudia Sheinbaum has stopped short of saying Trump mischaracterized their call in late November. But she said Friday that Trump “has his own way of communicating, like when we had the phone call and he wrote that we were going to close the border. That was never talked about in the phone call.” Earlier this week, Mexico carried out what it claimed was its largest seizure of fentanyl pills ever. Seizures over the summer had been as little as 50 grams per week, and after the Trump call, they seized more than a ton. Security analyst David Saucedo said that "under the pressure by Donald Trump, it appears President Claudia Sheinbaum’s administration is willing to increase the capture of drug traffickers and drug seizures that Washington is demanding.” Biden, too, tried to take credit for the seizure in a statement Friday night. ___ Associated Press writers Matthew Lee, Aamer Madhani, Colleen Long and Ellen Knickmeyer in Washington and Mark Stevenson in Mexico City contributed to this report.

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