Nick Kern came off the bench for 20 points and 13 rebounds as Penn State remained unbeaten with an 85-66 thumping of Fordham in a semifinal of the Sunshine Slam on Monday in Daytona Beach, Fla. The Nittany Lions (6-0), who will play either San Francisco or Clemson for the tournament title on Tuesday, put four other players in double figures. Zach Hicks scored 16 points, while Puff Johnson added 15. Ace Baldwin and Yanic Konan Niederhauser each chipped in 12 points. Penn State sank nearly 53 percent of its field goal attempts and earned a 38-30 advantage on the boards, more than enough to offset missing 12 of its 32 foul shots. Four players reached double figures for the Rams (3-4), led by 15 points apiece from Jackie Johnson III and reserve Joshua Rivera. Romad Dean and Jahmere Tripp each added 13. Fordham was as close as 56-49 after Tripp made a layup with 14:25 left in the game. But the Nittany Lions responded with a 16-1 run, capped with a layup by Kern for a 22-point lead at the 9:33 mark, and they never looked back. The main storyline prior to tipoff was whether Penn State could continue its torrid early start that saw it come into the day leading Division I in steals and ranked second in scoring at 98.2 points per game. The Nittany Lions certainly played to their billing for most of the first half, establishing a 21-8 lead at the 10:08 mark via Hicks' three-point play. Fordham predictably struggled early with the pressure defense, committing four turnovers in the first four minutes. But the Rams got their bearings over the last 10 minutes and made some shots. They got as close as four on two occasions late in the half before Penn State pushed the lead to 42-34 at the half. The officials were busy in the half, calling 23 fouls and administering 27 free throws. --Field Level Media
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Awareness session on education system held Rawalpindi:An awareness session was held here on Tuesday at Women University Rawalpindi, Sixth Road, under the auspices of the Board of Intermediate and Secondary Education (BISE) and Punjab's Cantab Publishers, regarding the transition of exams in Punjab to a conceptual examination model. Punjab Education Minister Rana Sikander Hayat graced the event as the chief guest. The session was attended by Chairman BISE Rawalpindi Muhammad Adnan, Chairman Lahore Board Mian Zahid, Chairman HEC Dr. Mukhtar Ahmed, Secretary Higher Education Dr. Farrukh Naveed, Vice-Chancellor Women University Rawalpindi, CEO Education Rawalpindi Amanullah Khan, Controller of Examinations Rawalpindi Board Tanveer Asghar, Professor Shazia Naeem, Dr. Naeem, vice-chancellors of other universities and, teachers, and a large number of distinguished guests. Dr. Mukhtar Ahmed emphasised the importance of proper education and training for students to guide them in the right direction. Professor Shazia Naeem stated that Pakistani children are not lacking in talent; however, instead of turning them into rote learners, we need to equip them to face new technologies through conceptual learning. Dr. Naeem highlighted that there is no shortage of opportunities in Pakistan. While governments create policies, their implementation often lags behind. He stressed the vital role of teachers, as they bear the significant responsibility of educating and training students. Without proper training for teachers, students cannot be guided effectively. He further added that the education system needs to transition matriculation to O-level and intermediate to A-level standards, emphasising the need for changes in examinations. Teachers are tasked with shaping the nation, and the curriculum is the core of any institution. Dr. Naeem stated that we need children equipped with modern technology and able to benefit from it. The current education system must change, as it does not prepare children for self-reliance. This is the era of computers, where robots have started to take over many tasks. He also referenced Lord Macaulay's examination methods, where questions were based on critical thinking, contrasting them with the lack of such practices in current education. Despite having a comprehensive National Education Policy, implementation is hindered by the monopoly of the textbook board. Punjab Chief Minister Maryam Nawaz and Education Minister Sikander Hayat are seriously working on introducing conceptual exams for students and have established a task force for this purpose. Conceptual learning, they believe, will enable children to compete in modern technology. The Education Minister announced that the government is launching a teacher training program and highlighted the need for practical learning. He stated that school and college heads will be empowered and all issues in the education department will be resolved within the next three months. Collaboration with Google is also underway to transform the system. Only education, he said, can produce good citizens and good human beings.Homelist Introduces the LH1 Forest Light Full Spectrum Eye-Care Floor Lamp: A Groundbreaking Lighting Solution for Eye and ComfortPM Internship Scheme: 6.21 lakh applications received for 1.27 lakh opportunitiesThe Ajyal Film Festival 2024, organised by the Doha Film Institute (DFI), continues its activities with an array of filmmakers sharing their cinematic journeys and stories behind their works. On this occasion, the DFI organised a press meeting with Oscar-nominated photographer and filmmaker Misan Harriman, and Jianjie Lin, the director of the film *Brief History of a Family. "I've never heard of a major film festival opening with a film about Sudan, where the world witnesses the largest loss of lives," says Harriman. "That Ajyal recognised it by opening with *Sudan, Remember Us, to me is an extremely revolutionary moment." He was further moved by the fact that Ajyal 2024 was bringing *From Ground Zero, set against the backdrop of the ongoing war on Palestine, with 22 short films created by filmmakers from Gaza. "I have many colleagues in Gaza, some of them no more, and to see the reality of what is happening reflected in real-time in this way is crucial,” he added. An ambassador for Save the Children, Harriman said that the films at Ajyal reflect the reality of Palestinian children, adding that the event's ethos intersects with his own commitments from documenting the hunger crisis in north Africa to the migrant crisis in Sicily. The founder of “What We See”, Harriman said it has evolved as a “web 3” phenomenon, and he is leveraging the platform to integrate technology and culture to create a level playing field that helps the vulnerable. Through his work as a photographer and filmmaker, Harriman challenges conventional narratives and advocates for social change. "When there is injustice, I turn my lens to that," he said. Harriman, whose journey as a photographer began at age 40 when he was gifted a camera by his wife, is today one of the most influential voices in contemporary photography. His work gained global recognition during the Black Lives Matter protests, where his powerful images captured the raw emotion and humanity of the movement. "I was shooting my own trauma," Harriman said. "I see the invisible scars in the people I photograph and it feels like taking their pain and holding it." "When I'm shooting something I love, it's not just about the highlights and shadows," he added. "As the great photographer Robert Frank said, 'The eye should learn to listen'. Throughout my life, my eye has learned to listen deeply." From shooting a British *Vogue cover to his Oscar nomination for *The After, his short film about grief and healing, Harriman's work focuses on underrepresented voices and stories. "I could have just been the guy who shot the *Vogue cover, going from yacht to castle to party," he said. "But I didn't want my daughters growing up with a father who only chased fame and fortune. I shot heroes who risked everything to bring change." Harriman shares Ajyal's mission of nurturing meaningful dialogue through art. "We have to decide to decolonise our minds and look for the truth,” he said. “In today's world, simply telling the truth has become a revolutionary act." Jianjie Lin, the director of *Brief History of a Family (China, France, Denmark, Qatar), shared the view that human concepts are global. "This is my first feature and it observes the familial structure and how it reacts to social change,” he said. “The movie addresses the one-child policy and how it affected middle-class families who are figuring out their new life with the anxiety of losing everything.” “It also talks about the individual's identity versus what parents may impose on their children,” he added. Lin said that what makes Ajyal special is how it includes young people in the conversation, adding that the support by the DFI helped him reach global audiences, with members of the team he worked with coming from different backgrounds. – QNA Related Story Powerful lineup at Ajyal Monday 'Voices from Palestine' at Ajyal 2024
Finalists revealed for South Wales Health and Care Awards Carer in the Home AwardAlberta’s government says it will invest up to $50 million to support the creation of a first-in-Canada drilling test site to support technology development in the oil, gas, geothermal and lithium industries. The Alberta Drilling Accelerator is intended to be an open-access, industry-led site where companies can test drilling technologies at deep depths, high temperatures and varying rock types. A location for the hub site has yet to be determined. While no binding contracts have been signed, the province says several companies have expressed strong interest in serving as anchor tenants, including Calgary-based geothermal company Eavor Technologies, Tourmaline Oil Corp. and international oilfield service supermajor Halliburton. The money the province is providing will come from the industry-funded Technology Innovation and Emissions Reduction (TIER) program, which Alberta’s heavy emitters are required to pay into as part of the province’s industrial carbon pricing system. The provincial government says the Alberta Drilling Accelerator could start drilling in 2026.
NEW YORK (AP) — New York City Mayor Eric Adams met with President-elect Donald Trump's incoming “border czar” on Thursday, with the Democratic mayor expressing an enthusiasm to work with the incoming administration to pursue violent criminals in the city while Trump promises mass deportations. The mayor's meeting with Tom Homan, who will oversee the southern and northern borders and be responsible for deportation efforts in the Trump administration, came as Adams has welcomed parts of the president-elect's hardline immigration platform. Adams told reporters at a brief news conference that he and Homan agreed on pursuing people who commit violent crimes in the city but did not disclose additional details or future plans. “We’re not going to be a safe haven for those who commit repeated violent crimes against innocent migrants, immigrants and longstanding New Yorkers,” he said. “That was my conversation today with the border czar, to figure out how to go after those individuals who are repeatedly committing crimes in our city.” Homan said the two connected as career law enforcement officers and that he came away from the meeting with “a whole new outlook on the mayor.” “I’ve called him out this past year, many times, about being more of a politician than a police officer. I was wrong,” Homan said during an interview with Dr. Phil McGraw on his Merit TV network. “He came through today as a police officer and a mayor that cares about the safety and security of his city.” The meeting marked Adams' latest and most definitive step toward collaborating with the Trump administration, a development that has startled critics in one of the country's most liberal cities. In the weeks since Trump’s election win, Adams has mused about potentially scaling back the city’s so-called sanctuary policies and coordinating with the incoming administration on immigration. He has also said migrants accused of crimes shouldn’t have due process rights under the Constitution, though he eventually walked back those comments. The mayor further stunned Democrats when he sidestepped questions last week on whether he would consider changing parties to become a Republican, telling journalists that he was part of the “American party.” Adams later clarified that he would remain a Democrat. For Adams, a centrist Democrat known for quarreling with the city's progressive left, the recent comments on immigration follow frustration with the Biden administration over its immigration policies and a surge of international migrants in the city. He has maintained his positions have not changed and argues he's trying to protect New Yorkers, pointing to the law-and-order platform he has staked out throughout his political career and while running for mayor. At his news conference Thursday, Adams reiterated his commitment to New York’s generous social safety net. “We’re going to tell those who are here, who are law-abiding, to continue to utilize the services that are open to the city, the services that they have a right to utilize, educating their children, health care, public protection,” he said. “But we will not be the safe haven for those who commit violent acts.” While the education of all children present in the U.S. is already guaranteed by a Supreme Court ruling, New York also offers social services like healthcare and emergency shelter to low-income residents, including those in the country illegally. City and state grants also provide significant access to lawyers, which is not guaranteed in the immigration court as they are in the criminal court. Still, Adams’ recent rhetoric has been seen by some critics as an attempt to cozy up to Trump, who could potentially offer a presidential pardon in his federal corruption case. Adams has been charged with accepting luxury travel perks and illegal campaign contributions from a Turkish official and other foreign nationals looking to buy his influence. He has pleaded not guilty. Homan, who was Trump’s former acting U.S. Immigration and Customs Enforcement director, also met this week with Republicans in Illinois, where he called on Gov. J.B. Pritzker and Chicago Mayor Brandon Johnson, both Democrats, to start negotiations over how Trump's mass deportation plans, according to local media. While meeting with Adams, Homan said, “We traded ideas, we traded, strategies. He told me what he liked and didn’t like about immigration policies. ... There’s things we don’t agree on, but we agree on the most important things.” Separately, New York City officials this week announced continued efforts to shrink a huge emergency shelter system for migrants because of a steady decline in new arrivals. Among planned shelter closures is a massive tent complex built on a federally owned former airport in Brooklyn, which advocates warned could be a prime target for Trump's mass deportation plan. Elsewhere, Republican governors and lawmakers in some states are rolling out proposals that could help Trump carry out his promised deportations. Izaguirre reported from Albany, New York.Vikings staying on track and in control behind Sam Darnold's composure and confidenceSafe Supply Streaming Co. Ltd. Announces Board Member Resignation
Tweet Facebook Mail Scuffles and fistfights broke out between ruling party and opposition lawmakers in Serbia's parliament overnight, weeks after a deadly rail station roof collapse that ignited tensions in the Balkan state. The opposition wanted to discuss who is responsible for the crash that killed 15 people in the northern city of Novi Sad on November 1, while governing officials, who have a majority in Serbia's legislature, sought to adopt a bill on next year's state budget. The opposition displayed a banner showing a red hand print reading "blood is on your hands". The ruling party responded with a banner accusing the opposition of wanting "war while Serbia wants to work". READ MORE: Special counsel Jack Smith drops election subversion case against Donald Trump A fight broke out in Serbia's parliament amid a heated debate. (AP) Scuffles erupted when the two sides tried to grab each other's banner. The rail station, a major hub, was recently renovated as part of a Serbian-Chinese partnership. Critics allege that corruption, poor oversight and inadequate construction work contributed to the tragedy. The collapse has fueled widespread anger toward the government and protests, becoming a flashpoint for broader dissatisfaction with Serbia's authoritarian rule. There are growing public demands for transparency while the country undertakes large infrastructure projects, mostly with Chinese state companies. READ MORE: Tourist yacht sinks in high waves, 17 people missing The opposition accused the government of having blood on their hands. (AP) Serbia's parliament speaker Ana Brnabic yesterday accused the opposition of wanting to come to power by force with help from outside. "There is not a hint, not a grain of doubt, that these are people who are well organised, who were trained quite well, I believe paid well, to create chaos in Serbia and destabilise our country," she said. Serbia's autocratic President Aleksandar Vucic said on Instagram that the "daily bullying" and "the savage behaviour" of the opposition would not be tolerated. READ MORE: Judge delays sentencing decision for killer Menendez brothers "I want to reassure the citizens and tell them that we will respond to their rudeness, rudeness and arrogance with even more work in the future." he said. "Today they tried to prevent pensioners from receiving their increased pensions, public sector employees from their increased salaries. They won't succeed." Opposition leader Dragan Djilas said the speaker had "shut down" the parliament by refusing to allow a debate on who's responsible for the tragedy. "She started with that when she refused to put on the agenda the request of more than 80 members of the opposition for a debate on confidence in the government because of the murder and crime in Novi Sad," Djilas said. DOWNLOAD THE 9NEWS APP : Stay across all the latest in breaking news, sport, politics and the weather via our news app and get notifications sent straight to your smartphone. Available on the Apple App Store and Google Play .The Memphis Tigers made two technical free throws in the final minute of their overtime victory over UConn Huskies. The Memphis Tigers won the game by, well, two points in a 99-97 final. But UConn head coach Dan Hurley doesn't believe his technical foul cost his team the game. "I think it was the s--ty calls," he said, per Matt Norlander of CBS Sports. "I would expect to come to play in an event, and I don't know too many back-to-back national championship teams that get that type of a whistle." He also said he believes the technical was issued because he fell to the ground protesting an over-the-back call on an offensive rebound, adding "what I gave the cameras today was Oppenheimer" when discussing how he comes across on camera. "That was a joke," Hurley said of the technical, per Brendan Marks of The Athletic. "I mean, I just watched it ... I had a lot of issues with what went on in the game ... For that call to be made at that point in the game is a complete joke." He didn't stop there when complaining about the whistle: This article will be updated soon to provide more information and analysis. For more from Bleacher Report on this topic and from around the sports world, check out our B/R app , homepage and social feeds—including Twitter , Instagram , Facebook and TikTok .
Hardline activist who raised the idea of jailing women for abortions gets top policy job in Trump administration
PARADIGM CAPITAL MANAGEMENT LIVE WITH INDATADALLAS (AP) — Kevin Miller had 24 points in SMU's 98-82 victory over Longwood on Sunday. Miller also added five rebounds and seven assists for the Mustangs (11-2). Yohan Traore added 20 points while going 7 of 10 from the floor, including 2 for 4 from 3-point range, and 4 for 4 from the free-throw line while and grabbed 11 rebounds. Matt Cross shot 6 for 10 (2 for 5 from 3-point range) and 5 of 6 from the free-throw line to finish with 19 points. The Mustangs prolonged their winning streak to seven games. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.
The normally reliable centre-back passed the ball into his own net in the 26th minute after failing to spot goalkeeper Kasper Schmeichel’s positioning. But a brilliant turn and finish on the hour mark from Daizen Maeda changed the game and ultimately earned the Scottish champions a 1-1 home draw. On the opener, Rodgers said: “Mistakes happen and it was just unfortunate. He’s played that pass a million times and it’s gone back and then we’ve been able to play forward. It was just one of those unfortunate moments in the game that happens. “But he’s a really, really tough character. He’s a great guy, he picked himself up. He was really strong and aggressive again in the game and got on with it and had a real bravery in the second half, because he was the one carrying the ball forward for us to start the attack.” Despite the gift, Brugge were worthy of their lead and Rodgers admitted his side were too passive in their pressing in the opening half. Some tactical tweaks – and the introduction of Paulo Bernardo – helped Celtic dominate after Maeda’s equaliser, although Brugge had a goal disallowed for a marginal offside. “I can only credit the players for the second half, because we had to fight,” Rodgers said. “And we’re still one of those teams that’s really pushing to try and make a mark at this level. So to make the comeback, score the goal, play with that courage, I was so pleased. “You want to win but I’ve been here enough times to have lost a game like that, but we didn’t. We showed a real strong mentality and we kept pushing right to the very end and the players did well. “I thought they showed great courage in the second half because we weren’t at our level in the first half. Sometimes a game like that can get away from you, but it didn’t. “We stayed with it, showed that determination, showed that mentality, never to quit, to keep going. And then we were much, much better, much freer in the second half. “So we’re on eight points, nine to play for. We’re still very much on course to get to where we want to get to and still three games to go.” Rodgers added: “It’s 20 games now and we’ve won 16 and drawn three and lost one, so it shows you the mentality is there, and especially at this level, you need to have that.”New York Giants hand Shedeur Sanders an awkward wait after college superstar’s bold gamble
Nick Kern came off the bench for 20 points and 13 rebounds as Penn State remained unbeaten with an 85-66 thumping of Fordham in a semifinal of the Sunshine Slam on Monday in Daytona Beach, Fla. The Nittany Lions (6-0), who will play either San Francisco or Clemson for the tournament title on Tuesday, put four other players in double figures. Zach Hicks scored 16 points, while Puff Johnson added 15. Ace Baldwin and Yanic Konan Niederhauser each chipped in 12 points. Penn State sank nearly 53 percent of its field goal attempts and earned a 38-30 advantage on the boards, more than enough to offset missing 12 of its 32 foul shots. Four players reached double figures for the Rams (3-4), led by 15 points apiece from Jackie Johnson III and reserve Joshua Rivera. Romad Dean and Jahmere Tripp each added 13. Fordham was as close as 56-49 after Tripp made a layup with 14:25 left in the game. But the Nittany Lions responded with a 16-1 run, capped with a layup by Kern for a 22-point lead at the 9:33 mark, and they never looked back. The main storyline prior to tipoff was whether Penn State could continue its torrid early start that saw it come into the day leading Division I in steals and ranked second in scoring at 98.2 points per game. The Nittany Lions certainly played to their billing for most of the first half, establishing a 21-8 lead at the 10:08 mark via Hicks' three-point play. Fordham predictably struggled early with the pressure defense, committing four turnovers in the first four minutes. But the Rams got their bearings over the last 10 minutes and made some shots. They got as close as four on two occasions late in the half before Penn State pushed the lead to 42-34 at the half. The officials were busy in the half, calling 23 fouls and administering 27 free throws. --Field Level Media
Drivers eagerly awaiting the reopening of the reversible center lanes on the Kennedy Expressway will have to wait a little bit longer. Reopening the express lanes, and the conclusion of the second of three years of construction on the highway, has been pushed back to January. Though lane closures began weeks earlier than usual this spring and work was initially slated to wrap up in the fall, integrating the technical components of the access system to the reversible lanes proved to be more complicated and time consuming than expected and pushed back the reopening date, officials with the Illinois Department of Transportation said. “The remaining work, which includes the configuring and connecting of the individual components to the overall system, is currently being completed behind the scenes,” said Jonathan Schumacher, IDOT’s bureau chief of construction. “Which is why it seems like there’s nobody out there working when you drive through the work zone.” IDOT now expects to reopen the lanes the week of Jan. 13. The agency plans to begin testing the reversible lane access system Jan. 2. The reopening of the lanes will mark the completion of the second year of the $150 million, traffic-snarling rehab of the Kennedy. The project, paid through the state’s capital program, is rehabbing 7.5 miles of the 10-lane highway from the I-94 split south to downtown. All told, it will include work on 36 bridges and the express lanes, replacing overhead signs, upgrading lighting, paving and painting. It has also included painting and installing new lighting at the Hubbard underpass between Ohio and Lake streets downtown. The first phase of the work took place in 2023 in the inbound, or southbound, lanes , leaving two closed at a time between March and December and the express lanes open only heading toward downtown. This year work moved to the express lanes and Hubbard’s Cave downtown beginning in March, and in spring work is set to begin on the outbound, or northbound, lanes. Once construction restarts, two outbound lanes will be closed at a time, and the express lanes will be open only heading north from downtown. This year’s work on the express lanes included both bridge repair and pavement work, and work on the system that controls access to the lanes, which was last upgraded in 1996. Many of the gates controlling access to the lanes will look similar to previous versions, Schumacher said, but the work is intended to make the system more reliable. The access system’s technology is being updated and will now be able to be controlled remotely from IDOT’s communications center. The bridge, pavement and sign work was finished in the fall, Schumacher said. Crews replaced 90,000 feet of power cable and installed some 150,000 feet of fiber optic cables, 120 gates and 54 cameras, he said. Since then, the focus has been on the express lane access system, including electrical and software work. That includes connecting individual pieces to the larger system, and getting the various components to work together and integrating closed circuit TV cameras into the system has taken longer than expected, Schumacher said. All the pieces of the system have now been installed, he said. “We are fully aware of the inconvenience this has been to the motorists,” he said. “However, this last step is crucial to the safety of those driving using the system. We need to ensure the system works properly and safely before we can open it to traffic.” While the lanes remained closed to the public, drivers might have seen the express lanes in use during the Democratic National Convention this summer. The Secret Service requested access to the lanes , but the gate system that controls access to the lanes was not yet working so the lanes could not be opened more broadly, spokeswoman Maria Castaneda said. The project has remained close to budget, Schumacher said. Contractors working on the road and the reversible lane access system have been working well and in contact with IDOT. “It’s just a lot of work to get done in a pretty quick timeframe,” Schumacher said. “This was always going to be the most challenging of the three years.”Hunter Syndrome Therapeutics Market Size in the 7MM is expected to grow by 2034, estimated DelveInsight 12-17-2024 07:42 PM CET | Health & Medicine Press release from: ABNewswire DelveInsight's "Hunter Syndrome Market Insight, Epidemiology, and Market Forecast - 2034" report delivers an in-depth analysis of Hunter Syndrome epidemiology, market, and clinical development in Hunter Syndrome. In addition to this, the report provides historical and forecasted epidemiology and market data as well as a detailed analysis of the hunter syndrome market trends in the United States, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan. Discover Key Insights into the Hunter Syndrome Market with DelveInsight's In-Depth Report @ Hunter Syndrome Market Size [ https://www.delveinsight.com/sample-request/hunter-syndrome-market?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr ] Key Takeaways from the Hunter Syndrome Market Report * The total number of Hunter Syndrome Diagnosed Prevalent Cases in the 7MM was nearly 1,200 cases in 2023 and is projected to increase during the forecasted period. * The total number of Hunter Syndrome Diagnosed Prevalent Cases in EU4 and the UK for hunter syndrome was estimated to be nearly 350 cases in 2023. Germany had the highest prevalent cases followed by the UK. * MPS II typically affects only males, with symptoms becoming apparent at approximately 2-4 years of age. * It is estimated that about two-third of MPS II patients develop cognitive impairment with onset of symptoms between 1 to 3 years of age in the neuronopathic form. * Patients with MPS II are often classified as severe MPS II or mild MPS II. Severe form accounts for 65-70% of the cases. However, it slightly varies from country to country. * The leading Hunter Syndrome Companies such as Homology Medicine, Denali Therapeutics, Regenxbio, Takeda, JCR Pharmaceuticals, GC Pharma, Regenxbio, Sangamo Therapeutics, ArmaGen , and others * Promising Hunter Syndrome Therapies such as HMI-203, DNL310, RGX-121, SHP-609/ TAK-60 , and others Stay ahead in the Hunter Syndrome Therapeutics Market with DelveInsight's Strategic Report @ Hunter Syndrome Market Outlook [ https://www.delveinsight.com/sample-request/hunter-syndrome-market?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr ] Hunter Syndrome Epidemiology * Total Hunter Syndrome Diagnosed Prevalent Cases * Hunter Syndrome Severity-specific Cases Download the report to understand which factors are driving Hunter Syndrome Epidemiology trends @ Hunter Syndrome Prevalence [ https://www.delveinsight.com/sample-request/hunter-syndrome-market?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr ] Hunter Syndrome Marketed Drugs * ELAPRASE (idursulfase): Takeda Pharmaceuticals ELAPRASE is the first enzyme replacement therapy to be approved for people suffering from Hunter syndrome and it was launched in the US in July 2006 and in 2007 in the EU and Japan. ELAPRASE has been shown to improve walking capacity in patients 5 years and older. In patients 16 months to 5 years of age, no data are available to demonstrate improvement in disease-related symptoms or long term clinical outcome; however, treatment with ELAPRASE has reduced spleen volume similarly to that of adults and children 5 years of age and older. The safety and efficacy of ELAPRASE have not been established in pediatric patients less than 16 months of age. * IZCARGO: JCR Pharmaceuticals IZCARGO is the world's first biological drug applied with the brain drug delivery technology J-Brain Cargo., which utilizes the transferrin receptor-mediated Fe/transferrin transport to the brain and was launched in Japan to treat patients with all forms of MPS II. In March 2021, JCR received approval in Japan for IZCARGO (10 mL, intravenous drip infusion), the first enzyme replacement therapy capable of crossing the blood-brain barrier. Sales of IZCARGO increased more than 10% year-on-year and progressing well. The revenue reached from JPY 1,070 million in Q1 2022 to JPY 1,372 in Q1 2024. Hunter Syndrome Emerging Drugs * Tividenofusp alfa (DNL310): Denali Therapeutics Tividenofusp alfa (DNL310) is a fusion protein composed of IDS fused to Denali's proprietary Enzyme Transport Vehicle (ETV), which is engineered to cross the BBB via receptor-mediated transcytosis into the brain and to enable broad delivery of IDS into cells and tissues throughout the body with the goal of addressing the behavioral, cognitive, and physical manifestations of MPS II. In March 2021, the US Food and Drug Administration granted Fast Track Designation to DNL310 for the treatment of patients with MPS II. In May 2022, the European Medicines Agency granted DNL310 Priority Medicines designation. * RGX-121: Regenxbio RGX121 is an investigational adeno-associated Virus (AAV) therapeutic for the treatment of MPS II. RGX121 is designed to use the NAV AAV9 vector to deliver the human IDS gene to cells in the Central Nervous System (CNS). RGX-121 is the only product in late-stage development with the potential to address neurocognitive development in patients diagnosed under the age of 2 years. In May 2023, RGX-121 received Regenerative Medicine Advanced Therapy (RMAT) designation. Moreover, the drug has also received Orphan Drug Designation (ODD, 2015), Rare Pediatric Drug Designation (RPDD, 2016), and Fast Track Drug Designation (FTD, 2018) from the US FDA. In October 2017, the EMA granted ODD to REGENXBIO for recombinant adeno-associated viral vector serotype 9 containing the human IDS gene. To know more about Hunter Syndrome treatment guidelines, visit @ Hunter Syndrome Treatment Market Landscape [ https://www.delveinsight.com/sample-request/hunter-syndrome-market?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr ] Hunter Syndrome Market Outlook The Hunter Syndrome Market is mainly dominated by ERT, along with a few major emerging products in the pipeline that are also based on the same principle of iduronate 2-sulfatase (I2S) ERT. The only approved therapy with idursulfase is ELAPRASE. However, one of the major drawbacks of ELAPRASE is its inability to cross the blood-brain barrier (BBB), which affects the product's efficacy. Hunter Syndrome Treatment Market The current Hunter syndrome treatment involves patients receiving infusion of the IDS enzyme, usually once a week. These infusions can help break down the accumulated glycosaminoglycans and can help alleviate symptoms and slow disease progression. However, the enzyme does not cross the blood-brain barrier, so the treatment does not help with cognitive or developmental symptoms. Learn more about the FDA-approved drugs for Hunter Syndrome @ Drugs for Hunter Syndrome Treatment [ https://www.delveinsight.com/sample-request/hunter-syndrome-market?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr ] Scope of the Hunter Syndrome Market Report * Coverage- 7MM * Study Period- 2020-2034 * Hunter Syndrome Companies- Homology Medicine, Denali Therapeutics, Regenxbio, Takeda, JCR Pharmaceuticals, GC Pharma, Regenxbio, Sangamo Therapeutics, ArmaGen, and others * Hunter Syndrome Therapies- HMI-203, DNL310, RGX-121, SHP-609/ TAK-60, and others * Hunter Syndrome Market Dynamics: Hunter Syndrome Market Drivers and Barriers * Hunter Syndrome Market Access and Reimbursement, Unmet Needs and Future Perspectives Table of Content 1. Key Insights 2. Hunter Syndrome Market Overview at a Glance 3. Hunter Syndrome Market Disease Background and Overview: Hunter Syndrome 4. Diagnostic Algorithm for Hunter Syndrome 5. Hunter Syndrome Epidemiology and Patient Population 6. Country-Wise Epidemiology of Hunter Syndrome 7. Hunter Syndrome Treatment 8. Recognized Establishments 9. Hunter Syndrome Unmet Needs 10. Hunter Syndrome Marketed Profile 11. Hunter Syndrome: 7 Major Market Analysis 12. Hunter Syndrome KOL Reviews 13. Case Reports 14. Hunter Syndrome Market Drivers 15. Hunter Syndrome Market Barriers 16. SWOT Analysis 17. Appendix 18. DelveInsight Capabilities 19. Disclaimer 20. About DelveInsight About Us DelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve. Media Contact Company Name: DelveInsight Business Research LLP Contact Person: Yash Bhardwaj Email:Send Email [ https://www.abnewswire.com/email_contact_us.php?pr=hunter-syndrome-therapeutics-market-size-in-the-7mm-is-expected-to-grow-by-2034-estimated-delveinsight ] Phone: 9650213330 Address:304 S. Jones Blvd #2432 City: Las Vegas State: NV Country: United States Website: https://www.delveinsight.com/case-study/respiratory-domain-conference-coverage This release was published on openPR.
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