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Zolak/iStock via Getty Images Shares of Trevi Therapeutics ( NASDAQ: TRVI ) tumbled 23% Tuesday post-market after the company reported topline results from a human abuse potential study of its drug Haduvio, or oral nalbuphine, for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis and refractoryNoneslot jackpot monitor apk

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Georgia QB Carson Beck's status for Sugar Bowl uncertain as he considers treatment options on elbowSan Francisco 49ers running back Christian McCaffrey and top backup Jordan Mason are being placed on injured reserve. McCaffrey left the snowy field in Buffalo on Sunday night after a 5-yard gain that was preceded by him heading to the sideline in apparent pain at the end of an 18-yard run. McCaffrey was diagnosed with a posterior cruciate ligament injury in his right knee and did not play in the second half. The 49ers also lost Jordan Mason, who emerged in a starting role with McCaffrey out the first two months of the season, to an ankle injury. Head coach Kyle Shanahan said Monday that Mason has a high-ankle sprain, which typically requires a recovery window of 4-6 weeks. Those moves push rookie Isaac Guerendo into the RB1 spot. He scored the team's only touchdown at Buffalo. The IR slots in San Francisco are manned by multiple starters, including wide receiver Brandon Aiyuk, linebacker Dre Greenlaw, defensive tackle Javon Hargrave and safety Talanoa Hufanga. Mason had a team-leading 789 rushing yards and scored three touchdowns. Being placed on IR means he's not eligible to play until the regular-season finale at Arizona. McCaffrey had 53 yards on seven carries on Sunday night and caught two passes for 14 yards before exiting. He was playing in just his fourth game of the season after missing the first eight because of Achilles tendinitis. McCaffrey was the NFL Offensive Player of the Year last season, when he led the league with 2,023 yards from scrimmage: a league-leading 1,459 rushing yards and 14 touchdowns plus 67 catches for 564 yards and seven scores. McCaffrey hasn't scored a touchdown in his four appearances this season. He has rushed for 202 yards on 50 carries and caught 15 passes for 146 yards. "It was frustrating," Shanahan said after the game. "He had a great week of practice and I could feel his urgency and stuff and thought he came out great, looking really good, and it looked like he just got his shoestring there. ... I hurt for him, and tough for our team not having him." The 49ers (5-7) played without defensive end Nick Bosa (oblique) and left tackle Trent Williams (ankle) in the 35-10 loss. San Francisco has lost three in a row heading into next Sunday's game against the Chicago Bears (4-8) in Santa Clara, Calif. San Francisco resides two games behind the NFC West-leading Seattle Seahawks (7-5) with five games remaining on the schedule. Seattle and San Francisco split their season series. --Field Level MediaHenry Schein Inc. stock underperforms Tuesday when compared to competitors

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WILMINGTON, N.C., Dec. 02, 2024 (GLOBE NEWSWIRE) -- nCino, Inc. (NASDAQ: NCNO), the leading provider of intelligent, best-in-class banking solutions, today announced its participation in the following investor conferences: Scotiabank Second Annual Global Technology Conference Presentation: Tuesday, December 10, at 12:45 p.m. ET Barclays 22 nd Annual Global Technology Conference Presentation: Wednesday, December 11, at 6:05 p.m. ET A live webcast of the Barclays presentation will be available on the Events & Presentations page of the Investor Relations section of the Company website or by clicking here . About nCino nCino (NASDAQ: NCNO) is powering a new era in financial services. The Company was founded to help financial institutions digitize and reengineer business processes to boost efficiencies and create better banking experiences. With over 1,800 customers worldwide - including community banks, credit unions, independent mortgage banks, and the largest financial entities globally - nCino offers a trusted platform of best-in-class, intelligent solutions. By integrating artificial intelligence and actionable insights into its platform, nCino is helping financial institutions consolidate legacy systems to enhance strategic decision-making, improve risk management, and elevate customer satisfaction by cohesively bringing together people, AI and data. For more information, visit www.ncino.com . CONTACTS INVESTOR CONTACT Harrison Masters nCino +1 910.734.7743 [email protected] MEDIA CONTACT Natalia Moose nCino [email protected]QB Josh Allen and coach Sean McDermott deserve credit in Bills latest AFC East-clinching season

The incoming head of the Senate Judiciary Committee, Republican Sen. Chuck Grassley, blasted FBI Director Christopher Wray on Monday for what he called “failed” leadership of the law-enforcement agency and said it was time for Wray to leave. In a letter to Wray that repeated many of President-elect Donald Trump’s complaints about the FBI, Grassley, R-Iowa, criticized the FBI search of Trump’s home at Mar-a-Lago , which recovered missing classified documents and led to federal charges against the former president , as “invasive and unwarranted.” Grassley also faulted the FBI investigation into Russian interference in the 2016 election for targeting Trump after not similarly scrutinizing former Secretary of State Hillary Clinton, and for failing to provide more information about alleged sexual misconduct at the agency. “These failures, are serious enough and their pattern widespread enough to have shattered my confidence in your leadership and the confidence and hope many others in Congress placed in you,” Grassley wrote in the 11-page letter. Trump appointed Wray, who has served seven years of a 10-year term. But Trump has been critical of Wray for years. After being reelected to the White House, Trump named Kash Patel, a former national security official, to succeed Wray as FBI director, implying that he plans to fire Wray. Grassley said Wray and Deputy Director Paul Abbate should each leave. “For the good of the country, it’s time for you and your deputy to move on to the next chapter in your lives,” Grassley wrote. The FBI issued a statement saying the agency has repeatedly demonstrated its commitment to responding to congressional oversight. "Director Wray and Deputy Director Abbate have taken strong actions toward achieving accountability in the areas mentioned in the letter and remain committed to sharing information about the continuously evolving threat environment facing our nation and the extraordinary work of the FBI," the statement said. Grassley’s letter comes a month before he reclaims the chairmanship of the committee that oversees the FBI, due to Republicans' flipping control of the Senate in the recent election. Grassley would lead the potential confirmation hearing for Patel. Patel, who advised the director of the national intelligence and the defense secretary during Trump’s first term, is a polarizing choice to lead the FBI. Republican supporters such as House Speaker Mike Johnson of Louisiana said he will bring a needed overhaul to the agency. But Patel has threatened to investigate Trump’s political enemies and shut down FBI’s headquarters in Washington to decentralize workers across the country. Bill Barr, a former attorney general for Trump, wrote in his memoir Patel’s appointment as deputy director of the FBI would happen “over my dead body.” Trump refused to confirm on NBC’s “Meet the Press” on Sunday that he would fire Wray, whom he appointed seven years ago, but said Patel would take his place. Trump criticized Wray for the 2022 raid on Mar-a-Lago, when FBI agents seized thousands of documents including hundreds classified records. Trump was charged with unlawfully retaining national defense records after leaving the White House, but a judge dismissed those charges in July on the grounds that the investigation was run by a special counsel whose appointment was ruled invalid. “I can’t say I’m thrilled with him. He invaded my home. I’m suing the country over it,” Trump said about Wray. “I’m very unhappy with the things he’s done.” Trump also complained that Wray initially testified at a House hearing the former president might have been hit in the ear by shrapnel rather than a bullet during an assassination attempt in July in Butler, Pa. Wray clarified the next day that Trump was struck by a bullet. “Where’s the shrapnel coming from?” Trump asked facetiously. “Is it coming from heaven? I don’t think so.” Grassley echoed several of Trump’s complaints about the FBI. The Mar-a-Lago raid occurred 18 months after Trump left office. Agents found boxes of records stashed around the property in unsecured locations, including a restroom. But Grassley wrote that Trump was cooperating because he had returned 15 boxes of records voluntarily. “This raid occurred despite serious questions about the need for it,” Grassley said. Trump has long complained about the FBI investigation into Russian interference in the 2016 election before Wray took the agency’s helm. Grassley wrote the FBI failed to vet derogatory information to obtain a search warrant for a Trump campaign aide. Grassley called the lapse “some of the most egregious, Orwellian conduct I’ve witnessed” in nearly 50 years in Congress. An inspector general blasted the wiretapping program . Wray overhauled training and how warrants are obtained from the Foreign Intelligence Surveillance Court, but defended the need for the surveillance program . Grassley also slammed the FBI after a Justice Department review found 665 former FBI employees, including 45 members of the senior executive staff, retired or resigned from 2004 to 2020 after allegations of sexual misconduct and before final disciplinary records were issued. Grassley said the FBI failed to provide more information about the allegations despite public pledges to do so. “Contrary to the assurances you made to gain confirmation to your position, the FBI has shown outright disdain for congressional oversight during your tenure,” Grassley wrote. “You didn’t live up to your word.”Masco Corp. stock underperforms Monday when compared to competitors

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CHICAGO (AP) — As begins to take shape, those on both sides of the abortion debate are watching closely for clues about how his picks might affect reproductive rights policy in the . offer a preview of how his administration could handle abortion after he repeatedly on the campaign trail. He attempted to distance himself from anti-abortion allies by deferring to states on abortion policy, even while boasting about nominating three Supreme Court justices who helped strike down the constitutional protections for abortion that had stood for half a century. In an NBC News interview that aired Sunday, Trump said he doesn’t plan to restrict medication abortion but also seemed to leave the door open, saying “things change.” “Things do change, but I don’t think it’s going to change at all,” he said. The of his , including nominations to lead health agencies, the Justice Department and event the Department of Veterans Affairs, has garnered mixed — but generally positive — reactions from anti-abortion groups. Abortion law experts said Trump’s decision to include fewer candidates with deep ties to the anti-abortion movement could indicate that abortion will not be a priority for Trump’s administration. “It almost seems to suggest that President Trump might be focusing his administration in other directions,” said Greer Donley, an associate law professor at the University of Pittsburgh School of Law. Karen Stone, vice president of public policy at , said while many of the nominees have “extensive records against reproductive health care,” some do not. She cautioned against making assumptions based on Trump’s initial cabinet selections. Still, many abortion rights groups are wary, in part because many of the nominees hold strong anti-abortion views even if they do not have direct ties to anti-abortion activists. They’re concerned that an administration filled with top-level officials who are personally opposed to abortion could take steps to restrict access to the procedure and funding. After Trump’s ambiguity about abortion during his campaign, “there’s still a lot we don’t know about what policy is going to look like,” said Mary Ruth Ziegler, a law professor at the University of California, Davis School of Law. That approach may be revealed as the staffs within key departments are announced. Trump he would nominate anti-vaccine activist to lead the Health and Human Services Department, which anti-abortion forces have long targeted as central to curtailing abortion rights nationwide. Yet Kennedy shifted on the issue during his own presidential campaign. In campaign videos, Kennedy said he until , which doctors say is sometime after 21 weeks, although there is no defined timeframe. But he also “every abortion is a tragedy” and a national ban after 15 weeks of pregnancy, a stance he quickly walked back. The head of Health and Human Services oversees Title X funding for a host of family planning services and has sweeping authority over agencies that directly affect abortion access, including the Food and Drug Administration and Centers for Medicare and Medicaid Services. The role is especially vital amid legal battles over a federal law known as EMTALA, which President administration has argued requires emergency abortion access nationwide, and FDA approval of the abortion pill mifepristone. Mini Timmaraju, president of the national abortion rights organization Reproductive Freedom for All, called Kennedy an “unfit, unqualified extremist who cannot be trusted to protect the health, safety and reproductive freedom of American families.” His potential nomination also has caused waves in the anti-abortion movement. Former Vice President , a staunch abortion opponent, urged the Senate to reject Kennedy’s nomination. Marjorie Dannenfelser, president of the national anti-abortion group Susan B. Anthony Pro-Life America, said the group had its own concerns about Kennedy. “There’s no question that we need a pro-life HHS secretary,” she said. Fox News correspondent is Trump’s pick to lead the FDA, which plays a critical role in access to medication abortion and contraception. Abortion rights groups have accused him of sharing misinformation about abortion on air. , a staunch anti-abortion conservative, has been nominated for director of the Office of Management and Budget. Vought was a key architect of , a right-wing blueprint for running the federal government. Among other actions to limit reproductive rights, it calls for eliminating access to medication abortion nationwide, cutting Medicaid funding for abortion and restricting access to contraceptive care, especially long-acting reversible contraceptives such as IUD’s. Despite distancing himself from the conservative manifesto on the campaign trail, Trump is with people who played central roles in developing Project 2025. Trump acknowledged that drafters of the report would be part of his incoming administration during the Sunday interview with NBC News, saying “Many of those things I happen to agree with.” “These cabinet appointments all confirm that Project 2025 was in fact the blueprint all along, and the alarm we saw about it was warranted,” said Amy Williams Navarro, director of government relations for Reproductive Freedom for All. , Trump’s choice to lead the Centers for Medicare and Medicaid Services, is a who has been accused of dubious medical treatments and products. He voiced contradictory abortion views during his in 2022. Oz has described himself as praised the Supreme Court decision , claimed and referred to abortion as But he also has Trump’s states-rights approach, arguing the federal government should not be involved in abortion decisions. “I want women, doctors, local political leaders, letting the democracy that’s always allowed our nation to thrive to put the best ideas forward so states can decide for themselves,” he said during a Senate debate two years ago. An array of reproductive rights groups opposed his Senate run. As CMS administrator, Oz would be in a key position to determine Medicaid coverage for family planning services and investigate potential EMTALA violations. As Florida’s attorney general, defended abortion restrictions, including a 24-hour waiting period. Now she’s Trump’s . Her nomination is being celebrated by abortion opponents but denounced by abortion rights groups concerned she may revive the , an anti-vice law passed by Congress in 1873 that, among other things, bans mailing of medication or instruments used in abortion. An anti-abortion and anti-vaccine former Florida congressman, has been chosen to lead the Centers for Disease Control and Prevention, which collects and monitors abortion data across the country. Former Republican congressman is Trump’s choice to lead the Department of Veterans Affairs amid a over and funding for troops and veterans. Collins voted consistently to restrict funding and access to abortion and celebrated the overturning of Roe v. Wade. “This is a team that the pro-life movement can work with,” said Kristin Hawkins, president of the national anti-abortion organization Students for Life.Ruben Amorim has warned fans that "a storm will come" despite his positive start as head coach. Amorim is unbeaten in his three games in charge and led United to their biggest league victory since 2021 with a over on Sunday. The 39-year-old takes his team to on Wednesday and has suggested they will eventually be "found out" while the players continue to get to grips with his methods. "I would like to say different things, but I have to say it again: the storm will come," Amorim said. "I don't know if you use that expression, but we are going to have difficult moments and we will be found out in some games. I know that because I know my players and I know football and I follow football. We are in the point in that we are putting simple things in the team, without training. "So let's focus on each game, on the performance, what we have to improve, trying to win games. And that is the focus. I know it's really hard to be a Manchester United coach and say these things in press conferences. "We want to win all the time, no matter what, we are going to try to win, but we know that we are in a different point, if you compare to Arsenal." While Amorim's players are still learning about his tactical system, Amorim is also learning about United. The Portuguese coach has been in the job for three weeks since , and he has admitted the attention and the workload which comes with managing one of the biggest clubs in the world has taken him by surprise. "A little bit, because you don't know how is life in this kind of club," he said. "So it's always a surprise. I think I can manage that, but you have to do so much more than coach the team. You improve and other things in yourself as a coach, you have to manage the time in a different way. "You have less time to prepare for the games, not just because you are playing after two days, but also because you have a lot to do. I can say I was a little bit surprised, but at the same time I was expecting something different."

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PHOENIX — One Arizona lawmaker isn't waiting for Robert Kennedy Jr. to pursue his promise of removing artificial ingredients from school lunch programs. State Rep. Leo Biasiucci is writing legislation that would bar public schools from serving what he calls "ultra-processed foods'' to students during the day, in the cafeteria but also through snack bars and school vending machines. The Lake Havasu City Republican has a very specific idea of what fits that definition. His proposal includes everything from potassium bromate, which is used in making bread, to a host of food colorings including Blue #2, which is a synthetic version of indigo used on baked goods, cereals and candies, and Yellow #6, the dye that gives Cheetos their distinctive color. Parents could still send lunches with their children that contain the targeted chemicals. And Biasiucci's legislation apparently would allow such items to be sold at the snack bar at football games, under an exception for "events held on the school grounds after the school day.'' Rep. Leo Biasiucci This comes amid heightened concern about food additives raised by Kennedy, who will have an outsized role in the issue as President-elect Donald Trump's pick to head the U.S. Department of Health and Human Services. That is the parent agency of the Food and Drug Administration, which decides which additives are "generally recognized as safe.'' There is precedent for at least some of the proposal. One of the items on Biasiucci's list, for example, is titanium dioxide, a food color additive found in baked goods, puddings, frostings and coffee creamers. The European Food Safety Authority has concluded the chemical isn't safe in food. Many of the companies that manufacture items with these chemicals make a separate version designed to pass European standards. So while Fruit Loops sold here have Red 40, Blue 1, and Yellow 5 and 6, what's available in Germany relies on fruit and vegetable concentrates, with the only listed coloring coming from carotene. Also, a California law that takes effect in 2028 will ban six specific artificial dyes from meals served at schools. Biasiucci told Capitol Media Services on Monday he has been thinking about the issue for some time. During a trip to Italy, he began looking at the ingredients in prepared foods and how they differ from similar products in the United States. "I think now, with RFK Jr. kind of getting in the spotlight and being in the position he is, I think this conversation has finally come to the forefront,'' Biasiucci said. "The timing is perfect. This is now becoming something that people actually are paying attention to.'' But Biasiucci said that, even with the incoming federal administration, he doesn't want Arizona to have to wait for the FDA to get around to reviewing and deciding whether to ban these chemicals. "I just never depend on the federal government,'' he said. "I just don't want to wait that long.'' A Tucson Unified School District cafeteria worker sorts chicken nuggets into bags for grab-and-go meals. He also pointed out that his proposal is far narrower than anything that would have to go through the federal bureaucracy, as it deal only with school lunches. "If we're providing this food for free to our children, which are the most vulnerable ... I want to make sure that that food we are providing them on the government dime is actually safe and it is not something that's toxic,'' he said. "They're the ones that are growing and need to make sure they're getting the most nutrients.'' Heidi Vega, spokeswoman for the Arizona School Boards Association, called what Biasiucci is trying to do "certainly a step in the right direction.'' But she added a caveat. "It's essential to ensure there's sufficient funding and transitional support available to local education agencies,'' Vega said. That funding is "crucial to prevent potential negative impacts on meal accessibility for Arizona's most vulnerable students," she said. Biasiucci acknowledged the financial issue. But he said there appear to be some options. During COVID, the U.S. Agriculture Department set up a program to help states deal with the challenges of supply chain disruptions. The department now is using those funds for "Try It Local,'' in which schools operating under the National School Lunch Program can be reimbursed for purchasing "unprocessed or minimally processed" locally or regionally produced food for their lunch programs. Arizona got nearly $4.4 million for the program. Strictly speaking, the program does not mention artificial dyes or other additives. But the list of items eligible would seem to preclude or minimize their use. They range from fruits and vegetables to meats, beans and dairy foods such as cheese or yogurt. Conversely, the program does not provide money for items such as breaded meats, muffins, cookies, frozen bread and ready-to-heat items like pre-made sandwiches and pizza. Biasiucci said even if that program and its funding are shut down, he believes the feeding of proper meals to students is a higher priority than some other things now funded by the federal government. State Superintendent of Public Instruction Tom Horne would like to do some research into the effects of these dyes and chemicals before taking a position, said an aide, Doug Nick. But he said Horne has a history of trying to limit what can be available to kids on campuses, noting he was behind rules adopted a decade ago to ban sugared sodas at schools. Howard Fischer is a veteran journalist who has been reporting since 1970 and covering state politics and the Legislature since 1982. Follow him on X, formerly known as Twitter, Bluesky , and Threads at @azcapmedia or email azcapmedia@gmail.com . Subscribe to stay connected to Tucson. A subscription helps you access more of the local stories that keep you connected to the community. Be the first to know Get local news delivered to your inbox!

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