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In the world of football, 2006 was a year that would be forever etched in the history books. As the footballing world witnessed Lionel Messi's first international omission in 18 years in 2024, it serves as a poignant reminder of the ebbs and flows of a player's career. However, let us rewind to 2006, a year marked by Italy's triumphant victory in the FIFA World Cup and Fabio Cannavaro's well-deserved recognition with the prestigious Ballon d'Or award.



To cater to the needs of modern travelers, the Fengtai Bus Station has also upgraded its amenities to offer a more comfortable and convenient waiting environment. Newly installed seating areas, passenger lounges, and restroom facilities provide passengers with a comfortable place to relax while waiting for their buses. Additionally, the station now features a range of dining options and retail outlets, allowing passengers to grab a quick bite or purchase essential items before embarking on their journeys.CHANHASSEN, Minn. , Nov. 24, 2024 /PRNewswire/ -- Alpheus Medical, Inc., a private, clinical-stage oncology company pioneering sonodynamic therapy (SDT) for the treatment of solid body cancers, today announced positive results from their Phase 1/2 clinical trial in patients with recurrent or refractory high-grade gliomas. The company's proprietary therapy demonstrated a strong safety profile and extended median overall survival (OS) and progression-free survival (PFS) compared to historical data. The data were presented by Michael Schulder , MD, at the 2024 Society of Neuro-Oncology (SNO) Annual Meeting. "Glioblastomas are the most common and aggressive primary brain cancer, presenting a devasting diagnosis for patients and their familes," said David Reardon , MD, Clinical Director of the Center for Neuro-Oncology at Dana-Farber Cancer Institute, and member of the Alpheus Medical Scientific Advisory Board. "Current treatment options are limited and often ineffective due to the diffuse spread of the disease across the blood-brain barrier and often across the entire hemisphere, making it universally fatal with a rapid timeline. The early clinical results of Alpheus's therapy are promising, offering hope for this new approach. I look forward to further exploring the potential benefits of their SDT therapy for this patient population who is in critical need of an effective solution." Alpheus Medical's non-invasive SDT treatment, which can be delivered in an outpatient setting, combines low-intensity diffuse ultrasound (LIDU TM ) with oral 5-aminolevulinic acid (5-ALA) to target and kill cancer cells across the entire hemisphere without the need for imaging or sedation. Key findings from the study include: "In addition to the strong safety data and early indications of efficacy, Alpheus' non-invasive SDT therapy stands out for its ease of use - a significant improvement over the uncomfortable and often toxic treatments currently available for this rapidly fatal condition," stated Dr. Schulder, Director of the Brain Tumor Center at Northwell Health, and one of the trial's primary investigators. "We look forward to expanding the ability for patients to receive this promising therapy." The Phase 1/2 trial ( NCT05362409 ) is an open-label, multicenter, duration-escalation study evaluating the safety, optimal dose, and efficacy of Alpheus Medical's proprietary SDT platform. Twelve patients were enrolled across three cohorts, with treatment durations escalating to 60, 90, and 120 minutes per monthly session. The company plans to initiate a randomized, controlled trial at multiple centers across the U.S. in 2025. About Alpheus Medical, Inc. Alpheus Medical is a private, clinical-stage oncology company revolutionizing the treatment of solid body cancers with its pioneering sonodynamic therapy (SDT) platform that combines Low-Intensity Diffuse Ultrasound (LIDU TM ) with the sensitizing agent, oral 5-aminolevulinic acid (5-ALA). The company's proprietary, non-invasive technology is designed to selectively target and destroy cancer cells in the brain while preserving healthy tissue. Learn more at www.alpheusmedical.com . Media Contact Carla Benigni carla@sprigconsulting.com View original content to download multimedia: https://www.prnewswire.com/news-releases/alpheus-medical-announces-positive-phase-12-trial-results-for-the-treatment-of-recurrent-high-grade-gliomas-302314785.html SOURCE Alpheus MedicalThe public declaration from his son adds a new dimension to Musk's public image, highlighting the complexities of his personal and professional responsibilities. The relationship between father and son appears to be characterized by a mix of admiration, expectation, and perhaps even tension, as X Æ A-12 publicly challenges his father to step up to a perceived national duty.

Election canvassers getting used to talking to Ring doorbells and ‘apathy bordering on anger’

Chinese film about Covid-19 wins Taiwan's top Golden Horse prizesIn conclusion, the Beijing property market is currently experiencing a period of rapid growth and activity, with both new and old housing units seeing a surge in transactions. This dynamic and exciting trend reflects the city's ongoing development and expansion, as well as the strong demand for quality housing in one of China's most vibrant and cosmopolitan cities. Whether you're a first-time buyer, a seasoned investor, or simply curious about the latest real estate trends, the Beijing property market is definitely one to watch for those looking to make a smart investment decision in today's fast-paced and evolving property landscape.

Title: A-Share Market Surges: Three Major Indexes Open High and Soar to Start Trading DayScandal-scarred Anthony Weiner is considering a political comeback after prison stint for sexts with teenNow that former Rep. Matt Gaetz (R-FL) has officially withdrawn his name from consideration to be the next attorney general, President-elect Donald Trump is quickly moving on to his next choice. According to a report in NYSun.com , Trump's next attorney general-designate could be Texas Republican Attorney General Ken Paxton. The Sun reported that an unnamed source "with close ties to Trump's team" says Paxton — who has served as the top law enforcement official in the Lone Star State since 2015 — is "the ideal choice for the America First movement." As Texas' attorney general, Paxton led the charge at the state level to try to overturn the results of the 2020 election. Paxton was the lead plaintiff in the Texas v. Pennsylvania lawsuit that sought to prevent the certification of election results in the handful of battleground states that President Joe Biden narrowly won four years ago, unsuccessfully arguing that those states' Covid-19 pandemic voting procedures violated the U.S. Constitution. READ MORE: Senate Republican slams 'criminal' Texas attorney general for 'pushing Russian propaganda' Paxton is also likely to be agreeable to Trump's stated plans to use the Department of Justice as a vehicle to hound his political enemies. As Texas' attorney general, Paxton launched an investigation into Democratic-aligned advocacy group Media Matters for America in 2023. U.S. District Judge Amit Mehta ultimately shut down Paxton's attempts to probe Media Matters' financial records and internal communications. The Sun's Matthew Rice noted that in addition to presumably all Senate Democrats, one unlikely opponent Paxton could have in the Senate would be Sen. John Cornyn (R-TX), who has publicly feuded with Paxton in the recent past. In February, Cornyn was one of several Republicans who joined all Democrats in supporting a supplemental foreign aid package to help Israel , Taiwan and Ukraine . Paxton accused Cornyn of "stay[ing] up all night to defend other countries' borders, but not America." Cornyn clapped back, mentioning Paxton's criminal charges for alleged securities fraud ( which have since been dropped ). "Ken, your criminal defense lawyers are calling to suggest you spend less time pushing Russian propaganda and more time defending longstanding felony charges against you in Houston, as well as ongoing federal grand jury proceedings in San Antonio that will probably result in further criminal charges," Cornyn tweeted. Aside from Paxton, other potential attorneys general may include Sen. Mike Lee (R-Utah) — whose father served as solicitor general under President Ronald Reagan — and far-right attorney Mike Davis , who has blamed Democrats for the assassination attempts on then-candidate Trump .

Canadian Prime Minister Justin Trudeau is taking heat this weekend for being seen partying at a Taylor Swift concert while pro-Palestinian protesters were coursing through downtown Montreal and burning and looting as they went. Trudeau, who, along with being Labor Party Leader and the nation’s PM, also represents Papineau, a portion of Montreal, in the nation’s Parliament, but critics are blasting him for being about 330 miles away in Toronto for the Swift concert as his hometown burned. A viral video shows a carefree Trudeau dancing to Swift’s song, “You Don’t Own Me,” as news was breaking about the riot in Montreal, Fox News reported. As Trudeau danced, a mob of people protesting against NATO and Israel paraded through the streets of Montreal setting off smoke bombs, burning effigies of Israeli leader Benjamin Netanyahu, causing property damage to buildings and cars, and holding pro-Palestinian flags and banners. Montreal Police spokesperson Véronique Dubuc said at least three people were arrested for interfering with the police. And one civilian and several police officers suffered minor injuries. But protesters said nearly half a dozen were injured by police and had to seek medical treatment. The riot was reportedly organized by Divest for Palestine and the Convergence of Anti-Capitalist Struggles. Trudeau called the riot “appalling” and on X wrote, “Acts of antisemitism, intimidation, and violence must be condemned wherever we see them. There must be consequences, and rioters held accountable.” But several members of Parliament blasted Trudeau for dancing the night away while the crisis brewed. Don Stewart, a Member of Parliament (MP) representing part of Toronto, called for Canada to “bring back law and order.” “Lawless protesters run roughshod over Montreal in violent protest. The Prime Minister dances. This is the Canada built by the Liberal government,” he wrote on X. “Bring back law and order, safe streets and communities in the Canada we once knew and loved.” Conservative Leader Pierre Poilievre also blasted Trudeau over the concert frivolity and said that Trudeau was “too busy to condemn a violent Hamas takeover of our streets.” He also accused Trudeau of making Canada into “a playground for foreign interference.” Quebec Premier François Legault also took aim at Trudeau, saying, “Burning cars and smashing windows is not about sending a message, it’s about causing chaos. Such acts have no place in a peaceful society like Quebec.” Follow Warner Todd Huston on Facebook at: facebook.com/Warner.Todd.Huston , or Truth Social @WarnerToddHustonCelebrating a legend, celebrating a singer-awardee

Mount St. Mary's 76, Delaware St. 66Even before the rise of the great Maya civilization, the people who occupied Central America’s Yucatan Peninsula were applying their engineering skills to make the land more productive and liveable. This was made crystal clear by a recent discovery by a team of archaeologists and anthropologists, who discovered the most ancient fish-trapping operation ever identified anywhere in the region inside Belize’s largest inland wetland. Examining imagery collected by drones and Google Earth, the researchers from the Belize River East Archaeology (BREA) project were fascinated by an interconnected network of zigzag lines they saw running through the Crooked Tree Wildlife Sanctuary. Their concluded that this was likely a network of pre-Columbian canals , which had probably been constructed in Belize thousands of years ago (but had never been noticed at ground level). To verify this theory the researchers carried out a series of excavations inside the wildlife sanctuary, and their discoveries confirmed that a series of canals had indeed been dug there a long time ago, to guide and trap freshwater fish in holding ponds where they could be easily harvested. Excavations at Maya Settlement in Belize Tell Story of Maya Golden Age The Horrifying History of the Midnight Terror Cave in Belize Notably, the researchers found several barbed spearpoints within the boundaries of the fish-trapping system during their excavations, which presumably would have been tied to sticks to make spears for killing the fish. The size of the fish-trapping system was quite impressive, the researchers said. “The network of canals was designed to channel annual flood waters into source ponds for fish trapping and would have yielded enough fish to feed as many as 15,000 people year-round, conservatively," said University of New Hampshire anthropologist Eleanor Harrison-Buck, in a press release issued by her university. Researhers excavating sediment that will help them date the evidence of a large-scale pre-Columbian fish-trapping facility. ( Belize River East Archaeology (BREA) Project ). Harrison-Buck is the director of the Belize River East Archaeology (BREA) project, and has been leading the ongoing study of ancient fishing practices in Central America. She has been joined by colleagues from the United States and Australia, in a pursuit of knowledge about how ancient humans in the region interacted with wetlands and used them to help meet their survival needs. A Fish Harvesting Legacy from Deep in Prehistory At first, the researchers assumed they’d discovered a fish harvesting operation that had been set up by the Maya . But a series of radiocarbon dating tests carried out at various spots inside the canal network proved this wasn’t true. How Many Maya Gods Were Worshipped? Hint: There Were Hundreds Mexican Mayor Weds Alligator in Colorful Ancient Indigenous Ceremony! It seems the fish-trapping network was conceived of and constructed by the people who occupied the land before the rise of the great Maya civilization. These were a semi-nomadic people who settled along the Yucatan Peninsula coastal plain, and who constructed the canal system approximately 4,000 years ago. “Data collected from the largest inland wetland in Belize, Central America, demonstrate the presence of large-scale pre-Columbian fish-trapping facilities built by Late Archaic hunter-gatherer-fishers, which continued to be used by their Maya descendants during Formative times (approximately 2000 BCE to 200 CE),” the study authors wrote in an article published by Science Advances . The researchers believe the early practice of fish trapping on such a significant scale was an adaption to changes in environmental conditions in ancient Central America . Researchers searching for evidence of ancient fishing activity in the Crooked Tree Wildlife Sanctuary in Belize. ( Belize River East Archaeology (BREA) Project ) . “ We suggest that such landscape-scale intensification may have been a response to long-term climate disturbance recorded between 2200 and 1900 BCE,” they wrote. “Agricultural intensification after 2000 BCE has been credited for supporting the rise of pre-Columbian civilizations in Formative Mesoamerica, but we suggest that some groups relied more heavily on the mass harvesting of aquatic resources.” Sediment samples were collected along the walls of the excavation units, and they were tested for chemical elements that might reveal the types of environment changes that occurred in prehistoric times. These tests showed that tropical forests had dominated the landscapes of the Crooked Tree Wildlife Sanctuary 4,000 years ago, and that no cultivation of maize or any other crops had taken place during that time. Along with a lack of pollen from domesticated crops, there were no signs of the ditching or draining that would have been needed to prepare the land for agricultural use. As for the fish-trapping network, analysis showed it was used for approximately 1,000 years, or from approximately 2,000 to 1,000 BC. "It seems likely that the canals allowed for annual fish harvests and social gatherings, which would have encouraged people to return to this area year after year and congregate for longer periods of time," said study co-author Marieka Brouwer Burg, a professor of anthropology at the University of Vermont and the BREA project co-director. "Such intensive investments in the landscape may have led ultimately to the development of the complex society characteristic of the pre-Columbian Maya civilization, which subsequently occurred in this area by around 1200 BCE." Did Their Predecessors Help the Maya Thrive? The so-called “ Formative Period ” of the Maya civilization overlapped with the fishing system’s time in use. This suggests the Maya took advantage of this ingenious creation of their predecessors, relying on the harvest of freshwater fish to supplement what they were able to produce their their early ventures into agriculture. If this is so, the existence of this ancient fishing operation may have been a hidden factor that helps explains the rise of the Maya civilization , which grew to be the most advanced and sophisticated in all of ancient Mesoamerica . With the support of the local population, the BREA research team plans to return to Crooked Tree to continue their investigations soon. They will be looking for more signs of prehistoric land modification, which could reveal some fascinating facts about how ancient fishing practices led to significant cultural development in the Yucatan region later on. Top image: Crooked Tree Wildlife Sanctuary in Belize. Source: Bernt Rostad/ CC BY 2.0 . By Nathan Falde News Ancient Places History Belize maya Central America pre-columbian In a recent discovery, a team of researchers has uncovered what appears to be an underwater portal to the Maya underworld . The team had set out to explore the sacred pools of the ancient Maya,... Not even 50 years ago, Belize, in Central America, gained independence on September 21, 1981, but its history dates back to 9,000 years. In prehistory the territory was home to several ancient... Archaeologists studying Belize’s “Midnight Terror Cave” have discovered mysterious blue fibers in the tooth plaque of sacrificed teenagers, which suggests the young sacrifice victims had been gagged... Representatives of the Belize Institute of Archaeology have been working with graduate students from the University of Illinois Urbana-Champaign on a series of excavations in Central America. During... Something of a hidden gem, Caracol is one of the largest Maya sites of Central America, and certainly the largest in Belize, yet it receives far less footfall than other ruins in the region. The... A fresh analysis of artifacts collected from a salt-making facility submerged beneath a lagoon in Belize has revealed enlightening details about the organization and functioning of the Maya salt...

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