hand 777 slot online free Calgary Flames (12-8-4, in the Pacific Division) vs. Pittsburgh Penguins (9-12-4, in the Metropolitan Division) Pittsburgh; Saturday, 7 p.m. EST BETMGM SPORTSBOOK LINE: Penguins -122, Flames +101; over/under is 6 BOTTOM LINE: The Calgary Flames enter the matchup against the Pittsburgh Penguins after losing three in a row. Pittsburgh is 9-12-4 overall and 5-6-2 at home. The Penguins have conceded 96 goals while scoring 65 for a -31 scoring differential. Calgary is 12-8-4 overall and 3-5-4 in road games. The Flames have a 4-7-1 record in games they serve more penalty minutes than their opponents. The matchup Saturday is the second time these teams meet this season. The Flames won 4-3 in a shootout in the previous meeting. TOP PERFORMERS: Sidney Crosby has eight goals and 16 assists for the Penguins. Bryan Rust has four goals and three assists over the last 10 games. Rasmus Andersson has five goals and nine assists for the Flames. Mikael Backlund has scored three goals and added one assist over the last 10 games. LAST 10 GAMES: Penguins: 4-4-2, averaging 2.3 goals, four assists, 3.4 penalties and 7.1 penalty minutes while giving up 3.7 goals per game. Flames: 5-3-2, averaging 2.1 goals, 3.4 assists, 3.9 penalties and 9.5 penalty minutes while giving up 2.2 goals per game. INJURIES: Penguins: None listed. Flames: None listed. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .BENSALEM, Pa. , Dec. 12, 2024 /PRNewswire/ -- Law Offices of Howard G. Smith announces that investors with substantial losses have opportunity to lead the securities fraud class action lawsuit against ASP Isotopes Inc. ("ASP Isotopes" or the "Company") ASPI . Class Period: October 30, 2024 – November 26, 2024 Lead Plaintiff Deadline: February 3, 2025 Investors suffering losses on their ASP Isotopes investments are encouraged to contact the Law Offices of Howard G. Smith to discuss their legal rights in this class action at 215-638-4847 or by email to howardsmith@howardsmithlaw.com . The complaint filed alleges that, throughout the Class Period, Defendants failed to disclose to investors: (1) the Company overstated the potential effectiveness of its enrichment technology; (2) the Company overstated the development potential of its high assay low-enriched uranium facility; (3) the Company overstated the Company's nuclear fuels operating segment results; and (4) that, as a result of the foregoing, Defendants' positive statements about the Company's business, operations, and prospects were materially misleading and/or lacked a reasonable basis. To be a member of the class action you need not take any action at this time; you may retain counsel of your choice or take no action and remain an absent member of the class action. If you wish to learn more about this class action, or if you have any questions concerning this announcement or your rights or interests with respect to the pending class action lawsuit, please contact Howard G. Smith, Esquire , of Law Offices of Howard G. Smith , 3070 Bristol Pike, Suite 112, Bensalem, Pennsylvania 19020, by telephone at (215) 638-4847 or by email to howardsmith@howardsmithlaw.com , or visit our website at www.howardsmithlaw.com . This press release may be considered Attorney Advertising in some jurisdictions under the applicable law and ethical rules. Contacts Law Offices of Howard G. Smith Howard G. Smith, Esquire 215-638-4847 howardsmith@howardsmithlaw.com www.howardsmithlaw.com View original content: https://www.prnewswire.com/news-releases/aspi-investors-have-opportunity-to-lead-asp-isotopes-inc-securities-fraud-lawsuit-302330625.html SOURCE Law Offices of Howard G. Smith © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

AP – Global stocks were mixed yesterday after overnight political drama in South Korea added to regional uncertainties, though the Kospi in Seoul fell less than two per cent. France’s CAC 40 rose 0.3 per cent in early trading to 7,278.18, as the minority government was facing a no-confidence vote yesterday in Parliament following a divisive budget debate. Germany’s DAX added 0.4 per cent to 20,100.80, while Britain’s FTSE 100 declined 0.2 per cent to 8,343.17. The future contract for the S&P 500 edged 0.2 per cent higher and that for the Dow Jones Industrial Average was up 0.4 per cent. South Korean President Yoon Suk Yeol was facing possible impeachment after he suddenly declared martial law on Tuesday night, prompting troops to surround the Parliament. Yoon accused pro-North Korean forces of plotting to overthrow one of the world’s most vibrant democracies. The martial law declaration was revoked about six hours later. Yesterday, South Korea’s main opposition party called for President Yoon to resign immediately or face impeachment. Yoon’s move caused the won to plummet to a two-year low against the US dollar, with losses of up to two per cent, the sharpest one-day drop since the market’s seismic reaction to Donald Trump’s 2016 election victory. The won recovered some of those losses yesterday. The dollar was trading at 1,412.87 won, down from Tuesday’s peak at 1,443.40. South Korea’s Kospi closed 1.4 per cent lower to 2,464.00. Shares of Samsung Electronics, the country’s biggest company, fell 0.9 per cent. Meanwhile, the country’s financial regulator said they were prepared to deploy KRW10 trillion (USD7.07 billion) into a stock market stabilization fund at any time, the Yonhap news agency reported. Elsewhere in the region, China announced on Tuesday it was banning exports to the United States of gallium, germanium, antimony and other key high-tech materials with potential military applications. The Shanghai Composite fell 0.4 per cent to 3,364.65. Japan’s benchmark Nikkei 225 rose 0.1 per cent to 39,276.39. Australia’s S&P/ASX 200 dropped 0.4 per cent to 8,462.60. On Tuesday, US stocks tiptoed to more records, tacking a touch more onto what’s already been a stellar year. The S&P 500 edged up less than 0.1 per cent to 6,049.88, setting an all-time high for the 55th time this year.

Hologic Statement on USPSTF Draft Cervical Cancer Screening GuidelinesEvents taking place at Clearview and High Plains library districts, Loveland Public Library for Dec. 1-6Sam Hicks, defense lead Abilene Christian over Northern Arizona 24-0 to extend 1st trip to playoffs

BY MELISSA GOLDIN Social media users are misrepresenting a report released Thursday by the Justice Department inspector general’s office, falsely claiming that it’s proof the FBI orchestrated the Capitol riot on Jan. 6, 2021. The watchdog report examined a number of areas, including whether major intelligence failures preceded the riot and whether the FBI in some way provoked the violence. Claims spreading online focus on the report’s finding that 26 FBI informants were in Washington for election-related protests on Jan. 6, including three who had been tasked with traveling to the city to report on others who were potentially planning to attend the events. Although 17 of those informants either entered the Capitol or a restricted area around the building during the riot, none of the 26 total informants were authorized to do so by the bureau, according to the report. Nor were they authorized to otherwise break the law or encourage others to do so. Here’s a closer look at the facts. CLAIM: A December 2024 report released by the Department of Justice’s Office of the Inspector General is proof that the Jan. 6 Capitol riot was a setup by the FBI. THE FACTS: That’s false. The report found that no undercover FBI employees were at the riot on Jan. 6 and that none of the bureau’s informants were authorized to participate. Informants, also known as confidential human sources, work with the FBI to provide information, but are not on the bureau’s payroll. Undercover agents are employed by the FBI. According to the report, 26 informants were in Washington on Jan. 6 in connection with the day’s events. FBI field offices only informed the Washington Field Office or FBI headquarters of five informants that were to be in the field on Jan. 6. Of the total 26 informants, four entered the Capitol during the riot and an additional 13 entered a restricted area around the Capitol. But none were authorized to do so by the FBI, nor were they given permission to break other laws or encourage others to do the same. The remaining nine informants did not engage in any illegal activities. None of the 17 informants who entered the Capitol or surrounding restricted area have been prosecuted, the report says. A footnote states that after reviewing a draft of the report, the U.S. attorney’s office in Washington said that it “generally has not charged those individuals whose only crime on January 6, 2021 was to enter restricted grounds surrounding the Capitol, which has resulted in the Office declining to charge hundreds of individuals; and we have treated the CHSs consistent with this approach.” The assistant special agent in charge of the Washington Field Office’s counterterrorism division told the inspector general’s office that he “denied a request from an FBI office to have an undercover employee engage in investigative activity on January 6.” He, along with then-Washington Field Office Assistant Director in Charge Steven D’Antuono, said that FBI policy prohibits undercover employees at First Amendment-protected events without investigative authority. Many social media users drew false conclusions from the report’s findings. “JANUARY 6th WAS A SETUP!” reads one X post that had received more than 11,400 likes and shares as of Friday. “New inspector general report shows that 26 FBI/DOJ confidential sources were in the crowd on January 6th, and some of them went into the Capitol and restricted areas. Is it a coincidence that Wray put in his resignation notice yesterday? TREASON!” The mention of Wray’s resignation refers to FBI Director Christopher Wray’s announcement Wednesday that he plans to resign at the end of President Joe Biden’s term in January. Other users highlighted the fact that there were 26 FBI informants in Washington on Jan. 6, but omitted key information about the findings of the report. These claims echo a fringe conspiracy theory advanced by some Republicans in Congress that the FBI played a role in instigating the events of Jan. 6, 2021, when rioters determined to overturn Republican Donald Trump’s 2020 election loss to Democrat Joe Biden stormed the Capitol in a violent clash with police. The report knocks that theory down. Wray called such theories “ludicrous” at a congressional hearing last year. Asked for comment on the false claims spreading online, Stephanie Logan, a spokesperson for the inspector general’s office, pointed The Associated Press to a press release about the report. In addition to its findings about the the FBI’s involvement on Jan. 6, the report said that the FBI, in an action its now-deputy director described as a “basic step that was missed,” failed to canvass informants across all 56 of its field offices for any relevant intelligence ahead of time. That was a step, the report concluded, “that could have helped the FBI and its law enforcement partners with their preparations in advance of January 6.” However, it did credit the bureau for preparing for the possibility of violence and for trying to identify known “domestic terrorism subjects” who planned to come to Washington that day. The FBI said in a letter responding to the report that it accepts the inspection general’s recommendation “regarding potential process improvements for future events.”Senators visit the Kings following Gaudette's 2-goal performanceCanucks visit the Red Wings after shootout win

Tahj Brooks shines in final home game as Texas Tech routs West Virginia 52-15

OpenAI's legal battle with Elon Musk reveals internal turmoil over avoiding AI 'dictatorship'Purdy senior Carter Keeling logged a game-high 28 points, including 14 in the opening quarter, as the Purdy High School Eagles defeated the Thomas Jefferson Cavaliers 72-64 in boys hoops action Thursday night at Thomas Jefferson Independent Day School. TJ (3-3) hit a quick 3-pointer from sophomore Jack Twiss in the opening seconds of the first quarter, but Purdy (5-3) went on a 10-0 run, capped off by a Will Henderson trey at 5:52. Twiss stopped the bleeding with his second trey of the quarter at 5:40 to pull the Cavaliers within 4 at 10-6. TJ regained the lead at 3:30 off a 3-pointer by freshman Will Twiss that made it a 13-12 game. Purdy took the lead back seconds later with a Keeling bucket and led until 1:14, when Jack Twiss put the Cavaliers up 18-17 with a free throw. Cavaliers junior Kohl Thurman dropped in a score to close the quarter with TJ leading 20-17. TJ opened the second quarter with a Will Twiss 3-pointer, but Purdy answered with a trey of it own, courtesy of senior Teagan Manwarren. Will Twiss had the answer again as he buried another 3-pointer to give TJ a 26-20 lead. A 3-pointer by Thurman put the Cavaliers up 31-22 with a little more than five minutes left in the half. The Cavaliers claimed a 14-point lead off a Simon Studer trey with about 30 seconds left, but Purdy pared that lead to 11 on a Will Henderson 3-pointer to close out the half with TJ up 41-30. Jack Twiss gave the Cavaliers back their 14-point lead, opening the third quarter with another 3-pointer, but Purdy rallied back to within 6 points at 46-52 at the end of the third after outscoring the Cavaliers 16-12 in the remainder of the third quarter. TJ got a transition bucket from Jack Twiss to open the fourth quarter, but Purdy went on an 8-0 run and tied the game at 54-54 on a Damon Mahurin bucket with 5:50 left in the game. The Eagles took their first lead since the first quarter of the game at the 4:50 mark of the final frame with a Daniel Aldaba score at 4:50. Jack Twiss ended a more than four-minute scoring drought for TJ with a 3-pointer at 3:12 that pulled the Cavaliers within a point at 57-58, but Purdy went on another 8-0 run that gave them a 66-57 lead with 58 seconds left. TJ endured a handful of costly turnovers down the stretch as Purdy held on for the 72-64 win. Despite the loss, the young TJ squad has already matched its win total from last season. "We're a young basketball team that's coming off a three-win season last year," Cavaliers head coach Chris Myers said. "Where we're at is encouraging. We did a lot of really good things tonight. Obviously, we didn't finish the game well, but that is pretty typical of a young team. The more you are in these situations, the more you learn from them and improve your chances of executing in those moments during the second half of the season." Jack Twiss led TJ with 27 points, including five 3-pointers. Thurman logged 13 points and Spencer Long chipped in with 9. Myers talked about brothers Jack and Will Twiss. "All of our kids' efforts tonight was phenomenal, but we do kind of lean heavily on our dual point guard system with the Twiss brothers." Myers said. "They play their hearts out. It becomes contagious, and their teammates follow them." In addition to Keelings' 28 points, the Eagles got 10 from Henderson and 9 from Mahurin. TJ hosts Lockwood High School (2-2) on Monday, while Purdy will travel to Exeter High School (1-6) on Monday.

FACT FOCUS: Inspector general’s Jan. 6 report misrepresented as proof of FBI setupPromotion Affirms Company's Commitment to Galvanize New Era of Tech-Driven Real Estate Investment NEW YORK , Dec. 12, 2024 /PRNewswire/ -- Underscoring its commitment to revolutionize investment strategies by leveraging advanced technologies to drive investor value, real estate investment firm AWH Partners announces the promotion of Devashish (Dev) Sharma to director of analytics. Sharma, who has been with the New York -based firm since July 2023 , has played a pivotal role in enhancing returns for investors by strengthening the integration of technology and data analytics in his previous role in asset management. In this new position, he will leverage the firm's data assets to create insights that sharpen acquisition strategies, improve asset performance, and strengthen overall decision-making and corporate governance, ultimately driving superior outcomes for stakeholders. In leading this newly created role, Sharma will focus on enhancing AWH Partners' cross-functional data ecosystem and optimizing technology-enabled processes to deliver actionable investment insights, streamline analysis, automate recurring tasks, and identify market opportunities ahead of industry trends. By developing business intelligence tools and mechanisms, he will ensure the firm's leadership and continuity in hospitality real estate, delivering enhanced transparency and scalability of tech-driven initiatives to foster sustainable growth and maximize investor returns. With dual master's degrees in business administration and hospitality management from Cornell University , Sharma has 13 years' experience across investment banking, real estate financing, hotel acquisition and hotel asset management. Before relocating to the U.S. for his graduate studies, Sharma was the investment manager at SAMHI Hotels, which specializes in hotel investments in India , and an associate investment manager at Piramal Fund Management, one of the first firms to enter real estate fund management in India . His global expertise in real estate financing and operational excellence has directly contributed to the success of the firm's high-value investment portfolios. "Dev brings a truly exceptional background to this new role with his experience in real estate financing and data analytics, as well as earning advanced degrees in business and hospitality from one of this country's premier Ivy League universities. Since joining AWH, he has demonstrated dedication and passion for helping the firm realize the next level of data-driven decision-making," said Chad Cooley , co-founder and managing partner of AWH Partners. "His work has strengthened our ability to deliver consistent value to our investors, helping us stand out in an increasingly competitive market." AWH Partners has made substantial investments in technology to identify and acquire differentiated investment opportunities in a highly competitive marketplace. This position underscores the firm's strategic focus on combining innovation and expertise to generate superior investor outcomes. By empowering its team with leadership opportunities, AWH Partners fosters an environment where talent thrives, furthering its goal of shaping the future of real estate investment. Sharma's leadership will continue to advance the firm's mission to deliver sustainable growth and performance across its portfolio. A native of India , Sharma is a chartered accountant and earned his bachelor's degree in finance from Sri Venkateswara College at the University of Delhi in 2009. Sharma's global perspective and track record of integrating analytics into investment strategies position him as a key player in advancing AWH Partners' investor-centric vision. "My goal is to further integrate analytics into every aspect of our investment process to ensure we are at the forefront of data and technology use in real estate investment worldwide," he said. About AWH Partners: AWH Partners (AWH) is a leading national platform for hotel real estate investment, management and development. Privately held, it was founded in 2010 by alumni of The Blackstone Group and The Related Companies. The firm partners with marquee institutional investors, family offices, and high-net-worth individuals around the world. Its portfolio includes properties from renowned brands, including the Marriott and Hilton corporations, as well as independently branded assets. View original content to download multimedia: https://www.prnewswire.com/news-releases/awh-partners-promotes-dev-sharma-as-director-of-analytics-302330763.html SOURCE AWH PartnersA voter-approved Maine limit on PAC contributions sets the stage for a legal challenge

But alongside his stark warning of the threats facing Britain and its allies, Admiral Sir Tony Radakin said there would be only a “remote chance” Russia would directly attack or invade the UK if the two countries were at war. The Chief of the Defence Staff laid out the landscape of British defence in a wide-ranging speech, after a minister warned the Army would be wiped out in as little as six months if forced to fight a war on the scale of the Ukraine conflict. The admiral cast doubt on the possibility as he gave a speech at the Royal United Services Institute (Rusi) defence think tank in London. He told the audience Britain needed to be “clear-eyed in our assessment” of the threats it faces, adding: “That includes recognising that there is only a remote chance of a significant direct attack or invasion by Russia on the United Kingdom, and that’s the same for the whole of Nato.” Moscow “knows the response will be overwhelming”, he added, but warned the nuclear deterrent needed to be “kept strong and strengthened”. Sir Tony added: “We are at the dawn of a third nuclear age, which is altogether more complex. It is defined by multiple and concurrent dilemmas, proliferating nuclear and disruptive technologies and the almost total absence of the security architectures that went before.” He listed the “wild threats of tactical nuclear use” by Russia, China building up its weapon stocks, Iran’s failure to co-operate with a nuclear deal, and North Korea’s “erratic behaviour” among the threats faced by the West. But Sir Tony said the UK’s nuclear arsenal is “the one part of our inventory of which Russia is most aware and has more impact on (President Vladimir) Putin than anything else”. Successive British governments had invested “substantial sums of money” in renewing nuclear submarines and warheads because of this, he added. The admiral described the deployment of thousands of North Korean soldiers on Ukraine’s border alongside Russian forces as the year’s “most extraordinary development”. He also signalled further deployments were possible, speaking of “tens of thousands more to follow as part of a new security pact with Russia”. Defence minister Alistair Carns earlier said a rate of casualties similar to Russia’s invasion of Ukraine would lead to the army being “expended” within six to 12 months. He said it illustrated the need to “generate depth and mass rapidly in the event of a crisis”. In comments reported by Sky News, Mr Carns, a former Royal Marines colonel, said Russia was suffering losses of around 1,500 soldiers killed or injured a day. “In a war of scale – not a limited intervention, but one similar to Ukraine – our Army for example, on the current casualty rates, would be expended – as part of a broader multinational coalition – in six months to a year,” Mr Carns said in a speech at Rusi. He added: “That doesn’t mean we need a bigger Army, but it does mean you need to generate depth and mass rapidly in the event of a crisis.” Official figures show the Army had 109,245 personnel on October 1, including 25,814 volunteer reservists. Mr Carns, the minister for veterans and people, said the UK needed to “catch up with Nato allies” to place greater emphasis on the reserves. The Prime Minister’s official spokesman said Defence Secretary John Healey had previously spoken about “the state of the armed forces that were inherited from the previous government”. The spokesman said: “It’s why the Budget invested billions of pounds into defence, it’s why we’re undertaking a strategic defence review to ensure that we have the capabilities and the investment needed to defend this country.”

The Washington Commanders released 2023 first-rounder Emmanuel Forbes on Saturday, cutting ties with another high draft pick from the previous regime. All of previous coach Ron Rivera's first-rounders — including edge rusher Chase Young in 2020, linebacker Jamin Davis in ‘21 and wide receiver Jahan Dotson in '22 — are now gone. Forbes never showed progress to the new staff led by coach Dan Quinn and was a healthy scratch twice this season and did not play in two other games during which the 23-year-old was in uniform. Javascript is required for you to be able to read premium content. Please enable it in your browser settings. Get any of our free email newsletters — news headlines, obituaries, sports, and more.

nCino Reports Third Quarter Fiscal Year 2025 Financial ResultsOpenAI has teased , and repeatedly delayed, the release of Sora for nearly a year. On Tuesday, the company finally unveiled a fully functional version of the new video-generation model destined for public use and, despite the initial buzz, more and more early users of the release don’t seem overly impressed. And neither am I. The company first introduced Sora last February to critical acclaim for its hyperrealistic video renderings. “Sora can generate videos up to a minute long while maintaining visual quality and adherence to the user’s prompt,” OpenAI wrote in its announcement blog at the time. “The model understands not only what the user has asked for in the prompt, but also how those things exist in the physical world.” The company released more Sora-generated footage in March, this time of an elephant made of leafs , further hyping the model’s capabilities. The Sora program subsequently ran into a series of development delays, which OpenAI’s chief product officer Kevin Weil blamed in a recent Reddit AMA on the “need to perfect the model, get safety/impersonation/other things right, and scale compute.” At the same time, The Information reported that early iterations of Sora suffered from poor performance and struggled to maintain a focus on the user’s prompts, requiring up to 10 real-world minutes to generate a minute-long clip. The model was also recently leaked online by a group of disgruntled beta testers who objected to OpenAI’s “art-washing” practices , however, the company swiftly had the group’s unauthorized UI removed from Hugging Face in response. While OpenAI was tweaking and refining Sora’s performance, the company’s competition was eating its lunch. Adobe’s Firefly AI , Runway’s Gen 3 Alpha , Meta’s Movie Gen , and Kuaishou Technology’s Kling (not to mention countless free-to-use options ) proliferated throughout the internet this past year, with many offering clips of superior quality and faster inference times than what OpenAI had repeatedly promised. On Tuesday, OpenAI officially unveiled the production-ready version of Sora and released it to its $20-a-month Plus and $200-a-month (lol) Pro subscribers. Or, at least, the company did for a few hours. As technology commentator Ed Zitron noted on Bluesky Wednesday , “mere hours — maybe even less — after saying Sora was out, OpenAI stopped accepting new account registrations with no clear timeline. OpenAI bait-and-switched the entire tech media. There’s no way this company can afford to have their video generator available to the public.” For the folks who did manage to gain access, the videos that Sora managed to generate were less than impressive. As YouTube personality Marques Brownlee pointed out during his hands-on video with the model, it required multiple minutes to generate a single 20-second-long 1080p resolution clip and had significant difficulty in generating a subject’s legs and their movements, with the front and rear legs unnaturally swapping positions throughout the clip. One need only look at the generated video below of a gymnast swapping their arms, legs, and head on the fly as they tumble across a mat to see what he meant. Bluesky user Peter Labuza, who posted the gymnastics video, did not hold back on his criticism of the model, stating : “I’m sorry, but if you make a text-to-video generator and you tell it “make a cat run through a field” and you give it the starting image, and the cat simply STANDS, your generator Does Not Work.” Bluesky user Chris Offner held a similar opinion, sarcastically noting that “Sora is a data-driven physics engine” while sharing an absolutely bonkers clip of a skier defying most, if not all, known laws of physics. The Verge also tried out the model, bemoaning the fact that it still couldn’t avoid unsightly inclusions like “additional limbs or distorted objects.” Not everybody hated Sora on sight, mind you. X user Nathan Shipley showed off the model’s “remix” feature, which enables users to mask a generated video to the movements of objects in an uploaded sample. In this case, he made a generated crane’s head move in the same manner as a pair of scissors he videotaped himself holding. There’s no word yet on when the company will be able to reliably reopen account signups for interested Sora users. Whether OpenAI can court Hollywood with Sora in its current state, as Runway recently did with Gen 3 and Lionsgate , also remains to be seen. One thing remains certain, OpenAI, despite its initial lead in the AI boom, is quickly being surpassed by the rest of the industry, and lackluster product releases like what we just saw with Sora will only further harm the company’s reputation.

Ingram Micro Awarded Two 2024 AWS Partner AwardsCOPENHAGEN, Denmark, Dec. 12, 2024 (GLOBE NEWSWIRE) -- Ascendis Pharma A/S ASND today announced that the U.S. Food & Drug Administration (FDA) has accepted for review its supplemental Biologics License Application (sBLA) in adult growth hormone deficiency (GHD) for TransCon hGH (lonapegsomatropin-tcgd; marketed as SKYTROFA ® for pediatric GHD). The FDA set a Prescription Drug User Fee Act (PDUFA) goal date of July 27, 2025. "This marks another step towards achieving our objective to expand SKYTROFA's label beyond pediatric GHD and expand its reach to address new groups of patients," said Jan Mikkelsen, Ascendis Pharma's President and Chief Executive Officer. "Adult GHD is an undertreated condition associated with significant comorbidities and higher annual healthcare costs compared to the 5-10% of patients who receive treatment, indicative of the high unmet need." The sBLA submission is based on results from foresiGHt, a Phase 3 randomized, parallel-arm, placebo-controlled (double-blind) and active-controlled (open-label) trial that compared the efficacy and safety of weekly TransCon hGH with weekly placebo and daily human growth hormone (hGH) in adults with GHD. The trial evaluated 259 adults with GHD aged 23 to 80 years old, randomized 1:1:1, titrated to receive a target fixed dose of TransCon hGH, placebo, or daily hGH based on age and oral estrogen intake with approximately equivalent hGH mg/week for TransCon hGH and daily hGH. TransCon hGH demonstrated superiority on its primary efficacy and key secondary efficacy endpoints at Week 38, with TransCon hGH-treated participants showing a statistically significant reduction from baseline in trunk fat and increase in total body lean mass at Week 38 compared to placebo. In the trial, TransCon hGH was generally safe and well tolerated, with no discontinuations related to study drug and with comparable safety and tolerability to daily hGH treatment. About Adult Growth Hormone Deficiency Growth hormone plays an essential role in the health of children and adults, promoting normal growth in children and maintenance of normal body composition and cardiometabolic health throughout adulthood. In adults, growth hormone boosts protein production, promotes fat utilization, enhances muscle mass, and helps regulate blood sugar levels. Adult GHD is a condition in which an individual's body does not produce enough growth hormone. Symptoms and morbidity can include central obesity, metabolic syndrome, decreased bone density, alterations in lipid profile and markers of cardiovascular risk, fatigue, general weakness, lack of muscle tone, and psychological symptoms such as cognitive impairment, social isolation, lack of motivation, and depression. 1 About Ascendis Pharma A/S Ascendis Pharma is applying its innovative TransCon technology platform to build a leading, fully integrated biopharma company focused on making a meaningful difference in patients' lives. Guided by its core values of Patients, Science, and Passion, Ascendis uses its TransCon technologies to create new and potentially best-in-class therapies. Ascendis is headquartered in Copenhagen, Denmark and has additional facilities in Europe and the United States. Please visit ascendispharma.com to learn more. Forward-Looking Statements This press release contains forward-looking statements that involve substantial risks and uncertainties. All statements, other than statements of historical facts, included in this press release regarding Ascendis' future operations, plans and objectives of management are forward-looking statements. Examples of such statements include, but are not limited to, statements relating to (i) the PDUFA goal date for SKYTROFA, (ii) Ascendis' objective to expand SKYTROFA's label and reach to address new groups of patients, (iii) Ascendis' ability to apply its TransCon technology platform to build a leading, fully integrated biopharma company, and (iv) Ascendis' use of its TransCon technologies to create new and potentially best-in-class therapies. Ascendis may not actually achieve the plans, carry out the intentions or meet the expectations or projections disclosed in the forward-looking statements and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions, expectations, and projections disclosed in the forward-looking statements. Various important factors could cause actual results or events to differ materially from the forward-looking statements that Ascendis makes, including the following: dependence on third party manufacturers, distributors and service providers for Ascendis' products and product candidates; unforeseen safety or efficacy results in Ascendis' development programs or on-market products; unforeseen expenses related to commercialization of any approved Ascendis products; unforeseen expenses related to Ascendis' development programs; unforeseen selling, general and administrative expenses, other research and development expenses and Ascendis' business generally; delays in the development of its programs related to manufacturing, regulatory requirements, speed of patient recruitment or other unforeseen delays; Ascendis' ability to obtain additional funding, if needed, to support its business activities; the impact of international economic, political, legal, compliance, social and business factors. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to Ascendis' business in general, see Ascendis' prospectus supplement filed on September 20, 2024 and Ascendis' current and future reports filed with, or submitted to, the U.S. Securities and Exchange Commission (SEC), including its Annual Report on Form 20-F filed with the SEC on February 7, 2024. Forward-looking statements do not reflect the potential impact of any future licensing, collaborations, acquisitions, mergers, dispositions, joint ventures, or investments that Ascendis may enter into or make. Ascendis does not assume any obligation to update any forward-looking statements, except as required by law. Ascendis, Ascendis Pharma, the Ascendis Pharma logo, the company logo, TransCon, and SKYTROFA ® , are trademarks owned by the Ascendis Pharma group. © December 2024 Ascendis Pharma A/S. Investor Contacts: Media Contact: Scott Smith Melinda Baker Ascendis Pharma Ascendis Pharma ir@ascendispharma.com +1 (650) 709-8875 media@ascendispharma.com Patti Bank ICR Westwicke +1 (415) 513-1284 patti.bank@icrhealthcare.com 1 . Hoffman AR, Mathison T, Andrews D, Murray K, Kelepouris N, Fleseriu M. Adult Growth Hormone Deficiency: Diagnostic and Treatment Journeys From the Patients' Perspective. J Endocr Soc. 2022;6(7):bvac077. Published 2022 May 12. doi:10.1210/jendso/bvac077 © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

NoneLudhiana: A 43-year-old woman thwarted a mobile snatching attempt in Janakpuri, sustaining injuries while hanging on to her attacker. With help from onlookers, she captured one suspect, Charandeep Singh , while two others escaped. Police have lodged an FIR.. We also published the following articles recently ED team attacked while conducting raids in Delhi; FIR lodged During raids on a suspected cybercrime network in Delhi, Enforcement Directorate officials were attacked, injuring an additional director. The agency's High-Intensity Unit targeted chartered accountants allegedly involved in laundering funds from phishing, QR code fraud, and job scams. Five individuals were involved in the attack in Bijwasan, with one escaping. Guwahati woman injured in failed chain snatching attempt A woman walking with her husband in Guwahati's Sundarpur area was attacked during a thwarted chain-snatching attempt on Saturday morning. Two motorcycle-borne assailants tried to grab her chain, but it snagged in her hair. Resisting, she was injured with a sharp weapon and pushed into a drain. Criminal injured while trying to escape Following a burglary report in Kanpur on November 25th, police swiftly apprehended two suspects and a juvenile, recovering stolen goods. Further investigation led to the arrest of Abrar and a female accomplice. While leading police to a hidden firearm, Abrar attacked an officer and opened fire, prompting police to shoot him in the leg. Stay updated with the latest news on Times of India . Don't miss daily games like Crossword , Sudoku , and Mini Crossword .OpenAI's legal battle with Elon Musk reveals internal turmoil over avoiding AI 'dictatorship'

None(The Center Square) – Adoption of institutional neutrality is supported by better than 6 in 10 tenured and nontenured faculty at the University of North Carolina, Wake Forest University and Duke University, a report says. Nationally, 66% of faculty say “colleges and universities should not take positions on political and social issues,” says Silence in the Classroom, the 2024 FIRE Faculty Survey Report. At Duke, the percentage is 71%, at Carolina 65%, and at Wake 64%. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.By Charles Hymas A "close confidant" of the Duke of York is an alleged Chinese spy who has been banned from entering the UK on national security grounds. The man, known only as H6, was once a junior civil servant in China and was so close to Prince Andrew that he had been told he could act on the royal's behalf when dealing with potential investors in China, according to a secret hearing. He was also invited to the Duke's birthday party in 2020, and was described by the judges overseeing the case as a " close confidant of the Duke ". READ MORE: 'Worst' thing Tim Davies was forced to 'battle through' live on air However, the Home Office decided to exclude H6, aged 50, from the UK in July 2023 after MI5 deemed him to be an agent who had engaged in "covert and deceptive activity" on behalf of the Chinese Communist Party (CCP) and that he posed a threat to national security. A letter from a senior adviser to the Duke was found on H6's phone, stating that he was authorised to act on behalf of the royal in engagements with potential partners and investors in China. H6 challenged this, but a special immigration commission has now ruled that Suella Braverman, the home secretary at the time, was justified in her decision to ban him from the UK. For a daily dose of 9honey, subscribe to our newsletter here . In their 53-page ruling, the judges said that the Duke could have been made "vulnerable" to the misuse of H6's influence. In a ruling on Thursday, Mr Justice Bourne, Judge Stephen Smith and Sir Stewart Eldon said: "The secretary of state was entitled to conclude that the applicant represented a risk to the national security of the United Kingdom and that she was entitled to conclude that his exclusion was justified and proportionate." The Special Immigration Appeals Commission (SIAC) initially granted H6 anonymity but this was lifted by the judges to take effect from Thursday (December 12). READ MORE: The one place you should never take your dog for a walk H6 appealed the lifting of the anonymity order and was granted "interim relief", meaning that it will be decided by the High Court at a future date whether he should be named. The SIAC hearing was told that the contents of the businessman's mobile telephone were downloaded when he was stopped under counter-terrorism laws at a UK border in 2021. The mobile's contents revealed that the Duke authorised the man to set up an international financial initiative known as the Eurasia Fund to engage with potential partners and investors in China. The phone contained a March 2021 letter from Dominic Hampshire, a senior adviser to the Duke, confirming the businessman could act on behalf of the royal in engagements with potential partners and investors in China. FOLLOW US ON WHATSAPP HERE : Stay across all the latest in celebrity, lifestyle and opinion via our WhatsApp channel. No comments, no algorithm and nobody can see your private details. The letter states: "I also hope that it is clear to you where you sit with my principal and indeed his family. You should never underestimate the strength of that relationship ... outside of his closest internal confidants, you sit at the very top of a tree that many, many people would like to be on." It added that after a meeting with the Duke, they had "wisely navigated our way around former private secretaries and we have found a way to carefully remove those people who we don't completely trust". It said: "Under your guidance, we found a way to get the relevant people unnoticed in and out of the house in Windsor." The immigration judges were told that in a briefing for the home secretary in July 2023, officials claimed H6 had been in a position to generate relationships between prominent UK figures and senior Chinese officials "that could be leveraged for political interference purposes". They also said that H6 had downplayed his relationship with the Chinese state, which combined with his relationship with the Duke represented a threat to national security. At a hearing in July, the specialist tribunal heard that the businessman was told by an advisor to the Duke that he could act on his behalf when dealing with potential investors in China and that H6 had been invited to Andrew's birthday party in 2020. They said: "The applicant won a significant degree, one could say an unusual degree, of trust from a senior member of the Royal family who was prepared to enter into business activities with him. "That occurred in a context where, as the contemporaneous documents record, the Duke was under considerable pressure and could be expected to value the applicant's loyal support. "It is obvious that the pressures on the Duke could make him vulnerable to the misuse of that sort of influence. "That does not mean that the home secretary could be expected to exclude from the UK any Chinese businessman who formed a commercial relationship with the Duke or with any other member of the Royal family." In 2020, the Duke found himself under increasing pressure following the disastrous Newsnight interview about his connections with Jeffrey Epstein, the convicted paedophile who died in 2019. He was effectively sacked as a working member of the Royal family, and stripped of all honorary military titles and patronages. The Duke is understood to have paid about $US12 million (approx. $18.9 million) to settle the case brought against him by Virginia Giuffre, who accused him of raping and abusing her three times in 2001 when she was 17. The Duke vehemently denies Ms Giuffre's claims. King Charles is thought to have funded the Duke after he left public life, with a reported annual allowance of £1 million (approx. $2 million) per year. However, the King is understood to have severed the allowance earlier this year. Recently, he has been involved in wrangling with his brother over whether he has sufficient funds to continue living at Royal Lodge. As the UK's special representative for trade and investment, the Duke was said to have particularly close ties to China, visiting the country on several occasions between 2004 and 2011 when he stepped down amid criticism over his friendship with Epstein. In October 2014, he returned to Beijing, where he opened a campus at Harrow International School. In 2014, he also called on British businesses to grasp opportunities offered by China, telling the BBC they needed to be less polite, more competitive, "more bullish" and embrace the Chinese market. In 2015, he played a high-profile role during an incoming state visit by Xi Jinping, the Chinese president, joining the CCP leader on multiple engagements. The three judges said that H6 had enjoyed a private life in the UK, which had been described as the businessman's "second home", adding: "He has settled status, a home and extensive business interests in the United Kingdom. He was regarded as a close confidant of the Duke." The judges continued the home secretary was "rationally entitled to decide" that there was a potential to leverage the relationship, adding H6 was "not candid" about his links to the CCP. © Telegraph Media Group Limited 2024