Imagine the deep frustration of countless men who long to become fathers, only to face infertility due to a genetic condition they can't control. For those with Klinefelter syndrome, this painful reality is a constant struggle. How does an extra X chromosome lead to infertility in men? Professor Qiao Jie and her team at Peking University Third Hospital revealed why Klinefelter syndrome, a common genetic condition affecting one in every 600 men, often leads to infertility-;and they've identified a potential way to treat it. Their research, titled "How the extra X chromosome impairs the development of male fetal germ cells," published in Nature Cells ( DOI: 10.1038/s41586-024-08104-6 ) provides new insights into the molecular mechanisms at play and even offers potential treatment avenues. The problem: Why many men with Klinefelter syndrome can't have children Men with Klinefelter syndrome have an extra X chromosome, meaning their genetic makeup is "47, XXY" instead of the usual "46, XY." They usually lose large amounts of key reproductive cells before puberty. This means they produce very few or no sperm and, until now, have no reliable treatment options. While some can still father children with advanced reproductive technology, nearly half still struggle to find usable sperm. The research: Examining cells before they are lost The team studied fetal germ cells (FGCs) from Klinefelter patients, which develop early in life before disappearing. They found that the presence of the extra X chromosome causes both X chromosomes to remain active in fetal germ cells, causing an overload of certain genes. This gene surge disrupts important biological pathways and prevents the cells from maturing properly. Additionally, these cells could not move to the right location in the testes, which is necessary for them to grow into mature, sperm-producing cells. With abnormal gene activity and disrupted movement, these cells are lost early, well before they can develop into functional sperm. Key findings and potential treatments The team found that using TGF-β inhibitors could help these fetal germ cells mature normally, pointing to possible treatments for infertility in men with Klinefelter syndrome. With this study, Professor Qiao Jie's team brings new understanding and hope to men facing infertility, highlighting the significant contributions of Peking University Third Hospital to advancing reproductive health science. Peking UniversityWake Forest keeps trying new things early in the season, even if not all of the adjustments are by design. The Demon Deacons will try to stick to the script when Detroit Mercy visits for Saturday's game in Winston-Salem, N.C. The Demon Deacons (5-1) will be at home for the final time prior to three consecutive road games. Detroit Mercy (3-2) already has two more victories than all of last season. After a couple of narrow wins and a loss at Xavier, Wake Forest had a smoother time earlier this week in defeating visiting Western Carolina 82-69 on Tuesday night. Yet these are games when teams have to figure where contributions are going to come from in certain situations. The experimenting took a turn for Wake Forest in the Western Carolina game. Center Efton Reid III had limited minutes because of migraines, so there was a shift in responsibilities. Normal backcourt players Cameron Hildreth and Juke Harris logged time at the power forward slot. "That's just part of it," coach Steve Forbes said. "They did a good job adjusting. We ran a lot of stuff and there are several guys learning different positions. ... I give credit to those guys for doing the best job that they could do on the fly and adjusting to the play calls that we ran and the stuff that we changed." Wake Forest could excel if both Parker Friedrichsen and Davin Cosby can be consistent 3-point threats. Friedrichsen slumped with shooting in the first few games of the season and was replaced in the starting lineup by Cosby. In Tuesday's game, Friedrichsen drained four 3-pointers, while Cosby hit two. "It was really good to see Parker and Davin both make shots together," Forbes said. Not everything was solved for the Demon Deacons. Western Carolina collected 12 offensive rebounds, and that took some of the shine off Wake Forest's defensive efforts. "We can't be a good defensive team, or a really good defensive team, unless we rebound the ball," Forbes said. "It's demoralizing to your defense to get stops and then not get the ball." In Detroit Mercy's 70-59 win at Ball State on Wednesday, Orlando Lovejoy tallied 19 points, seven rebounds and five assists. "We got the ball to the shooters and playmakers," first-year Titans coach Mark Montgomery said. "You could tell by the guys' body language that we were going to get a road win. It had been a long time coming." On Saturday, the Titans will look for their second road victory since February 2023. The outcome at Ball State seemed significant to Montgomery. "We had to get over the hump," he said. "Our guys grinded it out." --Field Level Media#acegame888 。

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