download nice88 THOUSAND OAKS, Calif. , Dec. 2, 2024 /PRNewswire/ -- Amgen (NASDAQ:AMGN) will present at Citi's 2024 Global Healthcare Conference at 9:30 a.m. ET on Thursday , Dec. 5, 2024. Peter Griffith , executive vice president and chief financial officer at Amgen, Jay Bradner , executive vice president of Research and Development and chief scientific officer at Amgen, and Susan Sweeney , executive vice president of Obesity and Related Conditions at Amgen, will participate in a fireside chat at the conference. The webcast will be broadcast over the internet simultaneously and will be available to members of the news media, investors and the general public. The webcast, as with other selected presentations regarding developments in Amgen's business given by management at certain investor and medical conferences, can be found on Amgen's website, www.amgen.com , under Investors. Information regarding presentation times, webcast availability and webcast links are noted on Amgen's Investor Relations Events Calendar. The webcast will be archived and available for replay for at least 90 days after the event. About Amgen Amgen discovers, develops, manufactures and delivers innovative medicines to help millions of patients in their fight against some of the world's toughest diseases. More than 40 years ago, Amgen helped to establish the biotechnology industry and remains on the cutting-edge of innovation, using technology and human genetic data to push beyond what's known today. Amgen is advancing a broad and deep pipeline that builds on its existing portfolio of medicines to treat cancer, heart disease, osteoporosis, inflammatory diseases and rare diseases. In 2024, Amgen was named one of the "World's Most Innovative Companies" by Fast Company and one of "America's Best Large Employers" by Forbes, among other external recognitions . Amgen is one of the 30 companies that comprise the Dow Jones Industrial Average ® , and it is also part of the Nasdaq-100 Index ® , which includes the largest and most innovative non-financial companies listed on the Nasdaq Stock Market based on market capitalization. Amgen is one of the 30 companies that comprise the Dow Jones Industrial Average and is also part of the Nasdaq-100 index. In 2023, Amgen was named one of "America's Greatest Workplaces" by Newsweek, one of "America's Climate Leaders" by USA Today and one of the "World's Best Companies" by TIME. For more information, visit Amgen.com and follow us on X (formerly known as Twitter), LinkedIn , Instagram , TikTok , YouTube and Threads . Amgen Forward-Looking Statements This news release contains forward-looking statements that are based on the current expectations and beliefs of Amgen. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including any statements on the outcome, benefits and synergies of collaborations, or potential collaborations, with any other company (including BeiGene, Ltd. or Kyowa Kirin Co., Ltd.), the performance of Otezla ® (apremilast) (including anticipated Otezla sales growth and the timing of non-GAAP EPS accretion), our acquisitions of Teneobio, Inc., ChemoCentryx, Inc., or Horizon Therapeutics plc (including the prospective performance and outlook of Horizon's business, performance and opportunities, any potential strategic benefits, synergies or opportunities expected as a result of such acquisition, and any projected impacts from the Horizon acquisition on our acquisition-related expenses going forward), as well as estimates of revenues, operating margins, capital expenditures, cash, other financial metrics, expected legal, arbitration, political, regulatory or clinical results or practices, customer and prescriber patterns or practices, reimbursement activities and outcomes, effects of pandemics or other widespread health problems on our business, outcomes, progress, and other such estimates and results. Forward-looking statements involve significant risks and uncertainties, including those discussed below and more fully described in the Securities and Exchange Commission reports filed by Amgen, including our most recent annual report on Form 10-K and any subsequent periodic reports on Form 10-Q and current reports on Form 8-K. Unless otherwise noted, Amgen is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise. No forward-looking statement can be guaranteed and actual results may differ materially from those we project. Our results may be affected by our ability to successfully market both new and existing products domestically and internationally, clinical and regulatory developments involving current and future products, sales growth of recently launched products, competition from other products including biosimilars, difficulties or delays in manufacturing our products and global economic conditions. In addition, sales of our products are affected by pricing pressure, political and public scrutiny and reimbursement policies imposed by third-party payers, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international trends toward managed care and healthcare cost containment. Furthermore, our research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. We or others could identify safety, side effects or manufacturing problems with our products, including our devices, after they are on the market. Our business may be impacted by government investigations, litigation and product liability claims. In addition, our business may be impacted by the adoption of new tax legislation or exposure to additional tax liabilities. If we fail to meet the compliance obligations in the corporate integrity agreement between us and the U.S. government, we could become subject to significant sanctions. Further, while we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors, or we may fail to prevail in present and future intellectual property litigation. We perform a substantial amount of our commercial manufacturing activities at a few key facilities, including in Puerto Rico , and also depend on third parties for a portion of our manufacturing activities, and limits on supply may constrain sales of certain of our current products and product candidate development. An outbreak of disease or similar public health threat, such as COVID-19, and the public and governmental effort to mitigate against the spread of such disease, could have a significant adverse effect on the supply of materials for our manufacturing activities, the distribution of our products, the commercialization of our product candidates, and our clinical trial operations, and any such events may have a material adverse effect on our product development, product sales, business and results of operations. We rely on collaborations with third parties for the development of some of our product candidates and for the commercialization and sales of some of our commercial products. In addition, we compete with other companies with respect to many of our marketed products as well as for the discovery and development of new products. Discovery or identification of new product candidates or development of new indications for existing products cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate or development of a new indication for an existing product will be successful and become a commercial product. Further, some raw materials, medical devices and component parts for our products are supplied by sole third-party suppliers. Certain of our distributors, customers and payers have substantial purchasing leverage in their dealings with us. The discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. Our efforts to collaborate with or acquire other companies, products or technology, and to integrate the operations of companies or to support the products or technology we have acquired, may not be successful. There can be no guarantee that we will be able to realize any of the strategic benefits, synergies or opportunities arising from the Horizon acquisition, and such benefits, synergies or opportunities may take longer to realize than expected. We may not be able to successfully integrate Horizon, and such integration may take longer, be more difficult or cost more than expected. A breakdown, cyberattack or information security breach of our information technology systems could compromise the confidentiality, integrity and availability of our systems and our data. Our stock price is volatile and may be affected by a number of events. Our business and operations may be negatively affected by the failure, or perceived failure, of achieving our environmental, social and governance objectives. The effects of global climate change and related natural disasters could negatively affect our business and operations. Global economic conditions may magnify certain risks that affect our business. Our business performance could affect or limit the ability of our Board of Directors to declare a dividend or our ability to pay a dividend or repurchase our common stock. We may not be able to access the capital and credit markets on terms that are favorable to us, or at all. CONTACT: Amgen, Thousand Oaks Elissa Snook , 609-251-1407 (media) Justin Claeys , 805-313-9775 (investors) View original content to download multimedia: https://www.prnewswire.com/news-releases/amgen-to-present-at-citis-2024-global-healthcare-conference-302319891.html SOURCE AmgenHow Greg Vanney unlocked Galaxy greatness in one of the most stunning MLS turnarounds

LOS ANGELES (AP) — After struggling to run the ball consistently all season, the Los Angeles Rams finally made some progress on the ground in New Orleans. Kyren Williams and rookie Blake Corum carried the Rams (6-6) to a 21-14 win that kept them squarely in the playoff race for another week. Los Angeles racked up a season-high 156 yards rushing against the Saints, with Williams going for 104 yards and a touchdown while Corum added 42 yards on a season high-tying eight carries. The game was the inverse of most afternoons this season for the Rams, who came into the week averaging fewer than 100 yards rushing per game. The running game was sturdy and productive, while Matthew Stafford and his receivers struggled to get into a rhythm at the Superdome. Coach Sean McVay always prefers to use his run game to set up the pass, and it finally worked for once this season. “I thought Kyren ran really well," McVay said. “I thought Corum ran really well. I thought our offensive line set the line of scrimmage in the run game. We really started slow in the pass game, but I thought Matthew was excellent in the second half. We were able to get some different things off of those run actions going, and that ended up being the difference in the game.” Not coincidentally, the Rams' running game worked well on the Sunday when the offensive line finally had a starting five uncompromised by injuries or suspension for the first time all season. Right tackle Rob Havenstein returned from an ankle injury, making the group whole around rookie center Beaux Limmer, who has beaten out high-priced free agent Jonah Jackson for a starting job. The Rams still had yet another slow start in a season full of them. They ran only three plays in the entire first quarter, and they were held scoreless in the first half when their other two drives resulted in a turnover on downs and a punt. But Los Angeles rebounded with an 11-play scoring drive to open the second half featuring seven runs by Williams. He eventually moved up to fifth in the NFL with 926 yards rushing despite averaging just 4.2 yards per carry — nearly a yard less than he had last season, and the lowest average among the league's top 10 rushers this season. The Rams have thrived without a strong rushing attack before: They averaged just 99.0 yards per game on the ground, ranking 25th in the NFL, during their Super Bowl championship season in 2021-22. But McVay prefers his first option to be a strong running attack, which he had during his first three seasons in charge with Todd Gurley in the backfield and Andrew Whitworth at left tackle. “Anytime the guys up front are moving them, and (Williams) is making great reads and moves on the second level, then that is a fun feeling for the offense," Stafford said. “It’s great when you can hand the ball off and get big creases. We converted when we needed to in short-yardage stuff. I thought our guys did a really great job up front, and Kyren ran it great.” The Rams have struggled in the red zone all season, but they scored touchdowns on all three trips in New Orleans. They did it by committing to the run game up the middle, setting up TD passes on the outside to Demarcus Robinson and Puka Nacua. Alvin Kamara racked up 112 yards rushing in the latest strong game by an opposing running back. Los Angeles is 28th in the league against the run, allowing 144.2 yards rushing per game — including 194 per game over the past three weeks. Rookie edge rusher Jared Verse had another outstanding game, racking up five tackles, three quarterback hits and numerous big plays that don't show up on stat sheets. He capped the performance by hitting Derek Carr from behind and forcing an incompletion from the Los Angeles 9 on New Orleans' final play. Cornerback Darious Williams gave up a touchdown pass to Marquez Valdes-Scantling and the ensuing 2-point conversion pass to Dante Pettis early in the fourth quarter, capping a second straight rough week for the free-agent signee. Williams is the Rams' best cornerback, but they haven't had an above-average shutdown pass defender since trading Jalen Ramsey. Robinson injured his hand during the game. 17 — Cooper Kupp's yards receiving. That's his lowest total in a game in which he didn't get injured since Oct. 18, 2020. Kupp had only six targets, few downfield routes and curiously scant chances to make big plays. The Rams are home underdogs this week against powerhouse Buffalo, followed by a Thursday night game at San Francisco. Getting even one win out of these two matchups will be difficult, but probably necessary to keep pace with Seattle and Arizona in the NFC West. AP NFL: https://apnews.com/NFL

NJ residents ramp up protests over town council's American flag flap: 'It hit a nerve'NoneBy James Royal, Ph.D., Bankrate.com Cryptocurrencies are enormously volatile, but that volatility can create opportunities for profit if you’re looking to trade these digital assets. Cryptos such as Bitcoin and Ethereum have risen a lot since their debut — but they’ve also experienced tremendous boom-bust cycles along the way. Experienced traders have been speculating on cryptocurrencies for years, but how can you get started if you’re new to the crypto market? Here’s how to start investing in cryptocurrency and the significant risks you need to watch out for. First things first, if you’re looking to invest in crypto, you need to have all your finances in order. That means having an emergency fund in place, a manageable level of debt and ideally a diversified portfolio of investments . Your crypto investments can become one more part of your portfolio, one that helps raise your total returns, hopefully. Pay attention to these five other things as you’re starting to invest in cryptocurrencies. As you would for any investment, understand exactly what you’re investing in. If you’re buying stocks, it’s important to read the annual report and other SEC filings to analyze the companies thoroughly. Plan to do the same with any cryptocurrencies , since there are literally thousands of them, they all function differently and new ones are being created every day. You need to understand the investment case for each trade. In the case of many cryptocurrencies , they’re backed by nothing at all, neither hard assets nor cash flow of an underlying entity. That’s the case for Bitcoin , for example, where investors rely exclusively on someone paying more for the asset than they paid for it. In other words, unlike stock, where a company can grow its profits and drive returns for you that way, many crypto assets must rely on the market becoming more optimistic and bullish for you to profit. Some of the most popular coins include Bitcoin, Ethereum, Solana , Dogecoin and Tether (a stablecoin) . So before investing, understand the potential upside and downside. If your financial investment is not backed by an asset or cash flow, it could end up being worth nothing. A mistake that many new investors make is looking at the past and extrapolating that to the future. Yes, Bitcoin used to be worth pennies, but now is worth much more . The key question, however, is “Will that growth continue into the future, even if it’s not at quite that meteoric rate?” Investors look to the future, not to what an asset has done in the past. What will drive future returns? Traders buying a cryptocurrency today need tomorrow’s gains, not yesterday’s. The prices of cryptocurrencies are about as volatile as an asset can get. They could drop quickly in seconds on nothing more than a rumor that ends up proving baseless. That can be great for sophisticated investors who can execute trades rapidly or who have a solid grasp on the market’s fundamentals, how the market is trending and where it could go. For new investors without these skills — or the high-powered algorithms that direct these trades — it’s a minefield. Volatility is a game for high-powered Wall Street traders, each of whom is trying to outgun other deep-pocketed investors. A new investor can easily get crushed by the volatility. That’s because volatility shakes out traders, especially beginners, who get scared. Meanwhile, other traders may step in and buy on the cheap. In short, volatility can help sophisticated traders “buy low and sell high” while inexperienced investors “buy high and sell low.” If you’re trading any asset on a short-term basis, you need to manage your risk , and that can be especially true with volatile assets such as cryptocurrency. So as a newer trader, you’ll need to understand how best to manage risk and develop a process that helps you mitigate losses. And that process can vary from individual to individual: Newer traders should consider setting aside a certain amount of trading money and then using only a portion of it, at least at first. If a position moves against them, they’ll still have money in reserve to trade with later. The ultimate point is that you can’t trade if you don’t have any money. So keeping some cash in reserve means you’ll always have a bankroll to fund your trading. It’s important to manage risk, but that will come at an emotional cost. Selling a losing position hurts, but doing so can help you avoid worse losses later. Finally, it’s important to avoid putting money that you need into speculative assets. If you can’t afford to lose it — all of it — you can’t afford to put it into risky assets such as cryptocurrency, or other speculative assets, for that matter. Whether it’s a down payment for a house or an important upcoming purchase, money that you need in the next few years should be kept in safe accounts so that it’s there when you need it. And if you’re looking for an absolutely sure return, your best option is to pay off high-interest debt. You’re guaranteed to earn (or save) whatever interest rate you’re paying on the debt. You can’t lose there. Finally, don’t overlook the security of any exchange or broker you’re using. You may own the assets legally, but someone still has to secure them, and their security needs to be tight. If they don’t think their cryptocurrency is properly secured, some traders choose to invest in a crypto wallet to hold their coins offline so they’re inaccessible to hackers or others. Remember that investing in cryptocurrency can be part of a broader investment strategy, but shouldn’t be your only one. While investing directly in cryptocurrency is popular, traders have other ways to get into the crypto game, some more directly than others. These include: Each of these methods varies in its riskiness and exposure to cryptocurrency, so you’ll want to understand exactly what you’re buying and whether it fits your needs. In theory it takes only a few dollars to invest in cryptocurrency. Most crypto exchanges, for example, have a minimum trade that might be $5 or $10. Other crypto trading apps might have a minimum that’s even lower. However, it’s important to understand that some trading platforms will take a huge chunk of your investment as a fee if you’re trading small amounts of cryptocurrency. So it’s important to look for a broker or exchange that minimizes your fees. In fact, many so-called “free” brokers embed fees — called spread mark-ups — in the price you pay for your cryptocurrency. Cryptocurrency is based on blockchain technology . Blockchain is a kind of database that records and timestamps every entry into it. The best way to think of a blockchain is like a running receipt of transactions. When a blockchain database powers cryptocurrency, it records and verifies transactions in the currency, verifying the currency’s movements and who owns it. Many crypto blockchain databases are run with decentralized computer networks. That is, many redundant computers operate the database, checking and rechecking the transactions to ensure that they’re accurate. If there’s a discrepancy, the networked computers have to resolve it. Some cryptocurrencies reward those who verify the transactions on the blockchain database in a process called mining. For example, miners involved with Bitcoin solve very complex mathematical problems as part of the verification process. If they’re successful, miners receive a predetermined award of Bitcoins. To mine Bitcoins , miners need powerful processing units that consume huge amounts of energy. Many miners operate gigantic rooms full of such mining rigs in order to extract these rewards. As of October 2024, running the Bitcoin system burned as much energy per year as the country of Poland. If you’re looking to invest in Bitcoin, you have a variety of ways to do so, and you can work with a number of companies, including: If you’re looking to buy Bitcoin, pay particular attention to the fees that you’re paying. Here are other key things to watch out for as you’re buying Bitcoin . An altcoin is an alternative to Bitcoin. Many years ago, traders would use the term pejoratively. Since Bitcoin was the largest and most popular cryptocurrency, everything else was defined in relation to it. So, whatever was not Bitcoin was lumped into a catch-all category called altcoins . While Bitcoin is still the largest cryptocurrency by market capitalization by far, it’s no longer the only game in town. Other altcoins such as Ethereum and Solana have grown in popularity, making the term altcoin somewhat outmoded. Now with a reported 15,000 or more cryptocurrencies in existence, it makes less sense than ever to define the industry as “Bitcoin and then everything else.” Cryptocurrency is a highly speculative area of the market, and many smart investors have decided to put their money elsewhere. For beginners who want to get started trading crypto, however, the best advice is to start small and only use money that you can afford to lose. Bankrate’s Brian Baker contributed to an update of this story. ©2024 Bankrate.com. Distributed by Tribune Content Agency, LLC.

NoneHealthcare workers protest Israel’s targeting of healthcare infrastructure, workers

AI pioneer Geoffrey Hinton receives Nobel Prize in physics in proud moment for U of T

How to start investing in cryptocurrency: A guide for beginnersMELBOURNE: Spotify has just released its 2024 Spotify Wrapped, the music streaming site’s annual presentation of each user’s yearly listening habits. It gives you a fun recap of your most listened to songs, artists and genres from the past year – complete with stats like how many minutes you listened and your top genre “phases” or “moments”. The tradition has seized the cultural zeitgeist throughout the whole year, with a lot of online discourse surrounding what music will top your listens for the year. In addition to the exciting way the list is presented (aesthetically pleasing tiles, interactive elements), the answer to its ability to captivate may be found in one simple idea: We inherently like understanding ourselves. But what does this mean? We can unpack this further in the psychological theories of self-concept, social comparison and social connection. SELF-CONCEPT Self-concept is how we see ourselves. It develops from our experiences and our responses to these experiences. Music is one of those unique mediums that reflects what we’ve experienced (for example, a break-up) and how we feel (sadness and yearning). So, when we see a yearly list of our top artists, genres and songs, it’s like looking into a mirror that tells us who we’ve been throughout the year. This drive towards self-reflection is likely because it fulfils some of our most fundamental human needs. Remember that time when everyone was doing the Myers-Briggs personality test? In 1943, the American psychologist Abraham Maslow developed his theory of human needs. According to this theory, humans have a need for esteem (gaining respect and recognition within our communities) and self-actualisation (realisation of one’s potential). Neither of these can occur without first an understanding of who we currently are. Sharing a list, then, is a way of saying to others, “this is me!”. But sharing your Wrapped list serves more functions than simply self-expression. It facilitates social comparison and social connection. SOCIAL COMPARISON In 1954, American social psychologist Leon Festinger published his social comparison theory. He believed humans are naturally inclined to compare themselves to others. We constantly evaluate where we stand in relation to those around us. When you post your Wrapped list, you aren’t just saying, “this is what I listened to” or “this is who I am”. You’re also inviting others to engage in a subtle social dialogue. Seeing someone else with the same song on their list might spark a sense of connection. Seeing that you’re in the top 1 per cent of Taylor Swift fans might make you feel even a little superior (and others a little envious). (As a side note, I hope this happens to me again this year.) Seeing someone else’s Wrapped can also inspire and validate. If a friend’s list includes a mix of genres you’ve never explored, you might feel encouraged to branch out. Or you might see someone else’s list and feel relieved you’re not the only one obsessed with an artist. Whether conscious or subconscious, these comparisons drive engagement with Spotify. SOCIAL CONNECTION Sharing our Spotify Wrapped satisfies another fundamental human need: Belonging. Humans are inherently social creatures who want to feel loved and accepted. Music is one of the oldest ways we’ve connected with one another. Sharing our Wrapped lists isn’t just about showing off who we are, but about finding common ground. It’s about finding your tribe, a group of people we can feel safely connected to. This is even more important during a period in which people’s opinions are becoming more divided and for a younger generation where loneliness is becoming an increasing problem. BUILDING ON YOUR OWN WRAP This urge to know about yourself and to share is very human. This year, however, I challenge you to go beyond just dropping a like on someone’s story. Sure, the dopamine hit is great and is part of what keeps us coming back to this yearly ritual. But it takes more than that to meet our need for connection. This year, use Spotify Wrapped to start up a conversation with someone. Maybe about how their experiences and feelings this year led to the songs appearing on their list. You might learn something new about them and create or revitalise a meaningful connection. And that’s a wrap. Kelvin Shiu Fung Wong is Senior Lecturer in Clinical Psychology at Swinburne University of Technology. This commentary first appeared on The Conversation.

How to start investing in cryptocurrency: A guide for beginnersSKOPJE, North Macedonia -- A political party in North Macedonia on Saturday demanded authorities ban social networks whose content incites violence and self-destructive behavior after several young people were seriously injured in connection with the popular “Superman challenge” on TikTok. Health authorities said at least 17 students, ages 10 to 17, were brought to hospitals in the capital Skopje and other towns over the past week with broken bones, contusions and bruises. The children were injured after being thrown into the air by their friends to fly like superheroes and get applause on the internet. The Liberal-Democratic Party, which was part of the left-led coalition that ruled the country from 2016 to earlier in 2024, issued a press statement Saturday strongly condemning “the irresponsible spread of dangerous content on social media, such as the latest TikTok 'challenge' known as ‘Superman,’ which has injured six children across (the country) in the past 24 hours.” “The lack of adequate control over the content of social media allows such ‘games’ to reach the most vulnerable users,” the party statement said. It demanded the “immediate introduction of measures to ban content that incites violence and self-destructive behavior, increase surveillance, and sanction platforms that enable dangerous trends.” North Macedonia’s education minister Vesna Janevska said students should focus on education, not TikTok challenges. “The ban on mobile phones in schools will not have an effect. Phones will be available to children in their homes, neighborhoods and other environments,” she said. Psychologists have warned that the desire to be “in” with the trends on social networks, combined with excessive use of mobile phones, is the main reason for the rise in risky behaviors among children. They urged parents and schools to talk with students.