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U.S. District Court Upholds Validity of CINVANTI® PatentsNone

BOSTON, Dec. 03, 2024 (GLOBE NEWSWIRE) -- X4 Pharmaceuticals (Nasdaq: XFOR), a company driven to improve the lives of people with rare diseases of the immune system, today announced that, effective on December 2, 2024, the company issued inducement awards to new employees under the X4 Pharmaceuticals, Inc. 2019 Inducement Equity Incentive Plan (the "2019 Inducement Plan”). The 2019 Inducement Plan is used exclusively for the grant of equity awards to individuals who were not previously an employee of X4. The inducement awards consist of options to purchase an aggregate of 396,824 shares of X4's common stock. These stock awards were granted as an inducement material to the new employees entering into employment with X4 in accordance with Nasdaq Listing Rule 5635(c)(4) and were approved by X4's Compensation Committee of the Board of Directors. The options have a ten-year term and an exercise price of $0.371 per share, which is equal to the closing price of X4's common stock on December 2, 2024. Each option will vest over a four-year period, with 25% of the shares vesting after 12 months and the remaining shares vesting monthly over the following 36 months, subject to the employee's continued employment with X4 on such vesting dates. The options are subject to the terms and conditions of the 2019 Inducement Plan and the terms and conditions of an award agreement covering the grant. About X4 Pharmaceuticals X4 is delivering progress for patients by developing and commercializing innovative therapies for those with rare diseases of the immune system and significant unmet needs. Leveraging our expertise in CXCR4 and immune system biology, we have successfully developed mavorixafor, which has received U.S. approval as XOLREMDI® (mavorixafor) capsules in its first indication. We are also evaluating the use of mavorixafor in additional potential indications. X4 corporate headquarters are in Boston, Massachusetts and our research center of excellence is in Vienna, Austria. For more information, please visit our website at www.x4pharma.com . Company Contact: José Juves Head of Corporate & Patient Affairs [email protected] Investor Contact: Daniel Ferry Managing Director, LifeSci Advisors [email protected] (617) 430-7576Marine Biologics Acquires Biochemical Engineering Leader Spoitz Enterprises

A teen has been arrested for allegedly leaving a deceased baby girl in a Safe Haven Baby Box in Blackfoot, Idaho, police said. “The Blackfoot Police Department (BPD) said officers arrested 18-year-old Angel N. Newberry in Twin Falls on a felony Bingham County arrest warrant for not reporting the death. She has been transported to the Bingham County Jail,” KTVB7 reported on Friday. Due to the sensitive nature of the case, police said they are limiting the information they release to the public. However, they said there is a potential for more charges to be filed in the case, according to the report. Law enforcement officials said: The Safe Haven Baby Box is intended to safely and anonymously allow custodial parents to surrender a newborn under 30 days old without legal repercussions, provided the child is unharmed. Unfortunately, the placement of a harmed or deceased infant is not protected under this system or Idaho law. As Breitbart News previously r eported , the deceased newborn baby girl was found in Idaho’s only Safe Haven Baby Box on Oct. 13, at the Grove Creek Medical Center in Blackfoot, which is about two hours from Twin Falls. Staff with Grove Creek Medical Center immediately responded to an alarm that indicated that a baby had been placed in the box and removed her within a minute, Safe Haven Baby Boxes said in a press release posted to Facebook. Upon removal, staff “quickly realized” the infant had died long before she had been placed in the baby box, according to the organization. Idaho’s Safe Haven law allows for the surrender of an infant who is unharmed and healthy, meaning this surrender was not legal. “We are heartbroken. Let this be clear: this is an illegal, deadly abandonment. Anonymity is only allowed when an infant is safely surrendered completely unharmed,” Safe Haven Baby Boxes Founder Monica Kelsey said in a statement at the time. “We are fully cooperating with the investigation and providing all information we possess to local authorities. When the baby was placed in the box, she was wrapped in a blanket with the placenta still attached.” “As the only organization that provides an anonymous surrender option, we are on the front lines of educating the public on how this program works. We will continue to educate citizens on the stark differences between illegal abandonment and legal, safe surrender of an unharmed newborn,” she added. Kelsey posted a video update to Facebook soon after the discovery, stating that the parent’s identity was known to police. Baby boxes are temperature-controlled incubators often built into exterior walls of fire stations, police stations, and hospitals that can be accessed from the inside. At-risk mothers can safely and legally place their newborns inside. Once a baby is inside the baby box, the outside door locks, and the mother has time to leave before an alarm goes off alerting first responders or hospital staff to the child’s presence. The baby is then quickly removed and sent to a hospital for a wellness check. From there, the baby is usually placed into state custody and is often adopted quickly. The Idaho box, which is located at 350 N Meridian, was officially blessed in July. Idaho lawmakers unanimously passed an amendment to the existing Safe Haven Baby Act in March allowing Safe Haven Baby Boxes to be used, according to the Idaho State Journal . Idaho Gov. Brad Little (R) quickly signed the law, and it went into effect on July 1. In Idaho, healthy, unharmed infants up to 30-days-old may be surrendered to baby boxes or face to face to hospitals, fire stations, EMS providers, physicians, and nurses, according to Safe Haven Baby Boxes. Fifty-two infants have been legally surrendered to Safe Haven Baby Boxes since 2017, and each infant has been adopted, according to the organization. Katherine Hamilton is a political reporter for Breitbart News. You can follow her on X @thekat_hamilton .NY Dem leader Jay Jacobs opposes higher taxes on rich — but backs controversial congestion pricing toll on everyday New Yorkers

Macron to name new French PM Friday after days of deadlockNew Jersey sports stadium gets a new name

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No ex-president had a more prolific and diverse publishing career than Jimmy Carter. His more than two dozen books included nonfiction, poetry, fiction, religious meditations and a children’s story. His memoir “An Hour Before Daylight” was a Pulitzer Prize finalist in 2002, while his 2006 best-seller “Palestine: Peace Not Apartheid” stirred a fierce debate by likening Israel’s policies in the West Bank to the brutal South African system of racial segregation. > Philadelphia news 24/7: Watch NBC10 free wherever you are And just before his 100th birthday, the Dayton Literary Peace Prize Foundation honored him with a lifetime achievement award for how he wielded "the power of the written word to foster peace, social justice, and global understanding.” In one recent work, “A Full Life,” Carter observed that he “enjoyed writing” and that his books “provided a much-needed source of income.” But some projects were easier than others. “Everything to Gain,” a 1987 collaboration with his wife, Rosalynn, turned into the “worst threat we ever experienced in our marriage,” an intractable standoff for the facilitator of the Camp David accords and winner of the Nobel Peace Prize. According to Carter, Rosalynn was a meticulous author who considered “the resulting sentences as though they have come down from Mount Sinai, carved into stone.” Their memories differed on various events and they fell into “constant arguments.” They were ready to abandon the book and return the advance, until their editor persuaded them to simply divide any disputed passages between them. “In the book, each of these paragraphs is identified by a ‘J’ or an ‘R,’ and our marriage survived,” he wrote. Here is a partial list of books by Carter: “Keeping Faith: Memoirs of a President” “The Blood of Abraham: Insights into the Middle East” (With Rosalynn Carter) “Everything to Gain: Making the Most of the Rest of Your Life” “An Outdoor Journal: Adventures and Reflections” “Turning Point: A Candidate, a State, and a Nation Come of Age” “Always a Reckoning, and Other Poems” (With daughter Amy Carter) “The Little Baby Snoogle-Fleejer” “Living Faith” “The Virtues of Aging” “An Hour Before Daylight: Memories of a Rural Boyhood” “Christmas in Plains: Memories” “The Hornet’s Nest: A Novel of the Revolutionary War” “Our Endangered Values: America’s Moral Crisis” “Faith & Freedom: The Christian Challenge for the World” “Palestine: Peace Not Apartheid” “A Remarkable Mother” “Beyond the White House” “We Can Have Peace in the Holy Land: A Plan That Will Work” “White House Diary” “NIV Lessons from Life Bible: Personal Reflections with Jimmy Carter” “A Call to Action: Women, Religion, Violence, and Power” “A Full Life: Reflections at Ninety”Breaking News Don't miss out on the headlines from Breaking News. Followed categories will be added to My News. President Emmanuel Macron is to name a new prime minister on Friday, aides said, after days of deadlock over finding a candidate to replace Michel Barnier whose ousting by parliament pushed France into a fresh crisis. Barnier was toppled in a historic no-confidence vote on December 4 and there had been expectations Macron would announce his successor in an address to the nation even a day later. But in a sign of the stalemate in French politics after inconclusive legislative elections this summer, he did not name his successor then and has now missed a 48-hour deadline he gave at a meeting meeting of party leaders on Tuesday. On Thursday, Macron left France on a day-long trip to key EU and NATO ally Poland but shortened the visit in an apparent bid to finalise the appointment. "The statement naming the prime minister will be published tomorrow (Friday) morning," said an aide to to the president, asking not to be named, late Thursday just after Macron touched down from the trip to Poland. "He is finishing his consultations," the aide added, without giving further details. - 'Stuck' - Whoever is named will be the sixth prime minister of Macron's mandate after the toppling of Barnier, who lasted only three months, and faces an immediate challenge in thrashing out a budget to pass parliament. Each premier under Macron has served successively less time in office and there is no guarantee for the new premier that they will not follow this pattern. Macron remains confronted with the complex political equation that emerged from the snap parliamentary polls -- how to secure a government against a no-confidence vote in a bitterly divided lower house where no party or alliance has a majority. All the candidates widely floated so far have encountered objections from at least one side of the political spectrum. "They are stuck," said a person close to Macron, asking not to be named and lamenting that "each name gets blocked." "No one is in agreement around the president," added the source, expressing hope Macron will surprise everyone with an unexpected choice. Macron's rumoured top pick, veteran centrist Francois Bayrou, raises hackles on the left -- wary of continuing the president's policies -- and on the right, where he is disliked by influential former president Nicolas Sarkozy. Beyond Bayrou, prime ministerial contenders include former Socialist prime minister Bernard Cazeneuve, current Defence Minister Sebastien Lecornu, a Macron loyalist, and former foreign minister Jean-Yves Le Drian. Another name being discussed in the media is Roland Lescure, a former industry minister, but the nomination of the former Socialist risks inflaming the right. - 'Fresh wind' - These "are names that have been around for years and haven't seduced the French. It's the past. I want us to look to the future," Greens leader Marine Tondelier said. "The French public want a bit of enthusiasm, momentum, fresh wind, something new," she told France 2 television. Polls indicate the public is fed up with the crisis. Just over two-thirds of respondents to one Elabe poll published on Wednesday said they want politicians to reach a deal not to overthrow a new government. But confidence is limited, with around the same number saying they did not believe the political class could reach agreement. In a separate IFOP poll, far-right National Rally (RN) figurehead Marine Le Pen was credited with 35 percent support in the first round of a future presidential election -- well ahead of any likely opponent. She has said she is "not unhappy" that her far-right party was left out of the horse-trading around the government, appearing for now to benefit from the chaos rather than suffer blame for bringing last week's no-confidence vote over the line. In a critical looming moment, Le Pen on March 31, 2025 faces the verdict in an embezzlement trial on charges she denies. If convicted, she could lose the chance of standing in the 2027 elections and with it her best chance yet of winning the Elysee. burs-tgb-sjw/rlp Originally published as Macron to name new French PM Friday after days of deadlock More related stories News Qantas strike hits major airports Hundreds of Qantas engineers have walked off the job at airports around the country on one of the busiest travel days of the year. Read more Breaking News Gaza rescuers say Israeli strikes kill 58, hit flour trucks Gaza rescuers say Israeli strikes kill 58, hit flour trucks Read more

The U.S. economy continues to outpace earlier expectations, but rural industries are disproportionately exposed to federal policy and face downside risks in the coming year DENVER, Dec. 12, 2024 (GLOBE NEWSWIRE) -- The U.S. continues to benefit from solid economic growth, low unemployment and moderating inflation. From today's vantage point, the U.S. economy seems likely to continue on that trajectory into 2025. However, the outlook for the rural economy is more volatile and uncertain. Rural industries are disproportionately exposed to federal policy, and the outcome of the 2024 election cycle promises to bring significant changes in the federal government's approach to everything from international trade and immigration to energy exploration and rural economic development. According to a comprehensive year-ahead outlook report from CoBank's Knowledge Exchange , the high level of policy uncertainty facing rural industries adds to their already long list of headwinds and challenges. "The environment we enter in 2025 hasn't fully defined itself yet, but many of the policies proposed by the incoming administration would likely have a negative impact on U.S. agriculture,” said Rob Fox , director of CoBank's Knowledge Exchange. "Open access to export markets and labor availability are critically important for agricultural producers and processors. Depending on how policy plays out, those two areas could be big challenges in 2025 and beyond.” The CoBank 2025 outlook report examines several key factors that will shape agriculture and market sectors that serve rural communities throughout the U.S. U.S. Economy: A New Economic Era Begins Most economists are forecasting 2025 U.S. GDP growth around 2.5%-3.0%, essentially the same as today. However, those forecasts are based on rather mild assumptions on forthcoming policy changes. When taken in isolation, President-elect Trump's proposed policies - tax cuts, decreased labor supply and tariffs on imported goods - are all inflationary. Consequently, longer-term interest rates have already edged higher, and the market has downshifted expectations for further Fed rate cuts in 2025. There is a good chance the proposed tariffs and the crackdown on undocumented immigrants will be more disruptive than markets have priced in, particularly in industries like construction and agriculture. U.S. Government: Trump Administration, Congress Set for Bustling January Start Congress is expected to wrap up the lame duck session of the 118th Congress by Dec. 19, hopefully addressing important pieces of unfinished business. A one-year extension of the 2018 Farm Bill is increasingly likely. President-elect Trump is expected to pursue an ambitious first-100 days of executive orders and other legislative activity that will likely include many of his campaign promises. These may include significant deportation efforts and immigration reform, implementation of tariffs, extending the 2017 tax cuts and providing regulatory relief rolling back the Biden administration's initiatives. The 119th Congress will have a long and challenging to-do list when members return to Washington on Jan. 3. U.S. Agricultural Economy: Trade War Could Send Ag Economy from Bad to Worse The short-lived commodity boom precipitated by global droughts, the war in Ukraine and COVID-19 supply issues is now a distant memory. Row crop prices are down nearly 50% from their 2022 highs. But production costs have remained elevated, and profitability has plunged to decade-plus lows. The silver lining is that dairy and livestock producers are generally profitable due to low feed costs and resilient consumer demand. However, more headwinds may be coming for both the crop and livestock sectors. President-elect Trump rode to victory on two main economic policy proposals: enact significant import tariffs and reduce immigration while deporting undocumented residents. In theory, these policies could achieve some limited objectives, but it is hard to paint them as anything but negative for the U.S. farm economy. Grains, Farm Supply & Biofuels: Policy Uncertainty Weighs on Exports, Biofuels A strengthening U.S. dollar, combined with the potential for trade disputes and record-large South American crops, weigh heavily on the outlook for grain and oilseed prices in 2025. U.S. farmers are widely expected to struggle with further margin compression as weaker commodity prices test farmers' ability to lower production costs. Crop input decisions will be evaluated much more closely with a focus on inputs that provide the greatest return on investment. The bearish outlook for oil prices diminishes the demand picture for ethanol, biodiesel and renewable diesel. Uncertainty over U.S. biofuel policy under the new administration also clouds the demand outlook for biofuels. Animal Protein: Rising Margins Improve Prospects for Growth Falling feed costs and rising producer margins have renewed expansion interest in animal protein segments. However, labor, construction and land costs remain elevated, tempering expectations for any meaningful supply growth in the near term. U.S. beef cow herd expansion is not expected to start until 2026 or 2027. The smaller herd will further support higher feeder and fed cattle prices in the coming year. With consumers now pushing back on beef prices already near historic highs, packer margins will remain under pressure well into 2025. Dairy: Record Investment Will Continue to Grow the Category The U.S. will see an unprecedented $8 billion in new dairy processing investment through 2026. Some of the new plants are poised to come online in 2025, with about half of the investment in the cheese category. The expected surge in cheese and whey output will likely put downward pressure on dairy product prices in the second half of the year. Sourcing additional milk supplies to fill new plant capacity is a looming question. 2023 and 2024 will go down as the first back-to-back years since the late 1960s that U.S. milk production took a downturn. On the flip side, higher component levels in farmgate milk, largely butterfat and protein, have lifted finished product yields. Food & Beverage: Health and Nutrition Take Center Stage The headline news for food, beverage and consumer packaged goods in 2025 is President-elect Trump's nomination of Robert F. Kennedy Jr. to lead the Department of Health and Human Services. Kennedy's purported goals include eliminating ingredients banned in other countries and "getting the chemicals out” of America's food supply. Meanwhile, consumers' renewed focus on their health and the popularity of GLP-1 weight-loss drugs are showing signs of impacting food manufacturers. GLP-1 users purchase around 8% less food compared with average consumers, according to J.P. Morgan research. Food and beverage manufacturers' concerns about volume attrition are likely to continue well into 2025. Power & Energy: What an IRA Rollback Might Look Like President-elect Trump's return to the White House will signal a significant shift in U.S. energy policy. While he has promised to end the Inflation Reduction Act, slowing the clean energy momentum that has accelerated under the IRA may be more difficult than imagined. Popular programs in the IRA have directed significant investments to many rural and economically distressed communities. And more than a dozen House Republicans have voiced concern that repealing the IRA could jeopardize ongoing development in their communities. Clawing back IRA funds that have already been allocated could prove to be very difficult. The more likely scenario is that unallocated IRA funding will be redirected to other priorities. Digital Infrastructure: Rural Connectivity Faces New Challenges Political uncertainty and low participation in the Broadband, Equity, Access and Deployment program raises big questions for bridging the digital divide in the year ahead. The $42.5 billion BEAD program, created by the Infrastructure Investment and Jobs Act, includes an unprecedented level of government support. However, a lack of operator participation could blunt the impact of this well-intended program to bring reliable broadband access to underserved rural areas. Many small operators lack the specialized expertise or financial resources to meet some of the complicated BEAD requirements. Read the full report, The Year Ahead: Forces That Will Shape the U.S. Rural Economy in 2025 . About CoBank CoBank is a cooperative bank serving vital industries across rural America. The bank provides loans, leases, export financing and other financial services to agribusinesses and rural power, water and communications providers in all 50 states. The bank also provides wholesale loans and other financial services to affiliated Farm Credit associations serving more than 77,000 farmers, ranchers and other rural borrowers in 23 states around the country. CoBank is a member of the Farm Credit System, a nationwide network of banks and retail lending associations chartered to support the borrowing needs of U.S. agriculture, rural infrastructure and rural communities. Headquartered outside Denver, Colorado, CoBank serves customers from regional banking centers across the U.S. and also maintains an international representative office in Singapore. CONTACT: Corporate Communications CoBank 800-542-8072 [email protected]Bitcoin deserves a spot in traditional multi-asset portfolios for interested investors, but only to a "reasonable" extent, BlackRock said on Thursday. The world's largest asset manager said that investors interested in bitcoin should allocate 1%-2% of their portfolio toward the cryptocurrency. Such weighting would result in a similar level of risk to holding the Magnificent Seven mega-cap stocks in a traditional portfolio. "In a traditional portfolio with a mix of 60% stocks and 40% bonds, those seven stocks each account for, on average, about the same share of overall portfolio risk as a 1-2% allocation to bitcoin," analysts in a recent research note from Blackrock Investment Institute. "We think that's a reasonable range for a bitcoin exposure," they added. A share over 2%, though, would make the risk associated with the crypto much higher, it added. "Going beyond that would sharply increase bitcoin's share of the overall portfolio risk," the analysts said. The firm said that the framework is helpful for considering the potential risks of including bitcoin in a portfolio given its reputation for volatility. The cryptocurrency has soared in recent weeks, up 48% since Donald Trump won the US presidential election last month/ Trump has since picked several crypto supporters for posts in his administration, including Paul Atkins as chair of the Securities and Exchange Commission. That announcement last week helped push bitcoin above the key threshold for the first time ever. The cryptocurrency has gained about 136% this yea. "On top of having over time, bitcoin has also suffered sharp selloffs. In an extreme case, should there no longer be any prospect of broad bitcoin adoption, the loss could be the entire 1-2% allocation," they said. However, the analysts said allocating up to 2% to bitcoin would provide a diverse source of risk compared to pouring into mega-cap tech stocks while still managing risk exposure. "Even though bitcoin's correlation to other assets is relatively low, it's more volatile, making its effect on total risk contribution similar overall. A bitcoin allocation would have the advantage of providing a diverse source of risk, while an overweight to the magnificent 7 would add to existing risk and to portfolio concentration," the analysts said. They added that wider adoption and trading of the cryptocurrency could reduce its volatility, bringing down its share of portfolio risk and potentially allowing investors to increase their allocation. On the flip side, broader adoption could also mean it loses the structural catalyst for , they said. "The case for a permanent holding may then be less clear-cut and investors may prefer to use it tactically to hedge against specific risks, similar to gold," they said. Broader adoption and trading appear likely, given easier avenues for gaining exposure to bitcoin, like the dozen spot bitcoin ETFs from firms including BlackRock. Since they were launched in January, the ETFs have garnered over $113 billion in assets. Read the original article on

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TSB investigating plane landing incident at Halifax Stanfield International AirportUnited Airlines is one of the first major airlines to adopt one of Apple’s new features, integrating the AirTag Share Item Location feature. Apple announced a new iOS 18.2 feature in November, one that would allow uses to share the location of an AirTag via a secure link. The implications and potential applications of the feature are myriad, with tracking lost luggage being one of the prime options. The company described the feature in a November press release. Apple has introduced Share Item Location, a new iOS feature that helps users locate and recover misplaced items by easily and securely sharing the location of an AirTag or Find My network accessory with third parties such as airlines. Share Item Location is available now in most regions worldwide as part of the public beta of iOS 18.2, which will soon be available to all users as a free software update for iPhone Xs and later. Find My is built with privacy and safety at its core. The shared location will be disabled as soon as a user is reunited with their item, can be stopped by the owner at any time, and will automatically expire after seven days. “Find My is an essential tool for users around the world to keep track of and find their belongings,” , Apple’s senior vice president of Services. “The Find My network and AirTag have proven to be a powerful combination for users while traveling, providing invaluable location information when bags have been misplaced or mishandled. With Share Item Location, we’re excited to give users a new way to easily share this information directly with third parties like airlines, all while protecting their privacy.” United Integrates the Feature Barely a month later, United has become one of the first airlines to adopt the new feature, counting on it to help drive improved customer service. United today announces the integration of Apple’s new Share Item Location feature for AirTag into its mobile app, a move that’s expected to drive a much-improved customer service experience for the fewer than 1% of customers whose bags arrive on a later flight. The airline says the feature will help it better serve customers in those rare instances where things don’t go as planned. While more than 99% of customer bags flew with – or even beat – their owner to their destination so far this year, this new digital innovation is the latest example of United’s infrastructure, training and technology investments geared towards making travel easier and bag handling more seamless, especially when plans don’t go as expected. “For years, every customer has been able to track the journey of their bag through the United app as it is scanned on and off the plane, and previously, they didn’t have a way to directly share their AirTag information with our baggage team,” , United’s Chief Customer Officer. “Now, Apple’s new Share Item Location feature will help customers travel with even more confidence, knowing they have another way to access to their bag’s precise location with AirTag or their Find My accessory of choice. They can easily and securely share that with us in the United app, and our team can use the location information to find the bag and get it reunited with its owner much more quickly.” United outlined how the feature will work. It’s good to see United adopting such a useful feature. Hopefully other airlines will follow suit quickly.STOCK MARKET SNAPSHOT FOR 04/12/2024

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Ashlon Jackson scores career-best 30 points as No. 13 Duke beats No. 9 Kansas State 73-62Canadian minister says Trump was joking when he said Canada could become the 51st state

CHARLESTON, S.C. (AP) — Mitch Mascari's 22 points helped Drake defeat Florida Atlantic 75-63 on Friday. Mascari shot 6 for 9 (6 for 8 from 3-point range) and 4 of 4 from the free-throw line for the Bulldogs (5-0). Bennett Stirtz scored 17 points and added six assists. Tavion Banks had 12 points and shot 2 of 5 from the field and 8 of 10 from the free-throw line. The Owls (4-3) were led in scoring by Leland Walker, who finished with 14 points and five assists. Matas Vokietaitis and Tre Carroll each scored 10 points. Drake entered halftime up 32-28. Mascari paced the team in scoring in the first half with 11 points. Drake took the lead for what would be the final time on Banks' free throw with 14:22 left in the second half. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .Expanded CFP field draws more bets and on more teams