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(BPT) - This article was sponsored and developed by Neurocrine Biosciences, Inc. Cerebral palsy (CP) is a neurodevelopmental disorder affecting movement and posture that begins in early childhood development. It is the most common cause of motor disability in children, affecting about one in 345 children in the United States. 1-2 It may happen as a result of lack of oxygen during or around birth, stroke, infection, a problem with metabolism or other problems that cause injury or affect the development of parts of the brain involved in movement control in the first few years of life. 3 CP is a permanent condition, affecting a person for their entire life. People living with CP typically have motor problems, which may include spasticity (abnormal muscle tightness), dyskinesia (uncontrolled movements) or ataxia (poor muscle control), and many people have a mix of these motor disorders. 4 Dyskinesia due to CP (DCP) is one of the most disabling forms of CP and impacts approximately 10% to 20% of people living with CP. 5-6 According to the Cerebral Palsy Foundation (CPF), the combination of irregular and unpredictable movements (chorea) and twisting and repeating movements (dystonia) often disrupt activities and cause significant functional impairment, including the ability to maintain balance, walk or fine motor control. 7 Heather Riordan, M.D., Neurologist and Movement Disorders Specialist, Director of the Phelps Center for Cerebral Palsy at the Kennedy Krieger Institute, discusses the symptoms of chorea and impact on patients in a video shared on the CPF website here . About 30% of people with DCP are affected mostly by these involuntary and irregular movements (chorea), while dystonia is the predominant motor finding in the remaining 70%. 8 However, it is common for both chorea and dystonia movements to be present together. 6 For people living with DCP, these movements can occur in any region of the body, including the arms and legs, torso and face and may vary in severity. They are often triggered or made worse by stimulation or stress. Because dyskinesia can occur at rest and/or when actively using the body, the problems with movement are very burdensome in day-to-day living, with discomfort and pain affecting the quality of life for people and their caregivers. 9 Jen Lyman, mom to a son with DCP, highlights how dyskinesia makes communicating more difficult. "The most difficult thing about dyskinesia is watching my son struggle to do things that he wants to do, but the extra movements get in the way...special things, such as using a touch screen to video chat with his grandmother, are nearly impossible despite his best efforts to use his hands and fingers. Something so simple, yet so special for him should be effortless." DCP has a wide-ranging impact on the individual, including lifelong challenges with movement, a higher risk of other medical issues, a higher rate of mental health challenges and difficulties with communication. 10-12 "Those of us who have the privilege to serve patients with dyskinetic, hyperkinetic or mixed cerebral palsy see the functional impact of this very challenging type of tone every day," said Susan Biffl, M.D., Rehabilitation Medicine Specialist at Rady Children's Hospital-San Diego and Assistant Professor at UC San Diego School of Medicine. "Patients face challenges with self-care, independence, mobility, communication, fine motor skills that affect occupational and recreational activities, swallowing, social interactions and even sleep. As this tone is variable, it is much more challenging to treat than more consistent tone issues, such as spasticity." Treatment Options There are currently no Food and Drug Administration-approved treatments for DCP. Dystonia and chorea are often managed separately as they respond differently to various treatments, which can make treatment challenging. 3 Most drugs being investigated for DCP have focused on dystonia, and more research is needed to determine potential treatments for chorea. New treatment options are needed to help manage these movement disorders and improve daily function and quality of life for those affected. "After 20 years of caring for individuals with cerebral palsy, I continue to find those with dyskinetic cerebral palsy among the most challenging to treat, largely due to the limited effectiveness of available pharmacologic options," said Joyce Oleszek, M.D., Professor, Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine. "There is an urgent need for more robust evidence to support pharmacologic treatments for this condition, given its profound impact on function, comfort and quality of life." Ongoing Research Clinical studies are important in the development of treatment options, allowing researchers to evaluate the safety and effectiveness of new medicines. The data from clinical studies are used to determine if an investigational treatment can be approved for use to treat certain disorders. There are ongoing clinical studies evaluating potential treatments for DCP, including one for chorea. Neurocrine Biosciences is conducting the KINECT ® -DCP clinical study, a Phase 3, randomized, double-blind placebo-controlled study investigating the study drug, valbenazine, for the treatment of DCP. The clinical study is currently enrolling children, adolescents and adults six to 70 years of age who have been diagnosed with DCP. "The Cerebral Palsy Foundation is excited to partner with Neurocrine Biosciences on this study," said Rachel Byrne, Executive Director of the Cerebral Palsy Foundation. "We are proud to support strong research that can potentially bring meaningful change to the lives of those living with cerebral palsy." If you or someone you know may be eligible for this research study, please visit the study website for additional information here: FindADCPStudy.com . REFERENCES © 2024 Neurocrine Biosciences, Inc. All Rights Reserved. CAP-NBI-US-0115 12/2024 NBI-98854-DCP3018_11DecMatRelease_v1.0_25November2024

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Tweet Facebook Mail A woman has died and two others have been rushed to hospital, including a nine-year-old child, following a horror crash in northern Victoria . Police believe the woman was driving east along the Axedale Toolleen Road in Toolleen when the car crashed into a tree about 2.45pm yesterday. The 63-year-old Toolleen woman died at the scene. READ MORE: 'We're going to grow him': Human composting is rising in popularity as an earth-friendly life after death Her passenger, a nine-year-old child, suffered lower body injuries and was taken by road ambulance to hospital in a non-life-threatening condition. A 70-year-old Toolleen man suffered serious injuries and was airlifted to hospital in a serious condition. Police are investigating the incident and said the exact circumstances surrounding the crash are yet to be determined. Toolleen is located about 142km north of Melbourne. Anyone who witnessed the crash or who has footage is urged to contact Crime Stoppers on 1800 333 000. DOWNLOAD THE 9NEWS APP : Stay across all the latest in breaking news, sport, politics and the weather via our news app and get notifications sent straight to your smartphone. Available on the Apple App Store and Google Play .SAO PAULO (AP) — Police have formally accused Brazil’s former President Jair Bolsonaro and 36 others of attempting a coup to keep the right-wing leader in office after his electoral defeat in 2022. Their allegations threaten to torpedo Bolsonaro's hopes of returning to politics. Brazil’s Supreme Court said Friday that police findings were delivered to Justice Alexandre de Moraes, who next week will relay them to Prosecutor-General Paulo Gonet. He will decide whether to formally charge Bolsonaro or toss the investigation. Bolsonaro told the news website Metropoles on Thursday that he is waiting for his lawyer to review the police report, which is reportedly about 700 pages long, but that he would fight the case. He dismissed the investigation as the result of “creativity.” The former president denies that he tried to stay in office after his narrow electoral defeat in 2022 to leftist President Luiz Inácio Lula da Silva. Bolsonaro has since faced a series of legal threats. That police are seeking formal charges indicates the investigation found evidence of “a crime and its author,” and it is likely there are legal grounds for the prosecutor-general to file charges, said Eloísa Machado de Almeida, a law professor at Getulio Vargas Foundation, a university in Sao Paulo. On Friday, the attorney for Bolsonaro’s former right hand, Lt. Col. Mauro Cid, said in a live television interview that his client had informed the Supreme Court that Bolsonaro was aware of the coup plot. “The then-president knew it all. Actually, he led this organization,” Cid’s attorney, Cezar Bitencourt, told network GloboNews. Just minutes later, Bitencourt partially retracted his statement. "I didn’t say Bolsonaro knew it all. ‘All’ is a lot. He was evidently aware of some things.” Police said the Supreme Court agreed to the release all 37 names in the police report “to avoid the dissemination of incorrect news.” Among them are dozens of former and current Bolsonaro aides, including: Gen. Walter Braga Netto, who was his running mate in the 2022 campaign; former Army commander Gen. Paulo Sérgio Nogueira de Oliveira; Valdemar Costa Neto, the chairman of Bolsonaro’s Liberal Party; and his veteran former adviser, Gen. Augusto Heleno. Braga Netto’s lawyers said they would wait to formally receive the police documents before making any comments. The retired general shared their statement on X late Thursday. Bolsonaro is already accused separately of smuggling diamond jewelry into Brazil and directing Lt. Col. Cid to falsify his and others’ COVID-19 vaccination statuses. Bolsonaro has denied those charges. Another probe found he abused his authority by casting doubt on Brazil's electoral system, and judges on the top electoral court barred him from running again until 2030. Still, he insists he will run in 2026, and many in his orbit were heartened by President-elect Donald Trump's recent election win despite his swirling legal troubles. Local media report that Gonet is already under pressure to move forward with multiple investigations against the former president, and politicians say if the 69-year-old Bolsonaro does stand trial his allies and rivals will race to seize his influence with voters. “Bolsonaro is no longer the sole leader of the right-wing. He is coming out of mayoral elections in which most of his candidates lost. All these probes don’t help him at all,” said Carlos Melo, a political science professor at Insper, a university in Sao Paulo. “The governor of Sao Paulo, Tarcísio de Freitas, the radical candidate for Sao Paulo mayorship Pablo Marçal, the governor of Goias state, Ronaldo Caiado ... There are politicians lining up to court Bolsonaro voters,” Melo said. Creomar de Souza, a political analyst of Dharma Political Risk and Strategy, said the formal accusation is “obviously bad” for Bolsonaro, but that it might not impede him if he does decide to run for office again. “This could give those targeted a chance to portray themselves as being persecuted,” de Souza said, adding that could benefit them. Bolsonaro's allies in Congress have been negotiating a bill to pardon individuals who stormed the Brazilian capital and rioted on Jan. 8, 2023, in an attempt to keep the former president in power. Analysts have speculated that lawmakers want to extend the legislation to cover the former president himself. However, efforts to push a broad amnesty bill would be “politically challenging” in light of the new allegations against Bolsonaro and others, Machado said. On Tuesday, Federal Police arrested four military and a Federal Police officer, accused of plotting to assassinate Lula and Supreme Court Justice Alexandre de Moraes in an effort to overthrow the government following the 2022 elections. Last week, a man tried to enter the Supreme Court in the capital Brasilia with explosives but was blocked by guards. He threw the explosives outside the building , killing himself.Terrazzo Flooring Market Driven by Demand for Immersive Technologies Across Industries

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