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Middle East latest: Israel bombs 100s of sites in Syria as army pushes into border zoneAnother standout feature of "Empresses in the Palace" is its stunning costume and set design. The elaborate traditional costumes, intricate hair accessories, and ornate palace settings create a visually enchanting world that immerses viewers in the grandeur of the Qing Dynasty. The attention to detail and historical accuracy in the production design have garnered praise from South Korean viewers who appreciate the aesthetic beauty of the drama.fb7777.ph



In the final days before Romania’s parliamentary elections this weekend, the governing parties’ leaders both quit, pollsters gave up on projecting the results and the nation’s top court cast serious doubt on the integrity of the voting process. And the stakes couldn’t be higher. Sunday’s parliamentary contest pits the pro-European establishment against far-right insurgents and will help to determine whether a critical NATO member and Ukrainian ally lurches closer to Moscow. It takes place in an atmosphere of scarcely believable chaos and confusion. Romania is in the middle of three consecutive weekend ballots for both a new parliament and a new president. Events spun off the rails in the first round of the presidential election on Nov. 24, when a Russia sympathizer with barely any public profile emerged as the shock winner. Calin Georgescu reported zero spending on a campaign that was mainly driven by social media videos on TikTok recorded from his living room. His victory sparked fears that Romania’s democratic process had been hacked by the Kremlin. In the country’s biggest political crisis since the communist regime collapsed over three decades ago, the constitutional court has ordered a recount of the presidential ballots, but it won’t have the fresh results until Sunday night and there is mounting speculation that it may order a rerun. As voters prepare to return to the polls on Sunday, there are major questions hanging over the process that they simply do not have answers to. The prospect of a far-right surge has sent hundreds to take the streets in freezing temperatures. In Bucharest, demonstrators chanted “We want freedom, not fascism.” For all the concerns about Russian interference, there’s also deep frustration, especially outside the major cities, with the mainstream candidates who were ejected in the first presidential ballot. Romania’s two most established parties, the Social Democrats and the Liberals, have governed in coalition for the past three years and the country has suffered rising inequality and rampant inflation. The vote puts 19 million Romanians at the heart of the struggle between the democratic institutions of the European Union and Russia’s expansionary ambitions. To the north, Romania borders Ukraine, where the Russian army has been fighting for almost three years to restore what President Vladimir Putin says is his country’s historic territorial rights. To the east is Moldova, where a pro-Western president survived another election earlier this month amid widespread reports of Kremlin interference. Putin’s ally Viktor Orban governs Hungary to the west. Romania, too, an EU member, could soon have a pro-Russian president and a far-right government, if the next two weeks of voting break in their favor. Many Romanians only began to learn after the vote about 62-year-old Georgescu, the agricultural engineer who languished in the single digits in polls just weeks before the election. A one-time ally of ultranationalist Alliance for the Unity of Romanians, Georgescu has denounced military support for Ukraine, called for a quick end to the war and cast doubt on the benefits of the country’s NATO membership. “I do not want to leave NATO, I do not want to leave the European Union,” he said on Tuesday, pushing back against his characterization by the local media. “I am a Romanian — I have no connection with Russia, I’m not a legionnaire, I’m not an antisemite.” Some of the comments collide with previous statements, in which he laid blame for Russia’s invasion of Ukraine with NATO — and raised the prospect of leaving the military alliance if it didn’t guarantee peace. In 2020, Georgescu praised Putin as one of the worlds few true leaders. The alarm deepened after Georgescu said he had no campaign funding — and that supporter financing had been donated. The claim raised hackles from critics who pointed out that the candidate’s high-resolution videos, including some with sweeping landscape shots — featuring him on horseback, performing judo moves, dipping into a mountain lake — could only have been produced by professionals. An investigation by local news website G4media suggested the effort was artificially amplified by foreign interference. Georgescu’s profile was heavily promoted by a volunteers who were prompted to spread posts in exchange for “undisclosed rewards,” the website reported. A similar scheme took place during the vote in Moldova. Romania’s Supreme Defense Council, which includes top government and intelligence officials, issued a statement Thursday saying that one candidate — it didn’t name Georgescu — benefited from “massive exposure and preferential treatment.” The panel cited Russian influence operations that aimed to shift public opinion in Romania — and accused TikTok of failing to label the candidate’s videos as election material as required by Romanian law. Kremlin spokesman Dmitry Peskov, who has frequently misled the media over previous disinformation campaigns, said Friday that allegations of Russian interference in Romanian elections are unfounded and unsupported, according to the Interfax news agency. TikTok said it was “categorically false” to claim that it treated Georgescu’s account differently from other candidates. Adding to the sense of a country spinning out of control, Social Democrat Prime Minister Marcel Ciolacu resigned his party’s leadership while his coalition partners, the Liberals, ousted their leader. After pollsters completely missed Georgescu’s victory last week, they’ve opted not to release any further surveys, so voters, candidates and officials are all essentially flying blind ahead of Sunday’s vote. Before the voluntary polling blackout, the ultranationalists tied to another candidate George Simion, had been making steady gains and were running second place behind the Social Democrats. Now though, no one is really sure where they stand. “The situation is very fluid,” said Remus Stefureac, the director of research firm INSCOP. He predicted that Romania’s pro-European would still get between 50% and 60%, enabling them to form a government, but without much conviction. “In a background of increased social tensions, a sovereign movement can get a temporary boost,” he said. ——— (With assistance from Slav Okov and Demetrios Pogkas.) ©2024 Bloomberg L.P. Visit bloomberg.com. Distributed by Tribune Content Agency, LLC.Dallas Cowboys star guard Zack Martin is doubtful for Sunday's game against the Washington Commanders due to ankle and shoulder injuries. Martin didn't practice at all this week. He also physically struggled during Monday night's loss to the Houston Texas. Martin, who turned 34 on Wednesday, has started all 162 games played in 11 seasons with the Cowboys. He's a nine-time Pro Bowl selection and a seven-time first-team All-Pro. Tight end Jake Ferguson (concussion) and safety Markquese Bell (shoulder) have been ruled out. Neither player practiced this week after being hurt against the Texans. Cornerback DaRon Bland (foot) practiced in full this week and will make his season debut. He was injured in August. Star wideout CeeDee Lamb (back/foot) was a full practice participant on Friday and is good to go. Cornerback Trevon Diggs (groin/knee) and receiver Brandin Cooks (knee) are among six players listed as questionable. The others are offensive tackle Chuma Edoga (toe), guard Tyler Smith (ankle/knee), defensive end Marshawn Kneeland (knee) and linebacker Nick Vigil (foot). This article first appeared on Field Level Media and was syndicated with permission.The Free National Movement (FNM) has rejected the prime minister’s version of yesterday’s events and charged that House Speaker Patricia Deveaux’s life was not in danger when when FNM Deputy Leader Shanendon Cartwright grabbed the mace sitting in front of her and hurled it out of the House of Assembly’s window. “Prime minister and his army of spin masters and propogandists are trying to paint an ugly picture of yesterday's events, claiming that, among other lies, the opposition's actions were a planned and coordinated assault,” the FNM said in a statement. “He is taking absolute nonsense, and the tape tells the tale. [Prime Minister Philip] Davis must have forgotten that the Bahamian people have eyes and ears, which is why no one is buying their sob story. Yesterday, St. Barnabas Member of Parliament and FNM Deputy Leader Shanendon Cartwright seized and threw the ceremonial mace of the House of Assembly out of the rear right window. “Opposition members of Parliament then endured a series of overly aggressive actions by members of the Royal Bahamas Police Force to push, pull, drag and haul them outside the House of Assembly by any means necessary. We have the scars, ripped clothing and bruises to prove it. At no time was the Speaker of the House of Assembly's life in danger, as she dramatically and inexplicably claimed. At no time did any opposition member lay hands on a government member—it was the recklessly thrown arm of a police officer that landed the North Eleuthera Member of Parliament in hospital. We wish him a speedy recovery. “Witnesses, including every major news house in the country, published videos that chronicled the day's events as they unfolded. “Internationally, yesterday's demonstration was accurately referenced against the backdrop that contributed to it. As Reuters noted, the Opposition's actions come "after U.S. federal prosecutors charged several high-ranking Bahamian police officials with facilitating the flow of cocaine into the U.S. in exchange for bribes." The opposition has been consistently denied the opportunity to speak on this matter of national importance. The people are fed up, outraged and offended “The world now knows the Opposition will not sit idly by and allow the people's voice to be silenced.” Speaking in the House of Assembly yesterday following the uproar, Deveaux said she feared for her life and was “assaulted” and “almost hit” when Cartwright grabbed the mace and hurled it out of the window. Deputy Speaker Sylvanus Petty received “a blow to the head” during the incident, prompting him to go to the hospital and a police officer was hurt in the leg, she said. “This is a dark day in this political arena that we call politics,” said Deveaux. Last evening, in a national address, Prime Minister Davis said, “[The opposition’s] conduct in the House today cannot be justified. We hope that they will learn to be more serious about the business of the people.” He accused the opposition of putting on a show during a time when the country’s reputation is under fire.

With her heart pounding and her mind clouded with fear, Emily made a split-second decision to flag down a passing police car for help. The officer, Officer Smith, immediately recognized the distress in Emily's eyes and offered his assistance without hesitation.One of the key strengths of Three-Dimensional Universe is its focus on customization. Unlike other low-code platforms that offer a one-size-fits-all solution, 3DU allows users to tailor the platform to their unique requirements. From creating custom templates and components to defining workflows and business rules, the possibilities are endless with 3DU. This level of customization ensures that businesses can create applications that align perfectly with their goals and objectives, giving them a competitive edge in the market.

As fans eagerly await the release of the new update, the developers have teased additional surprises and enhancements that are sure to enhance the overall gaming experience. From improved graphics and performance optimizations to new gameplay modes and online features, the update is shaping up to be a game-changer for "Black Myth: Wukong" fans.

The Cannabist Company and Flower by Edie Parker Launch Partnership in Virginia and Colorado

Kendrick Lamar surprises with new album 'GNX' LOS ANGELES (AP) — Kendrick Lamar gave music listeners an early holiday present with a new album. The Grammy winner released his sixth studio album “GNX” on Friday. The 12-track project is the rapper’s first release since 2022’s “Mr. Morale & The Big Steppers.” Lamar’s new album comes just months after his rap battle with Drake. The rap megastar will headline February's Apple Music Super Bowl Halftime Show in New Orleans. The 37-year-old has experienced massive success since his debut album “good kid, m.A.A.d city” in 2012. Since then, he’s accumulated 17 Grammy wins and became the first non-classical, non-jazz musician to win a Pulitzer Prize. NBA memo to players urges increased vigilance regarding home security following break-ins MIAMI (AP) — The NBA is urging its players to take additional precautions to secure their homes following reports of recent high-profile burglaries of dwellings owned by Milwaukee Bucks forward Bobby Portis and Kansas City Chiefs teammates Patrick Mahomes and Travis Kelce. In a memo sent to team officials, a copy of which was obtained by The Associated Press, the NBA revealed that the FBI has connected some burglaries to “transnational South American Theft Groups” that are “reportedly well-organized, sophisticated rings that incorporate advanced techniques and technologies, including pre-surveillance, drones, and signal jamming devices.” Ancient meets modern as a new subway in Greece showcases archaeological treasures THESSALONIKI, Greece (AP) — Thessaloniki, Greece’s second-largest city, is opening a new subway system, blending ancient archaeological treasures with modern transit technology like driverless trains and platform screen doors. The project, which began in 2003, uncovered over 300,000 artifacts, including a Roman-era thoroughfare and Byzantine relics, many of which are now displayed in its 13 stations. Despite delays caused by preserving these findings, the inaugural line has been completed, with a second line set to open next year. Conor McGregor must pay $250K to woman who says he raped her, civil jury rules LONDON (AP) — A civil jury in Ireland has awarded more than $250,000 to a woman who says she was raped by mixed martial arts fighter Conor McGregor in a Dublin hotel penthouse after a night of heavy partying. The jury on Friday awarded Nikita Hand in her lawsuit that claimed McGregor “brutally raped and battered” her in 2018. The lawsuit says the assault left her heavily bruised and suffering from post-traumatic stress disorder. McGregor testified that he never forced her to do anything and that Hand fabricated her allegations after the two had consensual sex. McGregor says he will appeal the verdict. At least 19 people are sick in Minnesota from ground beef tied to E. coli recall U.S. health officials say at least 19 people in Minnesota have been sickened by E. coli poisoning tied to a national recall of more than 167,000 pounds of potentially tainted ground beef. Detroit-based Wolverine Packing Co. recalled the meat this week after Minnesota state agriculture officials reported multiple illnesses and found that a sample of the product tested positive for E. coli O157:H7, which can cause life-threatening infections. Symptoms of E. coli poisoning include fever, vomiting, diarrhea and signs of dehydration. Actor Jonathan Majors’ ex-girlfriend drops assault and defamation lawsuit against once-rising star NEW YORK (AP) — Jonathan Majors’ ex-girlfriend has dropped her assault and defamation lawsuit against the once-rising Hollywood star after reaching a settlement. Lawyers for Majors and Grace Jabbari agreed to dismiss the case with prejudice Thursday. Jabbari is a British dancer who had accused Majors of subjecting her to escalating incidents of physical and verbal abuse during their relationship. Representatives for Majors didn’t respond to emails seeking comment Friday. Jabbari’s lawyer said the suit was “favorably settled” and her client is moving on with “her head held high.” Majors was convicted of misdemeanor assault and harassment last December and sentenced to a yearlong counseling program. Hyundai, Kia recall over 208,000 electric vehicles to fix problem that can cause loss of power DETROIT (AP) — Hyundai and Kia are recalling over 208,000 electric vehicles to fix a pesky problem that can cause loss of drive power, increasing the risk of a crash. The recalls cover more than 145,000 Hyundai and Genesis vehicles including the 2022 through 2024 Ioniq 5, the 2023 through 2025 Ioniq 6, GV60 and GV70, and the 2023 and 2024 G80. Also included are nearly 63,000 Kia EV 6 vehicles from 2022 through 2024. The affiliated Korean automakers say in government documents that a transistor in a charging control unit can be damaged and stop charging the 12-volt battery. Dealers will inspect and replace the control unit and a fuse if needed. They also will update software. Christmas TV movies are in their Taylor Swift era, with two Swift-inspired films airing this year Two of the new holiday movies coming to TV this season have a Taylor Swift connection that her fans would have no problem decoding. “Christmas in the Spotlight” debuts Saturday on Lifetime. It stars Jessica Lord as the world’s biggest pop star and Laith Wallschleger, playing a pro football player, who meet and fall in love, not unlike Swift and her boyfriend, Kansas City Chiefs tight end Travis Kelce. On Nov. 30, Hallmark will air “Holiday Touchdown: A Chiefs Love Story.” Instead of a nod to Swift, it’s an ode to family traditions and bonding, like rooting for a sports team. Hallmark’s headquarters is also in Kansas City. Top football recruit Bryce Underwood changes commitment to Michigan instead of LSU, AP source says ANN ARBOR, Mich. (AP) — Top football recruit Bryce Underwood has flipped to Michigan after pledging to play at LSU. That's according to a person familiar with the situation who spoke to The Associated Press on condition of anonymity because they were not authorized to share the recruit’s plans to join the Wolverines. Underwood pinned a post on his Instagram account, showing a post in which On3.com reported that he has committed to Michigan. The 6-foot-3 quarterback played at Belleville High School about 15 miles east of Michigan's campus, and told LSU nearly a year ago he intended to enroll there. Emperor penguin released at sea 20 days after waddling onto Australian beach MELBOURNE, Australia (AP) — The only emperor penguin known to have swum from Antarctica to Australia has been released at sea 20 days after he waddled ashore on a popular tourist beach. The adult male was found on Nov. 1 on sand dunes in temperate southwest Australia about 2,200 miles north of the Antarctic coast. He was released Wednesday from a boat that traveled several hours from Western Australia state's most southerly city of Albany. His caregiver Carol Biddulph wasn't sure at first if the penguin would live. She said a mirror was important to his rehabilitation because they provide a sense of company. Biddulph said: “They’re social birds and he stands next to the mirror most of the time.”In a surprising turn of events, the suspect's gaming history on the popular platform Steam has been uncovered by authorities. It has been revealed that the suspect spent a significant amount of time playing first-person shooter games, leading some to speculate about the potential influence of violent video games on his actions. However, experts caution against jumping to conclusions about the relationship between video games and real-world violence, citing the need for a more nuanced understanding of the factors that contribute to such incidents.

NoneAP Business SummaryBrief at 1:36 p.m. EST

What did you Google in 2024? From the elections to Copa América, here's what search trends showCyclacel Pharmaceuticals Announces Its Exploration of Potential Strategic Alternatives and Reduction of Operating Costs

Docusign Announces Third Quarter Fiscal 2025 Financial ResultsUnlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.Looking ahead, Xiaomi Automotive is poised to continue its upward trajectory and further expand its market share in the electric vehicle sector. With a strong focus on technological innovation, product differentiation, and customer-centric approach, Xiaomi is well-positioned to capitalize on the growing demand for electric vehicles and solidify its position as a key player in the automotive industry. As the company continues to drive growth and innovation in the electric vehicle market, it is set to shape the future of mobility and redefine the automotive landscape.

Incidents such as these serve as a reminder of the unpredictable nature of air travel and the importance of vigilance and preparedness on the part of both passengers and crew. While in-flight emergencies are relatively rare, they underscore the critical role that well-trained and responsive personnel play in ensuring the safety and security of all those onboard.

This incident serves as a powerful reminder of the impact of our words and actions in the digital age. It highlights the importance of approaching differences with respect and empathy, rather than resorting to hostile rhetoric. By fostering understanding and open communication, we can bridge divides and create a more inclusive and harmonious online community.In conclusion, the arrest of Tang Renjian for alleged corruption is a troubling development that underscores the importance of effective deployment in the Ministry of Agriculture and Rural Affairs. It is essential for the government to take decisive action to address corruption, strengthen governance mechanisms, and promote integrity in the agricultural sector. By doing so, the Ministry can regain public trust, uphold the rule of law, and advance the development of agriculture and rural areas.

S&P/TSX composite rises Thursday, U.S. markets downSave my name, email, and website in this browser for the next time I comment. Δ document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() );

Illinois' New Right to Privacy in the Workplace Act Effective Jan. 1 Creates New I-9, E-Verify ObligationsIn their official statement, Alibaba emphasized their commitment to transparency and accountability in handling the situation. They have assured customers that all necessary steps are being taken to investigate the root cause of the fire, assess the extent of the damage, and implement appropriate measures to prevent similar incidents in the future. Additionally, Alibaba has activated its disaster recovery protocols to ensure that critical services are restored in a timely manner.Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.

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