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Brazil Programmatic Ad Seller Quality Rankings Q3 2024: Pubpower Tops Pixalate’s Web Seller Trust Index; Verve No. 1 on MobileTrump returns to world stage in Paris with Ukraine war on agenda

President-elect Donald Trump was welcomed back to the world stage on Saturday, sitting down with Ukraine’s Volodymyr Zelenskyy and French President Emmanuel Macron with a dramatic backdrop: the reopening of the Cathedral of Notre-Dame. With Trump set to return to the White House in January, the three leaders met at the Elysee Palace in Paris with diplomacy on the war in Ukraine in flux. Officials close to Macron and Zelenskyy said the meeting was positive, without providing details. “The world is going a little crazy right now and we’ll be talking about that,” Trump told reporters as he arrived for an initial two-way meeting with Macron. Macron had sought to engineer the talks to initiate a discussion on how to end the war in Ukraine, an official in his office said. Later, the French president hosted guests, including heads of state and global business leaders, at the cathedral that was painstakingly restored after a catastrophic 2019 fire. For Macron, the day’s events offered a brief fillip as he seeks a new prime minister after his government collapsed this week in a show of force by far-right leader Marine Le Pen. Almost three years after Russia’s full-scale invasion of Ukraine, Zelenskyy and his allies are anxiously watching Trump for signs of how he plans approach the conflict. U.S. weapons and financial aid have been a vital crutch for Kyiv, but Trump had promised he would engineer a swift end to the war on the campaign trail. That’s fueled concerns in Kyiv and other European capitals that the next U.S. administration might roll back support for Ukraine to pressure Zelenskyy to compromise. On the battlefield, Ukrainian forces have been on the back foot for most of the year and Russian gains have been accelerating in recent weeks. The incoming U.S. president faces a daunting range of geopolitical challenges, including war in the Middle East and long-running tensions with China. Shortly before arriving at the presidential palace, Trump posted on his Truth Social platform about the conflict in Syria, where rebels opposed to President Bashar Assad have made rapid advances. A withdrawal of its troops that are helping support Assad might be “the best thing that can happen” to Russia, he said. The U.S., he added, “should have nothing to do with it. This is not our fight.” The visit to Paris is Trump’s first trip abroad to meet with world leaders since he won back the White House in November and is a coup for Macron, who’s seen his political program decimated by the domestic opposition who forced out his prime minister with a no-confidence vote on Wednesday. Macron worked hard to engage Trump through his first term, despite Trump’s occasional barbs, inviting the U.S. leader to the Bastille Day ceremony in 2017 and taking him to dinner at the Eiffel Tower. Trump called Macron weak after the “Yellow Vest” protests broke out in 2018 and attacked him for cozying up to China. On Saturday, Macron deployed all his experience of dealing with Trump, welcoming him with a red-carpet ceremony at the Elysee and making him effectively the guest of honor at the cathedral. Trump was seated in the front row next to Macron and the two men were seen chatting during the service. Regardless of Macron’s domestic struggles, the meeting was testament to the unique soft power of France and the president’s ability to wield it. As Trump and Zelenskiy were speaking, an exclusive list of guests were arriving at the cathedral, which has been rebuilt at a cost of 700 million euros ($740 million). Bernard Arnault, Europe’s richest man, was among the early arrivals. Kering SA Chief Executive Officer Francois-Henri Pinault came with his wife, the actor Salma Hayek. Both men were major donors to the reconstruction effort. Billionaire John Elkann, who chairs automaker Stellantis SA, was also in attendance as was FIFA President Gianni Infantino. Italian Premier Giorgia Meloni chuckled as she posed for the cameras with Macron and his wife Brigitte. Zelenskyy embraced Macron as he arrived and appeared to say “thank you” to the French leader. The Ukrainian was given an ovation by the guests as he entered the nave. Trump was among the last of the grandees to be greeted by Macron outside the cathedral, though Elon Musk, a close ally of the president-elect, arrived shortly afterward, scurrying across the square in the rain. First lady Jill Biden followed soon before the ceremony started. After the ceremony at the cathedral, a select group of guests will attend a dinner back at Macron’s presidential palace. ©2024 Bloomberg L.P. Visit bloomberg.com. Distributed by Tribune Content Agency, LLC.

Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. Recommended Videos For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.

FORT MYERS, Fla. (AP) — Rashad King led Northeastern with 19 points, including the game-winning layup with three seconds remaining, and the Huskies beat Florida International 60-58 on Friday. King added eight rebounds for the Huskies (4-1). Harold Woods added 12 points while shooting 5 of 11 from the field and 2 for 4 from the line while he also had five rebounds. Vianney Salatchoum led the way for the Panthers (1-4) with 14 points, six rebounds and two blocks. Woods put up eight points in the first half for Northeastern, who led 30-27 at the break. King led Northeastern with 12 points in the second half. The Associated Press created this story using technology provided by and data from .

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A new report made in consultation with people who use drugs calls for federal decriminalization, expanded access to overdose prevention sites and several other measures designed to mitigate and eventually end the toxic drug crisis. Seven calls for action are laid out by the Canadian Drug Policy Coalition, which over three years held 13 public consultations. The coalition said nearly 800 people were included in the meetings. Beeta Senedjani, the coalition's community policy and network co-ordinator, hopes the report will provide Canadians — and, crucially, policy makers — insight into the damage the crisis and a lack of available services are inflicting on communities. “I believe that in terms of the general public, there's a misunderstanding that what is happening is an increase in substance use, whereas really it’s the supply that's creating such devastating consequences. That's a nuance that I think is not fully understood.” The toxic drug supply, poisoned by an influx of fentanyl, has killed over 15,000 British Columbians since the provincial government declared a crisis in 2016, as well as over 47,000 Canadians. Data released by Statistics Canada on Dec. 4 shows in 2023, followed by Alberta and Saskatchewan. But the coalition's report also comes as federal and provincial governments backtrack from programs meant to confront the crisis. The B.C. NDP ended its decriminalization pilot program due to public outcry, and last month closed the addictions ministry while making the crisis the responsibility of . Premier David Eby has also by former chief coroner Lisa Lapointe to add non-prescription drugs to its safe supply program. A has led to the closure of social sites such as Nelson's Coordinated Access Hub earlier this year. Conservative Leader Pierre Poilievre has also promised to end funding for safe supply programs in favour of expanded treatment facilities if he is elected prime minister in next year's federal election. Senedjani criticized the politicization of the drug crisis. The coalition's report, she said, offers evidence instead of rhetoric. “Whenever the most marginalized people in our community are being targeted by politicians, we need to ask ourselves why, and really look at that with a critical view, because usually it's not in our best interest as a collective.” The report features 87 recommendations under seven calls to action. They include: 1. The collection of disaggregated statistics for drug fatalities and hospitalizations to better show how the crisis is impacting diverse communities such as Indigenous, African, Caribbean and Black peoples. Senedjani said current reporting typically focuses on age and gender, and doesn't include more specific demographics for communities that can be used to show how they are being impacted by the crisis in ways that differ from the rest of Canada. 2. Expansion of access to harm reduction services, which are designed for public use and don't feature specialized supports for racialized, Indigenous or LGBTQ2 peoples. Vancouver's SisterSpace, an overdose prevention site exclusive to women, is a model for how other services might cater to certain demographics. “We don't want to then further marginalize people who have multiple marginalized identities in being able to access services that are already so hard to access.” 3. Decriminalization of all criminal penalties for substance use. Senedjani said feedback heard during the consultations included people who were unable to receive healthcare because they had been labelled as seeking drugs by medical professionals, which also dismissed the validity of their health concerns. 4. The displacement of the toxic drugs with increased access to safe supply that includes drugs of known content and dosage. B.C.'s safe supply program distributes pharmaceutical opioids, which have been criticized as ineffective substitutes for alternatives such as lab-tested heroin. “We need to think about alternatives, and we need to think about ways to make this make sense and have this meet the needs of the devastating issue that we're facing today.” 5. Meaningful consultation, and compensation, with people who use drugs when developing policy. As an example, Senedjani referred to Reclaim Collection, an advocacy group made up of people with lived experience. 6. Expanded affordable housing availability as well as a more diverse range of options for people in need of services. Senedjani said the drug and housing crises in Canada are intertwined. “I think that people as individuals are being blamed for a housing crisis and a toxic drug crisis, when really these are structural, systemic issues that are happening clean across the country, and they require work at the same time on both of those prongs in order to improve social wellness and improve our communities well across the country.” 7. Expanded harm reduction services in housing and shelter settings. The consultations heard from shelter workers who were traumatized by finding people poisoned to death by drugs at their facilities. Senedjani said Toronto's Integrated Prevention and Harm Reduction Initiative, which was designed to address drug deaths in city shelters by including supervised consumption and mental health case management, is a model that other municipalities should consider. “It's important for shelter providers to look at developing proper harm reduction policies, because whether they like it or not it's going to happen, and so they might as well make it safe for everyone involved, including the person accessing the service and the people who are supporting them and trying to do their jobs in a in a proper way.”Study finds connection between quantum theory, information theory

Real Madrid suffered a 2-1 LaLiga defeat at Athletic Bilbao as Kylian Mbappe missed from the penalty spot again. Alex Berenguer prodded the hosts ahead after 53 minutes before Mbappe – who failed to convert a Champions League penalty against Liverpool last week – sent his kick too close to Bilbao goalkeeper Julen Agirrezabala. Jude Bellingham appeared to have rescued a point for Real after scoring for the fourth successive league game 12 minutes from time. 📸 PORTERAZO. JULEN, JULEN! JULEN JULEN! #AthleticRealMadrid #AthleticClub 🦁 pic.twitter.com/w260s6xo79 — Athletic Club (@AthleticClub) December 4, 2024 But Federico Valverde’s mistake two minutes later gifted Gorka Guruzeta the winner in front of a delirious San Mames crowd. On a busy night of second-round Copa del Rey action, Villarreal suffered a shock 1-0 defeat at Pontevedra while there were wins for Real Betis, Rayo Vallecano and Valencia. Fiorentina went out of the Coppa Italia to Empoli on penalties on an emotional night at Stadio Artemio Franchi. Viola were back in action after Edoardo Bove’s health scare forced their weekend league fixture with Inter Milan to be abandoned during the first half. Midfielder Bove collapsed on the pitch and required emergency medical treatment. He was taken to hospital but regained consciousness in intensive care. Esposito's penalty books Empoli's place in the next round 💪 #FiorentinaEmpoli pic.twitter.com/UUxghH9l6b — Lega Serie A (@SerieA_EN) December 4, 2024 Empoli led at half-time through Emmanuel Ekong’s fourth-minute opener before Moise Kean and Riccardo Sottil put Fiorentina ahead. Sebastiano Esposito struck 15 minutes from time to make it 2-2 and take the last-16 tie into extra time, Empoli eventually winning 4-3 on penalties. Benjamin Sesko opened the scoring and Luis Openda struck twice as RB Leipzig brushed aside Eintracht Frankfurt 3-0 in the German DFB Pokal. Second-half goals from Denis Vavro, Jonas Wind and Yannick Gerhardt saw Wolfsburg beat Hoffenheim 3-0. Cologne knocked out Hertha Berlin 2-1 after extra time with Dejan Ljubicic converting a penalty in the final seconds, while Augsburg prevailed 5-4 on penalties against Karlsruhe after a 2-2 draw. We do not moderate comments, but we expect readers to adhere to certain rules in the interests of open and accountable debate.