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Jimmy Carter, former US president, dies aged 100The community behind the PC port of Ocarina of Time have been secretly working on a native version of Star Fox 64

Tears were shed in Langley on Friday, Dec. 13, when directors of the Langley Good Times Cruise-In car show began handing out the cheques to local charities from the $94,000 raised at this year's 25th show. Marilyn Piticco, founder of which runs weekly programs for local stroke survivors, said the Cruise-In has become a constant source of funding. "It lifts me up. It makes it so that I can do my work, that I have a team behind me plus my volunteers," she told The Star. Piticco runs two Hope After Stroke groups out of the Walnut Grove Community Centre, and has received more than $100,000 in donations from the charity car show in the last 10-plus years. And that's the name of the game. Cruise-In has always been about providing a spectacular car show that raises money for community causes. Thanks to sponsors, 100 per cent of the money raised goes to charity. "This journey is personal for me. It started because my dad couldn't speak, his bench is out front [of the community centre]. It was a personal thing of saying 'this is needed in our community,'" she shared. Piticco connected with Cruise-In and became one of its charities, quickly moving to be a returning one. "I feel very honoured," she said, adding that people interested in donating, volunteering, or joining the group can reach her at 604-882-4672. Marty Brown, president of the 2024 Cruise-In, said Hope After Stroke is a great group to support. "Marilyn is amazing, it's really good [what they do," he said. When he first saw the total amount raised this year, Brown said it surprised him but he immediately thought of the team behind the car show. "I just thought how we really pulled together, all the hard work we did, and our relationships with our sponsors, vendors, and the people that work with us were really strong this year. So, I felt like it was an appropriate number and I'm extremely proud of it." More than 1,200 vehicles were on display at the Langley Good Times Cruise-In charity car show in Aldergrove on Sept. 7. Crowds of almost 100,000 spectators strolled along Fraser Highway between 264 and 272 Streets for the show, which was closed for the event. Many of the 125 volunteers showed up as early as 4 a.m. to set up Fraser Highway for the event and guide registered car owners into their spots on the road. “Our car owners brought out their finest rides, our sponsors helped immensely this year, and the Township of Langley was right behind us all the best,” Brown told The Star. “It really takes an army of people and none of the show would happen without all the amazing volunteers, including the Cruise-In board, captains, and show day helpers. The power of people is amazing.” Among the recipients are five main charities of choice: Piticco’s Langley Community Support Group, Valley Therapeutic Equestrian Association, Langley Memorial Hospital Auxiliary, the Boys & Girls Club of Langley, Rotary Starfish Program, Aldergrove Veterans & Seniors Society, Parkside Elementary, Langley Meals on Wheels, Langley BMX Club, Bikers Against Child Abuse, Valley Therapeutic Riding Association, and Langley Food Bank. Ricardo Sestito, returning as president for 2025, said the board is already meeting to plan the next car show and they are seeking volunteers. Those interested can contact Heather Lehman at lehmanns@telus.net or 604-866-3977.

Qatar tribune Agencies Investors are expecting more gains for the US stock market in 2025 after two straight standout years, fueled by a solid economy supporting corporate profits, moderating interest rates and pro-growth policies from incoming president Donald Trump. The benchmark S&P 500 up over 23 percent year-to-date, even with a recent speed bump, and is on pace for its second straight year of gains exceeding 20 percent, lifted by megacap tech stocks and excitement over the business potential of artificial intelligence. Investors are more confident about the economy than this time a year ago, with consumers and businesses having absorbed higher interest rates and the Federal Reserve now lowering them - albeit by not as much as hoped. Corporate profits are also expected to be strong, with S&P 500 earnings projected to rise 14 percent in 2025, according to LSEG IBES. On the other side of the ledger, inflation remains stubborn, and Wall Street is wary of a rebound that could lead the Fed to change course on its easing cycle. Indeed, stocks pulled back sharply on Wednesday after the central bank projected fewer rate cuts next year as it braced for firmer inflation. Such prospects could become more likely if Trump implements tariffs on US imports that lead to higher consumer prices. Stock valuations, meanwhile, are around their steepest levels in more than three years, leaving greater potential for turbulence. “We’ve been on quite the tear coming off the lows back at the end of 2022. It’s been pretty eye-watering,” said Garrett Melson, portfolio strategist at Natixis Investment Managers. “Animal spirits... are certainly running pretty wild right now, but you might need to temper that a little bit as you start to move through the year,” said Melson, who thinks the stock market could still produce solid gains of around 10 percent in 2025 if not the returns of the prior two years. Wall Street firms are mostly projecting gains for the market next year, with S&P 500 year-end targets ranging from 6,000 to 7,000. The index was last hovering around 5,900. Optimistic investors can point to a bull market that is neither old nor over-extended, by historic measures. The current bull market for the S&P 500 that began in October 2022 is less than half as long as the average length of the 10 prior ones, according to Keith Lerner, co-chief investment officer at Truist Advisory Services. The S&P 500’s roughly 64 percent gain during this latest run trails the 108 percent median gain and 184 percent average rise of the prior bull markets, according to Lerner. “If you zoom out a little bit, yes, we have a lot of gains, but if you look at a typical bull market, it suggests that we still have further gains to go,” Lerner said. Other historic signs also bode well. The S&P 500 has gained an average of 12.3 percent following the eight instances of back-to-back 20 percent annual gains since 1950, according to Ryan Detrick, chief market strategist at Carson Group, compared to a 9.3 percent overall average increase over that time. The index increased six of the eight times. Bolstering the upbeat sentiment is the prevailing sense on Wall Street that the economy has weathered the rate hikes the Fed implemented starting in 2022 to quell inflation. A Natixis Investment Managers survey conducted in recent weeks found 73 percent of institutional investors said the US will avoid a recession in 2025. That’s a sharp turnaround from a year ago, when 62 percent projected such a downturn in the coming year. Citigroup’s economic surprise index, which measures how economic data performs versus expectations, has been solidly positive for the past two months, another rosy sign for investors. Adding to expectations of a solid economy, Trump is expected to pursue an agenda that includes tax cuts and deregulation that supports growth. “We’re leaving 2024 on pretty good footing, and we think there is some re-acceleration in 2025,” said Sameer Samana, senior global market strategist at Wells Fargo Investment Institute. “Markets tend to front-run the economy, so they will position for that economic re-acceleration sooner rather than later.” However, stocks are also leaving 2024 at elevated valuations: The S&P 500 is trading at nearly 22 times expected earnings over the next 12 months, according to LSEG. That is well above its long-term average of 15.8, and not far from the 22.6 level it reached earlier this month, its highest since early 2021. Investors maintain that valuations can stay high for long periods and do not necessarily indicate imminent declines. But future gains may rest more on earnings growth, while higher valuations could make stocks more easily rattled by any disappointments. Risks include policy uncertainty such as Trump’s expected push to raise tariffs on imports from China and other trading partners, which analysts estimate could hurt corporate profits. Higher tariffs could also increase inflation, which is another worry for investors. The pace of inflation has fallen dramatically since hitting 40-year highs in 2022, but remains above the Fed’s 2 percent target. The latest reading of the consumer price index found a 2.7 percent annual inflation rate. “How low we can get rates is really going to be dependent on how low we can get inflation,” said Michael Reynolds, vice president of investment strategy at Glenmede. “If we see inflation settling out to the 3-ish percent range, we think the Fed’s not going to be as aggressive next year.” Glenmede is recommending investors take a neutral posture on overall portfolio risk, including for equities. “Investors should be what I would call cautiously optimistic,” Reynolds said. “We ... have an economy that’s showing signs of late-stage expansion alongside valuations that are pretty rich.” Copy 30/12/2024 10South Korea lifts president's martial law decree after lawmakers vote against it SEOUL, South Korea (AP) — South Korean President Yoon Suk Yeol’s government has lifted the martial law he imposed during a tense night of political drama in which troops surrounded parliament and lawmakers voted to reject military rule. Yoon said early Wednesday that his government withdrew military personnel following a bipartisan parliamentary vote rejecting martial law, and the measure was formally lifted during a Cabinet meeting around 4:30 a.m. Yoon declared martial law late Tuesday, vowing to eliminate “anti-state” forces as he struggles against an opposition that controls the country’s parliament and that he accuses of sympathizing with communist North Korea. Less than three hours later, parliament voted to lift the declaration. President-elect Donald Trump’s lawyers urge judge to toss his hush money conviction NEW YORK (AP) — President-elect Donald Trump’s lawyers have formally asked a judge to throw out his hush money criminal conviction. Trump’s lawyers told Manhattan Judge Juan M. Merchan in court papers Monday that dismissal is warranted because of the extraordinary circumstances of his impending return to the White House. They argue continuing the case would present unconstitutional “disruptions to the institution of the Presidency." Prosecutors have said they will fight any efforts to dismiss the case but have indicated openness to delaying sentencing until after Trump’s second term ends in 2029. Trump team signs agreement to allow Justice to conduct background checks on nominees, staff WASHINGTON (AP) — President-elect Donald Trump’s transition team has signed an agreement to allow the Justice Department to conduct background checks on his nominees and appointees after a weeks-long delay. The step lets Trump transition aides and future administration staffers obtain security clearances before Inauguration Day to access classified information about ongoing government programs. It also allows those nominees who are up for Senate confirmation to get the background checks lawmakers want before voting on them. Trump's FBI pick has plans to reshape the bureau. This is what Kash Patel has said he wants to do WASHINGTON (AP) — Kash Patel has been well-known for years within Donald Trump’s orbit as a loyal supporter who shares the president-elect’s skepticism of the FBI and intelligence community. But he’s receiving fresh attention, from the public and from Congress, now that Trump has selected him to lead the FBI. As he braces for a bruising and likely protracted Senate confirmation fight, Patel can expect scrutiny not only over his professed fealty to Trump but also for his belief — revealed over the last year in interviews and his own book — that the century-old FBI should be radically overhauled. Hamas and Fatah are near an agreement on who will oversee postwar Gaza CAIRO (AP) — Palestinian officials say Fatah and Hamas are closing in on an agreement to appoint a committee of politically independent technocrats to administer the Gaza Strip after the war. It would effectively end Hamas’ rule and could help advance ceasefire talks with Israel. The rival factions have made several failed attempts to reconcile since Hamas seized power in Gaza in 2007. Israel has meanwhile ruled out any postwar role in Gaza for either Hamas or the Western-backed Palestinian Authority, which is dominated by Fatah. Thanks to peace, two unexpected words are echoing across Afghanistan's capital: Luxury housing KABUL, Afghanistan (AP) — Peace is driving up property prices in Kabul and fueling the luxury market. Afghans who spent years overseas are returning home, keen to take advantage of the country’s improved security after decades of war. They include those escaping deportation campaigns in Iran and Pakistan and are taking their cash with them. Kabul is less violent since the Taliban transitioned from insurgency to authority and foreign forces withdrew. The Taliban, sticklers for bureaucracy, have pledged to stamp out corruption and regulate legal and commercial matters. That means no more dealing with warlords or bribing local officials for land purchases or construction projects. Native American students miss school at higher rates. It only got worse during the pandemic SAN CARLOS, Ariz. (AP) — Years after COVID-19 disrupted American schools, nearly every state is still struggling with attendance. But attendance has been worse for Native American and Alaska Native students — a disparity that existed before the pandemic and has since grown, according to data collected by The Associated Press. Out of 34 states with data available for the 2022-2023 school year, half had absenteeism rates for Native students that were at least 9 percentage points higher than the state average. Many schools serving Native students have been working to build stronger connections with families. They must navigate distrust dating back to the U.S. government’s campaign to force Native kids into abusive boarding schools. Democrats stick with Schumer as leader. Their strategy for countering Trump is far less certain WASHINGTON (AP) — Senate Democrats reelected Chuck Schumer as party leader on Tuesday as the party moves into a deeply uncertain time, with no real consensus on a strategy as President-elect Donald Trump prepares to take office. Schumer faced no opposition in the party leadership elections, in which Illinois Sen. Dick Durbin was also re-elected to the No. 2 spot and Minnesota Sen. Amy Klobuchar became the new No. 3. Schumer said he was honored to move the party forward “during this crucial period for our country.” But it is a bleak moment for Senate Democrats, who lost four seats and the majority in November's election. The year in review: Influential people who died in 2024 O.J. Simpson’s “trial of the century” over the 1994 killings of his ex-wife and her friend bared divisions over race and law enforcement and brought an intersection of sports, crime, entertainment and class that was hard to turn away from. His death in April brought an end to a life that had become defined by scrutiny over the killings. But he was just one of many influential and noteworthy people who died in 2024. Alexei Navalny, who died in prison in February, was a fierce political foe of Russian President Vladimir Putin. And the music industry lost a titan in producer Quincy Jones, who died in November. 2024 in pop culture: In a bruising year, we sought out fantasy, escapism — and cute little animals NEW YORK (AP) — Did you have a “Brat summer” this year? Were you “demure,” and were you “mindful”? Did you enter a celebrity look-alike contest? All these were pop culture trends that emerged in 2024. But most of all, it seemed the theme was escapism. Whether it was the yellow brick road in “Wicked” or the beckoning seas of Oceania in “Moana 2” or adorable fuzzy animals like Moo Deng or even unlikely Olympic heroes making us proud, audiences gravitated to fantasy and feel-good moments.

Sneakers Bros Introduces its Selection of Footwear, Featuring the Best Brands Worldwide 11-25-2024 08:40 PM CET | Fashion, Lifestyle, Trends Press release from: Getnews / PR Agency: 38 Digital Market Image: https://www.getnews.info/wp-content/uploads/2024/11/1732285336.jpg November 25, 2024 - Wearing the right footwear is crucial. It can affect the wearer's comfort. Sneakers Bros has a pair of shoes for daily use, sports, or extreme activities. Good-quality shoes can make a huge difference. That is why offering high-quality footwear is the main goal of Sneakers Bros. Image: https://www.getnews.info/uploads/5e09886159b8251660b0a9d3a0878751.jpg There are many footwear stores online, but one of the most trusted when it comes to adidas samba rich and sporty [ https://sneakersbros.pt/ ] is Sneakers Bro. They offer a wide range of Adidas footwear that buyers may not find from other sellers online. Sneakers Bros offers the Adidas Samba. This is one of the highly sought-after online stores. It offers both style and comfort. It has become a staple in many shoe stores. And now, online stores like Sneakers Bros make sure that they have this iconic pair in stock at all times. Sneakers Bros also offers other exclusive Adidas footwear. From Adidas Campus, Adidas Gazelle, and adidas handball spezial [ https://sneakersbros.pt/ ], customers can choose from a wide range of selections online. Sneakers Bros also carries the best collection of footwear from other brands - Dunk, Jordan 4, Jordan 1, Air Force 1, and UGG. The seller also has pairs from Yeezy and New Balance. When buying shoes from Sneakers Bros, consider these factors: * Sizing. Check the available sizes before adding it to the cart. * Authenticity. Only buy from reputable stores like Sneakers Bros. * Quality. Sneakers Bros ensures high-quality shoes from the most popular brands. * Comfort. Read reviews on comfort and performance. * Return Policy. Read the return policy in case the shoes don't fit or meet expectations. Interested in buying a pair from Sneakers Bros? Visit the official website to check out the newest collection from the most popular shoe brands. It is easy to find shoes from the Sneakers Bros online store. The website has everything that an interested buyer needs. Choose from the available stocks and add them to the online cart. Stock is always updated online to ensure that buyers find what they need. The buyer cannot proceed with the transaction in case the item is out of stock. Make sure to only purchase from the official store to avoid encountering problems. Sneakers Bros ensures that it protects the privacy and security of its customers. Once added to the cart, buyers can proceed with the payment. The following methods are available at Sneakers Bros: * Multibanco * Credit/Debit Card * Paypal * Charge * Klarna * Mbway Sneakers Bros offers FREE SHIPPING to mainland Portugal and islands. The store accepts EXCHANGES or RETURNS within a period of 30 days, as long as the product arrives in the condition in which it was sent. It should also contain all the original accessories and packaging. The cost of return is covered by the seller. Check out the shoe collection in person by visiting the Sneakers Bros store at this address: 1070-294 Lisbon Portugal Media Contact For questions and general inquiries, contact Sneakers Bros at the following: Email: support@sneakersbros.pt Instagram: @sneakersbros.pt WhatsApp: (+351) 911 148 737 Media Contact Company Name: Sneakers Bros Contact Person: Representative Email: Send Email [ http://www.universalpressrelease.com/?pr=sneakers-bros-introduces-its-selection-of-footwear-featuring-the-best-brands-worldwide ] Country: Portugal Website: https://sneakersbros.pt/ This release was published on openPR.

Browns star Garrett, on the cusp of 100 sacks, is driven to be the best

NYC is officially the richest city in the world, report saysToll Brothers Announces New Community, Enchanted Bluff, is Now Open Near San Antonio, Texas

(BPT) - Tech gifts are consistently some of the most popular presents to give and receive during the holidays. In fact, according to the annual Consumer Technology Holiday Purchase Patterns report , a record 233 million U.S. adults (89%) will buy tech products during the 2024 holiday season. But with so many devices out there, it can be hard to decide on the perfect option for the loved one on your list. A tablet like the new Fire HD 8 from Amazon offers the versatility of an all-in-one device, with access to streaming, gaming, video chatting, reading or writing all at your fingertips. Fire HD 8 also features a vibrant 8-inch HD display and lightweight, portable design, for high-quality entertainment on the go. Plus, Fire HD 8 comes with three new AI features that can help you get the most out of your tablet experience. Check them out below and learn how they can help you with daily tasks this holiday season and beyond. 1. Meet your personal writing assistant Do you struggle with writing a heartfelt message or finessing a tricky email? Fear not! Writing Assist is here to help. Writing Assist works as part of your Fire tablet's device keyboard and compatible apps, including email, Word documents and social media. In just a few taps, you can transform your writing from good to great. Try Writing Assist's pre-set styles to turn a simple email into a professionally written note. Or, you can ask Writing Assist for grammar suggestions to make your writing more concise, or elaborate on your ideas. You can even "emojify" your writing to add more fun and personality. 2. Learn more in less time Say goodbye to scrolling through pages of information. The new Webpage Summaries feature allows you to learn pertinent information as quickly as possible. Available on the Silk browser on Fire tablets, Webpage Summaries provides quick insights on web articles. In a matter of seconds, this feature will distill the key points in an article or on a webpage into a clear, concise summary of what you need to know. 3. Get creative with your device wallpaper With Wallpaper Creator, you can easily add a touch of creative flair and customization to your tablet's home screen. You can choose from one of the curated prompts to get started on creating a unique background. Or, if you're ready to let your imagination run wild, type a description of what you'd like to see. For example, you can ask for an image of a tiger swimming underwater or a watercolor-style image of a desert landscape in space. Wallpaper Creator will then turn your vision into a reality, delivering a high-resolution image that you can use as your tablet's wallpaper. Celebrate an AI-powered holiday season Writing Assist, Webpage Summaries, and Wallpaper Creator are now available on Amazon's new Fire HD 8 and other compatible Fire tablet devices, including the latest Fire HD 10 and Fire Max 11 tablets. To learn more, or to order a new Fire tablet this gift-giving season, visit Amazon.com .

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Toll Brothers Announces New Community, Enchanted Bluff, is Now Open Near San Antonio, TexasUnions score a major win in Wisconsin with a court ruling restoring collective bargaining rightsJimmy Carter, the 39th US president, has died at 100

Playing The Long Game To Achieve Financial SuccessOliver Glasner: Crystal Palace are heading in right direction after Ipswich winMax George ‘staying positive’ amid hospital stay due to heart issuesLooking for the most recent Connections answers? Click here for today's Connections hints , as well as our daily answers and hints for The New York Times Mini Crossword, Wordle and Strands puzzles. The New York Times Connections puzzle might make you hungry today. Both the yellow and green categories involve food and drink. But as usual, it's the purple category that might get to you. Or, should I say, might! Get! To! You! (That's a hint.) Read on for today's Connections hints and answers. There's also news in the Connections world. The Times now has a Connections Bot , like the one it's had for some time for Wordle. Go there after you play to receive a numeric score and to have the program analyze your answers. And players who are registered with the Times Games section can now nerd out by following their progress , including number of puzzles completed, win rate, number of times they nabbed a perfect score and their win streak. Read more: Hints, Tips and Strategies to Help You Win at NYT Connections Every Time Hints for today's Connections groups Here are four hints for the groupings in today's Connections puzzle, ranked from the easiest, yellow group to the tough (and sometimes bizarre) purple group. Yellow group hint: Gimme a sub. Green group hint: Starbucks stuff. Blue group hint: Fork it over. Purple group hint: Aggressive punctuation. Answers for today's Connections groups Yellow group: Lunch orders. Green group: Used to make coffee. Blue group: Pay, with "up." Purple group: Names featuring "!" Read more: Wordle Cheat Sheet: Here Are the Most Popular Letters Used in English Words What are today's Connections answers? The theme is lunch orders. The four answers are club, hero, melt and wrap. The theme is used to make coffee. The four answers are beans, filter, grinder and water. The theme is pay, with "up." The four answers are ante, cough, pony and settle. The theme is names featuring "!" The four answers are Airplane, Jeopardy, Pink and Yahoo.

MELBOURNE, Australia, Nov. 21, 2024 (GLOBE NEWSWIRE) -- Immuron Limited (ASX: IMC; NASDAQ: IMRN) is pleased to advise our Chief Executive Officer, Steven Lydeamore presented early this morning at the 21st Virtual Investor Summit Microcap Event (November 21, US Eastern Time). A copy of the presentation is available on the Company’s website. https://www.immuron.com.au/corporate-presentations/ This release has been authorised by the directors of Immuron Limited. COMPANY CONTACT: Steven Lydeamore Chief Executive Officer steve@immuron.com About Immuron Immuron Limited (ASX: IMC, NASDAQ: IMRN), is an Australian biopharmaceutical company focused on developing and commercializing orally delivered targeted polyclonal antibodies for the treatment of infectious diseases. About Travelan® Travelan® is an orally administered passive immunotherapy that prophylactically reduces the likelihood of contracting travelers’ diarrhea, a digestive tract disorder that is commonly caused by pathogenic bacteria and the toxins they produce. Travelan® is a highly purified tabletized preparation of hyper immune bovine antibodies and other factors, which when taken with meals bind to diarrhea-causing bacteria and prevent colonization and the pathology associated with travelers’ diarrhea. In Australia, Travelan® is a listed medicine on the Australian Register for Therapeutic Goods (AUST L 106709) and is indicated to reduce the risk of Travelers’ Diarrhea, reduce the risk of minor gastro-intestinal disorders and is antimicrobial. In Canada, Travelan® is a licensed natural health product (NPN 80046016) and is indicated to reduce the risk of Travelers’ Diarrhea. In the U.S., Travelan® is sold as a dietary supplement for digestive tract protection. Travelers’ diarrhea (TD) TD is generally defined as the passage of ≥ 3 unformed stools per 24 hours plus at least one additional symptom (such as nausea, vomiting, abdominal cramps, fever, blood/mucus in the stools, or fecal urgency) that develop while abroad or within 10 days of returning from any resource-limited destinations ( Leung et al., 2006 ). Diarrhea continues to be the most frequent health problem among travelers to destinations in lower- and middle-income regions ( Steffen, 2017 ). Deployed US military personnel, essentially representing a long-term traveller population, are particularly affected given their population dynamics and the context in which they seek care and treatment ( Connor et al., 2012 ). Diarrhea is the leading infectious disease threat to the overall health and preparedness of deployed US armed forces, with diarrheagenic E. coli, Campylobacter spp., and Shigella spp. among the most commonly reported etiologies ( Riddle et al., 2006 ). Immuron Platform Technology Immuron’s proprietary technology is based on polyclonal immunoglobulins (IgG) derived from engineered hyper-immune bovine colostrum. Immuron has the capability of producing highly specific immunoglobulins to any enteric pathogen and our products are orally active. Bovine IgG can withstand the acidic environment of the stomach and is resistant to proteolysis by the digestive enzymes found in the Gastrointestinal (GI) tract. Bovine IgG also possesses this unique ability to remain active in the human GI tract delivering its full benefits directly to the bacteria found there. The underlying nature of Immuron’s platform technology enables the development of medicines across a large range of infectious diseases. The platform can be used to block viruses or bacteria at mucosal surfaces such as the Gastrointestinal tract and neutralize the toxins they produce. IMM-124E (Travelan®) IMM-124E was developed using Immuron’s platform technology. IMM-124E is produced from the colostrum of birthing cattle that have been immunised during pregnancy with a vaccine containing the outer antigens of multiple human derived ETEC. A total of 13 ETEC strains are used in the vaccine to produce high levels of antibodies against selected surface antigens from the most common strains of ETEC. The resultant hyperimmune colostrum IMM-124E from ETEC vaccinated cows contains significant levels of polyclonal antibodies specific for ETEC antigens LPS, CFA-I and Flagellin ( Sears et al., 2017 ). The antibodies produced in IMM-124E have been found to have a stronger binding and neutralizing activity (than the antibodies of unvaccinated cattle) against a wide range of LPS antigens including both the variable O-polysaccharide region and the preserved oligosaccharide core ‘R’ region of LPS from the 13 serotypes used in the ETEC vaccine. IMM-124E is manufactured into a tablet form referred to as Travelan®. IMM-529 Immuron is developing IMM-529 as an adjunctive therapy in combination with standard of care antibiotics for the prevention and/or treatment of recurrent Clostridioides difficile infection (CDI). IMM-529 antibodies targeting Clostridioides difficile (C. diff) may help to clear CDI infection and promote a quicker re-establishment of normal gut flora, providing an attractive oral preventative for recurrent CDI. Immuron is collaborating with Dr. Dena Lyras and her team at Monash University, Australia to develop vaccines to produce bovine colostrum-derived antibodies. Dairy cows were immunised to generate hyperimmune bovine colostrum (HBC) that contains antibodies targeting three essential C. diff virulence components. IMM-529 targets Toxin B (TcB), the spores and the surface layer proteins of the vegetative cells. This unique 3-target approach has yielded promising results in pre-clinical infection and relapse models, including (1) Prevention of primary disease (80% P =0.0052); (2) Protection of disease recurrence (67%, P

MicroStrategy Stock Is Down. It Just Boosted Its Bitcoin Holdings.

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