South Korean authorities seek warrant to detain impeached president
Plans Required to Cover Treatment for SOD1-ALS ARLINGTON, Va. , Dec. 11, 2024 /PRNewswire/ -- The Centers for Medicare & Medicaid Services (CMS) has announced a first-of-its-kind directive requiring Medicare Advantage plans to approve coverage for Qalsody, a treatment for people living with genetic SOD1-ALS. This decision reflects the ALS Association's commitment to ensuring that people living with ALS have access to promising ALS treatments without delay. "This is a victory for the entire ALS community," said Calaneet Balas, president and CEO of the ALS Association. "It's critical that FDA-approved treatments are made accessible rather than being labeled as 'experimental.' We are grateful to everyone in our community who helped make this day happen." Balas added: "We hope this sends a message to the entire rare disease community and pharmaceutical industry that new treatments can be developed and made accessible to those who will benefit from them. We need to ensure more ALS treatments are developed and approved that will help everyone living with ALS." The ALS Association played a key role in the historic CMS directive by participating and advocating for the research, approval, and accessibility of Qalsody for people living with ALS. In 2004, the ALS Association was the first to fund research into ALS-specific antisense oligonucleotide (ASO) technology, investing over $1.3 million in groundbreaking studies that laid the foundation for the development of Qalsody. This early commitment supported preclinical studies, safety trials, and the first-in-human phase 1 trial, which established SOD1 as a viable therapeutic target. In 2023, Qalsody became the first gene-based therapy approved for ALS , thanks in part to the ALS Association's efforts, including a united push from the ALS community for FDA accelerated approval. This new CMS directive provides precedent for state regulators to issue similar actions for other private insurers. According to the Valor study published in 2022 , Qalsody, which was developed specifically to target the RNA produced by mutated SOD1 genes, has demonstrated significant promise in clinical trials and real-world studies. In the phase 3 VALOR trial, Qalsody reduced levels of mutated SOD1 proteins in cerebral spinal fluid by 35% within eight weeks and decreased bloodstream levels of neurofilament light chain (NfL)—a key biomarker of neurodegeneration—by 50% within 12-16 weeks. These biological changes translated into measurable clinical benefits, including slower disease progression, improved respiratory function, and enhanced quality of life after 52 weeks of treatment. Real-world data has since validated these findings, with some patients stabilizing or even experiencing improvements in motor function and quality of life. When insurance companies began denying access to Qalsody, labeling it as "experimental," the ALS Association took decisive action, working directly with CMS to launch an investigation into these unjust denials. By presenting evidence of widespread insurance rejections and demonstrating the critical need for immediate intervention. In addition to working with CMS, the ALS Association actively engaged policymakers, held strategic meetings with state and federal legislators, and served as a staunch advocate for patients, ensuring their voices were heard and their rights to life-changing treatment were upheld. The ALS Association urges anyone previously denied Qalsody by their Medicare Advantage plan to contact their ALS specialist immediately to begin the process of securing access to this critical treatment. For more information on the CMS directive visit als.org About the ALS Association The ALS Association is the largest ALS organization in the world. The ALS Association funds global research collaborations, assists people with ALS and their families through its nationwide network of care and certified clinical care centers, and advocates for better public policies for people with ALS. The ALS Association is working to make ALS a livable disease while urgently searching for new treatments and a cure. For more information about the ALS Association, visit our website at www.als.org . About ALS Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. Over the course of the disease, people lose the ability to move, to speak, and eventually, to breathe. The disease is always fatal, usually within five years of diagnosis. Few treatment options exist, resulting in a high unmet need for new therapies to address functional deficits and disease progression. View original content to download multimedia: https://www.prnewswire.com/news-releases/groundbreaking-directive-ensures-als-patients-on-medicare-advantage-gain-access-to-qalsody-302329525.html SOURCE The ALS AssociationWINNIPEG — Mike O’Shea stood in front of reporters Friday and kept his cool while answering questions about the Winnipeg Blue Bombers’ 41-24 Grey Cup loss to the Toronto Argonauts last weekend. The head coach was asked if he made a mistake keeping injured quarterback Zach Collaros in the game, why star running back Brady Oliveira didn’t get the ball more and whether a flawed game plan led to Winnipeg’s third consecutive championship loss. “As an entire team, we didn’t have our best game,” O’Shea said in his end-of-the-season press conference. “We didn’t lack effort. We didn’t lack desire. “We didn’t have our best game as an entire team. Three phases. Coaches — everybody. Me especially.” O’Shea admitted he missed calling a timeout in the fourth quarter when there were only 11 Blue Bombers on the field instead of 12. “I don't get the count over the headset as quickly as I probably need to, we can't count. As I'm seeing a guy come off, that's the right time for that timeout that I should have used,” O’Shea said. He also said he should have used a challenge flag earlier on a play he didn’t identify, and checked on his players more during the game. But hindsight wouldn’t change his decision to put Collaros back in the game after the index finger on his throwing hand was cut deep when it hit a defender’s helmet. “He absolutely deserves every opportunity to lead this team,” O’Shea said. “From what I saw and from chatting with him very briefly, I felt really comfortable with that. I didn't think it was going to be easy, but I thought it's Zach, so...” The injury to Collaros’s finger happened late in the third quarter when the Blue Bombers were trailing the Argonauts 17-10. The veteran left the game and returned with a bandaged finger that needed five stitches and a numbing agent. He wore a glove on the hand and told reporters earlier this week it was difficult to grip the ball. Collaros said he warned receivers in the huddle his throws might not have the usual zip and they should be prepared to come back for the ball. “(I) saw him delivering the ball on the sidelines. Then you see him deliver a couple balls out there and some of them are pretty damn good, right?” O’Shea said. “The awareness of Zach to say to the receivers, ‘hey, work a little harder for me,’ I think it’s natural and what should be said. I think they already know that.” When Collaros re-entered the game, he threw interceptions in back-to-back series. “On one of them he got rid of the ball and I thought it was a good ball and the defensive player made a good play,” O’Shea said of the picks. “One slipped right out of his hand or I don't know if it got tipped or not. You've got to give him that opportunity.” Oliveira was questioning his lack of opportunities in the game when he spoke to reporters earlier in the week. The CFL’s newly minted most outstanding player and top Canadian only had 11 carries for 84 yards and one late touchdown. About 17 or 18 run plays were called, O’Shea said. “One starts off with a procedure penalty in the first and then six of those get pulled because there's X number of guys in the box or the read says this is not a run play anymore, this is now a pass play,” he said. “You call that many runs and then a pile of them get pulled because of the structure of the defence. That's OK with me at that point.” O’Shea said Bombers offensive co-ordinator Buck Pierce has been granted permission to talk to CFL teams with head-coaching job openings. The B.C. Lions are reportedly interested in Pierce. The Edmonton Elks also have a vacant head coach spot. If Pierce doesn’t become a head coach, O’Shea said he wants him to stay in Winnipeg. He believes Pierce had the offence “extremely well-prepared” for the Grey Cup. “I’m never going to question the play-calling, and I think what’s going on here is we’re questioning,” O’Shea said. “We’re trying to find blame and fault when that’s nowhere in our DNA of how we built this eight, nine, 10 years ago. We’re starting to try and find all these answers and question all these people that were 0-4 and 2-6 and then 10-1, and we just didn’t play our best game.” The Bombers finished 11-7 and claimed the West Division title that earned them a fifth consecutive trip to the Grey Cup. They won the championship in 2019 and ’21, but lost 28-24 to the Montreal Alouettes last year and 24-23 to Toronto in 2023. “We're the same group that got there, that went on a phenomenal run after a bad start, and a bad start for a lot of reasons that we overcame,” O’Shea said. “I just, I don't question any of it. I look for answers, too. I watch the film over and over and over again. And look to already make notes on how we're going to be better, how we're going to get back there again.” This report by The Canadian Press was first published Nov. 22, 2024. Judy Owen, The Canadian Press
Fancy 'chatting' with Dr. Jose Rizal? A veteran voice artist develops an AI Rizal for thatRobotic Dentistry Market Overview, Emerging Trends, Key Players Analysis, Competitive Landscape, and Revenue Forecast by 2028 12-16-2024 11:44 PM CET | Health & Medicine Press release from: ABNewswire The key players in the robotic dentistry market include Planmeca Oy (Finland), Align Technology Inc. (US), Intuitive Surgical Inc (US), DENTSPLY SIRONA Inc. (US), and Envista Holdings Inc. (US) Browse 133 market data Tables and 45 Figures spread through 182 Pages and in-depth TOC on "Robotic Dentistry Market by Product and Services (Standalone Robots, Robot Assisted Systems, Software, Services), Application (Implantology, Endodontics), End User (Dental Hospitals, Clinics, Dental Academic, Research Institute) - Global Forecast to 2028 Robotic Dentistry Market [ https://www.marketsandmarkets.com/Market-Reports/robotic-dentistry-market-48850788.html?utm_source=abnewswire.com&utm_medium=referral&utm_campaign=paidpr ] in terms of revenue was estimated to be worth $0.4 billion in 2023 and is poised to reach $1.0 billion by 2028, growing at a CAGR of 17.3% from 2023 to 2028 according to a new report by MarketsandMarkets Trademark . Developing countries such as China, India, the Middle East, and other APAC and Latin American countries present a lucrative opportunity for players in the market. This is mostly due to their expanding middle-class population, increasing disposable incomes, and the rising demand for dental tourism. Download an Illustrative overview: https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=48850788 [ https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=48850788&utm_source=abnewswire.com&utm_medium=referral&utm_campaign=paidpr ] "During the forecast period, the standalone robot is expected to be the fastest growing segment of the robotic dentistry market." Under type, the standalone robot is forecasted to grow at the highest CAGR from 2023 to 2028. The primary drivers of this market are the introduction of new technologies, which provide advantages for patients in terms of more accuracy and less time consumption. The standalone robot is used for minimally invasive surgeries and can be used for the precise placement of implants. In various dental applications, standalone robots can be used. "In 2022, by the end user, dental hospitals clinics segment held the largest share of robotic dentistry market." By end user, the robotic dentistry market can be segmented into dental hospitals and clinics segment, dental research and academic institutes, and other end users. Due to the large adoption of the robotic dentistry market at dental hospitals and clinics, this segment occupied the largest share of the market in 2022. Additionally, there has been an increase in rise in prevalence of oral diseases and dental tourism, which has contributed to the growth of the market. "During the forecast period, Asia Pacific is expected to be the fastest growing region in the robotic dentistry market. " The robotic dentistry is segmented into five major regions, namely, North America, Europe, Asia Pacific (APAC), Latin America, and the Middle East and Africa. Asia Pacific is expected to be the fastest-growing region in the robotic dentistry market during the forecast period. Growth in Asia Pacific in the robotic dentistry market is driven by the growing geriatric population, growing dental tourism, and factors such as the increasing number of dental professionals, the rising incidence of dental diseases, and the growing number of implant procedures. Request Sample Pages: https://www.marketsandmarkets.com/requestsampleNew.asp?id=48850788 [ https://www.marketsandmarkets.com/requestsampleNew.asp?id=48850788&utm_source=abnewswire.com&utm_medium=referral&utm_campaign=paidpr ] Robotic Dentistry Market Dynamics: Drivers: * Technological advancements in robotic dentistry Restraints: * High cost of robotic dentistry and dental procedures Opportunities: * Potential for growth in emerging countries Challenges: * Dearth of trained dental practitioners Key Market Players: The key players in the robotic dentistry market include Planmeca Oy (Finland), Align Technology Inc. (US), Intuitive Surgical Inc (US), DENTSPLY SIRONA Inc. (US), and Envista Holdings Inc. (US). These companies adopted strategies such as partnerships, acquisitions, and investments to strengthen their presence in the robotic dentistry market. Get 10% Free Customization on this Report: https://www.marketsandmarkets.com/requestCustomizationNew.asp?id=48850788 [ https://www.marketsandmarkets.com/requestCustomizationNew.asp?id=48850788&utm_source=abnewswire.com&utm_medium=referral&utm_campaign=paidpr ] Media Contact Company Name: MarketsandMarkets Trademark Research Private Ltd. Contact Person: Mr. Rohan Salgarkar Email:Send Email [ https://www.abnewswire.com/email_contact_us.php?pr=robotic-dentistry-market-overview-emerging-trends-key-players-analysis-competitive-landscape-and-revenue-forecast-by-2028 ] Phone: 18886006441 Address:1615 South Congress Ave. Suite 103, Delray Beach, FL 33445 City: Florida State: Florida Country: United States Website: https://www.marketsandmarkets.com/Market-Reports/robotic-dentistry-market-48850788.html This release was published on openPR.
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NAPLES, Fla. (AP) — Angel Yin was making putts from across the green and threatening to build a big lead until Jeeno Thitikul finished eagle-birdie for a 9-under 63 to share the lead Saturday going into the final round of the CME Group Tour Championship with $4 million on the line. Yin had a 69 after another day of big putts and one chip-in from some 60 feet for eagle on the par-5 sixth hole that put her comfortably ahead at Tiburon Golf Club. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.
CLEVLEAND (AP) — Shane Bieber's comeback with Cleveland has double meaning. And deeper meaning. The former Cy Young winner re-signed with the Guardians on Wednesday, a reunion that seemed unlikely when he became a free agent following last season. However, the 29-year-old Bieber decided to stick with the AL Central champions after making just two starts in 2024 before undergoing Tommy John surgery. There were other offers. None of them matched what he already had in Cleveland. “It's the relationships,” Bieber said on a Zoom call. "The development staff. The coaching staff. My teammates. Having continuity and familiarity in those realms I feel like can prove beneficial not only to me but my family and everybody really involved. "That was big for me to feel confident in my rehab where I’m at right now. Nobody knows me as well as Cleveland does and vice versa, so I’m happy to be continuing with them." Bieber agreed last week to a one-year, $14 million contract . The deal includes a $16 million player option for 2026. Not long ago, it seemed as if Bieber, who is 62-32 with a 3.22 ERA in 132 starts over seven seasons for Cleveland, was determined to continue his career elsewhere. He had turned down previous long-term offers in the past from the Guardians, and it was expected he would sign with another contender, likely on the West Coast. But the California native has a special connection with the Guardians, who selected him in the fourth round of the 2016 draft. And while a setback, the injury and surgery helped Bieber realize that he was already in the perfect place. “I had plenty of great meetings and beneficial and progressive meetings with other ball clubs,” he said. "Everybody handled everything first class all the way, and I’ve got great things to say about plenty of other organizations. “Ultimately, Cleveland made the call and I was happy to receive it and come to terms and so I’m happy with where I’m at. My family’s ecstatic. It was very clearly the right decision for not only myself, my family, and we’re excited to continue it.” Bieber, who won the AL Cy Young in the pandemic-shortened 2020 season, threw only 12 innings last season before lingering issues with his elbow forced him to have surgery. He is expected to join Cleveland's rotation at some point in 2025. He's throwing three days a week at 90 feet and encouraged by his progress. As for when he'll take the mound in a game, that's currently unknown. “I’m pushing, pushing, pushing.” he said. “I feel great. I haven’t skipped a beat. When I ask for a (return) date, they don’t even give me a date. So there’s a long way to go.” A two-time All-Star, Bieber burst onto the national stage in 2019 when he was named MVP of the midsummer event in Cleveland. He has the highest strikeout ratio per nine innings (10.2) and third-highest winning percentage (.660) in the franchise's 124-year history. Bieber is one of just three Cleveland pitchers to start five season openers, joining Stan Coveleski (1917-21) and Corey Kluber (2015-19). While Bieber had some elbow issues in the past, he didn't appear to be struggling before being shut down. He struck out 11 in six scoreless innings against Oakland on March 28, and followed that up with six more shutout innings at Seattle on April 2. Days later, and with his season officially over, Bieber became emotional during a news conference at Progressive Field. He knew that in the short-term his life would be different and baseball, as he had always known it, would be on the backburner. Bieber said it took a while before he “digested” his new reality. He coped by immersing himself in his recovery, and Bieber found joy in watching his teammates storm through an unexpected season to a division title. Although it may not have been the same because he wasn't contributing on the field the way he always had, the hardships may have given Bieber something he needed. “It’s provided a lot of perspective,” he said. “It was a hard season this year for me and my family, but it was a great one. We’re expecting a baby and it was a season full of growth and I’m very excited to continue that into 2025.” ___ AP MLB: https://apnews.com/hub/MLB Tom Withers, The Associated Pressa division of Körber Medipak Systems, NA provides state-of-the-art, automated packaging and handling equipment for the pharmaceutical industry, with a focus on efficiency, quality and reliability. offers creative design, flexible solutions, and responsive customer service to exceed client expectations. Syringe Transport Systems ’s syringe transportation systems provide lane management and overhead conveying, as well as complete non-contact operation and syringe buffer systems. The non-contact syringe conveying system is specially manufactured for accurate syringe handling, with flexible configuration. Advanced non-contact syringe transport removes interaction between syringes as they are conveyed throughout the manufacturing line. The product’s design flexibility enables any equipment layout and the option to carry syringes overhead, freeing up beneficial floor space. Each system is specifically designed for current good manufacturing practice (cGMP) atmosphere with easy access for observing and cleaning. Equipped with load levelling, the syringe lane management system has the ability to merge and separate the flow of syringe production. The system provides flexibility to run multiple syringe lines at once. Numerous input and output lanes source each downstream machine with syringes upon request and decoupling equipment to redirect syringe flow. In-feeds and out-feeds can be integrated to both upstream and downstream equipment, including custom parts and full controls to ensure the line operates resourcefully. ’s accumulator enables decoupling of the syringe line to allow stops and starts of the line without disturbing the performance of adjacent equipment. Depending on the platform, accumulations levels can range from a few hundred syringes to several thousand. The equipment controls allow full operation of the process and seamless integration between machines. Blister Accumulators / Sleevers for the Pharmaceutical Industry ’s blister accumulator / sleever can accumulate and sleeve incoming blisters. There is the option to bypass sleeving, allowing the product to continue directly to a secondary packaging if requested. This product is designed for ease of use and operates at high speed with optimal runtime. The blister accumulator/sleever controls are easy to support, sustain and incorporate with both upstream and downstream automated equipment. The machine has a clean design with a simple changeover, requiring no tools. Most parts can be replaced in minutes with no adjustments necessary. Programmable logic controller (PLC) format changes are carried out through human-machine interface (HMI) controls which are informative and easy to navigate. Outstanding Customer Service offers clients an opportunity to customise equipment to meet individual requirements. Throughout the design, clients will be consulted to verify all needs are being met. Furthermore, we offer inclusive services to develop Site Acceptance Testing (SAT) and Factory Acceptance Testing (FAT), as well as Installation Qualification (IQ) / Operational Qualification (OQ) / Performance Qualification (PQ), operations documentation and training. ’s talented technicians have experience assembling machines and provide on-site training to operators once the equipment has been installed on location. All after-sales service is dispatched from our headquarters, enabling clients to receive the best service technicians when required. About White Papers Körber is here to make the difference! With over 125 years of in-depth pharma technology expertise, we truly understand the process and regulation challenges you face day to day, from the beginning to the end of your production. Press Releases As of last month, Medipak Systems, a leading solutions provider for the pharmaceutical and biotech industries, presents itself under the Körber brand.
Award winners from the 90th Annual Huntsville Walker County Chamber of Commerce Gala
Two charged in connection with Iran drone strike that killed 3 US troops in the Middle EastOur community members are treated to special offers, promotions and adverts from us and our partners. You can check out at any time. More info Emily Atack gave fans a snapshot of her son Barney , and who has noticeably grown since his last appearance on social media. The 34-year-old star, known for her role in The Inbetweeners and her recent captivating performance in the Disney+ drama Rivals, welcomed her little one in June with her partner, scientist Alistair Garner. Now, at four months old, Barney is seen snuggling up to his mum in adorable denim dungarees. This festive update comes a year after Emily announced her pregnancy, proudly showing off her baby bump just before Christmas . As she embraces motherhood, Barney is gearing up for his very first Christmas celebration. The heartwarming post follows Emily's candid discussion about a frightening experience during her pregnancy when she suffered a haemorrhage. Recounting the ordeal, Emily expressed her initial fear: "I saw blood in the toilet and I was like, 'oh my god, I'm miscarrying' - it was just coming out of me and I thought that's it, biggest fear realised, I'm having a miscarriage." Opening up to Jamie Laing on his Great Company podcast, she revealed the relief that followed: "I had a scan and he [the doctor] said 'the baby's fine, you've had a haemorrhage, a hematoma but the baby's ok'. I couldn't believe it, I thought there's no way - I thought it was all over and I thought having to tell everybody, you feel like you're letting them all down, it's really awful." Emily bravely opened up about the heartache of miscarriage, saying, "I don't want to upset anyone who's been through baby loss, miscarriage but it's the most horrific thing ever. And a lot of that pain comes from feeling like you're going to have to let everybody down, because you've told them you're going to have this baby and it's going to be wonderful and then you're having to take that away. The pressure is ridiculous." She also expressed her concern about how casually miscarriages are often treated and added, "It's so like 'I know this girl who had a miscarriage...' because it's technically seen as common. But what is so awful, I get really angry even when doctors say it in the early days of your pregnancy, they talk about miscarriage like it is such a common thing." Emily continued, focusing on the emotional impact of such an incident: "That it's so flippant and so throwaway. But to that person who has just lost that baby it is the most devastating thing you could ever imagine. You have lost your child. But for some reason there's this really casual narrative, like it's so common that it's something you just sometimes have to go through. I can't even imagine the agony and it's just as women something that we are told to get on with."