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ChatGPT opened the floodgates. But many people don’t realize there’s a whole world of generative AI tools and applications out there, just waiting to be explored. Whether you’re struggling to overcome a case of writer’s block, lack the artistic aptitude to do your imagination justice, or just need a hand crafting efficient computer code, generative AI can help augment and streamline both your professional and creative endeavors. Yet, amid the seemingly endless variety of AI assistants currently on offer, finding the right one for your needs can prove a daunting task. So, let’s delve into some of the most impressive AI tools that are pushing the boundaries of innovation, including the best AI chatbots , the best AI image generators , and much more. The best AI tools for image generation One of the first AI image generators to be released back in 2022, Midjourney has proven immensely popular with users and art critics alike . It can output high-definition, photorealistic images in countless artistic styles based on natural language text prompts. Originally only available through the company’s Discord server, Midjourney can now be accessed through a streamlined web portal . While the website’s gallery of generated art is free to browse, you will need to subscribe to a monthly service plan (which range from $10 to $120) in order to generate images of your own. While not as creatively robust as Midjourney — only able to generate images in one of five preset artistic styles — Ideogram does offer a generous free tier that allows users to generate up to 40 images per day. Paid tiers range from $7 to $48 per month and offer a host of benefits, from additional compute resources and priority access to full-quality image downloads. The company also boasts an iOS app and an API that it claims will “offer superior image quality at a lower cost compared to other models.” This is OpenAI’s in-house text-to-image generator and runs atop the company’s GPT-4 model. Originally released in September 2023, it was initially only available to paid tier subscribers. OpenAI expanded its availability to free tier users this past August, though you’ll only be able to generate two images per day at that subscription level. Dall-E 3 is also available through Microsoft’s Copilot chatbot. If you’re looking to create high-quality images without the strict production limits that ChatGPT enforces, Google’s Imagen 3 is a solid option. It’s available through the Gemini chatbot , including the free tier, and offers higher-quality outputs with fewer artifacts than its previous versions. Note, however, that the system will not generate images of people, famous or not, unless you subscribe to Gemini Advanced (which costs $20 per month). Grok 2 is the text-to-image generator for people uninterested in adhering to copyright law. Developed for Elon Musk’s xAI company, and available on X, Grok 2 isn’t restricted by minor inconveniences like safety and legal guardrails, as other image generators are. Want to see Mickey Mouse fighting Darth Vader atop a 747 as it flies into the World Trade Center? Grok will generate it, no questions asked. You will, however, need to pony up $8 for a premium subscription to X in order to access it. Runway’s Gen 3 Alpha is a relatively new model, having been released in June of 2024, and is capable of creating both still images and video clips with nearly photorealistic quality based on the user’s natural language prompts. The company recently announced that it will begin integrating a new foundational model, dubbed Frames , into the Gen 3 platform that will offer unprecedented control over the image creation process, enabling users to generate multiple image variants while maintaining a specific aesthetic style, whether that’s mimicking 35mm disposable camera shots or retro anime motifs. Subscription prices run from $12 to $76 per month, though the company does offer a limited free tier as well. The best AI tools for image editing Skylum’s Luminar Neo is a photo editing suite designed with professional photographers in mind. It offers many of the same powerful tools as Adobe Photoshop, but outsources much of their functionality to AI. This enables users to accomplish numerous common tasks, from adjusting color balance and lighting levels to tweaking the look of the sky, water, and skin tones, with a single click. Luminar Neo might be a bit pricey for casual users, costing $421 for a yearly subscription or as a lifetime subscription for $577. It’s available on both Windows and Mac, as well as a plugin for Photoshop, Photos, and Lightroom. Canva is a multifunction creative platform that offers everything from digital whiteboarding, data visualization, and marketing material templates to photo, video, and YouTube editing features. While you can easily make minor adjustments like cropping, adding filters and adjusting aspect ratios using the site’s free editor, Canva Pro offers a number of additional AI-empowered tools. Select, move, resize, and even erase individual objects within an image; extract and modify text on flattened images; and even generatively expand the image’s background, all with a few simple clicks. Canva Pro costs $120 per year for a single user license. This online photo editing suite has served as a free and user-friendly alternative to Photoshop since it was released in 2008. Last November, the company debuted a number of AI features including image generation, a generative fill tool, AI background removal, AI face swap, and image expansion to help round out the tool set’s functionality. While the interface is geared more for casual users and may not be as precise and granular as what Photoshop offers, you can’t beat free. If you only need to do some light retouching work on your images, the Topaz Photo AI suite offers eight enhancement tools: Denoise, Sharpen, Upscale, Recover Faces, Remove Objects, Preserve Text, Adjust Lighting, and Balance Color. It’s not a true replacement for full-function photo editors like Photoshop, but it is available without an annual subscription, for a flat rate of just $199 with version upgrades costing $99. Adobe’s Firefly AI doesn’t just generate images and video from text prompts, it also empowers a number of AI features throughout the Adobe product ecosystem. That includes the Generative Fill tool in Photoshop, text effects in Adobe Express, vector and pattern generation in Illustrator, and Generative Extend in Premiere Pro. You will need to subscribe to Adobe’s Creative Cloud suite in order to access these features, though they can either be purchased individually (the image generator, for example, costs $5/month while Photoshop costs $23) or you can pick up all 20-plus Adobe apps for $60 per month. Best AI for video generation While Luma Dream Machine may be designed with fashion, marketing and filmmaking professionals in mind, it’s built as a subscription-based service with both casual and professional users in mind. Unlike conventional AI tools, Dream Machine does not require precise and exhaustive prompting to generate the desired effect, but rather, interprets the user’s natural language request intuitively. It also accepts multi-image prompting and single-image character references so users can show the AI what they have in mind. Luma does not offer a free tier, though a “hobbyist” subscription costs just $10 per month. Kling AI video-generation system from China’s Kuaishou Technology offers photorealistic outputs on par with what we’ve seen from OpenAI’s Sora and is already available to users around the world. It can generate high-definition videos up to two minutes in length (double what Sora can) at up to 30 frames per second and 720p resolutions (slightly less than Sora’s 1080p output). Each clip starts out at just five seconds in length but can be extended in 4.5-second increments by purchasing additional credits. Just be warned that the system is blocked from generating politically-sensitive subjects. Synthesia is a bit more niche than the other video generators we’ve discussed so far. It’s designed specifically to generate video avatars from the user’s text prompts making it ideal for business applications like onboarding and training videos, sales presentations, and internal communications. Users can choose from one of more than 130 avatar models speaking 140 different languages and over 60 video templates. The free tier allows you to generate a single three-minute video per month and your choice of nine avatars, while the $30/month Starter tier and $90/month creator tier offer significantly more benefits. Vyond offers similar functionality to Synthesia in that it generates AI avatars for training videos based on the user’s text prompts, however, this service relies on animated characters rather than live actors. You also have the option to record yourself performing specific actions or movements and Vyond will motion match its animation to them. Plans start at $49 per month, which also includes access to an added video editor, though anything you produce at that tier will be watermarked with Vyond’s logo. The best AI for text generation ChatGPT , the chatbot that launched the AI boom in 2022, remains at the forefront of the industry with an estimated 200 million active weekly users. Trained on huge quantities of written content including websites, books, social media posts, and news articles, ChatGPT is equally adept at answering general knowledge queries and compiling computer code as it is at generating creative prose . It was also the first chatbot to offer a conversational feature in Advanced Voice Mode that allows users to interact with the chatbot as if it were a person, doing away with the need for text-based prompts. ChatGPT is available on the web as well as on iOS and Android. It’s free to use, though subscribing to the $20/month ChatGPT-Plus plan will give you increased access to the company’s latest AI models and features. Copilot answers the question “what if ChatGPT worked natively within Microsoft’s 365 app ecosystem?” Which is exactly what it does. Microsoft has invested billions in OpenAI’s business and, as such, its Copilot AI runs atop the startup’s GPT-4o LLM. However, Copilot is more than just a reskinned ChatGPT. For one, Copilot does not restrict users from generating images without paying for a subscription to its premium plan as ChatGPT does. For another, its functionality can be integrated across Microsoft’s products, helping users generate text in Word , create graphs and tables in Excel , and draft emails in Outlook . Google’s Gemini chatbot may have gotten off to a bit of a rocky start upon its official debut in February but the AI assistant has quickly grown into a potent rival to ChatGPT, offering much of the same functions and features. Those include the ability to generate text, images, video, audio, and code, converse with users verbally with Gemini Live, and integrate with Google’s Workspace app suite. It can gin up email responses in Gmail, search for files in Drive, create content for Slides, and draft text in Docs, all through the user’s natural language prompts. Gemini is free to use and is available on the web as well as through its iOS and Android apps, but if you want to access the AI’s more advanced features (and Workspace integrations), you’ll need to subscribe to the company’s $20/month Google One AI Premium service. Perplexity’s AI assistant offers a unique alternative to traditional search engines. Rather than simply return a list of websites in response to a user’s query as Google search does, this chatbot scours the internet for relevant information, then synthesizes an answer to the user’s question directly in the chat window. It essentially eliminates the need to click through to individual websites to find the information you’re looking for. Built atop the GPT-4 model and available on Android, iOS, as well as on the web, Perplexity is free to use. The company also offers a Pro subscription plan for $20/month (or $200/year) that grants you access to additional AI models including GPT-4 Omni and Claude 3 Sonnet and Haiku , as well as a host of additional benefits. Unlike generalized chatbots like ChatGPT and Gemini, Jasper AI is all business. It is designed to generate text for emails, blogs, social media posts, and marketing materials, all while maintaining your company’s distinctive tone, voice, and brand style. The platform includes Jasper Chat, which assists with research tasks and offers writing advice, as well as can help maximize the SEO score of your marketing content. Jasper is only available on a subscription basis, with plans starting at $40 per month per user, though the company does offer a seven-day trial. The best AI for audio and voice generation ElevenLabs knows how to make a machine talk. The company is a leader in generative speech technology, offering a variety of audio-centric services from automatic voice dubbing and cloning to text-to-speech and text-to-SFX. Users can select from thousands of unique voices (including those of famous celebrities ), all trained on public domain and licensed data, in any of 32 languages. Ideal for podcasting, audio book narration, and conversational AI applications, the company’s products are available at a variety of pricing tiers ranging from free up to $99 per month. Why read a document when you can have Speechify read it to you four and a half times faster? The company’s voiceover technology can recite nearly any document you present to it in one of 200 voices (including your own through its voice cloning feature) in more than 60 languages. Speechify is available as a Chrome extension, a Mac app, a web app, iOS or Android app. The mobile apps can also read physical documents using your phone’s camera to scan the page. Speechify’s free tier limits you to simple text-to-speech in just 10 voices, while the $12/month premium tier unlocks the service’s full functionality. Respeecher specializes in voice cloning for celebrities, content creators, voice actors, game designers, and other professional applications. The company’s AI model essentially enables one person to speak in the voice of another. “We take recordings of the ‘target voice’ (the voice that is being replicated), train our system, and apply it to a ‘source speaker’ (the actor reading the lines),” the Respeecher’s FAQ explains. “It features all the emotions, intonations, and nuances of a real human voice.” The company offers a wide range of celebrity voices including Chris Farley and Richard Nixon, the latter of which earned Speechify an Emmy in 2019. Subscription plans start at $18 per month for basic text-to-speech (up to 100,000 characters per month and range up to $500 per month for the Power tier, which offers 900 minutes of speech-to-speech and 3 million characters of text-to-speech generation in more than 100 voices and 13 accents. If you fancy yourself a musician but can’t carry a tune, Controlla Voice can help. Its generative model can train an “AI Singing Voice” that sounds like you, based on 15-30 minutes of sample audio, then apply it to songs from the company’s extensive catalog, or blend your voice with others from their licensed stable of voice actors to generate unique vocals. You can even convert the vocals in existing songs from other artists into your voice for low-effort covers. Subscription prices run from $12 to $30 per month. The best AI for coding Anthropic’s Claude chatbot may not be able to generate images or speak to you conversationally, but it utterly excels at coding applications. Its latest iteration, Claude 3.5 Sonnet , drastically outperforms the likes of Gemini 1.5 Pro and ChatGPT-4o across a broad swath of leading industry benchmarks. Claude was also the first chatbot to offer a collaborative window (dubbed Artifacts ) that previews what the AI is generating outside of the chat stream. The chatbot is available free to all users on the web, iOS, and Android, though subscribing to the $20/month Pro or $30/month Teams tiers will grant you priority access to the latest and greatest models that Anthropic has to offer. Developed through a partnership between Github and OpenAI, GitHub Copilot acts as an AI autocomplete, to help users in the Visual Studio Code, Visual Studio, Neovim, and JetBrains IDEs generate code faster than they can on their own. Users can present Copilot with a coding problem, phrased in natural language, and the assistant will automatically generate a solution code. Conversely, it can also explain what a given snippet of code does as well as convert snippets between various coding languages. You can use Github Copilot for free, though upgrading to either the $4/month Pro or $21/month Enterprise tiers will, of course, give you additional resources and features. Similar to Copilot, Amazon’s CodeWhisperer is a general use coding assistant that will automatically generate suggestions and code recommendations based on your existing inputs, in real time. It’s available for the JetBrains and Visual Studio IDEs and also supports natural language-to-bash translation in the Mac command line. The free tier only offers limited access to the system’s more advanced features, so you’ll have to pony up $20/month if you want to unlock its full capabilities. Cursor AI is a coding assistant in the same vein as Codewhisperer but can offer autocomplete suggestions across multiple lines of code, based on your previous inputs. It also offers a smart rewrite function that automatically corrects your typos and syntax errors so you spend less time tracking down errant quotation marks and parentheses while debugging, as well as cursor prediction that guesses where your cursor needs to be next, enabling you to navigate through your project faster and more efficiently. It even offers a chatbot assistant (leveraging GPT-4, GPT-4o, and Claude 3.5 Sonnet) that can answer questions about either the entire active file or specific selected code blocks. The chatbot can even edit that highlighted code based on your natural language instructions. Cursor AI is available for the Mac, Windows, and Linux operating systems. You can try it out free for two weeks before a $20/month Pro or $40/user/month Business subscription is required. The best AI to integrate with the rest of your app ecosystem Meta, Facebook’s parent company, has been investing heavily in AI over the past few years and has recently begun incorporating the smart features found in rivals like Gemini and Copilot to its own product portfolio. “More than 400 million people are using Meta AI monthly, with 185 million people using it across our products each week,” the company boasted in a September blog post . The company now offers a conversational AI similar to Advanced Voice Mode in Messenger, Facebook, WhatsApp, and Instagram DM. It can answer questions about photos shared in your group chats, generate custom backgrounds for images you reshare from your feed to Instagram Stories, and automatically translate the audio of your Instagram Reels. It can also generate images to share on your feed, Stories, and set as your Facebook profile picture. So when you find yourself wondering why there’s so much AI slop clogging up Facebook and Insta, understand that it is a feature Meta has spent billions developing, not a bug. Microsoft has dumped north of $10 billion into its partnership with OpenAI, so of course it’s going to shoehorn ChatGPT’s generative capabilities into every single product it possibly can. In addition to the Copilot chatbot itself, Microsoft has developed and released Copilot Pages, which function much like Claude’s Artifacts or ChatGPT’s Canvas. The company has also integrated it into Outlook to help you manage your inbox by prioritizing which messages to respond to first and quickly draft email replies. 365 Copilot can also help you rapidly establish a cohesive narrative in your PowerPoint presentations by generating pitch decks whole cloth from your natural language prompt that maintain a consistent tone and brand voice. In Excel, Copilot does the heavy lifting of generating formulas, graphs, and charts based, again, on the user’s prompt. And in Teams, Copilot can monitor your video meetings and provide summaries of what happened as well as generate actionable item lists based on what was discussed. Gemini does for Google’s Workspace app suite what Copilot does for Microsoft’s. The AI assistant can help draft emails in Gmail , write documents in Docs, generate graphs and charts in Sheets, create and modify slides in Slides, find files in Drive, and provide live-translated captions and take notes in Meet. If you don’t already have a personal Google One AI Premium subscription, you’ll have to ask your Workspace admin to grant you access. Apple Intelligence may be the new kid on the AI block, but it is promising to be more deeply integrated within its product ecosystem than any other currently on the market. Designed to serve as an overarching agent acting on the user’s behalf, it promises to streamline monotonous everyday tasks, make Siri a better conversationalist, automate proofreading and text summarization across the company’s myriad apps, and offer lightning-fast image generation. It is currently available to all devices running iOS 18 , iPadOS 18 , and MacOS Sequoia — basically, the iPhone 15 Pro and 15 Pro Max (and newer), as well as iPads and Macs with M1 or newer chips.Local Republican Central Committee to host interviews for coroner replacement

MP’s swim-hole poses serious threat to marine ecosystemWASHINGTON (AP) — said he can't guarantee that his on key U.S. foreign trade partners won't for American consumers and he suggested once more that some who pursued legal cases against him should be imprisoned. The president-elect, in a wide-ranging interview with NBC's “Meet the Press” that aired Sunday, also touched on monetary policy, immigration, abortion and health care, and U.S. involvement in Ukraine, Israel and elsewhere. Trump often mixed declarative statements with caveats, at one point cautioning “things do change.” A look at some of the issues covered: Trump has threatened broad trade penalties, but said he didn’t believe that added costs on those imported goods for American companies would lead to higher prices for U.S. consumers. He stopped short of a pledge that U.S. households won't be paying more as they shop. “I can’t guarantee anything. I can’t guarantee tomorrow,” Trump said, seeming to open the door to accepting the reality of how import levies typically work as goods reach the retail market. That's a different approach from Trump's typical speeches throughout the 2024 campaign, when he framed his election as a sure way to curb inflation. In the interview, Trump defended tariffs generally, saying they are "going to make us rich.” He has pledged that, on his first day in office in January, he would impose 25% tariffs on all goods imported from Mexico and Canada unless those countries satisfactorily stop illegal immigration and the flow of illegal drugs such as fentanyl into the United States. He also has threatened additional tariffs on China to help force that country to crack down on fentanyl production. ”All I want to do is I want to have a level, fast, but fair playing field,” Trump said. He offered conflicting statements on how he would approach the justice system after winning election despite being convicted of 34 felonies in a New York state court and being indicted in other cases for his handling of national security secrets and efforts to overturn his 2020 loss to Democrat Joe Biden. “Honestly, they should go to jail,” Trump said of members of Congress who investigated the Capitol riot by his supporters who wanted him to remain in power. The president-elect underscored his contention that he can use the justice system against others, including special prosecutor Jack Smith, who led the case on Trump’s role in the siege on Jan. 6, 2021. Trump confirmed his plan to pardon supporters who were convicted for their roles in the riot, saying he would take that action on his first day in office. As for the idea of revenge driving potential prosecutions, Trump said: “I have the absolute right. I’m the chief law enforcement officer, you do know that. I’m the president. But I’m not interested in that." At the same time, Trump singled out lawmakers on a special House committee who had investigated the insurrection, citing Rep. Bennie Thompson, D-Miss., and former Rep. Liz Cheney, R-Wyo. “Cheney was behind it ... so was Bennie Thompson and everybody on that committee,” Trump said. Asked specifically whether he would direct his administration to pursue cases, he said, “No,” and suggested he did not expect the FBI to quickly undertake investigations into his political enemies. But at another point, Trump said he would leave the matter up to Pam Bondi, his pick as attorney general. “I want her to do what she wants to do,” he said. Such threats, regardless of Trump's inconsistencies, have been taken seriously enough by many top Democrats that Biden is considering issuing blanket, to protect key members of his outgoing administration. Trump did seemingly back off his campaign rhetoric calling for Biden to be investigated, saying, “I’m not looking to go back into the past.” Trump repeatedly mentioned his promises to seal the U.S.-Mexico border and deport millions of people who are in the U.S. illegally through a mass deportation program. “I think you have to do it,” he said. He suggested he would try to use executive action to end “birthright” citizenship under which people born in the U.S. are considered citizens — although such protections are spelled out in the Constitution. Asked specifically about the future for people who were brought into the country illegally as children and have been shielded from deportation in recent years, Trump said, “I want to work something out,” indicating he might seek a solution with Congress. But Trump also said he does not “want to be breaking up families” of mixed legal status, “so the only way you don’t break up the family is you keep them together and you have to send them all back.” Long a members for not spending more on their own defense, Trump said he “absolutely” would remain in the alliance “if they pay their bills.” Pressed on whether he would withdraw if he were dissatisfied with allies’ commitments, Trump said he wants the U.S. treated “fairly” on trade and defense. He waffled on a NATO priority of containing Russia and President Vladimir Putin. Trump suggested Ukraine should prepare for less U.S. aid in its defense against Putin’s invasion. “Possibly. Yeah, probably. Sure,” Trump said of reducing Ukraine assistance from Washington. Separately, Trump has . Asked about Putin, Trump said initially that he has not talked to the Russian leader since Election Day last month, but then hedged: “I haven’t spoken to him recently.” Trump said when pressed, adding that he did not want to “impede the negotiation.” The president-elect said he has no intention, at least for now, of asking Federal Reserve Chairman Jerome Powell to step down before Powell's term ends in 2028. Trump said during the campaign that presidents should have , including interest rates. Trump did not offer any job assurances for FBI Director Christopher Wray, whose term is to end in 2027. Asked about Wray, Trump said: “Well, I mean, it would sort of seem pretty obvious” that if the Senate confirms Kash Patel as his then “he’s going to be taking somebody’s place, right? Somebody is the man that you’re talking about.” Trump promised that the government efficiency effort led by Elon Musk and Vivek Ramaswamy will not threaten Social Security. “We're not touching Social Security, other than we make it more efficient,” he said. He added that “we're not raising ages or any of that stuff.” He was not so specific about abortion or his long-promised overhaul of the Affordable Care Act. On abortion, Trump continued and said he would “probably” not move to restrict access to the abortion pills that now account for a majority of pregnancy terminations, according to the Guttmacher Institute, which supports abortion rights. But pressed on whether he would commit to that position, Trump replied, “Well, I commit. I mean, are -- things do -- things change. I think they change.” Reprising a line from his against Vice President Kamala Harris, Trump again said he had “concepts” of a plan to substitute for the 2010 Affordable Care Act, which he called “lousy health care.” He added a promise that any Trump version would maintain insurance protections for Americans with preexisting health conditions. He did not explain how such a design would be different from the status quo or how he could deliver on his desire for “better health care for less money.” Barrow reported from Atlanta. Associated Press writers Adriana Gomez Licon in Fort Lauderdale, Florida, and Jill Colvin and Michelle L. Price in New York contributed to this report.

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( MENAFN - GlobeNewsWire - Nasdaq) SHENZHEN, CHINA, Dec. 08, 2024 (GLOBE NEWSWIRE) -- On 6 December, China Medical System Holdings Limited (“CMS” or the“Group”) is pleased to announce that the first prescriptions for the innovative drug Lumeblue® (Methylthioninium Chloride Enteric-coated Sustained-release Tablets) (the“Product”) have been issued in China, which marks that the first oral methylthioninium chloride enteric-coated sustained-release tablets in China has officially entered clinical application. The Product is indicated for enhancing visualization of colorectal lesions in adult patients undergoing screening or surveillance colonoscopies. Lumeblue® is an oral diagnostic drug that uses patented multi-matrix (MMXTM) technology to deliver active substances directly to the colon and release them locally in a controlled manner. As an enhancer dye, the Product increases the contrast between colorectal lesions and healthy mucosa. The results of the Phase III clinical trial in China show that the Product can significantly improve the detection rate of non-polypoid colorectal lesions (the primary endpoint of the study), leading to an improved detection rate of dangerous lesions such as non-polypoid adenomas (the secondary endpoint)[1]. In addition, the Product can be taken during the bowel preparation step, ensuring that colorectal staining is completed by the time colonoscopy is conducted. This not only enhances the detection rate of colorectal lesions but also potentially simplifies the colonoscopy procedure, making the examination more efficient and improving the screening benefits. According to the diagnosis and treatment data of the Digestive Endoscopy Branch of the Chinese Medical Association, approximately a total of 28 million gastroenteroscopies were completed nationwide in 2012, including 5.83 million colonoscopies. In 2019, approximately 38.73 million gastroenteroscopies were completed nationwide, an increase of 34.62% compared with 2012[2]. The Expert consensus on the early diagnosis and treatment of colorectal cancer in China (2023 edition) recommends colorectal cancer screening for individuals aged 40 to 74[3]. Based on the China Statistical Yearbook (2023), the total population of this age group in China is 643.36 million[4]. With the popularization of early colorectal cancer screening in China, the number of colonoscopies performed is expected to have significant growth potential in the future. Early diagnosis and removal of lesions are crucial for prevention. Lumeblue® provides an innovative solution for colorectal disease screening and management in response to this growing demand. The Product has been approved by the European Medicines Agency (EMA) to be commercialized in the European Union under the trade name Lumeblue® in August 2020. The Group obtained an exclusive license for the Product from Cosmo Technologies Ltd., a fully-owned subsidiary of Cosmo Pharmaceuticals NV, on 3 December 2020. Following its approval in China in June 2024, CMS worked collaboratively across its business segments to ensure the rapid importation of the first batch of products. The Group has also actively leveraged its existing gastroenterology portfolio and resources to orderly advance the commercialization and academic promotion of Lumeblue®, facilitating its successful prescriptions launch in China. With this milestone, CMS's five innovative drugs have been successfully approved in China and fully entered clinical application. This achievement demonstrates the Group's ongoing capability of innovation transformation, while reflecting CMS's commitment to focusing on medical value and fulfilling its corporate social responsibility. Looking ahead, CMS will continue to be patients-centered, efficiently advancing the clinical development and commercialization of innovative products. The Group is dedicated to improving the accessibility and affordability of innovative drugs, benefiting a broader patient population. About CMS CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs. CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients. CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development of its advantageous specialty fields and expand business boundaries. While strengthening the competitiveness of the cardio-cerebrovascular/gastroenterology business, CMS independently operates its dermatology and medical aesthetics business, and ophthalmology business, aiming to gain leading positions in specialty therapeutic fields, whilst enhancing the scale and efficiency. At the same time, CMS has expanded its business territory to the Southeast Asian market, striving to become a "bridgehead" for global pharmaceutical companies to enter the Southeast Asian market, further escorting the sustainable and healthy development of the Group. References: CMS Disclaimer and Forward-Looking Statements This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient's specific circumstances and in accordance with the drug package insert. This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group's market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections. Media Contact Brand: China Medical System Holdings Ltd. 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Local Republican Central Committee to host interviews for coroner replacement1 2 Jamshedpur: National Democratic Alliance's (NDA) poor electoral performance in Jharkhand isn't the end of their political journey, BJP leader and former chief minister Champai Soren said on Sunday. Speaking to media, Champai acknowledged that victories and defeats are natural in politics. "There's no end to the political journey. Probably we failed to convince people and effectively convey our message to voters," he said, adding the opposition camp (INDIA bloc) had misled people to secure votes. The BJP leader announced plans to launch a significant campaign against alleged illegal Bangladeshi immigrants in the state, focusing particularly on protecting tribal lands. IPL 2025 mega auction IPL Auction 2025 Live: Rishabh Pant, Shreyas, Venkatesh hit the jackpot IPL 2025 Auction LIVE: Updated Full Team Squads IPL Auction 2025: Who got whom "With elections now over, I will initiate a movement against infiltrators from Santhal Pargana . I have taken up the responsibility to protect the honour of the adivasis and restore their rights," Soren declared. His comments came within hours of Assam CM Himanta Biswa Sarma issuing a video message appealing to continue with the issue of infiltration in a strong way. He criticized Hemant govt's policies, holding them responsible for unchecked illegal immigration. "The BJP will battle it out both in the assembly and on the streets to get the flawed policies of the govt removed so that the infiltration is stopped," he emphasized, adding the party would soon formulate an action plan. Commenting on his seventh consecutive victory from the Seraikela (ST) seat, the 68-year-old leader expressed gratitude to his constituents. "The people have voted for me not to sit in power but to work towards improving the lives of the poor and marginalized," he stated. Soren outlined his commitment to accelerating infrastructure projects in his constituency that were initiated during his previous term. He assured that the party would thoroughly analyse the recent electoral outcome to identify areas that need improvement. The veteran leader predicted that his movement against illegal immigrants would create significant impact in tribal areas and influence the broader political landscape. The BJP plans to conduct a comprehensive assessment of the poll results to understand where they fell short and develop strategies for future electoral success. "Development of the constituency remains my priority," Champai said.

Governor, comptroller, state treasurer hail Connecticut's fiscal healthAMES, Iowa (AP) — Audi Crooks scored the winning shot as time expired and a season-high 33 points as No. 8 Iowa State survived with an 80-78 win over Drake on Sunday afternoon. Addy Brown added 13 points and eight rebounds, Emily Ryan scored 11 points with 12 assists and Kenzie Hare had 10 points as the Cyclones (5-1) avoided a second consecutive loss. The Bulldogs (2-3) were led by guard Katie Dinnebier, who scored 39 points on 13-of-16 shooting and went 8 of 10 from 3-point range. Dinnebier went 5 of 6 from the charity stripe. Anna Miller added 18 points in Drake's attempt to dethrone Iowa State, and Abbie Aalsma scored 11 off the bench. Takeaways Drake: The Bulldogs, who were picked to finish first in the Missouri Valley Conference in the preseason, tied a season high with 19 turnovers. Iowa State scored 24 points from those turnovers. Iowa State: The Cyclones found a way to bounce back after losing to Northern Iowa on Wednesday night. Key moment A 10-0 run in the first quarter was the difference in a close Cyclone win. Key stat The Cyclones were outrebounded 42-31 by the Bulldogs, marking the first time Iowa State was outrebounded this season. Up next Iowa State heads to Florida to play No. 1 South Carolina on Thursday in the Women's Fort Myers Tip-Off, the same day Drake plays Wyoming in the San Juan Shootout in Puerto Rico. ___ Get poll alerts and updates on the AP Top 25 throughout the season. Sign up . AP women’s college basketball: and Pavle Markovic, The Associated PressMark Young, Woolery's podcast co-host and friend, said in an email early Sunday that Woolery died at his home in Texas with his wife, Kristen, present. “Chuck was a dear friend and brother and a tremendous man of faith, life will not be the same without him,” Young wrote. Woolery, with his matinee idol looks, coiffed hair and ease with witty banter, was inducted into the American TV Game Show Hall of Fame in 2007 and earned a daytime Emmy nomination in 1978. In 1983, Woolery began an 11-year run as host of TV’s “Love Connection,” for which he coined the phrase, “We’ll be back in two minutes and two seconds,” a two-fingered signature dubbed the “2 and 2.” In 1984, he hosted TV’s “Scrabble,” simultaneously hosting two game shows on TV until 1990. “Love Connection,” which aired long before the dawn of dating apps, had a premise that featured either a single man or single woman who would watch audition tapes of three potential mates and then pick one for a date. A couple of weeks after the date, the guest would sit with Woolery in front of a studio audience and tell everybody about the date. The audience would vote on the three contestants, and if the audience agreed with the guest’s choice, “Love Connection” would offer to pay for a second date. Woolery told The Philadelphia Inquirer in 2003 that his favorite set of lovebirds was a man aged 91 and a woman aged 87. "She had so much eye makeup on, she looked like a stolen Corvette. He was so old he said, ‘I remember wagon trains.’ The poor guy. She took him on a balloon ride.” Other career highlights included hosting the shows “Lingo," “Greed” and “The Chuck Woolery Show,” as well as hosting the short-lived syndicated revival of “The Dating Game” from 1998 to 2000 and an ill-fated 1991 talk show. In 1992, he played himself in two episodes of TV’s “Melrose Place.” Woolery became the subject of the Game Show Network’s first attempt at a reality show, “Chuck Woolery: Naturally Stoned,” which premiered in 2003. It shared the title of the pop song in 1968 by Woolery and his rock group, the Avant-Garde. It lasted six episode and was panned by critics. Woolery began his TV career at a show that has become a mainstay. Although most associated with Pat Sajak and Vanna White, “Wheel of Fortune” debuted Jan. 6, 1975, on NBC with Woolery welcoming contestants and the audience. Woolery, then 33, was trying to make it in Nashville as a singer. “Wheel of Fortune” started life as “Shopper’s Bazaar,” incorporating Hangman-style puzzles and a roulette wheel. After Woolery appeared on “The Merv Griffin Show” singing “Delta Dawn,” Merv Griffin asked him to host the new show with Susan Stafford. “I had an interview that stretched to 15, 20 minutes,” Woolery told The New York Times in 2003. “After the show, when Merv asked if I wanted to do a game show, I thought, ‘Great, a guy with a bad jacket and an equally bad mustache who doesn’t care what you have to say — that’s the guy I want to be.’” NBC initially passed, but they retooled it as “Wheel of Fortune” and got the green light. After a few years, Woolery demanded a raise to $500,000 a year, or what host Peter Marshall was making on “Hollywood Squares.” Griffin balked and replaced Woolery with weather reporter Pat Sajak. Listen now and subscribe: Apple Podcasts | Google Podcasts | Spotify | RSS Feed | SoundStack “Both Chuck and Susie did a fine job, and ‘Wheel’ did well enough on NBC, although it never approached the kind of ratings success that ‘Jeopardy!’ achieved in its heyday,” Griffin said in “Merv: Making the Good Life Last,” an autobiography from the 2000s co-written by David Bender. Woolery earned an Emmy nod as host. Born in Ashland, Kentucky, Woolery served in the U.S. Navy before attending college. He played double bass in a folk trio, then formed the psychedelic rock duo The Avant-Garde in 1967 while working as a truck driver to support himself as a musician. The Avant-Garde, which toured in a refitted Cadillac hearse, had the Top 40 hit “Naturally Stoned,” with Woolery singing, “When I put my mind on you alone/I can get a good sensation/Feel like I’m naturally stoned.” After The Avant-Garde broke up, Woolery released his debut solo single “I’ve Been Wrong” in 1969 and several more singles with Columbia before transitioning to country music by the 1970s. He released two solo singles, “Forgive My Heart” and “Love Me, Love Me.” Woolery wrote or co-wrote songs for himself and everyone from Pat Boone to Tammy Wynette. On Wynette’s 1971 album “We Sure Can Love Each Other,” Woolery wrote “The Joys of Being a Woman” with lyrics including “See our baby on the swing/Hear her laugh, hear her scream.” After his TV career ended, Woolery went into podcasting. In an interview with The New York Times, he called himself a gun-rights activist and described himself as a conservative libertarian and constitutionalist. He said he hadn’t revealed his politics in liberal Hollywood for fear of retribution. He teamed up with Mark Young in 2014 for the podcast “Blunt Force Truth” and soon became a full supporter of Donald Trump while arguing minorities don’t need civil rights and causing a firestorm by tweeting an antisemitic comment linking Soviet Communists to Judaism. “President Obama’s popularity is a fantasy only held by him and his dwindling legion of juice-box-drinking, anxiety-dog-hugging, safe-space-hiding snowflakes,” he said. Woolery also was active online, retweeting articles from Conservative Brief, insisting Democrats were trying to install a system of Marxism and spreading headlines such as “Impeach him! Devastating photo of Joe Biden leaks.” During the early stages of the pandemic, Woolery initially accused medical professionals and Democrats of lying about the virus in an effort to hurt the economy and Trump’s chances for reelection to the presidency. “The most outrageous lies are the ones about COVID-19. Everyone is lying. The CDC, media, Democrats, our doctors, not all but most, that we are told to trust. I think it’s all about the election and keeping the economy from coming back, which is about the election. I’m sick of it,” Woolery wrote in July 2020. Trump retweeted that post to his 83 million followers. By the end of the month, nearly 4.5 million Americans had been infected with COVID-19 and more than 150,000 had died. Just days later, Woolery changed his stance, announcing his son had contracted COVID-19. “To further clarify and add perspective, COVID-19 is real and it is here. My son tested positive for the virus, and I feel for of those suffering and especially for those who have lost loved ones,” Woolery posted before his account was deleted. Woolery later explained on his podcast that he never called COVID-19 “a hoax” or said “it’s not real,” just that “we’ve been lied to.” Woolery also said it was “an honor to have your president retweet what your thoughts are and think it’s important enough to do that.” In addition to his wife, Woolery is survived by his sons Michael and Sean and his daughter Melissa, Young said.

Puppet show raises awareness on mental health for Vysarpadi youth

The London Fire Department was on scene of a house fire in the city on Sunday. The incident was in the 400 block of Alston Road. Crews arrived on scene just before 12:30 p.m. on Sunday. Crews said smoke was showing and they advanced an attack line. Fire was successfully extinguished and crews quickly transitioned to ventilation and overhaul operations. Two people have been displaced as a result and one cat died. The estimated damage is more than $200,000. The investigation is ongoing. London Top Stories Two displaced in $200,000 house fire Three people in hospital due to collision Assault at Santa Claus parade leads to charges Easton Cowan needs a point Sunday to tie 55-game OHL point streak record CPKC Holiday Train to stop in Southwestern Ontario Sunday night One community still undecided in nuclear waste willingness vote St. Thomas, Ont. and San Jose, Calif. celebrate hockey legend on night his jersey is retired Man charged in child abuse investigation: STPS CTVNews.ca Top Stories 'Still working full time on it:' One year later police continue to search for gunman in Caledon double murder linked to ex-Olympian One year after a couple was shot and killed in their Caledon home in what investigators have described as a case of mistaken identity, Ontario Provincial Police say they are still trying to figure out who pulled the trigger. A man called 911 for help during a home invasion. Las Vegas police fatally shot him A Las Vegas man called for police help during a home invasion before an officer fatally shot him, according to authorities and 911 calls. Scurvy resurgence highlights issues of food insecurity in Canada's rural and remote areas A disease often thought to only affect 18th century sailors is reemerging in Canada. Cat caught in hunting snare rescued by BC SPCA Donations are ramping up for a BC SPCA cat with a mangled paw after being caught in a hunting snare, one of a rising number of pets to fall prey to the hunting device. 'Very disturbing': Deepfake videos appear to target Canadian immigrants for thousands of dollars Artificially generated videos of a Toronto-based lawyer asking for money appear to be just one way some try to exploit newcomers to Canada during a time of confusion around new immigration rules. Lotto Max jackpot hits $80M for second time ever The Lotto Max jackpot has climbed to $80 million for just the second time in Canadian lottery history. Nova Scotia Tories appear safe with close battle for second between Liberals and NDP With two days left before Nova Scotians elect their next government, polls suggest Progressive Conservative Leader Tim Houston's decision to call an early vote will pay off and the real battle will be between the Liberals and NDP for second place. Montreal police chief expects additional arrests following anti-NATO protest Montreal's police chief says he expects more arrests stemming from a Friday anti-NATO protest that turned violent, with smashed windows and burned cars in downtown Montreal. 'Wicked' and 'Gladiator' make gravity-defying theatre debuts With a combined US$270 million in worldwide ticket sales, 'Wicked' and 'Gladiator II' breathed fresh life into a box office that has struggled lately. 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