url fb777 club Church Fr. Romans Antony, senior priest of the Kollam Archdiocese, stated in Karunagappally, Kollam district, that if the Munambam victims are evicted, people from the entire coastal belt would mobilize to support them. He was speaking at a Jan Jagaran Conclave conducted by the Hindu Aikyavedi organisation. Fr. Antony criticized the state for accusing the protestors of communalizing the issue. He remarked that depriving a section of people of their rights for vote-bank politics is not a sign of a healthy democracy. He also criticized Congress MP Hibi Eden, who is representing Ernakulam, for hiding the truth for the sake of political gain, stating that Eden would never enter the area because he cannot face the people. Fr. Antony further condemned the Kerala Communist government, calling it a “government with no spine” and accusing it of lacking the audacity to address critical issues. He highlighted that six months have passed since the killer landslides in Wayanad, yet the losses have neither been audited nor fully assessed. Church Fr. Antony said that a government without willpower cannot ensure justice for its people. He welcomed the Waqf Amendment Bill and praised the support extended by Hindu Aikyavedi and other like-minded organizations, emphasizing that the movement transcends caste and religious boundaries. Meanwhile, former Union Minister Rajeev Chandrasekhar stated that the Munambam Waqf issue is a constitutional matter. He said he has been supporting the people of Munambam since the very first day of their agitation and will continue to stand by them until a solution is found. He was addressing the Waqf victims at the Velankanni Church on December 22, where they are carrying out a relay hunger strike. He added that Munambam is facing an organized encroachment and criticized both political fronts—the ruling CPM-led Left Democratic Front (LDF) and the opposition Congress-led United Democratic Front (UDF)—for their double standards on the matter. The former minister emphasized that the Waqf Amendment Bill will be implemented in its entirety. He pointed out that leaders of both fronts had issued pro-victim statements during the by-elections in Wayanad, Palakkad, and Chelakkara but have since gone back on their words after the elections concluded. The Munambam victims submitted a memorandum to the former Union Minister. The Munambam Waqf case centers around a land dispute in the coastal area of Munambam, Ernakulam district, where nearly 600 families face the threat of displacement. Over 400 of these families are Christian, with the remainder being Hindu. The residents have been on a relay hunger strike for over four weeks. Prominent bishops and BJP MP Suresh Gopi also visited the protest site, expressing solidarity and pledging to fight for justice on behalf of the affected community. The visits and public speeches by various Christian dioceses, cardinals, bishops, religious leaders, and church-linked social, political, and cultural organizations underscore the importance the Church places on the issue.

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Wicked star Ariana Grande has said she and Cynthia Erivo were “insufferable” and “horrible” in the build-up to the film’s release. Grande, 31, also said her co-star was a “brilliant gift of a human being” while being interviewed by Gladiator star Paul Mescal for US news outlet Variety. Mescal told the singer and actor: “I’m watching you guys in the press tour. You’re obviously in love with each other.” To which she replied: “Insufferable. Yes. We’re horrible. It’s bad.” The 7 Rings singer plays Glinda, while her 37-year-old co-star plays Elphaba, in the film which is an adaption of the musical stage show of the same name and is set in The Land Of Oz before the events of The Wizard Of Oz. Their interviews for the film, which have seen the two being emotional towards one another and holding hands, have gone viral on social media. Speaking about Erivo, Grande said: “Cynthia is just an absolute brilliant gift of a human being. I think we tried to keep the pressure out of the room, obviously, as much as possible.” She also said she had not had any read throughs with her co-star before joining the cast. Grande said: “We never chemistry read together, it was three rounds for me, and I read with two different actresses. “I stayed for three and a half hours the final day, and I had cried so much. “We did Popular, Defying Gravity, (and) For Good (songs from the film), and I left my lashes on the mirror, because I left everything else in the room.” The film follows Elphaba, who is misunderstood because of her green skin, as she forges an unlikely friendship with Glinda, a student with a desire for popularity. Bullying of the green-skinned witch saw the movie, which also stars Peter Dinklage, Jeff Goldblum and Jonathan Bailey, given a PG rating by the British Board Of Film Classification (BBFC) for “discrimination”.

Aston Villa boss Unai Emery has set his sights on automatic qualification to the last 16 of the Champions League after a 3-2 win at RB Leipzig. Ross Barkley’s 85th-minute goal gave them victory in Germany after goals from John McGinn and Jhon Duran early in each half were cancelled out by Lois Openda and Christoph Baumgartner. That sent them up to third in the new league phase of the competition ahead of Wednesday’s games and with matches against Monaco and Celtic to come, Villa have an excellent chance of finishing in the top eight. That would mean they would avoid a play-off round to make it through to the last 16 and Emery says that is the target. “Today was key. Juventus at home, we were thinking more to win but in the end we accepted the draw because it was important for a point to be more or less in the top 24,” he told Amazon Prime. “Today was a match we were thinking at the beginning was key to be a contender to be in the top eight with the last two matches to be played. “It is going to be difficult and we have to get some more points but we now have the possibility to achieve this option. “We are going to enjoy and try to get top eight but we have to be happy because we are in the top 24 and maybe even the top 16. “We weren’t contenders in the beginning to get there but now we have to accept it.” Leipzig, who are flying high near the top of the Bundesliga, are out after losing all six matches. They did pose a threat to Villa, who inflicted some of their own problems on themselves, notably a rare gaffe from goalkeeper Emiliano Martinez for Openda’s equaliser. But Emery was happy with his side’s performance. “I try to enjoy and always we want to improve and sometimes it is hard but today the team were performing well, playing seriously and I was enjoying it,” he added. “We tried to overcome the mistakes we made and we did. More or less we were playing consistently. One mistake and they score but then we played very well. “Champions League is very difficult and we have to expect that every team playing at home are feeling strong. We played with consistency and domination.”

A new species of sicydiine goby named Stiphodon chlorestes is pictured in an undated photograph.Photo courtesy of National Sun Yat-sen University DISCOVERY:The small goby was first recorded in northern Taiwan in 2012, but improper storage of samples prevented the fish from being officially named By Huang Liang-chieh and Esme Yeh / Staff reporter, with staff writer A new species of fish has been discovered and named Stiphodon chlorestes by a research team from National Sun Yat-sen University (NSYSU). The research team led by Liao Te-yu (廖德裕), a professor of oceanography at NSYSU, identified the new species among specimens collected from rivers in Taiwan and northern Luzon in the Philippines. The research project was funded by the National Science and Technology Council and titled “Research on Habitat Assessments and Ecological Restoration Indicators of Isolated Creeks, with Three Rivers near the Northeast Coast as an Example.” Published in the Journal of Fish Biology in June, the research has garnered international attention and galvanized people into discussing habitat conservation of isolated creeks. The new species was first recorded in northern Taiwan in 2012, but it was not officially named due to improper storage of the specimen, said Chuang Wei-cheng (莊維誠), a NSYSU Department of Oceanography doctoral student. With more specimens collected in Taiwan and the Philippines for further research, the NSYSU research team finally identified the new species and gave it a name for the first time, he said. S chlorestes is a small migratory species of sicydiine goby, characterized by an olive-green body, a longitudinal band of dark brown oval spots on the sides, black and white spots on the pectoral fins and a short red or orange line on the caudal fin, as well as a metallic blue glow on the head of males. The fish was named S chlorestes, as it swims with its pectoral fins moving quickly, similar to a hummingbird flapping its wings, while the blue head and green body are reminiscent of the South African hummingbird Chlorestes cyanus. Isolated creeks — which run quickly from mountains into the ocean with a smaller basin area and fewer affluents — are habitats to various migratory fish, including Syngnathus, Stiphodon and Tetraroge niger. As research on fish diversity of isolated creeks continues to develop, more new species of migratory fish have been discovered, helping to promote the conservation of local isolated creek ecosystems. 新聞來源: TAIPEI TIMES 不用抽 不用搶 現在用APP看新聞 保證天天中獎 點我下載APP 按我看活動辦法‘John Wick’ Composer Sued for Creating Digital Replica of Singer’s Voice For Use in Productions

(PRNewsfoto/Neurocrine Biosciences, Inc.) Logo (PRNewsfoto/Neurocrine Biosciences, Inc.) Logo SAN DIEGO , Dec. 13, 2024 /PRNewswire/ -- Neurocrine Biosciences, Inc. (Nasdaq: NBIX) today announced the U.S. Food and Drug Administration has approved CRENESSITYTM (crinecerfont) capsules and oral solution as an adjunctive treatment to glucocorticoid replacement to control androgens in adult and pediatric patients four years of age and older with classic congenital adrenal hyperplasia (CAH), a rare, serious and lifelong genetic condition involving the adrenal glands. CRENESSITY, a potent and selective oral corticotropin-releasing factor type 1 receptor (CRF 1 ) antagonist, is the first and only classic CAH treatment that directly reduces excess adrenocorticotropic hormone (ACTH) and downstream adrenal androgen production, allowing for glucocorticoid dose reduction. It is a breakthrough in the treatment landscape for classic CAH. "For the last three decades, Neurocrine Biosciences, together with our late founder, Wylie W. Vale , has conducted groundbreaking research uncovering the critical role of corticotropin-releasing factor and its receptor, CRF 1 , in the pathophysiology of congenital adrenal hyperplasia," said Kyle W. Gano , Ph.D., Chief Executive Officer, Neurocrine Biosciences. "The approval of CRENESSITY is a significant milestone for the CAH community, and we are grateful to the individuals who participated in our clinical trials, including their families and caregivers, and to the clinical investigators who helped advance a new therapy and class of medicines." "Patients and families struggle to achieve balance between managing the symptoms of CAH and the side effects or complications of treatment with high-dose steroids, which may impact quality of life," said Dina Matos , Executive Director, CARES Foundation. "We are grateful to Neurocrine Biosciences for engaging with our community throughout the drug development process to understand our needs and ultimately providing this new medication that can help reduce excess adrenal androgens and the need for high-dose steroid treatment for individuals living with CAH." CRENESSITY is expected to be commercially available in approximately one week. The medication will be provided through PANTHERx Rare, a specialty pharmacy, to centralize and simplify CRENESSITY prescription fulfillment. Neurocrine Biosciences is committed to supporting patients in obtaining treatment with CRENESSITY by offering Neurocrine Access Support, a free, comprehensive assistance program created for patients, caregivers and healthcare providers. It offers a range of options to make sure patients have everything they need to begin and continue taking CRENESSITY. A dedicated Care Coordinator, backed by a team, is available to help patients and caregivers navigate the insurance process and identify appropriate financial assistance options. Most patients will pay $10 or less per month for CRENESSITY*. For more information, visit www.NBIaccess.com/crenessity or call 1-855-CRNSITY (276-7489) Monday-Friday 8 am-8 pm ET . *Additional terms and conditions apply. CAHtalyst TM Clinical Program Overview: The FDA approval is supported by the largest-ever clinical trial program of classic CAH, the CAHtalyst Pediatric and Adult Phase 3 global registrational studies. CAHtalyst Phase 3 data results in pediatric and adult patients with classic CAH were published in The New England Journal of Medicine . "The clinical results across both CAHtalyst studies support the efficacy and safety profile of CRENESSITY and its ability to reduce the overproduction of adrenal androgens, allowing for a meaningful reduction in glucocorticoid dosage, while maintaining or enhancing control of these androgens," said Richard Auchus , M.D., Ph.D., Professor, University of Michigan Health, Principal Investigator. "Chronic treatment with supraphysiologic glucocorticoids can cause a number of short- and long-term health consequences, such as obesity, hypertension and osteoporosis, so the ability for patients with CAH to lower their glucocorticoid dose to a more physiologic level can have profound benefits." In both CAHtalyst studies, CRENESSITY enabled lower steroid doses and decreased androgen levels. Phase 3 CAHtalyst Pediatric Study: Phase 3 CAHtalyst Adult Study: CRENESSITY was well tolerated with few treatment-related adverse events in both CAHtalyst studies. Pediatric and adult patients taking CRENESSITY had no treatment-related serious adverse events. Adrenal insufficiency and crisis are risks of living with CAH that CRENESSITY does not address and can occur when a patient's GC dose is too low. In the CAHtalyst Pediatric study, there were no cases of adrenal crisis among patients taking CRENESSITY or placebo. In the CAHtalyst Adult study, two patients (1.6%) taking CRENESSITY experienced adrenal crisis. No patients on placebo experienced adrenal crisis. However, one patient (1.7%) on placebo experienced adrenal insufficiency. Patients should work with their healthcare provider to manage GC dosing while taking CRENESSITY. For more information about CRENESSITY, visit Crenessity.com . About Congenital Adrenal Hyperplasia Congenital adrenal hyperplasia (CAH) is a rare genetic condition that results in an enzyme deficiency that alters the production of adrenal steroid hormones, such as cortisol, aldosterone and adrenal androgens, which are essential for life. Approximately 95% of CAH cases are caused by variants of the CYP21A2 gene that leads to deficiency of the enzyme 21-hydroxylase (21-OH). Severe deficiency of this enzyme leads to an inability of the adrenal glands to produce enough cortisol and, in approximately 75% of cases, aldosterone. Because individuals with CAH are still able to produce androgens, the unused precursors that would normally be used to make cortisol instead result in the production of excess amounts of androgens. If left untreated, CAH can result in salt wasting, dehydration and even death. Historically, exogenous glucocorticoids (GCs) have been used not only to correct the endogenous cortisol deficiency, but doses used are higher than cortisol replacement needed (supraphysiologic) to lower the levels of adrenocorticotropic hormone (ACTH) and adrenal androgens. However, GC treatment at high doses has been associated with serious and significant complications of steroid excess, including metabolic issues such as weight gain and diabetes, cardiovascular disease and osteoporosis. Additionally, long-term treatment with high-dose GCs may have psychological and cognitive impact, such as changes in mood and memory. Adrenal androgen excess has been associated with abnormal bone growth and development in pediatric patients, female health problems such as excess facial hair growth and menstrual irregularities, testicular rest tumors in males and fertility issues in both sexes. About The CAHtalystTM Studies The Phase 3 CAHtalystTM global registrational studies were designed to evaluate the safety, efficacy and tolerability of CRENESSITY in children and adults with classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. The CAHtalyst studies were the largest-ever clinical trial program in classic CAH, including 285 pediatric and adult patients. The CAHtalyst Pediatric study included 103 pediatric patients aged four to 17 years. The study tested two questions. The first question evaluated whether four weeks of CRENESSITY treatment could improve androgen control. The second question evaluated whether an additional 24 weeks of CRENESSITY treatment enabled customized glucocorticoid (GC) down-titration while androstenedione levels were maintained or improved. The CAHtalyst Adult study included 182 adult patients aged 18 to 58 years. Similarly, the first question of the study evaluated whether four weeks of CRENESSITY treatment could improve androgen control, and the second question evaluated whether an additional 20 weeks of CRENESSITY treatment enabled GC reduction to physiologic range while androstenedione levels were maintained or improved. Data from the CAHtalyst Phase 3 studies supported approval of CRENESSITY by the U.S. Food and Drug Administration in December 2024. The open-label extension treatment portions of both studies are ongoing. About CRENESSITYTM (crinecerfont) CRENESSITYTM is a potent and selective, oral corticotropin-releasing factor type 1 receptor (CRF 1 ) antagonist developed to reduce and control excess adrenocorticotropic hormone (ACTH) and adrenal androgens through a non-glucocorticoid (GC) mechanism for the treatment of classic congenital adrenal hyperplasia (CAH). Antagonism of CRF 1 receptors in the pituitary has been shown to decrease ACTH levels, which in turn decreases the production of adrenal androgens and potentially the symptoms associated with CAH. The robust clinical study data demonstrate that lowering adrenal androgen levels with CRENESSITY enables lower, more physiologic dosing of GCs to replace missing cortisol. CRENESSITY comes in capsules and an oral solution. The capsule formulation is available in 50 mg and 100 mg doses. The oral solution is available as a 50 mg/mL strength formulation. For adults 18 years and older, the recommended dosage is 100 mg twice daily taken orally with a meal. For pediatric patients four to 17 years of age weighing less than 55 kg (121 lbs), the recommended dosage is based on body weight and is administered twice daily, taken orally with a meal. For pediatric patients weighing more than 55 kg (121 lbs), the recommended dosage is 100 mg twice daily taken orally with a meal. Healthcare providers can work with patients to determine the appropriate formulation for use depending on patient needs. Patients receiving CRENESSITY should continue GC therapy for cortisol replacement. Important Information Approved Uses CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH). IMPORTANT SAFETY INFORMATION Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY. CRENESSITY may cause serious side effects, including : Allergic Reactions. Symptoms of an allergic reaction include tightness of the throat, trouble breathing or swallowing, swelling of the lips, tongue, or face, and rash. If you have an allergic reaction to CRENESSITY, get emergency medical help right away and stop taking CRENESSITY. Risk of Sudden Adrenal Insufficiency or Adrenal Crisis With Too Little Glucocorticoid (Steroid) Medicine. Sudden adrenal insufficiency or adrenal crisis can happen in people with congenital adrenal hyperplasia who are not taking enough glucocorticoid (steroid) medicine. You should continue taking your glucocorticoid (steroid) medicine during treatment with CRENESSITY. Certain conditions such as infection, severe injury, or shock may increase your risk for sudden adrenal insufficiency or adrenal crisis. Tell your healthcare provider if you get a severe injury, infection, illness, or have planned surgery during treatment. Your healthcare provider may need to change your dose of glucocorticoid (steroid) medicine. Before taking CRENESSITY, tell your healthcare provider about all of your medical conditions, including if you are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Tell your healthcare provider about all the medicines you take , including prescription and over-the counter medicines, vitamins, and herbal supplements. The most common side effects of CRENESSITY in adults include tiredness, headache, dizziness, joint pain, back pain, decreased appetite, and muscle pain. The most common side effects of CRENESSITY in children include headache, stomach pain, tiredness, nasal congestion, and nose bleeds. These are not all the possible side effects of CRENESSITY. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088. Dosage Forms and Strengths: CRENESSITY is available in 50 mg and 100 mg capsules and as an oral solution of 50 mg/mL. Please see full Prescribing Information About Neurocrine Biosciences, Inc. Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com , and follow the company on LinkedIn , X (formerly Twitter) and Facebook . (*in collaboration with AbbVie) The NEUROCRINE BIOSCIENCES Logo Lockup and YOU DESERVE BRAVE SCIENCE are registered trademarks of Neurocrine Biosciences, Inc. CRENESSITY and CAHtalyst are trademarks of Neurocrine Biosciences, Inc. Forward-Looking Statements In addition to historical facts, this press release contains forward-looking statements that involve a number of risks and uncertainties. These statements include, but are not limited to, statements regarding the potential benefits to be derived from CRENESSITY for the treatment of classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency; the value and benefits CRENESSITY brings to patients with CAH; the ability of Neurocrine Biosciences to ensure patients have access to CRENESSITY; and whether the results from our clinical trials of CRENESSITY are indicative of real-world results. Factors that could cause actual results to differ materially from those stated or implied in the forward-looking statements include, but are not limited to, the following: risks and uncertainties associated with Neurocrine Biosciences' business and finances in general, as well as risks and uncertainties associated with the commercialization of CRENESSITY; whether CRENESSITY receives adequate reimbursement from third-party payors; the degree and pace of market uptake of CRENESSITY; risks and uncertainties relating to competitive products and technological changes that may limit demand for CRENESSITY; risks associated with the Company's dependence on third parties for development and manufacturing activities related to CRENESSITY, and the ability of the Company to manage these third parties; risks that additional regulatory submissions for CRENESSITY or other product candidates may not occur or be submitted in a timely manner; risks that the FDA or other regulatory authorities may make adverse decisions regarding CRENESSITY; risks that post-approval CRENESSITY commitments or requirements may be delayed; risks that CRENESSITY may be precluded from commercialization by the proprietary or regulatory rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; risks and uncertainties relating to competitive products and technological changes that may limit demand for CRENESSITY; and other risks described in the Company's periodic reports filed with the Securities and Exchange Commission, including without limitation the Company's quarterly report on Form 10-Q for the quarter ended September 30, 2024 . Neurocrine Biosciences disclaims any obligation to update the statements contained in this press release after the date hereof other than required by law. © 2024 Neurocrine Biosciences, Inc. All Rights Reserved. CP-CFT-US-0070 12/2024 View original content to download multimedia: https://www.prnewswire.com/news-releases/neurocrine-biosciences-announces-fda-approval-of-crenessity-crinecerfont-a-first-in-class-treatment-for-children-and-adults-with-classic-congenital-adrenal-hyperplasia-302331772.html SOURCE Neurocrine Biosciences, Inc.

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MOREHEAD, Ky. (AP) — Steven Clay scored 15 points as Morehead State beat Alice Lloyd 94-63 on Saturday. Clay shot 6 for 12, including 3 for 8 from beyond the arc for the Eagles (7-6). Kenny White Jr. scored 14 points, finishing 7 of 9 from the floor. Jerone Morton, Tayler Brelsford and George Marshall all scored 13 points. Jared Strickland finished with 12 points and eight rebounds for the Eagles. Landon Napier added 10 points for Alice Lloyd. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .

Galei Kinneret, Tiberias Established two years before Israel's independence, the Galei Kinneret Hotel boasts a storied 78-year legacy of hospitality. It has welcomed numerous celebrities and politicians, with suites dedicated to David Ben Gurion and Yitzhak Navon. After substantial renovations totaling around $18.5 million, the hotel now features Assaf Granit's Lotte Restaurant, a Roman-style luxury spa with a jacuzzi, saunas, relaxation rooms, treatment areas, a fully equipped gym, a yoga room, a pool with views of the Sea of Galilee and the Golan Heights, a private beach, and a boat for guest excursions on the Kinneret. Access is available for guests aged 16 and above. Note, some facilities may be non-operational due to current conditions; check with reception in advance. Cost: Starting at approximately $695 per couple per night midweek in August. Galei Kinneret ( Video: Assaf Kozin ) Botanica Hotel, Haifa Opened two years ago in Haifa's German Colony, at the base of the Baha'i Gardens, the Botanica Hotel by Fattal offers prime access to Haifa's cafes, restaurants, vintage shops, bars, and markets. Guests can enjoy the rooftop pool, a luxurious spa with various treatments, and a culinary experience with unique cocktails. Entry is for guests aged 16 and above. Cost: Starting at around $440 per couple per night midweek in August. 16 View gallery Botanica Hotel ( Photo: Aya Ben-Ezri ) Pereh, Golan Heights The Pereh Resort, opened three years ago, offers a romantic escape for couples 18 and older. Set on eight acres, it features 27 exquisitely designed suites with luxurious bathrooms and private balconies, surrounded by stunning gardens and serene natural landscapes. The resort, on the site of a historic customs house, underwent extensive renovations. At its center is a pool surrounded by fruit trees, sunbathing areas, and a large heated hot tub. There's also a small spa, a wine cellar with Golan wines, and a chef's restaurant. Cost: Starting at approximately $565 per couple per night midweek in August. 16 View gallery Pereh ( Photo: Aya Ben-Ezri ) Carmel Forest In the heart of the Carmel Forest Nature Reserve, at the end of a winding mountain road, lies the ultimate retreat: Carmel Forests Estate. This sought-after spa hotel, one of seven luxury Isrotel properties, offers a peaceful, technology-free zone for guests aged 16 and older. Visitors come here to disconnect, enjoy gourmet dining, and indulge in body-mind treatments. Alongside standard suites, three boutique villas offer extra luxury and privacy, each with private parking, a pool, a hospitality area, a spacious living room, and a sleeping suite. The stay includes a spa treatment for each guest, daily treats from the chef, and a personal butler to cater to nearly every need. Cost: Starting at approximately $540 per night for a double room midweek, and $2,160 for a villa. 16 View gallery Carmel Forest Hotel ( Photo: Assaf Pinchuk ) Akotika, Acre Nestled in the narrow streets of Acre's Old City, right by the sea, Akotika is a "scattered" hotel with rooms spread across various stone buildings along an alley leading from the main building. Each of the 16 suites offers unique layouts and designs, equipped with a plush king-size bed, espresso machine, minibar, television, and bathroom. Amenities vary from a plunge pool to a sea-view balcony or indoor jacuzzi. Choose your preference at booking. The hotel's treatment area offers a variety of massages, and the rooftop terrace serves breakfasts inspired by the city, featuring local delicacies alongside traditional options. A luxury hotel by Fattal, with an investment of about $26.5 million, it’s an adults-only wellness hotel atop Mount Canaan, offering breathtaking views of Safed and the Galilee. The hotel has 119 rooms and suites, including environmentally conscious options with 200-year-old recycled teak furniture and soap bottles from recycled waste. The spa features 15 couples’ treatment rooms, an extensive treatment menu, an indoor pool, outdoor hot tubs with panoramic views, four saunas with large windows, a Turkish hammam, and a gym. Guests can also enjoy workshops and activities like yoga, meditation, painting classes, and lectures on mindfulness, herbal medicine, detoxification, and personal development. Soon, a wine bar named 26.8 will open, featuring a vegetarian kitchen with vegan dishes, with ingredients sourced within 26.8 kilometers, and wines from Upper Galilee and Golan wineries. Cost: Starting at around $350 per couple per night midweek in September 16 View gallery Akotika ( Photo: Aya Ben-Ezri ) Canaan Hotel, Safed One of Fattal's luxury hotels, with an investment of about 100 million shekels, this adults-only wellness hotel is perched atop Mount Canaan, offering breathtaking views of Safed and the Galilee. The hotel features 119 rooms and suites. For eco-conscious guests, two special suites are available, furnished with recycled teak wood approximately 200 years old, and soap bottles made from recycled materials. One suite overlooks the Sea of Galilee and the Golan, while the other faces the Galilee and Mount Meron. The spa complex includes 15 couples' treatment rooms, an extensive treatment menu, an indoor pool, outdoor jacuzzis with stunning views, four saunas with large windows (did we mention the view?), a Turkish hammam, and a fitness center. Additionally, there are rotating workshops and activities: yoga sessions, meditation guides, painting classes, and lectures on mindfulness, medicinal herbs, detoxification, and personal development. Soon, a wine bar named 26.8 will open in the hotel garden. It's named for the fact that the ingredients for its dishes are sourced within this distance from the bar. The bar will offer a vegetarian menu with a variety of vegan dishes, and wines will be sourced from wineries in the Upper Galilee and the Golan. Cost: Starting at approximately $350 per night for a couple midweek in September (currently fully booked for August). 16 View gallery Hot tubs in Safed ( Photo: Aya Ben-Ezri ) MUSE Boutique Hotel, Tel Aviv Nestled on Trumpeldor Street, close to the beach, promenade, and a vibrant array of bars and restaurants, MUSE Hotel offers an adults-only boutique escape in the heart of Tel Aviv. With 35 rooms adorned in colorful, contemporary decor featuring Israeli art, the hotel provides an intimate, tranquil, and refreshing experience. Breakfasts are themed—French, Israeli, vegan, or indulgent. For those mixing business with leisure, a plush lounge serves as a networking hub. Cost: Starting at around $260 per couple per night midweek in August. 16 View gallery MUSE in Tel Aviv ( Photo: Assaf Pinchuk ) PLAY Levontin, Tel Aviv The newest gem from the Isrotel chain, PLAY Levontin, offers a light, fun urban experience in the Electric Garden neighborhood, surrounded by charming cafes. With 34 spacious, Parisian-style rooms, some with balconies, this adults-only hotel also features business spaces, a spa, a private cinema, and the highlight: "Gila and Nancy" restaurant by Eyal Shani, celebrating pioneering transgender figures. The creative menu is complemented by cabaret-style drag performances. Cost: Starting at approximately $198 per couple per night midweek in August. 16 View gallery PLAY Levontin ( Photo: Max Kobalsky ) Indigo, Tel Aviv Located in the heart of the Diamond Exchange District, Indigo Tel Aviv is close to Tel Aviv's business centers and the Azrieli shopping complex. The hotel boasts a variety of rooms and suites, a spa with five treatment rooms, a restaurant, and a stunning rooftop on the tenth floor with an infinity pool, sunbeds, a cocktail bar, and an urban view. Entry is for guests aged 21 and older. Cost: Starting at around $164 per couple per night midweek in August. 16 View gallery Indigo ( Photo: Itay Sikolsky ) Poli Urban, Tel Aviv This Africa Israel boutique hotel, Poli Urban, is at the heart of Tel Aviv, offering a chic urban getaway. All major city attractions are within walking distance. The hotel has 52 rooms, a wine bar, a chef restaurant, and is open to guests aged 18 and above. The breakfast and other food services are non-kosher. Cost: Starting at approximately $169 per couple per night midweek in August. 16 View gallery Poli Urban ( Photo: Aya Ben-Ezri ) Gordonia, Ma'ale HaHamisha Perched atop one of the Jerusalem Mountains' highest peaks, Gordonia offers guests breathtaking views and serene tranquility at 800 meters above sea level. Committed to personalized hospitality, the hotel begins with a pre-arrival call to discuss personal preferences. It features 40 suites, 27 with private pools. Those without can enjoy a shared infinity pool, jacuzzi, and sauna in the hotel's beautiful garden. Cost: Starting at about $738 for a suite without a private pool, $940 for a suite with a private pool, per couple per night midweek in August. 16 View gallery A beautiful private pool in Gordonia ( Photo: Lee Bsor ) Almond, Neve Ilan Located en route to Jerusalem, about half an hour from Tel Aviv, Almond is a new adults-only boutique hotel by C Hotel, opened in January. Spanning three floors with 60 rooms of various types, all spacious and luxuriously equipped. The View restaurant offers a concept menu that changes throughout the day. The hotel also boasts a luxury spa with nine treatment rooms. Cost: Starting at approximately $400 per couple per night midweek in August. 16 View gallery Almond ( Photo: GPO ) Alegra Boutique, Ein Kerem In the heart of the Ein Kerem neighborhood, Alegra is a small, intimate boutique hotel housed in a beautiful two-story stone building. Each of its 14 rooms is elegantly designed to reflect the neighborhood's spirit, featuring high ceilings and eastern elements. The hotel offers a large green garden, a rooftop with views of the Judean Hills, and a spa. Cost: Starting at around $346 per couple per night midweek in August. 16 View gallery Alegra ( Photo: Aya Ben-Ezri ) Lear Sense, Gedera Lear Sense, a luxurious boutique hotel in Gedera, is housed in a historic building amidst three acres of orchard and greenery. It offers 24 adult-only rooms, some with private saunas and hot tubs. The rooftop is a sanctuary with a pool, sunbeds, a Turkish hammam, and a cocktail bar. Yoga and Pilates classes are available, along with a bar, bistro restaurant, and gym. Cost: Starting at approximately $276 per couple per night midweek in August. 16 View gallery Roof suite is something else in Lear Sense ( Photo: Simplex 360 ) Dream Island Resort, Sde Yoav Dream Island is a 60-acre paradise focused on wellness and relaxation. The resort features 26 luxurious suites, some with jacuzzis or private pools, dining options, a spa complex, a Turkish hammam, and a water area with various pools. The resort is for guests aged 18 and above. Cost: Starting at about $530 per couple per night midweek in August. Get the Ynetnews app on your smartphone: Google Play : https://bit.ly/4eJ37pE | Apple App Store : https://bit.ly/3ZL7iNv 16 View gallery Dream Island ( Photo: Assaf Rosen ) Oasis Spa Club, Dead Sea A fusion of two former Prima hotels, Oasis Spa Club offers a luxurious spa experience with a desert vibe. The resort is for guests aged 18 and above and offers five types of rooms, with the Garden Suite being the most luxurious. Guests can enjoy the Dead Sea's unique offerings or indulge in the hotel's Moroccan-style spa. Cost: Starting at around $520 per couple per night midweek in August. 16 View gallery Oasis ( Photo: Prima Hotels ) Herods Vitalis, Eilat Imagine a serene escape in Eilat during August—yes, it’s possible! At Herods Vitalis, an exclusive adults-only haven, you can truly unwind from the city’s hustle. Here, you can breathe deeply and recharge in tranquility. Mobile phone use is limited to your room, ensuring quietude in the public spaces. Plus, it's a smoke-free environment. This upscale spa hotel is dedicated to wellness. The extensive spa menu boasts 60 treatments, including unique options like massages with 'Tiger' sea shells from the Philippines. There are specialized massages for expectant mothers and a wide range of cosmetic treatments. For further pampering, enjoy the outdoor waterfall pool with hot or cold jets, a jacuzzi, wet and dry saunas, and a fitness center. Savor breakfast and dinner at Lawrence, the hotel’s gourmet restaurant. Cost: Starting at approximately $1,270 for a two-night stay for a couple midweek in August. 16 View gallery Herods Vitalis ( (Photo: Courtesy) ) Enjoy! >Qatar tribune PA Media/dpa London Manager Pep Guardiola has stressed Manchester City’s current malaise is not down to one player as he again defended Erling Haaland. City’s 2-1 loss at Aston Villa on Saturday, the Premier League champions’ ninth defeat in 12 matches in all competitions, saw Haaland fail to score for the fifth time in six outings. After the game the Norway striker told TNT Sports: “First I’m looking at myself. I haven’t been scoring my chances. I have to do better, I haven’t been good enough.” City boss Guardiola subsequently stuck up for Haaland, who has netted 108 times for the club since joining in 2022, saying that “without him we will be even worse” and that “he needs to be delivered the right balls in the right spots.” And speaking on Christmas Eve at his press conference ahead of the Boxing Day home clash with Everton, Guardiola said: “It’s about us, not just one player. “When in the past we score goals and Erling was so prolific, helping us, it was because of the team. “And when you have problems at the back, in the middle, it is for everyone, it is a team, it is not about one player. It would be easy, if it was just one player, the reason why. It’s not about that. “Erling is so important for us, will be so important for us, has been. (We have to) try to do things better, to use him better.” He added: “The guys are running, making effort more than ever. All the tendency ‘it’s because we don’t run, because we don’t fight, the reason why is this situation or this player or this manager’... It’s not about that. “It’s many little details or big details that make all together not as good as we were. But we have another opportunity on Boxing Day.” Copy 25/12/2024 10World Don't miss out on the headlines from World. Followed categories will be added to My News. An extensive report on the assassination attempts against Donald Trump during this year’s election campaign has blamed the incident on a procession of security failures, rather than any single catastrophic mistake. The country’s House of Representatives voted to set up a task force to investigate those failures after the first attempt on Mr Trump’s life in Butler, Pennsylvania on July 13, when the then-candidate’s ear was grazed by a bullet during an outdoor political rally. If the would-be assassin’s aim had been even centimetres more accurate, Mr Trump likely would have been killed. This was the attack that ended with an iconic image of a bloodied Mr Trump raising his fist to the crowd and shouting the word “fight”, before he was whisked away to safety by Secret Service agents. Snipers shot and killed the gunman, 20-year-old Thomas Crooks. Mr Trump raises a defiant fist to the crowd after the first attempt on his life in Butler, Pennsylvania. Picture: Anna Moneymaker/Getty Images via AFP In a second incident, on September 15, a gunman was spotted hiding in the bushes at Mr Trump’s golf club in Florida, where the candidate was playing a round. Secret Service officers shot at the man, subsequently identified as Ryan Wesley Routh, and he fled the scene before being arrested a short time later. Routh will face court early next year, and is looking at the prospect of life imprisonment. The 13-person task force to look into the incidents, and set up by Congress, was bipartisan, with seven Republican members and six Democrats. It ultimately conducted 46 interviews, reviewed more than 18,000 pages of documents, and visited the scene of each assassination attempt. Its report, published today, is quite thorough, running to 180 pages. You can read the whole thing here , should you be so inclined and sufficiently time-rich. “The task force found that the tragic and shocking events in Butler, Pennsylvania were preventable and should not have happened,” the 13 members of Congress concluded. “There was not, however, a singular moment or decision that allowed Thomas Matthew Crooks to nearly assassinate the former president. “The various failures in planning, execution, and leadership on and before July 13, 2024, and the pre-existing conditions that undermined the effectiveness of the human and material assets deployed that day, coalesced to create an environment in which the former president, and everyone at the campaign event, were exposed to grave danger.” The report is actually complimentary of the Secret Service’s work regarding the second attempt in September, saying “the events that transpired in West Palm Beach demonstrated how properly executed protective measures can foil an attempted assassination”. Secret Service agents surround Mr Trump after the shooting in Butler. Picture: Anna Moneymaker/Getty Images via AFP Mr Trump’s defiance. Picture: Anna Moneymaker/Getty Images via AFP The report identifies “several decision points” that “if handled differently, could have prevented” Crooks from firing eight shots at the stage, in Butler, while Mr Trump was giving a campaign speech. “Foremost, the failure to secure a recognised high-risk area immediately adjacent to the venue – specifically the American Glass Research (AGR) grounds and building complex – gave rise to several vulnerabilities that eventually allowed Crooks to evade law enforcement, climb on and traverse the roof of the AGR complex, and open fire,” it said. “Despite its proximity to a main road, clear sight lines to the stage, and elevated position, the Secret Service allowed a crowd that was not screened to gather at the fence line separating the secured area and the AGR complex. “The presence of the crowd outside the secured area made Crooks more difficult to interdict as his behaviour became increasingly suspicious.” That initial failure to secure the building upon whose roof Crooks took aim was “compounded by the fact that the area was not sufficiently monitored or patrolled to deter threats”. “The Secret Service did not provide clear guidance to its state and local partners about which entity was responsible for the area,” the committee said. “An expressed lack of manpower and assets was not sufficiently addressed, resulting in coverage gaps on the ground. “Further, local snipers on the property understood their responsibility to be overwatch of the crowd and the venue, not the area outside the secure perimeter where Crooks loitered and prepared, believing that area to have been secured by Secret Service counter-snipers.” The now-dead gunman, Thomas Crooks. Other failures involved “technology meant to supplement venue security” being down for hours, a “fragmented communication structure”, and “pre-existing issues” involving the Secret Service’s leadership and training. The task force’s report includes 25 recommendations, based on the events in Butler, which are intended to prevent a similarly perilous incident in the future. Most of them are redacted, though the publicly available report does recommend recording “all radio transmissions” at protective events and “considering staffing redundancies for high pressure moments”. “On July 13, the Secret Service did not record its radio communications,” the report says. “The absence of radio logs or recordings significantly limits the ability to reconstruct events for either investigative or evaluative purposes. To the extent that there are any technological limitations that prevent radio recordings or logs for all protective events, the Secret Service must prioritise addressing those challenges to enable this capability.” More generally, the committee concluded “Congress must ensure that the Secret Service determines ways to strengthen its capabilities and reduce the strain on its resources” if it’s to sufficiently protect presidential candidates going forward. More Coverage ‘Harm’: Doctors demand Covid vaccine pulled Frank Chung Israel wipes out Syria’s navy in bomb spree Shannon Molloy Originally published as ‘Grave danger’: Report into Donald Trump assassination attempts released Read related topics: Donald Trump More related stories News ‘Grave danger’: Scathing Trump security failure report A congressional taskforce investigating the assassination attempts on Donald Trump has released a scathing report into the Secret Service. 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