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What Next: TBD Is Sickle Cell Anemia...Cured? The new treatment is painful and expensive. It could also be life-saving. Listen & Subscribe Choose your preferred player: Apple Podcasts Spotify Amazon Music Overcast TuneIn RSS Feed For questions about subscriptions or your Slate Plus feed, check our FAQ . Please enable javascript to get your Slate Plus feeds. Get Your Slate Plus Podcast If you can't access your feeds, please contact customer support. Thanks! Check your phone for a link to finish setting up your feed. Please enter a 10-digit phone number. Listen on your phone: RECOMMENDED Enter your phone number and we'll text you a link to set up the podcast in your app: We'll only text you about setting up this podcast, no spam. Listen on your computer: Apple Podcasts will only work on MacOS operating systems since Catalina . We do not support Android apps on desktop at this time. Listen on your device: RECOMMENDED These links will only work if you're on the device you listen to podcasts on. Set up manually: How does this work? We are showing you options for a computer but if you're on a phone or tablet We are showing you options for a phone or a tablet but if you're on a computer , click here. If you still have questions about subscriptions or your Slate Plus Feed, check our FAQ. Loading... We're sorry, but something went wrong while fetching your podcast feeds. Please contact us at plus@slate.com for help. Episode Notes Last May, a 12-year-old with sickle cell anemia was the first person to receive a new gene therapy to treat the disease. The process is painful, expensive, and still frightening and uncertain, but biomedical researchers are cautiously calling it a “cure.” Guests: Gina Kolata, medical reporter for the New York Times Deb and Keith Cromer, parents to Kendric Cromer, the first person in the world to go through a commercially approved gene therapy for sickle cell anemia. Want more What Next TBD? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen. Podcast production by Evan Campbell, Patrick Fort, and Cheyna Roth. Genetics Health About the Show Every Friday, Slate’s popular daily news podcast What Next brings you TBD, a clear-eyed look into the future. From fake news to fake meat, algorithms to augmented reality, Lizzie O’Leary is your guide to the tech industry and the world it’s creating for us to live in. Host Cheyna Roth is a senior producer at Slate working on shows like Political Gabfest, The Waves, and more. She is also the author of two true crime books.Canada thumped Trinidad and Tobago 38-0 to win the Rugby Americas North (RAN) Sevens on Sunday and qualify for World Rugby’s second-tier Challenger Series. The tournament-favourite Canadian men outscored their opposition 169-0 over five matches in a first step back up the rugby sevens ladder since being relegated from the elite HSBC SVNS circuit in June. The top four teams from the three-event Challenger Series will face off against the bottom four from the HSBC SVNS at the SVNS World Championships May 3-4 in Carson, Calif., in a promotion/relegation playoff. “I think it’s just about continually building,” said Canada captain Elias Hancock. “We know what we’re capable of. We’ve shown it at times. It’s just time to get back to that place where we know we belong.” Prior to relegation, Canada had been a core team on the top sevens circuit since 2012-13 and lifted the trophy in Singapore in 2017. The Canadian men finished eighth at the Tokyo Olympics. Trinidad had plenty of the ball in the first half of Sunday’s final at Larry Gomes Stadium. But Canada, helped by several penalties, scored first with Hancock touching down under the posts for a try converted by Thomas Isherwood. Matt Oworu, beating two defenders, added another converted try for a 14-0 lead at the break. Cooper Coats added a converted try early in the second half. And Hancock, Jack Shaw and Noah Bain added late tries after Trinidad lost a man to the sin-bin for two minutes midway through the second half for an infraction off a Canadian kickoff. Earlier Sunday, the Canadians defeated Jamaica 26-0 in semifinal play and the Cayman Islands 38-0 in the quarterfinal. Trinidad and Tobago made it to the final — for the first time since 2013 — with a 19-7 comeback win over Mexico. Jamaica defeated Mexico 12-0 to finish third. Weather was a factor during the three-day tournament in Arima, some 30 kilometres east of Port of Spain. After enduring 30-plus C heat and humidity Friday, their final Pool A game against Barbados was abandoned Saturday due to a storm. On Sunday, the Canadians played the Cayman Islands in a downpour and the skies opened again at halftime of the Jamaica game. Alex Russell, Josiah Morra, Coats and Hancock scored tries against Jamaica for Canada, which led 12-0 at the break. Thomas Isherwood added three conversions. Morra and Hancock each scored two tries against the Caymans and Ethan Hager and D’Shawn Bowen added singles for Canada, which led 19-0 at the half. Canada added four conversions. Canada, which blanked Guyana 29-0 Friday, dispatched Bermuda 38-0 Saturday and was leading Barbados 10-0 when the game was halted in the first half due to heavy rain and high winds. While play eventually resumed, the interrupted Canada game was ruled a scoreless draw. The Canadian men are coming off a disastrous 3-36-0 HSBC SVNS season that ended with a 22-14 loss to Spain with relegation on the line. It was a 29th straight defeat. After being relegated, coach Sean White’s team fell short in an Olympic repechage tournament in late June in Monaco, finishing fourth after losing 26-0 to eventual winner South Africa in the semifinals. The Blitzboks went on to claim bronze in Paris. The 13-man roster for the RAN 7s includes six players who were part of the relegation playoff in Madrid: Hancock, Isherwood, Morra, Coats, Oworu and David Richard. Morra, Coats and Oworu joined the sevens team from Bucharest where they were part of Kingsley Jones’ Canadian 15s squad for test matches against Chile and Romania. The Canadian men are scheduled to play in an invitational men’s sevens tournament taking place at B.C. Place Stadium alongside the HSBC SVNS Vancouver stop in February. The Canadian women left Sunday for Dubai and the opening stop of the 2005 HSBC SVNS season. The Olympic silver-medallist Canadians open play next Saturday against Japan before facing Brazil and Olympic champion New Zealand.Nigerian Afrobeats singer, David Adeleke, better known as Davido and his wife, Chioma Adeleke, have gotten tongues wagging on social media with their loved-up video in Las Vegas. Sunday Telegraph gathered that Chioma accompanied by Davido and the 30BG crew, including Soso Soberekon and Israel DMW, is currently enjoying a vacation in the vibrant city. The pair also attended the 2024 World Champion game, adding a touch of excitement to their trip. Another post showed a loved-up video of the lovebirds posed at a dining table alongside their entourage which includes Chioma’s friends. Another heartwarming video showed Davido and Chioma in a tender embrace, radiating joy and togetherness. Davido shared a third pose flaunting his exquisite wristwatches, showcasing his signature opulent style. Fans and followers have taken to their comment section to admire the couple’s love and unity. Many praised Davido for prioritizing his family amid his busy career. Fans react to Davido and Chioma’s loved-up Las Vegas vacation; Makkie_isa wrote: “These ones just dey enjoy. Mtchewww.” Erawameggison said: “With a whole entourage. Have they ever travelled anywhere alone without all the hangers-on?” Prank Hottie reacted: “They’re young and living their life.” Mirabel Eze noted: “See sweet love.” Danzel62 added: “Love birds. Peace of mind wan wound these 2. Love them and they mind their business.” Jay Emprire24 said: “Singles you all should take heart. Happiness wan wound this couple, they really match abeg. Just enjoying themselves and minding their business.” Watch the videos
DEAR ABBY: My husband is miserable. Five years ago, he was fired from his job of more than 25 years, and the small issues he had with depression, alcohol and smoking have multiplied exponentially. He sleeps until 10 or 11 a.m., showers only two or three times a week, rarely eats and has a drink in his hand by 4 or 5 p.m. every day. He now suffers from COPD but has no plans to quit smoking. He would never consider therapy. My husband has lost so much weight and muscle mass, he's barely recognizable. He seems to miss sex, but even if he made an advance, his lack of physicality would make it miserable. Anyway, I'm no longer interested. He was never an affectionate person, but now he has poor personal hygiene, his breath smells of liquor and his hands smell of tobacco. Beyond the quiet misery of home, it's tough for him to go out. He has a hard time with stairs, walking very far and even ordering from a restaurant. I feel he is trying to hasten his own death. I honestly feel there is nothing I can do that I haven't already done. I'm fine, but numb. Do you have any advice for me? -- HOPELESS IN KANSAS DEAR HOPELESS: Your husband seems to feel he has nothing to live for. You mentioned that he seems to miss sex but is now in such bad shape that you are no longer interested. Have you told him the reason you are no longer interested is that he's no longer the person you fell in love with, and a giant step in the right direction would be for him to consult his doctor about his depression? If the answer is no, consider offering him that "carrot." If he's willing to try to get back on track, you might feel differently. There are nicotine substitutes for the truly addicted, which help users inhale fewer damaging byproducts. People with COPD can get some exercise with the help of supplemental oxygen, a subject that should also be discussed with his doctor. That said, the bottom line is your husband has to WANT to help himself. If he doesn't, it may be time for you to locate the nearest Al-Anon group (al-anon.org/info) and attend some meetings, which will help you to recognize that his self-destructive behavior is not your responsibility and only he can help himself. DEAR ABBY: A longtime friend is now a widow and doesn't have time to connect anymore. I have invited her for coffee and for dinner and sent notes of support. She waits days, even weeks to respond and has other social things to do. I understand loss and grief, but this feels like "NO. Go away," with a stiff arm. I guess it's time to go away. Right? -- UNEXPECTED IN INDIANA DEAR UNEXPECTED: You may have been overwhelming this woman in your attempt to comfort her. Depending on how long ago she lost her husband, it may be better for you to step back and allow her to regain her balance. The more you push her, the further she will distance herself.