TherapeuticsMD Inc. stock underperforms Tuesday when compared to competitors despite daily gainsShort Interest in Forafric Global PLC (NASDAQ:AFRIW) Decreases By 47.6%
General Motors is selling its stake in the nearly completed Ultium Cells battery cell plant in Lansing, Michigan, to its joint venture partner LG Energy Solution (LGES). GM’s step back from the factory comes amid weakening electric vehicle demand and the potential rollback of Biden administration incentives to produce clean energy domestically. GM and LGES initially teamed up in 2019 to form a joint venture to mass-produce battery cells for electric vehicles. Since then, the two have poured billions into three factories: The Lansing facility that LGES is acquiring; a Spring Hill, Tennessee , facility that started production in 2024; and a Lordstown, Ohio, factory that has been producing battery cells since 2022. The cells produced at the Ohio and Tennessee plants power vehicles like the Chevrolet Silverado EV, GMC Sierra EV, Cadillac LYRIQ, Chevrolet Blazer EV, and Chevrolet Equinox EV, as well as the GMC Hummer EV pickup and SUV. In October, GM dropped the Ultium battery brand name as part of a move to embrace new types of cells and chemistries, like lithium iron phosphate (LFP) batteries. GM helped set the stage for a movement among automakers and battery manufacturers to onshore battery production after the COVID-19 pandemic. President Joe Biden’s Inflation Reduction Act, which he signed in August 2022, included incentives geared toward helping the U.S. reduce reliance on China for batteries and served as a catalyst for a wave of new battery projects . Aside from LGES, GM also announced a joint venture with Samsung SDI to build a new battery plant in the United States in April 2023 and is working with a handful of startups dedicated to fostering new battery technology. The news of GM’s nonbinding agreement with LGES comes a few months after reports that GM and LGES were slowing the buildout of the Lansing plant, which was expected to start production in 2025. LGES did not respond in time to TechCrunch to confirm if that timeline is still accurate, nor whether the company still expects the plant’s capacity to reach 45 GWh at peak production. Neither company shared the acquisition price, but a spokesperson from GM said the company expects to recoup its initial investment. In a statement, GM said it expects the remaining two plants will be sufficient to meet current demand. GM didn’t share how much LGES is buying the factory for, but a spokesperson for the company said GM expects to recoup its initial investment. GM and LGES initially announced a $2.6 billion investment into the plant, but it’s not clear how much each company has spent. GM also announced Monday that it would work with LGES to jointly develop prismatic battery cells. Levy declined to share whether those cells would be produced at one of the remaining joint venture sites, or if they’ll be manufactured in a yet-to-be-announced facility. At the Ohio and Tennessee plants, GM and LGES have focused on making pouch cells, which have the benefit of being more affordable and flexible in shape. Prismatic cells, while heavier and more expensive, have a higher energy density, longer life cycle, and better heat management.UTAH VALLEY 77, WEST GEORGIA 74
ST. SIMONS ISLAND, Ga. — PGA Tour rookie Patrick Fishburn played bogey-free for an 8-under 64 for his first lead after any round. Joel Dahmen was 10 shots behind and had a bigger cause for celebration Friday in the RSM Classic. Dahmen made a 5-foot par putt on his final hole for a 2-under 68 in tough conditions brought on by the wind and cold, allowing him to make the cut on the number and get two more days to secure his PGA Tour card for next year. He is No. 124 in the FedEx Cup. "I still got more to write this weekend for sure," said Dahmen, who recently had said his story is not yet over. "But without having the opportunity to play this weekend, my story would be a lot shorter this year." Fishburn took advantage of being on the easier Plantation course, with trees blocking the brunt of the wind and two additional par 5s. He also was helped by Maverick McNealy, who opened with a 62 on the tougher Seaside course, making two bogeys late in his round and having to settle for a 70. People are also reading... Fishburn, who already has locked up his card for next year, was at 11-under 131 and led McNealy and Lee Hodges (63) going into the weekend. Michael Thorbjornsen had a 69 and was the only player who had to face Seaside on Friday who was among the top five. What mattered on this day, however, was far down the leaderboard. The RSM Classic is the final tournament of the PGA Tour season, and only the top 125 in the FedEx Cup have full status in 2025. That's more critical than ever with the tour only taking the top 100 for full cards after next season. Players like Dahmen will need full status to get as many playing opportunities as they can. That explains why he felt so much pressure on a Friday. He didn't make a bogey after his opening hole and was battling temperatures in the low 50s that felt even colder with the wind ripping off the Atlantic waters of St. Simons Sound. He made a key birdie on the 14th, hitting a 4-iron for his second shot on the 424-yard hole. Dahmen also hit wedge to 2 feet on the 16th that put him on the cut line, and from the 18th fairway, he was safely on the green some 40 feet away. But he lagged woefully short, leaving himself a testy 5-footer with his job on the line. "It was a great putt. I was very nervous," Dahmen said. "But there's still work to do. It wasn't the game-winner, it was like the half-court shot to get us to halftime. But without that, and the way I played today, I wouldn't have anything this weekend." His playing partners weren't so fortunate. The tour put three in danger of losing their cards in the same group — Zac Blair (No. 123), Dahmen and Wesley Bryan (No. 125). The cut was at 1-under 141. Blair and Bryan came to the 18th hole needing birdie to be assured of making the cut and both narrowly missed. Now they have to wait to see if anyone passes them, which is typically the case. Thorbjornsen in a tie for fourth and Daniel Berger (66 at Plantation) in a tie for 17th both were projected to move into the top 125. Dahmen, indeed, still has work to do. Fishburn gets a weekend to see if he can end his rookie year with a win. "I've had a lot of experience playing in cold growing up in Utah, playing this time of year, kind of get used to playing when the body's not moving very well and you've got to move your hands," said Fishburn, who played college golf at BYU. "Just pretty happy with how I played." Ludvig Aberg, the defending champion and No. 5 player in the world competing for the first time in more than two months because of knee surgery, bounced back with a 64 on Plantation and was back in the mix. Aberg played with Luke Clanton, the Florida State sophomore who looks like he belongs each week. Clanton, the No. 1 player in the world amateur ranking who received a sponsor exemption, had a 65 at Plantation and was two shots off the lead. Clanton already has a runner-up and two other top 10s since June. "Playing with him, it's pretty awesome to watch," Clanton said. "We were kind of fanboying a little it. I know he's a really good dude but to be playing with him and to see what he's done over the last couple years, it's pretty inspirational." Be the first to know Get local news delivered to your inbox!The Best Headphone Deals for Black Friday
Raiders TE Brock Bowers sets two rookie records, one team markWASHINGTON — President-elect Donald Trump launched a blitz of picks for his Cabinet, but he took his time before settling on billionaire investor Scott Bessent as his treasury secretary nominee. The Republican not only wanted someone who jibes with him, but an official who can execute his economic vision and look straight out of central casting while doing so. With his Yale University education and pedigree trading for Soros Fund Management before establishing his own funds, Bessent will be tasked with a delicate balancing act. Trump expects him to help reset the global trade order, enable trillions of dollars in tax cuts, ensure inflation stays in check, manage a ballooning national debt and still keep the financial markets confident. “Scott will support my Policies that will drive U.S. Competitiveness, and stop unfair Trade imbalances, work to create an Economy that places Growth at the forefront, especially through our coming World Energy Dominance,” Trump said in a statement. But for all the confidence, Trump was cautious in picking the 62-year-old, a sign that he understood the stakes after winning a presidential election largely shaped by inflation hitting a four-decade peak in 2022. He felt comfortable making faster decisions on Fox News host Pete Hegseth for defense secretary, Florida Sen. Marco Rubio for secretary of state and Robert F. Kennedy Jr. for health and human services secretary. His choice of Bessent went against the opinion of billionaire Elon Musk, who is co-leading Trump’s advisory panel known as the “Department of Government Efficiency” initiative. The head of Tesla and SpaceX posted on his social media site X before Trump’s selection that Bessent would be “a business-as-usual choice.” The pick also showed the internal tensions of a candidate who won by appealing to blue-collar voters but who depends on an administration staffed by those, who like Trump, enjoy a life of extreme wealth. Senate Finance Committee Chair Ron Wyden, D-Ore., was unimpressed by Bessent. “Donald Trump pretends to be an economic populist, but it wouldn’t be a Trump Treasury Department without a rich political donor running the show,” Wyden said in a statement rushed out immediately after the announcement Friday evening. “When it comes to the economy, the government under Trump is of, by, and for the ultra-wealthy.” Bessent caught Trump’s attention during the campaign with his ideas for 3% growth, a reduced budget deficit equal to 3% of gross domestic product and 3 million additional barrels a day of oil production. Larry Kudlow, the TV host and a director of the White House National Economic Council during Trump’s initial term, supported him. But critics in Trump’s orbit said Bessent was weak on tariffs. Another onetime contender, Howard Lutnick, the billionaire CEO of the investment firm Cantor Fitzgerald, was more pro-tariffs but less reassuring to some business leaders. Trump picked him to head the Commerce Department and take the lead on trade issues. Trump also looked at other candidates, including former Federal Reserve governor Kevin Warsh, Marc Rowan, the chief executive of Apollo Global Management, and Sen. Bill Hagerty, R-Tenn. Trump’s decision on his treasury chief is tied in part to most Republican voters’ biggest motivation for returning him to the White House: the state of the U.S. economy and the pressure from high prices. According to AP VoteCast , an early November survey of about 120,000 voters nationwide, about 3 in 10 voters said they wanted total upheaval in how the country is run. Bessent has been deeply critical of President Joe Biden’s economic policies, saying in remarks at the conservative Manhattan Institute that he was “alarmed” by the size of government spending and deficits and that Biden had embraced a “central planning” mindset that he thought belonged on “the scrap heap of history.” Biden, for his part, chose Janet Yellen, the former Federal Reserve chair, to be his treasury secretary, relying on her credibility as an economist as his administration successfully pushed for $1.9 trillion in pandemic aid in 2021. But inflation jumped as the United States recovered from pandemic shutdowns, driven by supply chain challenges, global conflict and — according to Biden administration critics — an excessive amount of pandemic aid. Government officials and economists are uncertain about what Trump would prioritize. The Republican campaigned on jacking up tariffs against China and other trade partners. But people in his economic orbit privately insist that what he cares about are fair terms in which other countries such as China don’t disadvantage the United States by subsidizing industries, manipulating currencies and suppressing their own workers’ wages. The president-elect wants to extend and expand his 2017 tax cuts, many of which are set to expire after 2025. He’s also proposed an array of tax cuts, such as no taxes on tips or overtime pay or Social Security benefits, that would create possible deficit increases. The Committee for a Responsible Federal Budget, an independent fiscal watchdog, estimated that Trump could possibly add between $1.7 trillion to $15.6 trillion to projected deficits over 10 years, a sign of the uncertainty regarding his economic plans. The economist Olivier Blanchard, a senior fellow at the Peterson Institute for International Economics, this week laid out the contradictions of “Trumponomics.” Deficit-funded tax cuts and tariff hikes could be inflationary, yet Trump won November’s election in large part because of voter frustration with inflation. There’s also his promise of deportations of unauthorized immigrants that could lower employment, though it’s not clear what Trump will do once in office. “The U.S. should be thinking about reducing the deficit, quite apart from Trump,” Blanchard said in a webcast. “Trump is probably going to make it worse.” Trump’s treasury secretary might ultimately face the additional responsibility of trying to pressure Fed Chair Jerome Powell to do as Trump wants, since the inflationary pressures outlined by Blanchard likely mean the Fed would try to slow growth to keep inflation from overheating, likely upsetting Trump. “The risk of a conflict between the Trump administration and the Fed is very high,” Blanchard said in a webcast.
Dorocubicel is under clinical development by ExCellThera and currently in Phase II for Myelodysplastic Syndrome. According to GlobalData, Phase II drugs for Myelodysplastic Syndrome have a 30% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Dorocubicel overview Dorocubicel (ECT-001) cell therapy is under development for the treatment of blood cancers, multiple myeloma, anemia, relapsed and refractory acute myeloid leukemia, relapsed and refractory acute lymphoid leukemia, relapsed myelodysplastic syndrome, chronic myelogenous leukemia, lymphoma. It is administered through intravenous route. The ECT-001 technology is a combination of a small molecule, UM171, and an optimized culture system expanding cord blood. It was also under development for the treatment of graft versus host disease (GVHD, blood cancer, thalassemia, sickle cell disease, Crohn's disease, colitis, autoimmune diseases, inflammatory diseases and metabolic diseases. ExCellThera overview ExCellThera is a biotechnology company that develops molecules and bioengineering solutions to treat hematologic disorders and malignancies by expanding stem and immune cells. It is investigating hematopoietic stem cell (HSC) based cell and gene therapies in the fields of oncology, hematology, and immunology. The company utilizes its ECT-001 cell therapy technology that integrates a proprietary small molecule and UM171 cell therapy used to treat blood cancers, including leukemias and myelodysplasias. It operates its offices in Canada. ExCellThera is headquartered in Montreal, Quebec, Canada. For a complete picture of Dorocubicel’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .AP News Summary at 5:25 p.m. EST
Nelistotug by GSK for Recurrent Head And Neck Squamous Cell Carcinoma: Likelihood of ApprovalHARRISBURG — Pennsylvania’s 2023-24 Legislative Session closed Dec. 1 and the next session, while officially underway, doesn’t fully begin until lawmakers are sworn into office Jan. 7. Looking back, members of the state House and Senate introduced 3,862 bills and 924 resolutions across the two-year session. There were 77 bills adopted into law in 2023 and 162 adopted in 2024. The combined total of 239 was far fewer than the previous six legislative sessions. There hasn’t been a lower total since 2009-10 when 226 bills advanced into law — the last time the Pennsylvania General Assembly had a partisan divide. Democrats controlled the House while Republicans led the Senate. Gov. Josh Shapiro, a Democrat, often cites the challenge of advancing legislation with a split government. That dynamic won’t change in 2025-26. Though there are 20 new members joining the Legislature — 16 in the House, four in the Senate — the respective parties defended their majorities. Republicans have a 28-22 advantage in the Senate while Democrats maintained a 102-101 margin in the House. This week, The Daily Item will offer look back at the outcome of legislation proposed last session by area lawmakers, the latest in the series features Jamie Flick, a Republican from the 83rd Legislative District. Flick, a Republican, returns to the Pennsylvania House in the 2025-26 Legislative Session for a second term. Flick ran unopposed in both the primary and general elections to represent the 83rd Legislative District which consists of parts of Lycoming and Union counties. His committee assignments during the 2023-24 session were Children & Youth, Game & Fisheries, Government Oversight, Human Services and Tourism & Economic & Recreational Development. He also served on the Subcommittee on Mental Health. Flick sponsored a combined 186 bills and resolutions in his first and only term, of which he introduced six bills and two resolutions as a prime sponsor. One of his bills advanced to the Senate and returned to the House for concurrence on amendments but ultimately none became law. One of Flick’s bills proposed to improve reimbursement paid to ambulance services for mileage, eliminating a rule that reimbursement didn’t begin until after 20 miles traveled with a patient. It advanced out of the House and passed through the Senate, too, but Republicans in the upper chamber amended the bill during 2023 budget negotiations in an attempt to adopt the school voucher-style program, Pennsylvania Award for Student Success Scholarship Program. The bill went no further and PASS remains a priority initiative for Republicans in the new session, however, lawmakers adopted a different bill into law with the same initial objective sought by Flick — it eliminated the 20-mile rule. Another proposal from Flick sought to create equality in time shared between parents and children under child custody agreements and eliminated “language that assumes the ‘custodial and noncustodial parent’ model of split custody.” He also proposed bills to waive the bachelor’s degree requirement to address Pennsylvania’s shortage of substitute teachers, remove Lycoming County from the commonwealth’s Vehicle Emissions Inspection and Maintenance Program, shift how county president judges are chosen to a majority vote of county judges rather than seniority, and make calibration requirements uniform for all police radar, speedometers and electronic timing devices. Flick voted against each budget adopted last session but he also championed the idea of bipartisanship in the State Capitol, helping form the “Meet Me in the Middle” Caucus to bring together lawmakers from across the aisle. He supported efforts to enable a ballot referendum on universal voter ID, voted to support the approved enhancement of Pennsylvania’s Property Tax and Rent Rebate Program for seniors, supported funding for state-related universities including Penn State’s, opposed Gov. Josh Shapiro’s directive to change voter registration at PennDOT locations from an “opt-in” program to an “opt-out program,” and voted in favor of a marriage equality bill.Israeli hospital says Netanyahu has undergone successful prostate surgeryNone
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President Claudia Sheinbaum and Mexico’s 32 governors signed a National Human Right to Water Agreement on Monday, a pact that aims to ensure equal access to water for Mexico’s public while also increasing agricultural and industrial efficiency and sustainability. The private sector joined as a voluntary participant, committing to cede contractual rights to at least 126 million cubic meters of water and promising to invest 21 billion pesos (more than US $1 billion) in infrastructure and technology improvements. Federal water districts and irrigation sectors have also agreed to cede control over 2.8 billion cubic meters of water. During the signing ceremony, Efraín Morales, director of Mexico’s National Water Commission (Conagua), said the accord seeks to “move past the mercantilist vision of water and recognize it as a human right and a strategic asset.” President Sheinbaum and other speakers at the event emphasized the need to recognize the intrinsic link between social equality, economic growth and the environment. “We must no longer view water as a commodity. It is a right,” Sheinbaum said, according to Radio Fórmula . “Every Mexican should have access to adequate water ... We must guarantee sufficient water for food production, for social and industrial development ... and institute a plan that provides sustainability and equitable development for the long term.” The agreement is derived from the government’s National Water Plan 2024–2030 — presented by Sheinbaum at her press conference last Thursday, a federal initiative to reassess hundreds of thousands of Mexico’s water concessions, clean up some of Mexico’s most polluted rivers, improve agricultural irrigation technology available to the nation’s farmers, and build water infrastructure projects – including a desalination plant in Baja California and flood mitigation projects in Mexico’s flood-prone southeast. The historic accord signed Monday by Mexico’s governors recognizes access to water as a human right, declares water a national asset and outlines benchmarks for sustainability, as well as reclamation and purification. “This agreement is just the beginning of a permanent effort to ensure Mexico has a sustainable and equitable future with regard to water,” Morales said, according to the magazine Fortuna. The pact includes plans to reinforce the nation’s hydraulic infrastructure, sets standards for water treatment plants, conserves and protects wetlands, establishes river cleanup projects and promotes reforestation and forest conservation endeavors. Last year, Conagua’s Drought Monitor indicated that more than 80% of Mexico’s territory is facing a water crisis, one that, according to the newspaper La Jornada, affects more than 35 million people. Last year, Mexico City’s water supplies were so low that the global press was talking about a “Day Zero” when the metropolis would run out of water . The drought is threatening 104 of the nation’s 757 drainage basins. In addition, of Mexico’s 653 aquifers, 114 are overexploited, according to Conagua. Plus, two-thirds of sites that Conagua monitors were classified as contaminated or heavily contaminated last year. “It is past time that we manage water more efficiently, that we incentivize treatment and re-use,” Environment Minister Alicia Bárcena told La Jornada. “The willingness to participate voluntarily is a great sign, and it should result in more productive agricultural and industrial sectors while also ensuring a more equitable distribution.” In addition to the give-back from the private sector, Sheinbaum said water contracts for industrial use would also be restricted and even restructured, the news outlet Infobae reported. Going forward, concessions would strictly prohibit alternate uses of water that do not benefit the public. With reports from Fortuna , Radio Fórmula , Infobae and La JornadaNC State and East Carolina meet in next season's opener. But first, the Military Bowl
Bennacer: Milan need to recover ‘winning spirit’Atlantic Liberal caucus calls for Trudeau's resignation in letterUTAH VALLEY 77, WEST GEORGIA 74
