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REIFFTON – Coach Calvin Everett was right. This isn’t the same Harrisburg Cougars assembly who opened the season with myriad questions and a lopsided defeat. Fortunately, the same defense that helped lean the Cougars toward another District 3 football title showed up Saturday at Don Thomas Stadium. • Sign up for PennLive’s daily high school sports newsletter Messiah Mickens scored twice and quarterback Jaiyon Lewis connected with Quincy Brannon and Elias Coke for touchdowns as Harrisburg slammed Wilson 42-14 to claim the program’s fourth consecutive 6A championship. The Bulldogs trailed 21-0 midway through the second quarter and was allowed minimal yardage no matter down and distance throughout. Mickens, from his post on the edge, registered three of Harrisburg’s four sacks, keeping talented Bulldogs QB Madyx Gruber busy throughout. And Wilson’s rushing attack? Doug Dahms’ troops carried 30 times for 37 yards. The Cougars (11-2) will travel West to meet WPIAL champion Pittsburgh Central Catholic in the state semifinal round. A venue and time will be announced. The Vikings dispatched State College 41-19 Friday in Altoona. The stars Coke provided a handful of big plays, including a 37-yard TD reception from in Harrisburg’s dominating third quarter. The Cougars rang up 21 points in just over a four-minute span to overwhelm the Bulldogs. D’Antae Sheffey’s 10-yard scoring run, which followed Wilson’s failed fake punt at its own 10, and Brannon’s 30-yard touch pass from Lewis added to the highlights. Earlier, RB Nehemiah Ewell’s 52-yard TD run helped the Cougars secure a 21-6 halftime edge. Lewis was 7 of 9 for 168 yards. Coke, who finished with three catches and 111 yards, was injured late in the third quarter while making a stop on Gruber’s scramble out of the pocket. Coke did not return. • What went into Harrisburg’s fourth straight D3 title? Brannon added 57 receiving yards. Gruber, meanwhile, was 12 of 20 with a pair of interception, one each by Trays Walker and Keijuan Sinkler. Walker’s pick came in the Harrisburg end zone on Wilson’s fourth-and-goal attempt in the second quarter. Game-winning moment Following Walker’s interception, Sheffey rushed three straight times for a combined 28 yards to push the Cougars near midfield. After a timeout, Ewell shot through the line of scrimmage and outraced the Bulldogs for a 21-0 edge. A sack by Mickens on Wilson’s third play of the second half handed possession right back to the Cougars. This time, Lewis found Coke to put the Bulldogs out of reach. They said it: “I saw green. I was reading the linebacker the whole team and he overflowed. I was out. Honestly, this title feels greater than the others. Earlier in the season, we lost my right hand, Shawn Lee Jr., and everybody knew it was going to be more difficult for us. Everybody doubted us, but I told them we have the pieces to the puzzle and we’re going to make it work.” – Harrisburg RB-LB Nehemiah Ewell “Our guys are, well, their emotions are running wild right now. This was an intense game, but we’ll come down and focus and be ready for next week.” – Harrisburg coach Calvin Everett Wilson 0-6-0-8 – 14 Harrisburg 7-14-21-0 – 42 First quarter H-Messiah Mickens 7 run (Gideon Fasanya kick), 2:59 Second quarter H-Mickens 4 run (Fasanya kick), 11:54 H-Nehemiah Ewell 52 run (Fasanya kick), 4:22 W-Madyx Gruber 1 run (kick failed), :14 Third quarter H-Elias Coke 37 pass from Lewis (Fasanya kick), 8:12 H-D’Antae Sheffey 10 run (Fasanya kick), 6:42 H-Quincy Brannon 30 pass from Lewis (Fasanya kick), 3:59 Fourth quarter W-Michael Glover 22 pass from Gruber (Monty Greer run), 10:56 Team statistics W H First downs: 13 13 Rush-yards: 30-37 30-143 Passing: 130 168 Comp-Att-Int: 13-21-2 7-10-0 Fumbles-lost: 0-0 0-0 Punts-Avg.: 3-34.5 0-0 Penalties-yards: 6-62 3-22 Individual statistics RUSHING: Wilson, Monty Greer 6-37, Correll Akings 10-24, Madyx Gruber 13-(minus-8), Team 1-(minus-16); Harrisburg, Nehemiah Ewell 1-52, D’Antae Sheffey 5-38, Messiah Mickens 8-34, Ja’auan Johnson 10-12, Jaiyon Lewis 4-7, Team 1-0. PASSING: Wilson, Gruber 12-20-2—134, Christo Hunsicker 1-1-0—(minus-4); Harrisburg, Lewis 7-10-0—168, Mikal Shank Jr. 0-1-0—0. RECEIVING: Wilson, Monty Greer 2-26, Christo Hunsicker 3-24, Correll Akings 3-27, Cam Zullinger 2-23, Michael Glover 1-22, Brady Kline 1-12, Ethan Harding, 1-(minus-4); Harrisburg, Elias Coke 3-111, Quincy Brannon 4-57. Follow Eric Epler on X/Twitter — @threejacker Thanks for visiting PennLive. Quality local journalism has never been more important. We need your support. Not a subscriber yet? Please consider supporting our work. ©2024 Advance Local Media LLC. Visit pennlive.com . Distributed by Tribune Content Agency, LLC.

Louisville wastes early lead, holds off Eastern Kentucky

Major change to Aussie passports coming within days Aussie passport price rises a second time in six months Latest rise slammed by Opposition as 'backdoor tax grab' READ MORE: Lily was told her Etihad flight back to Australia was overbooked and there was no space. Then staff found her a seat... but there was a glaring issue By PADRAIG COLLINS FOR DAILY MAIL AUSTRALIA Published: 12:11, 29 December 2024 | Updated: 12:12, 29 December 2024 e-mail View comments Time is running out for Aussies to renew or apply for a passport before yet another price hike comes into effect on January 1 . The latest increase, which has been slammed as a 'backdoor tax grab' will make a standard 10-year Australian passport the most expensive in the world at $412. The $14 increase, which comes into effect this Wednesday follows a previous rise of 15 per cent just six months ago . Passport fees have risen by a cumulative $104 since the Albanese government for elected to power in May 2022. The cost for a five year passport for children and seniors aged over-75, will also go up from $201 to $208 on January 1. If you lose your passport, the cost of a replacement will rise from $250 to $259. Opposition foreign affairs spokesman Simon Birmingham branded the latest hike is 'over the top revenue raising' that will increase the cost of an overseas trip and add to the cost of living crisis. He also accused the Labor government is 'ringing in the new year with another tax grab'. Australians have just two days to renew their passport before a second price hike within six months is enforced on January 1. Travellers at Sydney Airport is pictured 'Many Australians scrimp and save to afford a special holiday to Bali or Fiji , only to find the cost of a passport is similar to the cost of an airfare,' Senator Birmingham said on Sunday. 'Under Labor, Australians are paying record sums for the privilege of a passport that should be a basic entitlement, not an expensive luxury. 'What the Albanese government labelled as a 'modest' increase to passport fees can now clearly be seen for the backdoor tax grab that is it.' It's estimated that the last rise on July 1 will result in $924.5million in revenue, with more than half ($529million being profit to the federal government. 'Rather than responsible cost recovery, the Albanese government is engaging in gross profiteering through the pushing up of passport fees, charging significantly more than the cost of production,' Senator Birmingham added. 'This over the top revenue raising on a government issued document is just another demonstration of how Australians are being made to pay for Labor's out of control spending.' A Department of Foreign Affairs and Trade spokesperson defended the price hike, telling NewsCorp that annual indexation was a legislative requirement. 'The Australian passport is respected internationally as a high-quality travel document,' they said. 'It has a high level of technological sophistication, backed by rigorous anti-fraud measures, which ensures its integrity. This is a key reason why Australian passport holders receive visa-free access to over 180 countries.' It's just one of a raft of changes set to come into effect on January 1. A young woman is pictured holding her Australian passport, which is now the most expensive in the world Be the first to comment Be one of the first to comment Comments What you do you think of the latest passport fee hike? Comment now Read More Centrelink student boost, bans on plastic straws and gas rules: All the changes coming on January 1 Despite it being the most expensive in the world, a young woman recently exposed flaws in her new Australian passport, describing it as 'flimsy' and low quality . Natalie Vellozzi, 28, posted a video to social media where she compared her old and new passports and accused the government of skimping on quality. 'The quality definitely does not match the price of this passport,' she said. After the Sydney woman put both passports next to each other, the difference could be seen straight away, with the new one's cover curving upwards. Natalie Vellozzi, 28, (pictured) compared her new passport (left) with her old one (right) and found the new model 'flimsy' 'This is my old passport I have had for 10 years. It is definitely better quality,' Ms Vellozzi said. 'This new one looks like it was literally printed at Officeworks. I've had it for one day and it is already warping, it's already bending.' But DFAT trumpeted the new R series passport upon its launch in 2023, boasting it was manufactured in Australia. 'The next-generation passport is packed with advanced security features designed to keep Australians' identities safe,' a spokesperson said. But since its release, questions have been raised about the expensive document's quality. 'Maybe the material they're using is different,' Ms Vellozzi said. 'But I just noticed as soon as I got it, it was already curling and bending over. 'When they made it and bound it together, they're not putting enough weight on it to flatten it properly.' 'In the previous passport it was laminated paper and now I just feel it will snap.' Australian passports are ranked as the fifth most powerful internationally, according to the 2024 Henley Passport Index. Share or comment on this article: Major change to Aussie passports coming within days e-mail Add comment

GCC-4001 is under clinical development by Artiva Biotherapeutics and currently in Phase II for Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma). According to GlobalData, Phase II drugs for Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma) have a 17% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. GCC-4001 overview GCC-4001 (AB-101) is under development for the treatment of rheumatoid arthritis, systemic lupus erythematosus, pemphigus vulgaris, granulomatosis with polyangiitis and microscopic polyangiitis, B-cell non-Hodgkin lymphoma, relapsed or refractory chronic lymphocytic leukemia, diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, follicular lymphoma, Waldenstrom Macroglobulinemia, peripheral T-cell lymphomas (PTCL), angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma (ALCL), R/R classical Hodgkin lymphoma, lupus nephritis (LN) and autoimmune disorders. The therapeutic candidate is an allogeneic, non-engineered, cord blood-derived natural killer (NK) cell therapy. It is administered through intravenous route and is being developed based on AlloNK platform. Artiva Biotherapeutics overview Artiva Biotherapeutics is a biotechnology company developing allogeneic natural killer (NK) cell therapies to treat hematologic cancers or solid tumors. It is investigating AB-101, an allogeneic NK cell therapy used for the treatment of B-cell malignancies; AB-201, a CAR-NK (chimeric antigen receptor-modified natural killer) cell therapy targeting HER2 positive solid tumors; and AB-202 against CD19 positive B-cell malignancies. Artiva Biotherapeutics utilizes its proprietary CAR (chimeric antigen receptor) platform to improve NK cells’ therapeutic activity and tumor-targeting capability. Artiva Biotherapeutics is headquartered in San Diego, California, the US. For a complete picture of GCC-4001’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .

Dieter Kurtenbach: The end of the 49ers’ season is a referendum on Brock Purdy

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Though the Carolina Panthers don't play the Dallas Cowboys until Sunday, they have already earned one notable achievement this week. For the first time in exactly two years , the Panthers are favored to win an NFL game. That's right: the Panthers, who are 2.5-point favorites against Dallas, have previously been underdogs in every single one of their past 33 matchups. The last time they were favored was Week 15 of the 2022 season, when they played the Pittsburgh Steelers and promptly lost 24-16. With the Cowboys decimated by injuries while the Panthers have been markedly more competitive in recent weeks, this seems a good time for that streak to end. Carolina has taken one-possession losses in each of its past three contests , all to playoff-level opponents. Quarterback Bryce Young, the top overall pick in the 2023 NFL Draft, has finally begun to show signs of living up to his hype while Chuba Hubbard has been a revelation in the backfield this season. For the first time in several seasons, it seems as if there may be hope for the future in Carolina. If the Panthers win and cover the spread on Sunday, it will be the first time they've done so as favorites since September of 2021 against the Houston Texans . The Panthers won that Week 3 matchup 24-9, improving them to 3-0 on the season. That may have been the last time they were considered a competitive franchise. Attention regarding football in North Carolina this week is mostly centered around legendary coach Bill Belichick's surprising move to Chapel Hill. But it could be the Panthers who are slowly climbing out of the darkness.

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Two high school students and their families sued their high school and school district, alleging violations of their First and Fourteenth Amendment rights as well as Title IX protection. A California high school caved to a student uprising after hundreds of students showed up wearing T-shirts that read "Save Girls' Sports" to protest a trans athlete on the cross-country team, defying the school's latest dress code. The school had previously put students in detention for wearing the shirts. But a source told Fox News Digital that the school did not dress-code students when they showed up wearing the shirts on Wednesday. Parents of the school's students provided an update to California Family Council outreach director Sophia Lorey, claiming that administrators had a meeting Wednesday morning where faculty was instructed not to dress-code students, Lorey told Fox News Digital. "Today students once again wore their ‘Save Girls Sports’ shirts," Lorey wrote to Fox News Digital. "According to the email sent out earlier this week from MLK HS Principal Leann Iacuone only the shirts that stated ‘XX=/XY’ should receive a dress code. Yet, as of now no student who is wearing that shirt today has received a dress code. I received information that there was a staff meeting today before school were the staff was told not to dress code." CLICK HERE FOR MORE SPORTS COVERAGE ON FOXNEWS.COM Lorey added that students at neighboring schools have begun to wear the T-shirts as Martin Luther King's situation has garnered national attention. These schools include Arlington High School and Riverside Polytechnical High School, which share a school district with Martin Luther King. Ramona High School in Ramona, California, which is 83 miles south of Riverside, has also seen its students wear the shirts. The students have worn the shirts every Wednesday, resulting in discipline by school administrators. But detention and dress code violations never shuttered their spirit. Many students at the school have gone viral on social media by sharing details of the situation with photos and videos of them wearing the shirts. The student uprising came amid an ongoing lawsuit over two girls' cross-country runners who alleged their T-shirts were compared to swastikas by school administrators. Another student athlete on the school's cross-country team, Rylee Morrow, brought more national attention to the situation when she gave an impassioned speech at a school board meeting in November in a clip that went viral due to her conveyed fears of having to share a locker room with a biological male. Lorey commended the students for taking a stand and pushing the school district to withdraw its discipline on Wednesday. "By wearing their ‘Save Girls Sports’ shirts, these young leaders are showing that they won’t back down in the face of pressure or opposition - even from their own administration. It’s not just about athletics—it’s about standing up for the integrity and rights of female athletes everywhere," Lorey wrote. But anti-trans messaging isn't the only social media activity that has erupted from the school. SJSU TRANSGENDER VOLLEYBALL SCANDAL: TIMELINE OF ALLEGATIONS, POLITICAL IMPACT AND A RAGING CULTURE MOVEMENT On Wednesday, a trans athlete at the school allegedly made a private post on Instagram lashing out against detractors who have questioned and opposed trans inclusion on the school's girls' cross-country team. Multiple sources, including Lorey, have confirmed the message was posted to the athlete's private Instagram story. The athlete also allegedly expressed an intention to compete in girls' pole-vaulting and said that competing against male opponents resulted in disappointing finishes. In a statement previously provided to Fox News Digital, the Riverside Unified School District (RUSD) said it has allowed the transgender athlete to compete on the team because it must comply with California state law. "It is important to remember that RUSD is bound to follow California law which requires that students be 'permitted to participate in sex-segregated school programs and activities, including athletic teams and competitions consistent with his or her gender identity, irrespective of the gender listed on the pupil’s records,'" the statement said. "While these rules were not created by RUSD, the district is committed to complying with the law and CIF regulations. California state law prohibits discrimination of students based on gender, gender identity and gender expression and specifically prohibits discrimination on the basis of gender in physical education and athletics. The protections we provide to all students are not only aligned with the law but also with our core values, which include equity and well-being." The school said those who are upset by it should direct their anger to state and federal lawmakers. "As these matters play out in our courts and the media, opposition and protests should be directed at those in a position to affect those laws and policies, including officials in Washington, D.C., and Sacramento," the statement said. California has had laws in effect to protect transgender athletes in women's sports since 2014. That year, AB 1266 took effect , giving California students at scholastic and collegiate levels the right to "participate in sex-segregated school programs and activities, including athletic teams and competitions, and use facilities consistent with his or her gender identity, irrespective of the gender listed on the pupil’s records." Other high school and college students in California have expressed opposition to trans athletes in girls' sports. CLICK HERE TO GET THE FOX NEWS APP Students at Martin Luther King High School in Riverside, Calif., wear T-shirts with a slogan that says "Save Girls' Sports" to protest a trans athlete on the cross-country team. (Courtesy of Sophia Lorey) The girls' volleyball team at Stone Ridge Christian High School in Merced was scheduled to face San Francisco Waldorf in the Northern California Division 6 tournament in November, but it forfeited in an announcement just before the match over the presence of a trans athlete. Those girls were commended at a ceremony held by women's athletic rights activist Riley Gaines at their own high school on Dec. 4. Meanwhile, another California transgender high school volleyball player was booed and harassed at an Oct. 12 match between Notre Dame Belmont and Half Moon Bay High School, according to ABC 7. Half Moon Bay rostered the transgender athlete. At the college level, San Jose State's volleyball team was at the center of a national media firestorm this season over the presence of a transgender athlete on the team and a teammate being involved in multiple lawsuits over the issue. The team saw eight of its matches forfeited, including a conference tournament match, amid the controversy, which only brought more national attention to the team as it made it all the way to the Mountain West championship game. Follow Fox News Digital’s sports coverage on X and subscribe to the Fox News Sports Huddle newsletter . Jackson Thompson is a sports writer for Fox News Digital. He previously worked for ESPN and Business Insider. Jackson has covered the Super Bowl and NBA Finals, and has interviewed iconic figures Usain Bolt, Rob Gronkowski, Jerry Rice, Troy Aikman, Mike Trout, David Ortiz and Roger Clemens.

Giants release quarterback Daniel Jones just days after benching him EAST RUTHERFORD, N.J. (AP) — The Daniel Jones era in New York is over. The Giants quarterback was granted his release by the team just days after the franchise said it was benching him in favor of third-stringer Tommy DeVito. New York president John Mara said Jones approached the team about releasing him and the club obliged. Mara added he was “disappointed” at the quick dissolution of a once-promising relationship between Jones and the team. Giants coach Brian Daboll benched Jones in favor of DeVito following a loss to the Panthers in Germany that dropped New York's record to 2-8. Conor McGregor must pay $250K to woman who says he raped her, civil jury rules LONDON (AP) — A civil jury in Ireland has awarded more than $250,000 to a woman who says she was raped by mixed martial arts fighter Conor McGregor in a Dublin hotel penthouse after a night of heavy partying. The jury on Friday awarded Nikita Hand in her lawsuit that claimed McGregor “brutally raped and battered” her in 2018. The lawsuit says the assault left her heavily bruised and suffering from post-traumatic stress disorder. McGregor testified that he never forced her to do anything and that Hand fabricated her allegations after the two had consensual sex. McGregor says he will appeal the verdict. Week 16 game between Denver Broncos and Los Angeles Chargers flexed to Thursday night spot The Los Angeles Chargers have played their way into another prime time appearance. Justin Herbert and company have had their Dec. 22 game against the Denver Broncos flexed to Thursday night, Dec. 19. Friday’s announcement makes this the first time a game has been flexed to the Thursday night spot. The league amended its policy last season where Thursday night games in Weeks 13 through 17 could be flexed with at least 28 days notice prior to the game. The matchup of AFC West division rivals bumps the game between the Cleveland Browns and Cincinnati Bengals to Sunday afternoon. NBA memo to players urges increased vigilance regarding home security following break-ins MIAMI (AP) — The NBA is urging its players to take additional precautions to secure their homes following reports of recent high-profile burglaries of dwellings owned by Milwaukee Bucks forward Bobby Portis and Kansas City Chiefs teammates Patrick Mahomes and Travis Kelce. In a memo sent to team officials, a copy of which was obtained by The Associated Press, the NBA revealed that the FBI has connected some burglaries to “transnational South American Theft Groups” that are “reportedly well-organized, sophisticated rings that incorporate advanced techniques and technologies, including pre-surveillance, drones, and signal jamming devices.” Brock Purdy will miss Sunday's game for the 49ers with a shoulder injury SANTA CLARA, Calif. (AP) — San Francisco 49ers quarterback Brock Purdy will miss Sunday’s game against the Green Bay Packers with a sore throwing shoulder. Purdy injured his right shoulder in last Sunday’s loss to the Seattle Seahawks. Purdy underwent an MRI that showed no structural damage but the shoulder didn’t improve during the week and Purdy was ruled out for the game. Coach Kyle Shanahan said star defensive end Nick Bosa also will miss the game with injuries to his left hip and oblique. Left tackle Trent Williams is questionable with an ankle injury and will be a game-time decision. Red Bull brings wrong rear wing to Las Vegas in mistake that could stall Verstappen's title chances LAS VEGAS (AP) — Max Verstappen is suddenly in jeopardy of being denied a fourth consecutive Formula 1 title Saturday night. Red Bull apparently brought the wrong rear wing to Las Vegas and GPS data showed its two cars to be significantly slower on the straights than both McLaren and Mercedes, which led both practice sessions. Red Bull says it doesn’t have a replacement rear wing in Las Vegas to fix the issue and little chance of getting two flown in from England ahead of the race. Lawyer says ex-Temple basketball standout Hysier Miller met with NCAA for hours amid gambling probe PHILADELPHIA (AP) — A lawyer for former Temple basketball standout Hysier Miller says the 22-year-old sat for a long interview with the NCAA amid an investigation into unusual gambling activity. But neither the lawyer nor federal law enforcement officials on Friday would confirm reports that a federal probe is now under way. Lawyer Jason Bologna says Miller cooperated because he hopes to play again. Miller was released last month after transferring to Virginia Tech. Temple President John Fry says the Philadelphia school has not been asked for any information from federal law enforcement officials. Caitlin Clark to join Cincinnati bid for 16th National Women's Soccer League team WNBA star Caitlin Clark has joined Cincinnati’s bid for an expansion National Women’s Soccer League team. Major League Soccer franchise FC Cincinnati is heading the group vying to bring a women’s pro team to the city. The club issued a statement confirming Clark had joined the bid group. NWSL Commissioner Jessica Berman has said the league plans to announce the league’s 16th team by the end of the year. The league's 15th team will begin play in 2026 in Boston. Alyssa Nakken, first full-time female coach in MLB history, leaving Giants to join Guardians CLEVELAND (AP) — Alyssa Nakken, the first woman to coach in an MLB game, is leaving the San Francisco Giants to join the Cleveland Guardians. Nakken made history in 2022 when she took over as first-base coach following an ejection. A former college softball star at Sacramento State, Nakken joined the Giants in 2014 and was promoted to a spot on manager Gabe Kapler’s staff in 2020, becoming the majors’ first full-time female coach. Nakken has been hired as an assistant director within player development for the Guardians, who won the AL Central last season under first-year manager Stephen Vogt. Nakken, 34, will work with former Giants coaches Craig Albernaz and Kai Correa. Aaron Judge won't be bothered if Juan Soto gets bigger contract from Yankees than his $360M deal NEW YORK (AP) — Aaron Judge won’t be bothered if Juan Soto gets a bigger deal from the New York Yankees than the captain’s $360 million, nine-year contract. Speaking a day after he was a unanimous winner of his second MVP, Judge says “It ain’t my money” and adds "that’s never been something on my mind about who gets paid the most.” Judge led the major leagues with 58 homers, 144 RBIs and 133 walks while hitting .322. Soto batted .288 with 41 homers, 109 RBIs and 129 walks in his first season with the Yankees, then became a free agent at age 26.

Pure Storage Announces Third Quarter Fiscal 2025 Financial ResultsAidan O'Connell threw two touchdown passes, Daniel Carlson kicked four field goals, Ameer Abdullah had the first 100-yard rushing game of his career and the visiting Las Vegas Raiders defeated the New Orleans Saints 25-10 on Sunday afternoon. Abdullah, playing in the 141st game of his 10-year career, finished with 115 yards on 20 carries. O'Connell completed 20 of 35 passes for 242 yards as the Raiders (4-12) won their second straight after a 10-game losing streak. Brock Bowers added seven receptions for 77 yards, giving him 1,144 receiving yards, which broke the NFL single-season record for a rookie tight end, set by Mike Ditka with 1,076 yards in 14 games in 1961. Rookie Spencer Rattler passed for 218 yards with a touchdown and two interceptions and fell to 0-5 as the starter for the Saints (5-11). Las Vegas's first possession of the third quarter resulted in Carlson's 54-yard field goal, which increased its lead to 16-10 at the end of the period. Carlson's 25-yard field goal pushed the lead to 19-10 on the third play of the fourth quarter. O'Connell added an 18-yard touchdown pass to Tre Tucker to complete the scoring. The Raiders received the opening kickoff and held the ball for 17 plays before stalling. Carlson kicked a 31-yard field goal and the 3-0 lead held up through the end of the first quarter. On the first play of the second quarter, Rattler threw a 30-yard touchdown pass to former Raiders tight end Foster Moreau and the Saints took a 7-3 lead with their first points in the first half in three games. The ensuing possession ended with Carlson kicking a 39-yard field goal that trimmed the lead to 7-6. O'Connell threw a 3-yard touchdown pass to Jakobi Meyers to give Las Vegas a 13-7 lead with 57 seconds left in the second quarter. Rattler completed 5 of 7 for 54 yards in driving New Orleans to Blake Grupe's 34-yard field goal as time expired that trimmed the lead to 13-10 at halftime. --Field Level Media

(Azacitidine + cedazuridine) is under clinical development by Taiho Oncology and currently in Phase III for Chronic Myelomonocytic Leukemia (CMML). According to GlobalData, Phase III drugs for Chronic Myelomonocytic Leukemia (CMML) have a 57% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. (Azacitidine + cedazuridine) overview ASTX-030, a fixed dose combination of azacitidine and cedazuridine is under development for the treatment of myelodysplastic syndromes (MDS), chronic myelocytic leukemia (CML), refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, chronic myelomonocytic leukemia (CMML), and acute myeloid leukemia (AML). It is administered by oral route. It acts by targeting DNA (cytosine 5) methyltransferase 1 and cytosine deaminase (CDA). The drug candidate is being developed based on Pyramid technology. Taiho Oncology overview Taiho Oncology, a subsidiary of Taiho Pharmaceutical Co Ltd, is a provider of cancer treatments and solutions. The company manufactures and markets cancer anti-metabolites as well as targeted small molecule inhibitors. Its products portfolio includes oral drugs for the treatment of gastric cancer, colorectal cancer and a variety of solid tumours. Taiho Oncology’s pipeline products includes anti metabolic agents and selectively targeted agents. The company’s LONSURF is an anti-cancer drug for the treatment of metastatic colorectal cancer. Taiho Oncology is headquartered in Princeton, New Jersey, the US. For a complete picture of (Azacitidine + cedazuridine)’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .